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Protein

Embryonic growth/differentiation factor 1

Gene

Gdf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May mediate cell differentiation events during embryonic development.

Miscellaneous

This protein is produced by a bicistronic gene which also produces the CERS1 protein from a non-overlapping reading frame.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-1660661 Sphingolipid de novo biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Embryonic growth/differentiation factor 1
Short name:
GDF-1
Gene namesi
Name:Gdf1
Synonyms:Gdf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95683 Gdf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000003390024 – 237Sequence analysisAdd BLAST214
ChainiPRO_0000033901238 – 357Embryonic growth/differentiation factor 1Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 322By similarity
Disulfide bondi280 ↔ 354By similarity
Disulfide bondi284 ↔ 356By similarity
Disulfide bondi321InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20863
PRIDEiP20863

PTM databases

PhosphoSitePlusiP20863

Expressioni

Tissue specificityi

Expressed almost exclusively in the nervous system.

Gene expression databases

BgeeiENSMUSG00000087408 Expressed in 26 organ(s), highest expression level in Ammon's horn
CleanExiMM_GDF1
ExpressionAtlasiP20863 baseline and differential
GenevisibleiP20863 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045892

Structurei

3D structure databases

ProteinModelPortaliP20863
SMRiP20863
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP20863
KOiK05495
OrthoDBiEOG091G0C2J
TreeFamiTF351789

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20863-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPVCHRFCD HLLLLLLLPS TTLAPAPASM GPAAALLQVL GLPEAPRSVP
60 70 80 90 100
THRPVPPVMW RLFRRRDPQE ARVGRPLRPC HVEELGVAGN IVRHIPDSGL
110 120 130 140 150
SSRPAQPART SGLCPEWTVV FDLSNVEPTE RPTRARLELR LEAESEDTGG
160 170 180 190 200
WELSVALWAD AEHPGPELLR VPAPPGVLLR ADLLGTAVAA NASVPCTVRL
210 220 230 240 250
ALSLHPGATA ACGRLAEASL LLVTLDPRLC PLPRLRRHTE PRVEVGPVGT
260 270 280 290 300
CRTRRLHVSF REVGWHRWVI APRGFLANFC QGTCALPETL RGPGGPPALN
310 320 330 340 350
HAVLRALMHA AAPTPGAGSP CCVPERLSPI SVLFFDNSDN VVLRHYEDMV

VDECGCR
Length:357
Mass (Da):38,660
Last modified:July 27, 2011 - v2
Checksum:iCF3EA5056F9D6A49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145S → C in AAA37674 (PubMed:1704486).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57639 mRNA Translation: AAA37674.1
M62301 mRNA Translation: AAA37676.1
BC079555 mRNA Translation: AAH79555.1
CCDSiCCDS52571.1
PIRiA39364
RefSeqiNP_001156754.1, NM_001163282.2
NP_032133.2, NM_008107.4
UniGeneiMm.258280

Genome annotation databases

EnsembliENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000087408
ENSMUST00000207684; ENSMUSP00000146749; ENSMUSG00000109523
GeneIDi14559
KEGGimmu:14559
UCSCiuc009lzz.4 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57639 mRNA Translation: AAA37674.1
M62301 mRNA Translation: AAA37676.1
BC079555 mRNA Translation: AAH79555.1
CCDSiCCDS52571.1
PIRiA39364
RefSeqiNP_001156754.1, NM_001163282.2
NP_032133.2, NM_008107.4
UniGeneiMm.258280

3D structure databases

ProteinModelPortaliP20863
SMRiP20863
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045892

PTM databases

PhosphoSitePlusiP20863

Proteomic databases

PaxDbiP20863
PRIDEiP20863

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000087408
ENSMUST00000207684; ENSMUSP00000146749; ENSMUSG00000109523
GeneIDi14559
KEGGimmu:14559
UCSCiuc009lzz.4 mouse

Organism-specific databases

CTDi2657
MGIiMGI:95683 Gdf1

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP20863
KOiK05495
OrthoDBiEOG091G0C2J
TreeFamiTF351789

Enzyme and pathway databases

ReactomeiR-MMU-1660661 Sphingolipid de novo biosynthesis

Miscellaneous databases

PROiPR:P20863
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000087408 Expressed in 26 organ(s), highest expression level in Ammon's horn
CleanExiMM_GDF1
ExpressionAtlasiP20863 baseline and differential
GenevisibleiP20863 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDF1_MOUSE
AccessioniPrimary (citable) accession number: P20863
Secondary accession number(s): Q6AXH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: October 10, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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