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Protein

Ras GTPase-activating protein 1

Gene

RASA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: Reactome
  • GTPase activity Source: Reactome
  • GTPase binding Source: UniProtKB
  • phosphotyrosine residue binding Source: CAFA
  • potassium channel inhibitor activity Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-186763 Downstream signal transduction
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkiP20936
SIGNORiP20936

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 1
Short name:
GAP
Short name:
GTPase-activating protein
Short name:
RasGAP
Alternative name(s):
Ras p21 protein activator
p120GAP
Gene namesi
Name:RASA1
Synonyms:GAP, RASA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145715.14
HGNCiHGNC:9871 RASA1
MIMi139150 gene
neXtProtiNX_P20936

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.
Capillary malformation-arteriovenous malformation (CMAVM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
See also OMIM:608354
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072088528Y → C in CMAVM; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145752649EnsemblClinVar.1
Natural variantiVAR_072089530V → D in CMAVM. 1 Publication1
Natural variantiVAR_017744540C → Y in CMAVM. 1 PublicationCorresponds to variant dbSNP:rs137853217EnsemblClinVar.1
Natural variantiVAR_072090626A → E in CMAVM. 1 Publication1
Natural variantiVAR_072091763E → V in CMAVM; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373098580Ensembl.1
Parkes Weber syndrome (PKWS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDisorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
See also OMIM:608355

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi5921
GeneReviewsiRASA1
MalaCardsiRASA1
MIMi608354 phenotype
608355 phenotype
OpenTargetsiENSG00000145715
Orphaneti137667 Capillary malformation-arteriovenous malformation
90307 Parkes Weber syndrome
PharmGKBiPA34232

Polymorphism and mutation databases

BioMutaiRASA1
DMDMi121743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566361 – 1047Ras GTPase-activating protein 1Add BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei615PhosphotyrosineCombined sources1
Modified residuei831PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.
Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP20936
MaxQBiP20936
PaxDbiP20936
PeptideAtlasiP20936
PRIDEiP20936
ProteomicsDBi53828
53829 [P20936-2]

PTM databases

iPTMnetiP20936
PhosphoSitePlusiP20936

Miscellaneous databases

PMAP-CutDBiP20936

Expressioni

Tissue specificityi

In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000145715 Expressed in 233 organ(s), highest expression level in placenta
CleanExiHS_RASA1
ExpressionAtlasiP20936 baseline and differential
GenevisibleiP20936 HS

Organism-specific databases

HPAiCAB007789
HPA036393
HPA064556

Interactioni

Subunit structurei

Interacts with SQSTM1. Interacts with SPSB1; the interaction does not promote degradation. Interacts with CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1. Interacts with PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1.8 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111856, 57 interactors
CORUMiP20936
DIPiDIP-144N
IntActiP20936, 55 interactors
MINTiP20936
STRINGi9606.ENSP00000274376

Structurei

Secondary structure

11047
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20936
SMRiP20936
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20936

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 272SH2 1PROSITE-ProRule annotationAdd BLAST92
Domaini279 – 341SH3PROSITE-ProRule annotationAdd BLAST63
Domaini351 – 441SH2 2PROSITE-ProRule annotationAdd BLAST91
Domaini474 – 577PHPROSITE-ProRule annotationAdd BLAST104
Domaini581 – 676C2PROSITE-ProRule annotationAdd BLAST96
Domaini748 – 942Ras-GAPPROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 22Poly-Gly6
Compositional biasi135 – 141Poly-Pro7
Compositional biasi163 – 168Poly-Glu6

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000007794
HOVERGENiHBG060735
InParanoidiP20936
KOiK04352
OMAiEPYMEVV
OrthoDBiEOG091G022Q
PhylomeDBiP20936
TreeFamiTF105301

Family and domain databases

CDDicd10354 SH2_Cterm_RasGAP, 1 hit
cd10353 SH2_Nterm_RasGAP, 1 hit
cd11788 SH3_RasGAP, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028554 p120-RasGAP
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR035842 RasGAP_C_SH2
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR035841 RasGAP_N_SH2
IPR035652 RasGAP_SH3
IPR008936 Rho_GTPase_activation_prot
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10194 PTHR10194, 1 hit
PTHR10194:SF19 PTHR10194:SF19, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P20936-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP
60 70 80 90 100
GLVETGVAGT LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA
110 120 130 140 150
GVAGAAVAGP SGDMALTKLP TSLLAETLGP GGGFPPLPPP PYLPPLGAGL
160 170 180 190 200
GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ WYHGKLDRTI AEERLRQAGK
210 220 230 240 250
SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY IGGRRFSSLS
260 270 280 290 300
DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS
310 320 330 340 350
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI
360 370 380 390 400
WFHGKISKQE AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK
410 420 430 440 450
ICPTPNNQFM MGGRYYNSIG DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL
460 470 480 490 500
NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY LLKKGKGKRW KNLYFILEGS
510 520 530 540 550
DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC FQIVVQHFSE
560 570 580 590 600
EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI
610 620 630 640 650
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD
660 670 680 690 700
INRFEITLSN KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG
710 720 730 740 750
IEPGSLRVRA RYSMEKIMPE EEYSEFKELI LQKELHVVYA LSHVCGQDRT
760 770 780 790 800
LLASILLRIF LHEKLESLLL CTLNDREISM EDEATTLFRA TTLASTLMEQ
810 820 830 840 850
YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED VNTNLTHLLN
860 870 880 890 900
ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV
910 920 930 940 950
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE
960 970 980 990 1000
PYMEGVNPFI KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE
1010 1020 1030 1040
ICVAHSDELR TLSNERGAQQ HVLKKLLAIT ELLQQKQNQY TKTNDVR
Length:1,047
Mass (Da):116,403
Last modified:February 1, 1991 - v1
Checksum:iC35B6567F5BC5370
GO
Isoform 2 (identifier: P20936-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     178-180: TNQ → MKG

Show »
Length:870
Mass (Da):100,398
Checksum:iB328E701911065F9
GO
Isoform 3 (identifier: P20936-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-539: PN → CS
     540-1047: Missing.

Note: No experimental confirmation available.
Show »
Length:539
Mass (Da):58,037
Checksum:iD6D38EBC43450273
GO
Isoform 4 (identifier: P20936-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MMAAEAGSEEGGP → MRTGYSSVPSKLR
     14-180: Missing.

Note: No experimental confirmation available.
Show »
Length:880
Mass (Da):101,546
Checksum:iFE89B3A1E8126DD6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGC0E9PGC0_HUMAN
Ras GTPase-activating protein 1
RASA1
881Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti789R → A AA sequence (PubMed:8360177).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002650398R → L in basal cell carcinomas. 1 PublicationCorresponds to variant dbSNP:rs137853214EnsemblClinVar.1
Natural variantiVAR_002651400K → E in basal cell carcinomas. 1 PublicationCorresponds to variant dbSNP:rs137853215EnsemblClinVar.1
Natural variantiVAR_002652401I → V in basal cell carcinomas. 1 PublicationCorresponds to variant dbSNP:rs137853216EnsemblClinVar.1
Natural variantiVAR_072088528Y → C in CMAVM; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145752649EnsemblClinVar.1
Natural variantiVAR_072089530V → D in CMAVM. 1 Publication1
Natural variantiVAR_017744540C → Y in CMAVM. 1 PublicationCorresponds to variant dbSNP:rs137853217EnsemblClinVar.1
Natural variantiVAR_072090626A → E in CMAVM. 1 Publication1
Natural variantiVAR_072091763E → V in CMAVM; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373098580Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0016251 – 177Missing in isoform 2. 2 PublicationsAdd BLAST177
Alternative sequenceiVSP_0574321 – 13MMAAE…EEGGP → MRTGYSSVPSKLR in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05743314 – 180Missing in isoform 4. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_001626178 – 180TNQ → MKG in isoform 2. 2 Publications3
Alternative sequenceiVSP_057434538 – 539PN → CS in isoform 3. 1 Publication2
Alternative sequenceiVSP_057435540 – 1047Missing in isoform 3. 1 PublicationAdd BLAST508

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23379 mRNA Translation: AAA52517.1
M23612 mRNA Translation: AAA35865.1
AK300263 mRNA Translation: BAG62024.1
AK312739 mRNA Translation: BAG35610.1
CR749722 mRNA Translation: CAH18488.2
AC010410 Genomic DNA No translation available.
AC018754 Genomic DNA No translation available.
AC035142 Genomic DNA No translation available.
AC126776 Genomic DNA No translation available.
BC033015 mRNA Translation: AAH33015.1
CCDSiCCDS34200.1 [P20936-1]
CCDS47243.1 [P20936-2]
PIRiA40121
B40121
RefSeqiNP_002881.1, NM_002890.2 [P20936-1]
NP_072179.1, NM_022650.2 [P20936-2]
UniGeneiHs.664080

Genome annotation databases

EnsembliENST00000274376; ENSP00000274376; ENSG00000145715 [P20936-1]
ENST00000456692; ENSP00000411221; ENSG00000145715 [P20936-2]
ENST00000512763; ENSP00000422008; ENSG00000145715 [P20936-4]
ENST00000515800; ENSP00000423395; ENSG00000145715 [P20936-3]
GeneIDi5921
KEGGihsa:5921
UCSCiuc003kiw.4 human [P20936-1]
uc011ctv.3 human
uc063fdq.1 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23379 mRNA Translation: AAA52517.1
M23612 mRNA Translation: AAA35865.1
AK300263 mRNA Translation: BAG62024.1
AK312739 mRNA Translation: BAG35610.1
CR749722 mRNA Translation: CAH18488.2
AC010410 Genomic DNA No translation available.
AC018754 Genomic DNA No translation available.
AC035142 Genomic DNA No translation available.
AC126776 Genomic DNA No translation available.
BC033015 mRNA Translation: AAH33015.1
CCDSiCCDS34200.1 [P20936-1]
CCDS47243.1 [P20936-2]
PIRiA40121
B40121
RefSeqiNP_002881.1, NM_002890.2 [P20936-1]
NP_072179.1, NM_022650.2 [P20936-2]
UniGeneiHs.664080

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WERX-ray1.60A714-1047[»]
1WQ1X-ray2.50G714-1047[»]
2GQINMR-A282-339[»]
2GSBNMR-A341-446[»]
2J05X-ray1.50A/B281-341[»]
2J06X-ray1.80A/B281-341[»]
2M51NMR-A281-341[»]
4FSSX-ray2.25A/B/C281-341[»]
ProteinModelPortaliP20936
SMRiP20936
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111856, 57 interactors
CORUMiP20936
DIPiDIP-144N
IntActiP20936, 55 interactors
MINTiP20936
STRINGi9606.ENSP00000274376

PTM databases

iPTMnetiP20936
PhosphoSitePlusiP20936

Polymorphism and mutation databases

BioMutaiRASA1
DMDMi121743

Proteomic databases

EPDiP20936
MaxQBiP20936
PaxDbiP20936
PeptideAtlasiP20936
PRIDEiP20936
ProteomicsDBi53828
53829 [P20936-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274376; ENSP00000274376; ENSG00000145715 [P20936-1]
ENST00000456692; ENSP00000411221; ENSG00000145715 [P20936-2]
ENST00000512763; ENSP00000422008; ENSG00000145715 [P20936-4]
ENST00000515800; ENSP00000423395; ENSG00000145715 [P20936-3]
GeneIDi5921
KEGGihsa:5921
UCSCiuc003kiw.4 human [P20936-1]
uc011ctv.3 human
uc063fdq.1 human

Organism-specific databases

CTDi5921
DisGeNETi5921
EuPathDBiHostDB:ENSG00000145715.14
GeneCardsiRASA1
GeneReviewsiRASA1
HGNCiHGNC:9871 RASA1
HPAiCAB007789
HPA036393
HPA064556
MalaCardsiRASA1
MIMi139150 gene
608354 phenotype
608355 phenotype
neXtProtiNX_P20936
OpenTargetsiENSG00000145715
Orphaneti137667 Capillary malformation-arteriovenous malformation
90307 Parkes Weber syndrome
PharmGKBiPA34232
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000007794
HOVERGENiHBG060735
InParanoidiP20936
KOiK04352
OMAiEPYMEVV
OrthoDBiEOG091G022Q
PhylomeDBiP20936
TreeFamiTF105301

Enzyme and pathway databases

ReactomeiR-HSA-186763 Downstream signal transduction
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkiP20936
SIGNORiP20936

Miscellaneous databases

ChiTaRSiRASA1 human
EvolutionaryTraceiP20936
GeneWikiiRAS_p21_protein_activator_1
GenomeRNAii5921
PMAP-CutDBiP20936
PROiPR:P20936
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145715 Expressed in 233 organ(s), highest expression level in placenta
CleanExiHS_RASA1
ExpressionAtlasiP20936 baseline and differential
GenevisibleiP20936 HS

Family and domain databases

CDDicd10354 SH2_Cterm_RasGAP, 1 hit
cd10353 SH2_Nterm_RasGAP, 1 hit
cd11788 SH3_RasGAP, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028554 p120-RasGAP
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR035842 RasGAP_C_SH2
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR035841 RasGAP_N_SH2
IPR035652 RasGAP_SH3
IPR008936 Rho_GTPase_activation_prot
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10194 PTHR10194, 1 hit
PTHR10194:SF19 PTHR10194:SF19, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASA1_HUMAN
AccessioniPrimary (citable) accession number: P20936
Secondary accession number(s): B2R6W3
, B4DTL2, Q68CU6, Q9UDI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 219 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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