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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

KGD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).3 Publications

Miscellaneous

Present with 14300 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Activity regulationi

Catabolite repressed.

GO - Molecular functioni

  • oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GO_Central
  • thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  • 2-oxoglutarate metabolic process Source: SGD
  • tricarboxylic acid cycle Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandThiamine pyrophosphate

Enzyme and pathway databases

BioCyciYEAST:YIL125W-MONOMER
ReactomeiR-SCE-389661 Glyoxylate metabolism and glycine degradation
R-SCE-71064 Lysine catabolism
R-SCE-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:KGD1
Synonyms:OGD1
Ordered Locus Names:YIL125W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

SGDiS000001387 KGD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000002043631 – 10142-oxoglutarate dehydrogenase, mitochondrialAdd BLAST984

Proteomic databases

MaxQBiP20967
PaxDbiP20967
PRIDEiP20967

PTM databases

iPTMnetiP20967

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KGD2P192626EBI-12459,EBI-12464

Protein-protein interaction databases

BioGridi34866, 120 interactors
ComplexPortaliCPX-1293 Mitochondrial 2-oxoglutarate dehydrogenase complex
DIPiDIP-365N
IntActiP20967, 47 interactors
MINTiP20967
STRINGi4932.YIL125W

Structurei

3D structure databases

ProteinModelPortaliP20967
SMRiP20967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000063092
HOGENOMiHOG000259586
InParanoidiP20967
KOiK00164
OMAiIDMVCYR
OrthoDBiEOG092C0B3K

Family and domain databases

InterProiView protein in InterPro
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078 2-oxogl_dehyd_N, 1 hit
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20967-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRFVSSQTC RYSSRGLLKT SLLKNASTVK IVGRGLATTG TDNFLSTSNA
60 70 80 90 100
TYIDEMYQAW QKDPSSVHVS WDAYFKNMSN PKIPATKAFQ APPSISNFPQ
110 120 130 140 150
GTEAAPLGTA MTGSVDENVS IHLKVQLLCR AYQVRGHLKA HIDPLGISFG
160 170 180 190 200
SNKNNPVPPE LTLDYYGFSK HDLDKEINLG PGILPRFARD GKSKMSLKEI
210 220 230 240 250
VDHLEKLYCS SYGVQYTHIP SKQKCDWLRE RIEIPEPYQY TVDQKRQILD
260 270 280 290 300
RLTWATSFES FLSTKFPNDK RFGLEGLESV VPGIKTLVDR SVELGVEDIV
310 320 330 340 350
LGMAHRGRLN VLSNVVRKPN ESIFSEFKGS SARDDIEGSG DVKYHLGMNY
360 370 380 390 400
QRPTTSGKYV NLSLVANPSH LESQDPVVLG RTRALLHAKN DLKEKTKALG
410 420 430 440 450
VLLHGDAAFA GQGVVYETMG FLTLPEYSTG GTIHVITNNQ IGFTTDPRFA
460 470 480 490 500
RSTPYPSDLA KAIDAPIFHV NANDVEAVTF IFNLAAEWRH KFHTDAIIDV
510 520 530 540 550
VGWRKHGHNE TDQPSFTQPL MYKKIAKQKS VIDVYTEKLI SEGTFSKKDI
560 570 580 590 600
DEHKKWVWNL FEDAFEKAKD YVPSQREWLT AAWEGFKSPK ELATEILPHE
610 620 630 640 650
PTNVPESTLK ELGKVLSSWP EGFEVHKNLK RILKNRGKSI ETGEGIDWAT
660 670 680 690 700
GEALAFGTLV LDGQNVRVSG EDVERGTFSQ RHAVLHDQQS EAIYTPLSTL
710 720 730 740 750
NNEKADFTIA NSSLSEYGVM GFEYGYSLTS PDYLVMWEAQ FGDFANTAQV
760 770 780 790 800
IIDQFIAGGE QKWKQRSGLV LSLPHGYDGQ GPEHSSGRLE RFLQLANEDP
810 820 830 840 850
RYFPSEEKLQ RQHQDCNFQV VYPTTPANLF HILRRQQHRQ FRKPLALFFS
860 870 880 890 900
KQLLRHPLAR SSLSEFTEGG FQWIIEDIEH GKSIGTKEET KRLVLLSGQV
910 920 930 940 950
YTALHKRRES LGDKTTAFLK IEQLHPFPFA QLRDSLNSYP NLEEIVWCQE
960 970 980 990 1000
EPLNMGSWAY TEPRLHTTLK ETDKYKDFKV RYCGRNPSGA VAAGSKSLHL
1010
AEEDAFLKDV FQQS
Length:1,014
Mass (Da):114,416
Last modified:February 1, 1995 - v2
Checksum:iEF987C4DECE3F09F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325 – 327SEF → LNL in AAA34721 (PubMed:2503710).Curated3
Sequence conflicti513Q → R in AAA34721 (PubMed:2503710).Curated1
Sequence conflicti568A → T in AAA34721 (PubMed:2503710).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26390 Genomic DNA Translation: AAA34721.1
Z46833 Genomic DNA Translation: CAA86867.1
BK006942 Genomic DNA Translation: DAA08428.1
PIRiS49884 DEBY
RefSeqiNP_012141.1, NM_001179473.1

Genome annotation databases

EnsemblFungiiYIL125W; YIL125W; YIL125W
GeneIDi854681
KEGGisce:YIL125W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26390 Genomic DNA Translation: AAA34721.1
Z46833 Genomic DNA Translation: CAA86867.1
BK006942 Genomic DNA Translation: DAA08428.1
PIRiS49884 DEBY
RefSeqiNP_012141.1, NM_001179473.1

3D structure databases

ProteinModelPortaliP20967
SMRiP20967
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34866, 120 interactors
ComplexPortaliCPX-1293 Mitochondrial 2-oxoglutarate dehydrogenase complex
DIPiDIP-365N
IntActiP20967, 47 interactors
MINTiP20967
STRINGi4932.YIL125W

PTM databases

iPTMnetiP20967

Proteomic databases

MaxQBiP20967
PaxDbiP20967
PRIDEiP20967

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL125W; YIL125W; YIL125W
GeneIDi854681
KEGGisce:YIL125W

Organism-specific databases

SGDiS000001387 KGD1

Phylogenomic databases

GeneTreeiENSGT00530000063092
HOGENOMiHOG000259586
InParanoidiP20967
KOiK00164
OMAiIDMVCYR
OrthoDBiEOG092C0B3K

Enzyme and pathway databases

BioCyciYEAST:YIL125W-MONOMER
ReactomeiR-SCE-389661 Glyoxylate metabolism and glycine degradation
R-SCE-71064 Lysine catabolism
R-SCE-71403 Citric acid cycle (TCA cycle)

Miscellaneous databases

PROiPR:P20967

Family and domain databases

InterProiView protein in InterPro
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078 2-oxogl_dehyd_N, 1 hit
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiODO1_YEAST
AccessioniPrimary (citable) accession number: P20967
Secondary accession number(s): D6VVG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
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Main funding by: National Institutes of Health

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