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Entry version 234 (12 Aug 2020)
Sequence version 1 (01 Feb 1991)
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Protein

Ras GTPase-activating protein 1

Gene

RASA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P20936

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-186763, Downstream signal transduction
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-5218921, VEGFR2 mediated cell proliferation
R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P20936

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P20936

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras GTPase-activating protein 1
Short name:
GAP
Short name:
GTPase-activating protein
Short name:
RasGAP
Alternative name(s):
Ras p21 protein activator
p120GAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASA1
Synonyms:GAP, RASA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000145715.14

Human Gene Nomenclature Database

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HGNCi
HGNC:9871, RASA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
139150, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20936

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.
Capillary malformation-arteriovenous malformation 1 (CMAVM1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome. CMAVM1 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072088528Y → C in CMAVM1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145752649EnsemblClinVar.1
Natural variantiVAR_072089530V → D in CMAVM1. 1 Publication1
Natural variantiVAR_017744540C → Y in CMAVM1. 1 PublicationCorresponds to variant dbSNP:rs137853217EnsemblClinVar.1
Natural variantiVAR_072090626A → E in CMAVM1. 1 Publication1
Natural variantiVAR_072091763E → V in CMAVM1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373098580Ensembl.1

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
5921

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
RASA1

MalaCards human disease database

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MalaCardsi
RASA1
MIMi608354, phenotype

Open Targets

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OpenTargetsi
ENSG00000145715

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
137667, Capillary malformation-arteriovenous malformation
90307, Parkes Weber syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34232

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P20936, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121743

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566361 – 1047Ras GTPase-activating protein 1Add BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei615PhosphotyrosineCombined sources1
Modified residuei831PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1548

Encyclopedia of Proteome Dynamics

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EPDi
P20936

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P20936

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P20936

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P20936

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20936

PeptideAtlas

More...
PeptideAtlasi
P20936

PRoteomics IDEntifications database

More...
PRIDEi
P20936

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5112
53828 [P20936-1]
53829 [P20936-2]
66031

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P20936

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P20936

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P20936

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145715, Expressed in placenta and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P20936, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P20936, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000145715, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SQSTM1.

Interacts with SPSB1; the interaction does not promote degradation.

Interacts with CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1.

Interacts with PDGFRB (tyrosine phosphorylated).

Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1.

Interacts with tyrosine-phosphorylated EPHB4 (PubMed:8955277).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111856, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P20936

Database of interacting proteins

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DIPi
DIP-144N

Protein interaction database and analysis system

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IntActi
P20936, 136 interactors

Molecular INTeraction database

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MINTi
P20936

STRING: functional protein association networks

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STRINGi
9606.ENSP00000274376

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P20936, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11047
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P20936

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P20936

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 272SH2 1PROSITE-ProRule annotationAdd BLAST92
Domaini279 – 341SH3PROSITE-ProRule annotationAdd BLAST63
Domaini351 – 441SH2 2PROSITE-ProRule annotationAdd BLAST91
Domaini474 – 577PHPROSITE-ProRule annotationAdd BLAST104
Domaini577 – 690C2PROSITE-ProRule annotationAdd BLAST114
Domaini748 – 942Ras-GAPPROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 22Poly-Gly6
Compositional biasi135 – 141Poly-Pro7
Compositional biasi163 – 168Poly-Glu6

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3508, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_500517_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P20936

KEGG Orthology (KO)

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KOi
K04352

Identification of Orthologs from Complete Genome Data

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OMAi
KEPYMEV

Database for complete collections of gene phylogenies

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PhylomeDBi
P20936

TreeFam database of animal gene trees

More...
TreeFami
TF105301

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10354, SH2_Cterm_RasGAP, 1 hit
cd10353, SH2_Nterm_RasGAP, 1 hit
cd11788, SH3_RasGAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR028554, p120-RasGAP
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR035842, RasGAP_C_SH2
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR035841, RasGAP_N_SH2
IPR035652, RasGAP_SH3
IPR008936, Rho_GTPase_activation_prot
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR10194, PTHR10194, 1 hit
PTHR10194:SF19, PTHR10194:SF19, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF00169, PH, 1 hit
PF00616, RasGAP, 1 hit
PF00017, SH2, 2 hits
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401, SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SM00252, SH2, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS50001, SH2, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P20936-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP
60 70 80 90 100
GLVETGVAGT LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA
110 120 130 140 150
GVAGAAVAGP SGDMALTKLP TSLLAETLGP GGGFPPLPPP PYLPPLGAGL
160 170 180 190 200
GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ WYHGKLDRTI AEERLRQAGK
210 220 230 240 250
SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY IGGRRFSSLS
260 270 280 290 300
DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS
310 320 330 340 350
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI
360 370 380 390 400
WFHGKISKQE AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK
410 420 430 440 450
ICPTPNNQFM MGGRYYNSIG DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL
460 470 480 490 500
NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY LLKKGKGKRW KNLYFILEGS
510 520 530 540 550
DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC FQIVVQHFSE
560 570 580 590 600
EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI
610 620 630 640 650
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD
660 670 680 690 700
INRFEITLSN KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG
710 720 730 740 750
IEPGSLRVRA RYSMEKIMPE EEYSEFKELI LQKELHVVYA LSHVCGQDRT
760 770 780 790 800
LLASILLRIF LHEKLESLLL CTLNDREISM EDEATTLFRA TTLASTLMEQ
810 820 830 840 850
YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED VNTNLTHLLN
860 870 880 890 900
ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV
910 920 930 940 950
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE
960 970 980 990 1000
PYMEGVNPFI KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE
1010 1020 1030 1040
ICVAHSDELR TLSNERGAQQ HVLKKLLAIT ELLQQKQNQY TKTNDVR
Length:1,047
Mass (Da):116,403
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC35B6567F5BC5370
GO
Isoform 2 (identifier: P20936-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     178-180: TNQ → MKG

Show »
Length:870
Mass (Da):100,398
Checksum:iB328E701911065F9
GO
Isoform 3 (identifier: P20936-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-539: PN → CS
     540-1047: Missing.

Show »
Length:539
Mass (Da):58,037
Checksum:iD6D38EBC43450273
GO
Isoform 4 (identifier: P20936-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MMAAEAGSEEGGP → MRTGYSSVPSKLR
     14-180: Missing.

Show »
Length:880
Mass (Da):101,546
Checksum:iFE89B3A1E8126DD6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGC0E9PGC0_HUMAN
Ras GTPase-activating protein 1
RASA1
881Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti789R → A AA sequence (PubMed:8360177).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002650398R → L in basal cell carcinomas. 1 PublicationCorresponds to variant dbSNP:rs137853214EnsemblClinVar.1
Natural variantiVAR_002651400K → E in basal cell carcinomas. 1 PublicationCorresponds to variant dbSNP:rs137853215EnsemblClinVar.1
Natural variantiVAR_002652401I → V in basal cell carcinomas. 1 PublicationCorresponds to variant dbSNP:rs137853216EnsemblClinVar.1
Natural variantiVAR_072088528Y → C in CMAVM1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145752649EnsemblClinVar.1
Natural variantiVAR_072089530V → D in CMAVM1. 1 Publication1
Natural variantiVAR_017744540C → Y in CMAVM1. 1 PublicationCorresponds to variant dbSNP:rs137853217EnsemblClinVar.1
Natural variantiVAR_072090626A → E in CMAVM1. 1 Publication1
Natural variantiVAR_072091763E → V in CMAVM1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373098580Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0016251 – 177Missing in isoform 2. 2 PublicationsAdd BLAST177
Alternative sequenceiVSP_0574321 – 13MMAAE…EEGGP → MRTGYSSVPSKLR in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05743314 – 180Missing in isoform 4. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_001626178 – 180TNQ → MKG in isoform 2. 2 Publications3
Alternative sequenceiVSP_057434538 – 539PN → CS in isoform 3. 1 Publication2
Alternative sequenceiVSP_057435540 – 1047Missing in isoform 3. 1 PublicationAdd BLAST508

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23379 mRNA Translation: AAA52517.1
M23612 mRNA Translation: AAA35865.1
AK300263 mRNA Translation: BAG62024.1
AK312739 mRNA Translation: BAG35610.1
CR749722 mRNA Translation: CAH18488.2
AC010410 Genomic DNA No translation available.
AC018754 Genomic DNA No translation available.
AC035142 Genomic DNA No translation available.
AC126776 Genomic DNA No translation available.
BC033015 mRNA Translation: AAH33015.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34200.1 [P20936-1]
CCDS47243.1 [P20936-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A40121
B40121

NCBI Reference Sequences

More...
RefSeqi
NP_002881.1, NM_002890.2 [P20936-1]
NP_072179.1, NM_022650.2 [P20936-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274376; ENSP00000274376; ENSG00000145715 [P20936-1]
ENST00000456692; ENSP00000411221; ENSG00000145715 [P20936-2]
ENST00000512763; ENSP00000422008; ENSG00000145715 [P20936-4]
ENST00000515800; ENSP00000423395; ENSG00000145715 [P20936-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5921

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5921

UCSC genome browser

More...
UCSCi
uc003kiw.4, human [P20936-1]
uc011ctv.3, human
uc063fdq.1, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23379 mRNA Translation: AAA52517.1
M23612 mRNA Translation: AAA35865.1
AK300263 mRNA Translation: BAG62024.1
AK312739 mRNA Translation: BAG35610.1
CR749722 mRNA Translation: CAH18488.2
AC010410 Genomic DNA No translation available.
AC018754 Genomic DNA No translation available.
AC035142 Genomic DNA No translation available.
AC126776 Genomic DNA No translation available.
BC033015 mRNA Translation: AAH33015.1
CCDSiCCDS34200.1 [P20936-1]
CCDS47243.1 [P20936-2]
PIRiA40121
B40121
RefSeqiNP_002881.1, NM_002890.2 [P20936-1]
NP_072179.1, NM_022650.2 [P20936-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WERX-ray1.60A714-1047[»]
1WQ1X-ray2.50G714-1047[»]
2GQINMR-A282-339[»]
2GSBNMR-A341-446[»]
2J05X-ray1.50A/B281-341[»]
2J06X-ray1.80A/B281-341[»]
2M51NMR-A281-341[»]
4FSSX-ray2.25A/B/C281-341[»]
6PXBX-ray1.75A/B/C/D/E/F174-280[»]
6PXCX-ray1.60A174-280[»]
SMRiP20936
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111856, 58 interactors
CORUMiP20936
DIPiDIP-144N
IntActiP20936, 136 interactors
MINTiP20936
STRINGi9606.ENSP00000274376

PTM databases

iPTMnetiP20936
MetOSiteiP20936
PhosphoSitePlusiP20936

Polymorphism and mutation databases

BioMutaiRASA1
DMDMi121743

Proteomic databases

CPTACiCPTAC-1548
EPDiP20936
jPOSTiP20936
MassIVEiP20936
MaxQBiP20936
PaxDbiP20936
PeptideAtlasiP20936
PRIDEiP20936
ProteomicsDBi5112
53828 [P20936-1]
53829 [P20936-2]
66031

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P20936, 9 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24766, 506 antibodies

Genome annotation databases

EnsembliENST00000274376; ENSP00000274376; ENSG00000145715 [P20936-1]
ENST00000456692; ENSP00000411221; ENSG00000145715 [P20936-2]
ENST00000512763; ENSP00000422008; ENSG00000145715 [P20936-4]
ENST00000515800; ENSP00000423395; ENSG00000145715 [P20936-3]
GeneIDi5921
KEGGihsa:5921
UCSCiuc003kiw.4, human [P20936-1]
uc011ctv.3, human
uc063fdq.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5921
DisGeNETi5921
EuPathDBiHostDB:ENSG00000145715.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RASA1
GeneReviewsiRASA1
HGNCiHGNC:9871, RASA1
HPAiENSG00000145715, Tissue enriched (placenta)
MalaCardsiRASA1
MIMi139150, gene
608354, phenotype
neXtProtiNX_P20936
OpenTargetsiENSG00000145715
Orphaneti137667, Capillary malformation-arteriovenous malformation
90307, Parkes Weber syndrome
PharmGKBiPA34232

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3508, Eukaryota
GeneTreeiENSGT00940000155846
HOGENOMiCLU_500517_0_0_1
InParanoidiP20936
KOiK04352
OMAiKEPYMEV
PhylomeDBiP20936
TreeFamiTF105301

Enzyme and pathway databases

PathwayCommonsiP20936
ReactomeiR-HSA-186763, Downstream signal transduction
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-5218921, VEGFR2 mediated cell proliferation
R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkiP20936
SIGNORiP20936

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5921, 2 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RASA1, human
EvolutionaryTraceiP20936

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAS_p21_protein_activator_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5921
PharosiP20936, Tbio

Protein Ontology

More...
PROi
PR:P20936
RNActiP20936, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145715, Expressed in placenta and 244 other tissues
ExpressionAtlasiP20936, baseline and differential
GenevisibleiP20936, HS

Family and domain databases

CDDicd10354, SH2_Cterm_RasGAP, 1 hit
cd10353, SH2_Nterm_RasGAP, 1 hit
cd11788, SH3_RasGAP, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR028554, p120-RasGAP
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR035842, RasGAP_C_SH2
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR035841, RasGAP_N_SH2
IPR035652, RasGAP_SH3
IPR008936, Rho_GTPase_activation_prot
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR10194, PTHR10194, 1 hit
PTHR10194:SF19, PTHR10194:SF19, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00169, PH, 1 hit
PF00616, RasGAP, 1 hit
PF00017, SH2, 2 hits
PF00018, SH3_1, 1 hit
PRINTSiPR00401, SH2DOMAIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SM00252, SH2, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS50001, SH2, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20936
Secondary accession number(s): B2R6W3
, B4DTL2, Q68CU6, Q9UDI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: August 12, 2020
This is version 234 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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