Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 135 (03 Jul 2019)
Sequence version 2 (21 Mar 2012)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Collagen alpha-1(XI) chain

Gene

Col11a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1623CalciumBy similarity1
Metal bindingi1625CalciumBy similarity1
Metal bindingi1626Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1628Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1631CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1442490 Collagen degradation
R-RNO-1650814 Collagen biosynthesis and modifying enzymes
R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-3000171 Non-integrin membrane-ECM interactions
R-RNO-8874081 MET activates PTK2 signaling
R-RNO-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XI) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col11a1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
2372 Col11a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000041594635 – 511N-terminal propeptideSequence analysisAdd BLAST477
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000005780512 – 1561Collagen alpha-1(XI) chainAdd BLAST1050
PropeptideiPRO_00000057811562 – 1804C-terminal propeptideAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60 ↔ 242PROSITE-ProRule annotation1 Publication
Disulfide bondi181 ↔ 235PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei610AllysineBy similarity1
Modified residuei1450AllysineBy similarity1
Disulfide bondi1605 ↔ 1637PROSITE-ProRule annotation
Disulfide bondi1628InterchainPROSITE-ProRule annotation
Glycosylationi1638N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1646 ↔ 1801PROSITE-ProRule annotation
Glycosylationi1707N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1712 ↔ 1755PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P20909

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20909

PRoteomics IDEntifications database

More...
PRIDEi
P20909

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P20909

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20909

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000023148 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20909 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is probably a post-translational modification of alpha 1(II).

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P20909, 32 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000023794

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20909

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 242Laminin G-likeAdd BLAST173
Domaini440 – 488Collagen-like 1Add BLAST49
Domaini530 – 584Collagen-like 2Add BLAST55
Domaini581 – 639Collagen-like 3Add BLAST59
Domaini607 – 664Collagen-like 4Add BLAST58
Domaini641 – 698Collagen-like 5Add BLAST58
Domaini746 – 804Collagen-like 6Add BLAST59
Domaini1391 – 1449Collagen-like 7Add BLAST59
Domaini1442 – 1492Collagen-like 8Add BLAST51
Domaini1481 – 1539Collagen-like 9Add BLAST59
Domaini1575 – 1803Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni229 – 417Nonhelical regionAdd BLAST189
Regioni418 – 506Triple-helical region (interrupted)Add BLAST89
Regioni507 – 509Short nonhelical segment3
Regioni510 – 527TelopeptideAdd BLAST18
Regioni528 – 1540Triple-helical regionAdd BLAST1013
Regioni1541 – 1561Nonhelical region (C-terminal)Add BLAST21

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154535

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085654

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20909

KEGG Orthology (KO)

More...
KOi
K19721

Identification of Orthologs from Complete Genome Data

More...
OMAi
QQARIAM

Database of Orthologous Groups

More...
OrthoDBi
199083at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P20909-1) [UniParc]FASTAAdd to basket
Also known as: +V1a+V2, p6A+8

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPWSRWKTK RWIWDLTIST LVLTFLFQAR EVRGAAPVDI LKALDFHNSP
60 70 80 90 100
VGISKTTGFC TSRKNSKDPD IAYRVTEEAQ ISAPTKQLFP GGIFPQDFSI
110 120 130 140 150
LFTIKPKKGT QAFLLSLYNE HGIQQLGVEV GRSPVFLFED HTGKPTPENY
160 170 180 190 200
PLFSTVNIAD GKWHRVAISV EKKTVTMIVD CKKKITKPLD RSERSIVDTN
210 220 230 240 250
GIMVFGTRIL ETDVFQGDIQ QFLITGDPKA AYDYCDHYSP DCDLTSKAAQ
260 270 280 290 300
AQEPHIDEYA PEDIIEYDYE YGETDYKEAE SVTEMPTVTE ETVAQTEANI
310 320 330 340 350
VDDFQDYNYG TMETYQTESP RRVSGSNEPN PVEEGFTEEY LTGEDYDVQR
360 370 380 390 400
NISEDILYGN KGIDGRDSDL LVDGDLGEYD FYEYKEYEER TTTSPNEEFG
410 420 430 440 450
PGVPAETDFT ETSINGHGAY GEKGQKGEPA VVEPGMLVEG PPGPAGPAGL
460 470 480 490 500
MGPPGLQGPS GLPGDPGDRG PPGRPGLPGA DGLPGPPGTM LMLPFRYGGD
510 520 530 540 550
GSKGPTISAQ EAQAQAILQQ ARIALRGPPG PMGLTGRPGP VGGPGSAGAK
560 570 580 590 600
GESGDPGPQG PRGVQGPPGP TGKPGKRGRP GADGGRGMPG EPGSKGDRGF
610 620 630 640 650
DGLPGLPGDK GHRGERGPQG PPGLPGDDGM RGEDGEIGPR GLPGEAGPRG
660 670 680 690 700
LLGPRGTPGP PGQPGIGGID GPQGPKGNMG PQGEPGPPGQ QGNPGPQGLP
710 720 730 740 750
GPQGPIGPPG EKGPQGKPGL AGLPGADGPP GHPGKEGQSG EKGALGPPGP
760 770 780 790 800
QGPIGYPGPR GVKGADGVRG LKGSKGEKGE DGFPGFKGDM GLKGDRGEVG
810 820 830 840 850
QVGPRGEDGP EGPKGRAGPT GDPGPSGQAG EKGKLGVPGL PGYPGRQGPK
860 870 880 890 900
GSTGFPGFPG ANGEKGARGI AGKPGPRGQR GPTGPRGSRG ARGPTGKPGP
910 920 930 940 950
KGTSGGDGPP GPPGERGPQG PQGPVGFPGP KGPPGPAGKD GLPGHPGQRG
960 970 980 990 1000
ETGFQGKTGP PGPGGVVGPQ GPTGETGPIG ERGHPGTPGP PGEQGLPGAA
1010 1020 1030 1040 1050
GKEGAKGDPG PQGISGKDGP AGIRGFPGER GLPGAQGAPG LKGGEGPQGP
1060 1070 1080 1090 1100
QGPIGSPGER GSAGTAGPIG LPGRPGPQGP PGPAGEKGAP GEKGPQGPAG
1110 1120 1130 1140 1150
RDGVQGPVGL PGPAGPAGSP GEDGDKGEIG EPGQKGSKGD KGENGPPGPP
1160 1170 1180 1190 1200
GLQGPVGAPG IAGGDGEAGP RGQQGMFGQK GDEGARGFPG PPGPIGLQGL
1210 1220 1230 1240 1250
PGPPGEKGEN GDVGPMGPPG PPGPRGPQGP NGADGPQGPP GSIGSVGGVG
1260 1270 1280 1290 1300
EKGEPGEAGN PGPPGEAGSG GPKGERGEKG EAGPPGAAGP PGIKGPPGDD
1310 1320 1330 1340 1350
GPKGNPGPVG FPGDPGPPGE PGPAGQDGVG GDKGEDGDPG QPGPPGPSGE
1360 1370 1380 1390 1400
AGPPGPPGKR GPPGASGSEG RQGEKGAKGE AGAEGPPGKT GPVGPQGPSG
1410 1420 1430 1440 1450
KPGPEGLRGI PGPVGEQGLP GAAGQDGPPG PLGPPGLPGL KGDPGSKGEK
1460 1470 1480 1490 1500
GHPGLIGLIG PPGEQGEKGD RGLPGTQGSP GAKGDGGIPG PAGPIGPPGP
1510 1520 1530 1540 1550
PGLPGPAGPK GNKGSSGPTG QKGDSGMPGP PGPPGPPGEV IQPLPILSPK
1560 1570 1580 1590 1600
KTRRHTESIQ ADAGDNILDY SDGMEEIFGS LNSLKQDIEH MKFPMGTQTN
1610 1620 1630 1640 1650
PARTCKDLQL SHPDFPDGEY WIDPNQGCSG DSFKVYCNFT AGGETCIYPD
1660 1670 1680 1690 1700
KKSEGVRLSS WPKEKPGSWY SEFKRGKLLS YLDVEGNSIN MVQMTFLKLL
1710 1720 1730 1740 1750
TASARQNFTY NCHQSTAWYD VLSGSYDKAL RFLGSNDEEM SYENNPHIKA
1760 1770 1780 1790 1800
LYDGCASRKG YEKTVIEINT PKIDQVPIID VMINDFGDQN QKFGFEVGPA

CFLG
Length:1,804
Mass (Da):181,027
Last modified:March 21, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i666A4E0FDCC0BA3B
GO
Isoform 2 (identifier: P20909-2) [UniParc]FASTAAdd to basket
Also known as: +V1b+V2, p6B+8

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: YAPEDIIEYD...VTEETVAQTE → KKKSNYTKKK...ATAKAKLGVQ

Show »
Length:1,816
Mass (Da):182,258
Checksum:i6BFB79E300FC1557
GO
Isoform 3 (identifier: P20909-3) [UniParc]FASTAAdd to basket
Also known as: +V2, p8

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.

Show »
Length:1,765
Mass (Da):176,505
Checksum:i94FAC45C05007DCA
GO
Isoform 4 (identifier: P20909-4) [UniParc]FASTAAdd to basket
Also known as: +V1a, p6A

The sequence of this isoform differs from the canonical sequence as follows:
     329-413: Missing.

Show »
Length:1,719
Mass (Da):171,370
Checksum:i4B3D6137A5097BFA
GO
Isoform 5 (identifier: P20909-5) [UniParc]FASTAAdd to basket
Also known as: +V1b, p6B

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: YAPEDIIEYD...VTEETVAQTE → KKKSNYTKKK...ATAKAKLGVQ
     329-413: Missing.

Show »
Length:1,731
Mass (Da):172,601
Checksum:iBB53A77411763C20
GO
Isoform 6 (identifier: P20909-6) [UniParc]FASTAAdd to basket
Also known as: -V1-V2, p0

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
     329-413: Missing.

Show »
Length:1,680
Mass (Da):166,848
Checksum:i588F418A9DDDF8B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti394S → A in AAA92358 (PubMed:7721875).Curated1
Sequence conflicti394S → A in AAA92359 (PubMed:7721875).Curated1
Sequence conflicti394S → A in AAA92360 (PubMed:7721875).Curated1
Sequence conflicti394S → A in AAK83570 (PubMed:7721875).Curated1
Sequence conflicti1371R → G no nucleotide entry (PubMed:3182841).Curated1
Sequence conflicti1702A → S no nucleotide entry (PubMed:3182841).Curated1
Sequence conflicti1743E → D no nucleotide entry (PubMed:3182841).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042438259 – 297YAPED…VAQTE → KKKSNYTKKKRTLATNSKKK SKMSTTPKSEKFASKKKKRN QATAKAKLGVQ in isoform 2 and isoform 5. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_042439259 – 297Missing in isoform 3 and isoform 6. CuratedAdd BLAST39
Alternative sequenceiVSP_042440329 – 413Missing in isoform 4, isoform 5 and isoform 6. CuratedAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR03012126 Genomic DNA No translation available.
AABR03013126 Genomic DNA No translation available.
AABR03014171 Genomic DNA No translation available.
AABR03015382 Genomic DNA No translation available.
AABR03015832 Genomic DNA No translation available.
AABR03016562 Genomic DNA No translation available.
AABR03017847 Genomic DNA No translation available.
AABR03017951 Genomic DNA No translation available.
AABR03018245 Genomic DNA No translation available.
AABR03019675 Genomic DNA No translation available.
AABR03023874 Genomic DNA No translation available.
U20116 Genomic DNA Translation: AAK83682.1
U20118 Genomic DNA Translation: AAK83568.2
U20118 Genomic DNA Translation: AAK83569.2
U20118 Genomic DNA Translation: AAK83570.2
U20118 Genomic DNA Translation: AAK83571.2
U20118 Genomic DNA Translation: AAA92358.3
U20118 Genomic DNA Translation: AAA92359.3
U20121 mRNA Translation: AAA92360.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B31795

NCBI Reference Sequences

More...
RefSeqi
NP_037249.1, NM_013117.1 [P20909-1]
XP_006233272.1, XM_006233210.3 [P20909-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000068413; ENSRNOP00000061595; ENSRNOG00000023148 [P20909-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25654

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25654

UCSC genome browser

More...
UCSCi
RGD:2372 rat [P20909-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012126 Genomic DNA No translation available.
AABR03013126 Genomic DNA No translation available.
AABR03014171 Genomic DNA No translation available.
AABR03015382 Genomic DNA No translation available.
AABR03015832 Genomic DNA No translation available.
AABR03016562 Genomic DNA No translation available.
AABR03017847 Genomic DNA No translation available.
AABR03017951 Genomic DNA No translation available.
AABR03018245 Genomic DNA No translation available.
AABR03019675 Genomic DNA No translation available.
AABR03023874 Genomic DNA No translation available.
U20116 Genomic DNA Translation: AAK83682.1
U20118 Genomic DNA Translation: AAK83568.2
U20118 Genomic DNA Translation: AAK83569.2
U20118 Genomic DNA Translation: AAK83570.2
U20118 Genomic DNA Translation: AAK83571.2
U20118 Genomic DNA Translation: AAA92358.3
U20118 Genomic DNA Translation: AAA92359.3
U20121 mRNA Translation: AAA92360.1
PIRiB31795
RefSeqiNP_037249.1, NM_013117.1 [P20909-1]
XP_006233272.1, XM_006233210.3 [P20909-2]

3D structure databases

SMRiP20909
ModBaseiSearch...

Protein-protein interaction databases

IntActiP20909, 32 interactors
STRINGi10116.ENSRNOP00000023794

PTM databases

CarbonylDBiP20909
iPTMnetiP20909

Proteomic databases

jPOSTiP20909
PaxDbiP20909
PRIDEiP20909

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068413; ENSRNOP00000061595; ENSRNOG00000023148 [P20909-1]
GeneIDi25654
KEGGirno:25654
UCSCiRGD:2372 rat [P20909-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1301
RGDi2372 Col11a1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000154535
HOGENOMiHOG000085654
InParanoidiP20909
KOiK19721
OMAiQQARIAM
OrthoDBi199083at2759
TreeFamiTF323987

Enzyme and pathway databases

ReactomeiR-RNO-1442490 Collagen degradation
R-RNO-1650814 Collagen biosynthesis and modifying enzymes
R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-3000171 Non-integrin membrane-ECM interactions
R-RNO-8874081 MET activates PTK2 signaling
R-RNO-8948216 Collagen chain trimerization

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P20909

Gene expression databases

BgeeiENSRNOG00000023148 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP20909 RN

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 7 hits
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOBA1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20909
Secondary accession number(s): F1LSI4
, Q62750, Q63391, Q63392, Q63393, Q8VBY8, Q920Z7, Q920Z8, Q920Z9, Q921A0, Q921A1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 21, 2012
Last modified: July 3, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again