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Entry version 170 (12 Aug 2020)
Sequence version 1 (01 Feb 1991)
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Protein

PTS system fructose-specific EIIB'BC component

Gene

fruA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.4 µM for fructose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei112Phosphocysteine intermediate; for EIIB activity1 Publication1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: EcoCyc

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processPhosphotransferase system, Sugar transport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:FRUA-MONOMER
    ECOL316407:JW2154-MONOMER
    MetaCyc:FRUA-MONOMER

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    4.A.2.1.1, the pts fructose-mannitol (fru) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    PTS system fructose-specific EIIB'BC component1 Publication
    Alternative name(s):
    EIIB'BC-Fru1 Publication
    Including the following 2 domains:
    PTS system fructose-specific EIIB component1 Publication (EC:2.7.1.2021 Publication1 Publication)
    Alternative name(s):
    EIII-Fru1 Publication
    Fructose-specific phosphotransferase enzyme IIB component1 Publication
    PTS system fructose-specific EIIC component1 Publication
    Alternative name(s):
    Fructose permease IIC component1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:fruA1 Publication
    Synonyms:ptsF
    Ordered Locus Names:b2167, JW2154
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei236 – 256HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei274 – 294HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei304 – 324HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei349 – 369HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei382 – 402HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei430 – 450HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei463 – 483HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei489 – 509HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei518 – 538HelicalPROSITE-ProRule annotationAdd BLAST21

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001865081 – 563PTS system fructose-specific EIIB'BC componentAdd BLAST563

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei112Phosphocysteine; by EIIAPROSITE-ProRule annotation1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P20966

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P20966

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P20966

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By fructose.By similarity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4260463, 42 interactors
    851014, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    P20966, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b2167

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P20966

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 85PTS EIIB type-2 11 PublicationAdd BLAST85
    Domaini104 – 201PTS EIIB type-2 2PROSITE-ProRule annotationAdd BLAST98
    Domaini226 – 561PTS EIIC type-2PROSITE-ProRule annotationAdd BLAST336

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.PROSITE-ProRule annotation
    In the N-terminal, the PTS system fructose-specific possesses a duplicated EIIB domain (EIIB' domain) which lacks the active site and functions to facilitate phosphoryl transfer between the EIIA domain of diphosphoryl transfer protein (DTP) and the EIIB domain. Construction of a protein lacking the EIIB' domain shows that it is functional for fructose transport in vivo as well as fructose phosphorylation in vitro. The presence of the EIIB' domain, however, is required for normal high affinity recognition of DTP by the PTS system fructose-specific as well as for normal rates of phosphoryl transfer between the EIIA and EIIB domains of DTP and PTS system fructose-specific, respectively.1 Publication
    The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG1299, Bacteria
    COG1445, Bacteria
    COG3925, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_013155_4_1_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P20966

    KEGG Orthology (KO)

    More...
    KOi
    K02770

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P20966

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd05569, PTS_IIB_fructose, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036095, PTS_EIIB-like_sf
    IPR013011, PTS_EIIB_2
    IPR003501, PTS_EIIB_2/3
    IPR003352, PTS_EIIC
    IPR013014, PTS_EIIC_2
    IPR003353, PTS_IIB_fruc
    IPR006327, PTS_IIC_fruc

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02378, PTS_EIIC, 1 hit
    PF02302, PTS_IIB, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52794, SSF52794, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00829, FRU, 1 hit
    TIGR01427, PTS_IIC_fructo, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51099, PTS_EIIB_TYPE_2, 1 hit
    PS51104, PTS_EIIC_TYPE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P20966-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKTLLIIDAN LGQARAYMAK TLLGAAARKA KLEIIDNPND AEMAIVLGDS
    60 70 80 90 100
    IPNDSALNGK NVWLGDISRA VAHPELFLSE AKGHAKPYTA PVAATAPVAA
    110 120 130 140 150
    SGPKRVVAVT ACPTGVAHTF MAAEAIETEA KKRGWWVKVE TRGSVGAGNA
    160 170 180 190 200
    ITPEEVAAAD LVIVAADIEV DLAKFAGKPM YRTSTGLALK KTAQELDKAV
    210 220 230 240 250
    AEATPYEPAG KAQTATTESK KESAGAYRHL LTGVSYMLPM VVAGGLCIAL
    260 270 280 290 300
    SFAFGIEAFK EPGTLAAALM QIGGGSAFAL MVPVLAGYIA FSIADRPGLT
    310 320 330 340 350
    PGLIGGMLAV STGSGFIGGI IAGFLAGYIA KLISTQLKLP QSMEALKPIL
    360 370 380 390 400
    IIPLISSLVV GLAMIYLIGK PVAGILEGLT HWLQTMGTAN AVLLGAILGG
    410 420 430 440 450
    MMCTDMGGPV NKAAYAFGVG LLSTQTYGPM AAIMAAGMVP PLAMGLATMV
    460 470 480 490 500
    ARRKFDKAQQ EGGKAALVLG LCFISEGAIP FAARDPMRVL PCCIVGGALT
    510 520 530 540 550
    GAISMAIGAK LMAPHGGLFV LLIPGAITPV LGYLVAIIAG TLVAGLAYAF
    560
    LKRPEVDAVA KAA
    Length:563
    Mass (Da):57,519
    Last modified:February 1, 1991 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC066A96A94DBA05
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M23196 Genomic DNA Translation: AAA62624.1
    U00007 Genomic DNA Translation: AAA60524.1
    U00096 Genomic DNA Translation: AAC75228.1
    AP009048 Genomic DNA Translation: BAA15976.2
    X53948 Genomic DNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A34962

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_416672.1, NC_000913.3
    WP_000854447.1, NZ_SSZK01000027.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC75228; AAC75228; b2167
    BAA15976; BAA15976; BAA15976

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    946672

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW2154
    eco:b2167

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.72

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M23196 Genomic DNA Translation: AAA62624.1
    U00007 Genomic DNA Translation: AAA60524.1
    U00096 Genomic DNA Translation: AAC75228.1
    AP009048 Genomic DNA Translation: BAA15976.2
    X53948 Genomic DNA No translation available.
    PIRiA34962
    RefSeqiNP_416672.1, NC_000913.3
    WP_000854447.1, NZ_SSZK01000027.1

    3D structure databases

    SMRiP20966
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4260463, 42 interactors
    851014, 1 interactor
    IntActiP20966, 2 interactors
    STRINGi511145.b2167

    Protein family/group databases

    TCDBi4.A.2.1.1, the pts fructose-mannitol (fru) family

    Proteomic databases

    jPOSTiP20966
    PaxDbiP20966
    PRIDEiP20966

    Genome annotation databases

    EnsemblBacteriaiAAC75228; AAC75228; b2167
    BAA15976; BAA15976; BAA15976
    GeneIDi946672
    KEGGiecj:JW2154
    eco:b2167
    PATRICifig|1411691.4.peg.72

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0332

    Phylogenomic databases

    eggNOGiCOG1299, Bacteria
    COG1445, Bacteria
    COG3925, Bacteria
    HOGENOMiCLU_013155_4_1_6
    InParanoidiP20966
    KOiK02770
    PhylomeDBiP20966

    Enzyme and pathway databases

    BioCyciEcoCyc:FRUA-MONOMER
    ECOL316407:JW2154-MONOMER
    MetaCyc:FRUA-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P20966

    Family and domain databases

    CDDicd05569, PTS_IIB_fructose, 1 hit
    InterProiView protein in InterPro
    IPR036095, PTS_EIIB-like_sf
    IPR013011, PTS_EIIB_2
    IPR003501, PTS_EIIB_2/3
    IPR003352, PTS_EIIC
    IPR013014, PTS_EIIC_2
    IPR003353, PTS_IIB_fruc
    IPR006327, PTS_IIC_fruc
    PfamiView protein in Pfam
    PF02378, PTS_EIIC, 1 hit
    PF02302, PTS_IIB, 1 hit
    SUPFAMiSSF52794, SSF52794, 2 hits
    TIGRFAMsiTIGR00829, FRU, 1 hit
    TIGR01427, PTS_IIC_fructo, 1 hit
    PROSITEiView protein in PROSITE
    PS51099, PTS_EIIB_TYPE_2, 1 hit
    PS51104, PTS_EIIC_TYPE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTFBC_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20966
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: August 12, 2020
    This is version 170 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome
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