The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P20967 (ODO1_YEAST)
Protein
2-oxoglutarate dehydrogenase, mitochondrial
Gene
KGD1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
3 PublicationsMiscellaneous
Present with 14300 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- (R)-N6-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = (R)-N6-(S8-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2EC:1.2.4.2
Cofactori
Activity regulationi
Catabolite repressed.
GO - Molecular functioni
- oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GO_Central
- thiamine pyrophosphate binding Source: InterPro
GO - Biological processi
- 2-oxoglutarate metabolic process Source: ComplexPortal
- tricarboxylic acid cycle Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Tricarboxylic acid cycle |
Ligand | Thiamine pyrophosphate |
Enzyme and pathway databases
Reactomei | R-SCE-389661, Glyoxylate metabolism and glycine degradation R-SCE-71064, Lysine catabolism R-SCE-71403, Citric acid cycle (TCA cycle) |
Names & Taxonomyi
Protein namesi | Recommended name: 2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)Alternative name(s): 2-oxoglutarate dehydrogenase complex component E1 Short name: OGDC-E1 Alpha-ketoglutarate dehydrogenase |
Gene namesi | Name:KGD1 Synonyms:OGD1 Ordered Locus Names:YIL125W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001387, KGD1 |
VEuPathDBi | FungiDB:YIL125W |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial alpha-ketoglutarate dehydrogenase complex Source: ComplexPortal
- mitochondrial nucleoid Source: SGD
- mitochondrial oxoglutarate dehydrogenase complex Source: SGD
- mitochondrion Source: ComplexPortal
Other locations
- oxoglutarate dehydrogenase complex Source: GO_Central
Keywords - Cellular componenti
Mitochondrion, Mitochondrion nucleoidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 30 | MitochondrionSequence analysisAdd BLAST | 30 | |
ChainiPRO_0000020436 | 31 – 1014 | 2-oxoglutarate dehydrogenase, mitochondrialAdd BLAST | 984 |
Proteomic databases
MaxQBi | P20967 |
PaxDbi | P20967 |
PRIDEi | P20967 |
PTM databases
iPTMneti | P20967 |
Interactioni
Binary interactionsi
P20967
With | #Exp. | IntAct |
---|---|---|
KGD2 [P19262] | 6 | EBI-12459,EBI-12464 |
Protein-protein interaction databases
BioGRIDi | 34866, 135 interactors |
ComplexPortali | CPX-1293, Mitochondrial 2-oxoglutarate dehydrogenase complex |
DIPi | DIP-365N |
IntActi | P20967, 47 interactors |
MINTi | P20967 |
STRINGi | 4932.YIL125W |
Miscellaneous databases
RNActi | P20967, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the alpha-ketoglutarate dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0450, Eukaryota |
GeneTreei | ENSGT00950000183125 |
HOGENOMi | CLU_004709_1_0_1 |
InParanoidi | P20967 |
OMAi | RDSYCRT |
Family and domain databases
Gene3Di | 3.40.50.11610, 1 hit |
InterProi | View protein in InterPro IPR032106, 2-oxogl_dehyd_N IPR011603, 2oxoglutarate_DH_E1 IPR001017, DH_E1 IPR031717, KGD_C IPR042179, KGD_C_sf IPR029061, THDP-binding IPR005475, Transketolase-like_Pyr-bd |
PANTHERi | PTHR23152, PTHR23152, 1 hit |
Pfami | View protein in Pfam PF16078, 2-oxogl_dehyd_N, 1 hit PF00676, E1_dh, 1 hit PF16870, OxoGdeHyase_C, 1 hit PF02779, Transket_pyr, 1 hit |
PIRSFi | PIRSF000157, Oxoglu_dh_E1, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 2 hits |
TIGRFAMsi | TIGR00239, 2oxo_dh_E1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P20967-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRFVSSQTC RYSSRGLLKT SLLKNASTVK IVGRGLATTG TDNFLSTSNA
60 70 80 90 100
TYIDEMYQAW QKDPSSVHVS WDAYFKNMSN PKIPATKAFQ APPSISNFPQ
110 120 130 140 150
GTEAAPLGTA MTGSVDENVS IHLKVQLLCR AYQVRGHLKA HIDPLGISFG
160 170 180 190 200
SNKNNPVPPE LTLDYYGFSK HDLDKEINLG PGILPRFARD GKSKMSLKEI
210 220 230 240 250
VDHLEKLYCS SYGVQYTHIP SKQKCDWLRE RIEIPEPYQY TVDQKRQILD
260 270 280 290 300
RLTWATSFES FLSTKFPNDK RFGLEGLESV VPGIKTLVDR SVELGVEDIV
310 320 330 340 350
LGMAHRGRLN VLSNVVRKPN ESIFSEFKGS SARDDIEGSG DVKYHLGMNY
360 370 380 390 400
QRPTTSGKYV NLSLVANPSH LESQDPVVLG RTRALLHAKN DLKEKTKALG
410 420 430 440 450
VLLHGDAAFA GQGVVYETMG FLTLPEYSTG GTIHVITNNQ IGFTTDPRFA
460 470 480 490 500
RSTPYPSDLA KAIDAPIFHV NANDVEAVTF IFNLAAEWRH KFHTDAIIDV
510 520 530 540 550
VGWRKHGHNE TDQPSFTQPL MYKKIAKQKS VIDVYTEKLI SEGTFSKKDI
560 570 580 590 600
DEHKKWVWNL FEDAFEKAKD YVPSQREWLT AAWEGFKSPK ELATEILPHE
610 620 630 640 650
PTNVPESTLK ELGKVLSSWP EGFEVHKNLK RILKNRGKSI ETGEGIDWAT
660 670 680 690 700
GEALAFGTLV LDGQNVRVSG EDVERGTFSQ RHAVLHDQQS EAIYTPLSTL
710 720 730 740 750
NNEKADFTIA NSSLSEYGVM GFEYGYSLTS PDYLVMWEAQ FGDFANTAQV
760 770 780 790 800
IIDQFIAGGE QKWKQRSGLV LSLPHGYDGQ GPEHSSGRLE RFLQLANEDP
810 820 830 840 850
RYFPSEEKLQ RQHQDCNFQV VYPTTPANLF HILRRQQHRQ FRKPLALFFS
860 870 880 890 900
KQLLRHPLAR SSLSEFTEGG FQWIIEDIEH GKSIGTKEET KRLVLLSGQV
910 920 930 940 950
YTALHKRRES LGDKTTAFLK IEQLHPFPFA QLRDSLNSYP NLEEIVWCQE
960 970 980 990 1000
EPLNMGSWAY TEPRLHTTLK ETDKYKDFKV RYCGRNPSGA VAAGSKSLHL
1010
AEEDAFLKDV FQQS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 325 – 327 | SEF → LNL in AAA34721 (PubMed:2503710).Curated | 3 | |
Sequence conflicti | 513 | Q → R in AAA34721 (PubMed:2503710).Curated | 1 | |
Sequence conflicti | 568 | A → T in AAA34721 (PubMed:2503710).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26390 Genomic DNA Translation: AAA34721.1 Z46833 Genomic DNA Translation: CAA86867.1 BK006942 Genomic DNA Translation: DAA08428.1 |
PIRi | S49884, DEBY |
RefSeqi | NP_012141.1, NM_001179473.1 |
Genome annotation databases
EnsemblFungii | YIL125W_mRNA; YIL125W; YIL125W |
GeneIDi | 854681 |
KEGGi | sce:YIL125W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26390 Genomic DNA Translation: AAA34721.1 Z46833 Genomic DNA Translation: CAA86867.1 BK006942 Genomic DNA Translation: DAA08428.1 |
PIRi | S49884, DEBY |
RefSeqi | NP_012141.1, NM_001179473.1 |
3D structure databases
AlphaFoldDBi | P20967 |
SMRi | P20967 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34866, 135 interactors |
ComplexPortali | CPX-1293, Mitochondrial 2-oxoglutarate dehydrogenase complex |
DIPi | DIP-365N |
IntActi | P20967, 47 interactors |
MINTi | P20967 |
STRINGi | 4932.YIL125W |
PTM databases
iPTMneti | P20967 |
Proteomic databases
MaxQBi | P20967 |
PaxDbi | P20967 |
PRIDEi | P20967 |
Genome annotation databases
EnsemblFungii | YIL125W_mRNA; YIL125W; YIL125W |
GeneIDi | 854681 |
KEGGi | sce:YIL125W |
Organism-specific databases
SGDi | S000001387, KGD1 |
VEuPathDBi | FungiDB:YIL125W |
Phylogenomic databases
eggNOGi | KOG0450, Eukaryota |
GeneTreei | ENSGT00950000183125 |
HOGENOMi | CLU_004709_1_0_1 |
InParanoidi | P20967 |
OMAi | RDSYCRT |
Enzyme and pathway databases
Reactomei | R-SCE-389661, Glyoxylate metabolism and glycine degradation R-SCE-71064, Lysine catabolism R-SCE-71403, Citric acid cycle (TCA cycle) |
Miscellaneous databases
PROi | PR:P20967 |
RNActi | P20967, protein |
Family and domain databases
Gene3Di | 3.40.50.11610, 1 hit |
InterProi | View protein in InterPro IPR032106, 2-oxogl_dehyd_N IPR011603, 2oxoglutarate_DH_E1 IPR001017, DH_E1 IPR031717, KGD_C IPR042179, KGD_C_sf IPR029061, THDP-binding IPR005475, Transketolase-like_Pyr-bd |
PANTHERi | PTHR23152, PTHR23152, 1 hit |
Pfami | View protein in Pfam PF16078, 2-oxogl_dehyd_N, 1 hit PF00676, E1_dh, 1 hit PF16870, OxoGdeHyase_C, 1 hit PF02779, Transket_pyr, 1 hit |
PIRSFi | PIRSF000157, Oxoglu_dh_E1, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 2 hits |
TIGRFAMsi | TIGR00239, 2oxo_dh_E1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ODO1_YEAST | |
Accessioni | P20967Primary (citable) accession number: P20967 Secondary accession number(s): D6VVG2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - SIMILARITY comments
Index of protein domains and families