KGD1

Functionⁱ

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO₂. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).3 Publications

Miscellaneous

Present with 14300 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.

Cofactorⁱ

thiamine diphosphate

Activity regulationⁱ

Catabolite repressed.

GO - Molecular functionⁱ

oxoglutarate dehydrogenase (succinyl-transferring) activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
thiamine pyrophosphate binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

2-oxoglutarate metabolic process
Source: SGD
Traceable author statementⁱ
- 9175438
tricarboxylic acid cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Tricarboxylic acid cycle
Ligand	Thiamine pyrophosphate

Enzyme and pathway databases

BioCycⁱ	YEAST:YIL125W-MONOMER
Reactomeⁱ	R-SCE-389661 Glyoxylate metabolism and glycine degradation R-SCE-71064 Lysine catabolism R-SCE-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2) Alternative name(s): 2-oxoglutarate dehydrogenase complex component E1 Short name: OGDC-E1 Alpha-ketoglutarate dehydrogenase
Gene namesⁱ	Name:KGD1 Synonyms:OGD1 Ordered Locus Names:YIL125W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000001387 KGD1

SGDⁱ

S000001387 KGD1

Keywords - Cellular componentⁱ

Mitochondrion, Mitochondrion nucleoid

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 30	MitochondrionSequence analysisAdd BLAST		30
ChainⁱPRO_0000020436	31 – 1014	2-oxoglutarate dehydrogenase, mitochondrialAdd BLAST		984

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P20967
PaxDbⁱ	P20967
PRIDEⁱ	P20967

PTM databases

iPTMnetⁱ	P20967

iPTMnetⁱ

P20967

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KGD2	P19262	6	EBI-12459,EBI-12464

With

Entry

#Exp.

IntAct

Notes

KGD2

P19262

6

EBI-12459,EBI-12464

Protein-protein interaction databases

BioGridⁱ	34866, 120 interactors
ComplexPortalⁱ	CPX-1293 Mitochondrial 2-oxoglutarate dehydrogenase complex
Database of interacting proteins More...DIPⁱ	DIP-365N
IntActⁱ	P20967, 47 interactors
Molecular INTeraction database More...MINTⁱ	P20967
STRINGⁱ	4932.YIL125W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P20967
SMRⁱ	P20967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the alpha-ketoglutarate dehydrogenase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063092
HOGENOMⁱ	HOG000259586
InParanoidⁱ	P20967
KEGG Orthology (KO) More...KOⁱ	K00164
OMAⁱ	IDMVCYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0B3K

Family and domain databases

InterProⁱ	View protein in InterPro IPR032106 2-oxogl_dehyd_N IPR011603 2oxoglutarate_DH_E1 IPR001017 DH_E1 IPR031717 KGD_C IPR029061 THDP-binding IPR005475 Transketolase-like_Pyr-bd
PANTHERⁱ	PTHR23152 PTHR23152, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16078 2-oxogl_dehyd_N, 1 hit PF00676 E1_dh, 1 hit PF16870 OxoGdeHyase_C, 1 hit PF02779 Transket_pyr, 1 hit
PIRSFⁱ	PIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTⁱ	View protein in SMART SM00861 Transket_pyr, 1 hit
SUPFAMⁱ	SSF52518 SSF52518, 2 hits
TIGRFAMsⁱ	TIGR00239 2oxo_dh_E1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P20967-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRFVSSQTC RYSSRGLLKT SLLKNASTVK IVGRGLATTG TDNFLSTSNA 
        60         70         80         90        100
TYIDEMYQAW QKDPSSVHVS WDAYFKNMSN PKIPATKAFQ APPSISNFPQ 
       110        120        130        140        150
GTEAAPLGTA MTGSVDENVS IHLKVQLLCR AYQVRGHLKA HIDPLGISFG 
       160        170        180        190        200
SNKNNPVPPE LTLDYYGFSK HDLDKEINLG PGILPRFARD GKSKMSLKEI 
       210        220        230        240        250
VDHLEKLYCS SYGVQYTHIP SKQKCDWLRE RIEIPEPYQY TVDQKRQILD 
       260        270        280        290        300
RLTWATSFES FLSTKFPNDK RFGLEGLESV VPGIKTLVDR SVELGVEDIV 
       310        320        330        340        350
LGMAHRGRLN VLSNVVRKPN ESIFSEFKGS SARDDIEGSG DVKYHLGMNY 
       360        370        380        390        400
QRPTTSGKYV NLSLVANPSH LESQDPVVLG RTRALLHAKN DLKEKTKALG 
       410        420        430        440        450
VLLHGDAAFA GQGVVYETMG FLTLPEYSTG GTIHVITNNQ IGFTTDPRFA 
       460        470        480        490        500
RSTPYPSDLA KAIDAPIFHV NANDVEAVTF IFNLAAEWRH KFHTDAIIDV 
       510        520        530        540        550
VGWRKHGHNE TDQPSFTQPL MYKKIAKQKS VIDVYTEKLI SEGTFSKKDI 
       560        570        580        590        600
DEHKKWVWNL FEDAFEKAKD YVPSQREWLT AAWEGFKSPK ELATEILPHE 
       610        620        630        640        650
PTNVPESTLK ELGKVLSSWP EGFEVHKNLK RILKNRGKSI ETGEGIDWAT 
       660        670        680        690        700
GEALAFGTLV LDGQNVRVSG EDVERGTFSQ RHAVLHDQQS EAIYTPLSTL 
       710        720        730        740        750
NNEKADFTIA NSSLSEYGVM GFEYGYSLTS PDYLVMWEAQ FGDFANTAQV 
       760        770        780        790        800
IIDQFIAGGE QKWKQRSGLV LSLPHGYDGQ GPEHSSGRLE RFLQLANEDP 
       810        820        830        840        850
RYFPSEEKLQ RQHQDCNFQV VYPTTPANLF HILRRQQHRQ FRKPLALFFS 
       860        870        880        890        900
KQLLRHPLAR SSLSEFTEGG FQWIIEDIEH GKSIGTKEET KRLVLLSGQV 
       910        920        930        940        950
YTALHKRRES LGDKTTAFLK IEQLHPFPFA QLRDSLNSYP NLEEIVWCQE 
       960        970        980        990       1000
EPLNMGSWAY TEPRLHTTLK ETDKYKDFKV RYCGRNPSGA VAAGSKSLHL 
      1010 
AEEDAFLKDV FQQS

Length:1,014

Mass (Da):114,416

Last modified:February 1, 1995 - v2

Checksum:ⁱEF987C4DECE3F09F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	325 – 327	SEF → LNL in AAA34721 (PubMed:2503710).Curated	3
Sequence conflictⁱ	513	Q → R in AAA34721 (PubMed:2503710).Curated	1
Sequence conflictⁱ	568	A → T in AAA34721 (PubMed:2503710).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M26390 Genomic DNA Translation: AAA34721.1 Z46833 Genomic DNA Translation: CAA86867.1 BK006942 Genomic DNA Translation: DAA08428.1
PIRⁱ	S49884 DEBY
NCBI Reference Sequences More...RefSeqⁱ	NP_012141.1, NM_001179473.1

Genome annotation databases

EnsemblFungiⁱ	YIL125W; YIL125W; YIL125W
GeneIDⁱ	854681
KEGGⁱ	sce:YIL125W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20967	YIL125Wp-like protein (Fragment)		YEAS6		568	UniRef100_P20967

Protein	Similar proteins		Species	Score	Length	Source
P20967	YIL125Wp-like protein (Fragment)		YEAS6		568	UniRef90_P20967
KGD1-like protein		SACEU		1014
Kgd1p		SACAR		1014
Alpha-ketoglutarate dehydrogenase		YEAS1		1014
Kgd1p		YEAS8		1014
+10

Protein	Similar proteins		Species	Score	Length	Source
P20967	YIL125Wp-like protein (Fragment)		YEAS6		568	UniRef50_P20967
Kgd1p		YEASX		1014
Kgd1p		SACCK		1014
Kgd1p		SACAR		1014
KGD1-like protein		SACEU		1014
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M26390 Genomic DNA Translation: AAA34721.1 Z46833 Genomic DNA Translation: CAA86867.1 BK006942 Genomic DNA Translation: DAA08428.1
PIRⁱ	S49884 DEBY
RefSeqⁱ	NP_012141.1, NM_001179473.1

3D structure databases

ProteinModelPortalⁱ	P20967
SMRⁱ	P20967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	34866, 120 interactors
ComplexPortalⁱ	CPX-1293 Mitochondrial 2-oxoglutarate dehydrogenase complex
DIPⁱ	DIP-365N
IntActⁱ	P20967, 47 interactors
MINTⁱ	P20967
STRINGⁱ	4932.YIL125W

PTM databases

iPTMnetⁱ	P20967

iPTMnetⁱ

P20967

Proteomic databases

MaxQBⁱ	P20967
PaxDbⁱ	P20967
PRIDEⁱ	P20967

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YIL125W; YIL125W; YIL125W
GeneIDⁱ	854681
KEGGⁱ	sce:YIL125W

Organism-specific databases

SGDⁱ	S000001387 KGD1

Phylogenomic databases

GeneTreeⁱ	ENSGT00530000063092
HOGENOMⁱ	HOG000259586
InParanoidⁱ	P20967
KOⁱ	K00164
OMAⁱ	IDMVCYR
OrthoDBⁱ	EOG092C0B3K

Enzyme and pathway databases

BioCycⁱ	YEAST:YIL125W-MONOMER
Reactomeⁱ	R-SCE-389661 Glyoxylate metabolism and glycine degradation R-SCE-71064 Lysine catabolism R-SCE-71403 Citric acid cycle (TCA cycle)

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P20967

PROⁱ

PR:P20967

Family and domain databases

InterProⁱ	View protein in InterPro IPR032106 2-oxogl_dehyd_N IPR011603 2oxoglutarate_DH_E1 IPR001017 DH_E1 IPR031717 KGD_C IPR029061 THDP-binding IPR005475 Transketolase-like_Pyr-bd
PANTHERⁱ	PTHR23152 PTHR23152, 1 hit
Pfamⁱ	View protein in Pfam PF16078 2-oxogl_dehyd_N, 1 hit PF00676 E1_dh, 1 hit PF16870 OxoGdeHyase_C, 1 hit PF02779 Transket_pyr, 1 hit
PIRSFⁱ	PIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTⁱ	View protein in SMART SM00861 Transket_pyr, 1 hit
SUPFAMⁱ	SSF52518 SSF52518, 2 hits
TIGRFAMsⁱ	TIGR00239 2oxo_dh_E1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ODO1_YEAST
Accessionⁱ	P20967Primary (citable) accession number: P20967 Secondary accession number(s): D6VVG2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	February 1, 1995
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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UniRef

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Supporting data

UniProtKB - P20967 (ODO1_YEAST)

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2-oxoglutarate dehydrogenase, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ