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Protein

Phosducin

Gene

PDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.1 Publication

GO - Molecular functioni

  • phospholipase inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision

Enzyme and pathway databases

SignaLinkiP20941
SIGNORiP20941

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Protein MEKA
Gene namesi
Name:PDC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116703.13
HGNCiHGNC:8759 PDC
MIMi171490 gene
neXtProtiNX_P20941

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5132
OpenTargetsiENSG00000116703
PharmGKBiPA33109

Polymorphism and mutation databases

BioMutaiPDC
DMDMi130134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637521 – 246PhosducinAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73Phosphoserine; by PKABy similarity1

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP20941
PeptideAtlasiP20941
PRIDEiP20941
ProteomicsDBi53830
53831 [P20941-2]

PTM databases

iPTMnetiP20941
PhosphoSitePlusiP20941

Expressioni

Gene expression databases

BgeeiENSG00000116703 Expressed in 60 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PDC
ExpressionAtlasiP20941 baseline and differential
GenevisibleiP20941 HS

Organism-specific databases

HPAiHPA062235

Interactioni

Subunit structurei

Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with CRX.1 Publication

Protein-protein interaction databases

BioGridi111159, 2 interactors
STRINGi9606.ENSP00000342033

Structurei

3D structure databases

ProteinModelPortaliP20941
SMRiP20941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 246Thioredoxin foldBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
GeneTreeiENSGT00930000150898
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiP20941
KOiK08327
OMAiAAEYPMV
OrthoDBiEOG091G0ISM
PhylomeDBiP20941
TreeFamiTF315179

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 2 hits
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P20941-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEAKSQSLE EDFEGQATHT GPKGVINDWR KFKLESQDSD SIPPSKKEIL
60 70 80 90 100
RQMSSPQSRN GKDSKERVSR KMSIQEYELI HKEKEDENCL RKYRRQCMQD
110 120 130 140 150
MHQKLSFGPR YGFVYELETG KQFLETIEKE LKITTIVVHI YEDGIKGCDA
160 170 180 190 200
LNSSLTCLAA EYPIVKFCKI KASNTGAGDR FSLDVLPTLL IYKGGELISN
210 220 230 240
FISVAEQFAE EFFAGDVESF LNEYGLLPER EVHVLEHTKI EEEDVE
Length:246
Mass (Da):28,246
Last modified:February 1, 1991 - v1
Checksum:iDF59C2C7C3308C90
GO
Isoform 2 (identifier: P20941-2) [UniParc]FASTAAdd to basket
Also known as: PhLOP1

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Show »
Length:194
Mass (Da):22,317
Checksum:i228ADD7757825F29
GO
Isoform 3 (identifier: P20941-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPESLDSPTSGRPGVTTHSTRTPGTEIQTIISNPVPKM

Show »
Length:283
Mass (Da):32,118
Checksum:iB9637E3DF21C470D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140I → L in AAA36210 (PubMed:2383274).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0438801 – 52Missing in isoform 2. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_0537781M → MPESLDSPTSGRPGVTTHST RTPGTEIQTIISNPVPKM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33478 mRNA Translation: AAA35486.1
M38059, M60720, M38058 Genomic DNA Translation: AAA36210.1
AF076463 mRNA Translation: AAD43141.1
AF076464 mRNA Translation: AAD43142.1
AL596220 Genomic DNA No translation available.
AL663036 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91212.1
CCDSiCCDS1370.1 [P20941-1]
CCDS41447.1 [P20941-2]
PIRiA35422
RefSeqiNP_002588.3, NM_002597.4 [P20941-1]
NP_072098.1, NM_022576.3 [P20941-2]
XP_011507905.1, XM_011509603.2 [P20941-1]
UniGeneiHs.654381

Genome annotation databases

EnsembliENST00000391997; ENSP00000375855; ENSG00000116703 [P20941-1]
ENST00000497198; ENSP00000422775; ENSG00000116703 [P20941-2]
GeneIDi5132
KEGGihsa:5132
UCSCiuc001grz.4 human [P20941-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Mutations of the PDC gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33478 mRNA Translation: AAA35486.1
M38059, M60720, M38058 Genomic DNA Translation: AAA36210.1
AF076463 mRNA Translation: AAD43141.1
AF076464 mRNA Translation: AAD43142.1
AL596220 Genomic DNA No translation available.
AL663036 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91212.1
CCDSiCCDS1370.1 [P20941-1]
CCDS41447.1 [P20941-2]
PIRiA35422
RefSeqiNP_002588.3, NM_002597.4 [P20941-1]
NP_072098.1, NM_022576.3 [P20941-2]
XP_011507905.1, XM_011509603.2 [P20941-1]
UniGeneiHs.654381

3D structure databases

ProteinModelPortaliP20941
SMRiP20941
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111159, 2 interactors
STRINGi9606.ENSP00000342033

PTM databases

iPTMnetiP20941
PhosphoSitePlusiP20941

Polymorphism and mutation databases

BioMutaiPDC
DMDMi130134

Proteomic databases

PaxDbiP20941
PeptideAtlasiP20941
PRIDEiP20941
ProteomicsDBi53830
53831 [P20941-2]

Protocols and materials databases

DNASUi5132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391997; ENSP00000375855; ENSG00000116703 [P20941-1]
ENST00000497198; ENSP00000422775; ENSG00000116703 [P20941-2]
GeneIDi5132
KEGGihsa:5132
UCSCiuc001grz.4 human [P20941-1]

Organism-specific databases

CTDi5132
DisGeNETi5132
EuPathDBiHostDB:ENSG00000116703.13
GeneCardsiPDC
H-InvDBiHIX0028533
HGNCiHGNC:8759 PDC
HPAiHPA062235
MIMi171490 gene
neXtProtiNX_P20941
OpenTargetsiENSG00000116703
PharmGKBiPA33109
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
GeneTreeiENSGT00930000150898
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiP20941
KOiK08327
OMAiAAEYPMV
OrthoDBiEOG091G0ISM
PhylomeDBiP20941
TreeFamiTF315179

Enzyme and pathway databases

SignaLinkiP20941
SIGNORiP20941

Miscellaneous databases

ChiTaRSiPDC human
GeneWikiiPhosducin
GenomeRNAii5132
PROiPR:P20941
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116703 Expressed in 60 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PDC
ExpressionAtlasiP20941 baseline and differential
GenevisibleiP20941 HS

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 2 hits
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHOS_HUMAN
AccessioniPrimary (citable) accession number: P20941
Secondary accession number(s): Q14816, Q9UP22, Q9UP23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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