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Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi439Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-211935 Fatty acids
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A7 (EC:1.14.14.1)
Alternative name(s):
CYPIIA7
Cytochrome P450 IIA4
Gene namesi
Name:CYP2A7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198077.10
HGNCiHGNC:2611 CYP2A7
MIMi608054 gene
neXtProtiNX_P20853

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1549
OpenTargetsiENSG00000198077
PharmGKBiPA27102

Polymorphism and mutation databases

BioMutaiCYP2A7
DMDMi215273959

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516691 – 494Cytochrome P450 2A7Add BLAST494

Proteomic databases

PaxDbiP20853
PeptideAtlasiP20853
PRIDEiP20853
ProteomicsDBi53821
TopDownProteomicsiP20853

PTM databases

iPTMnetiP20853
PhosphoSitePlusiP20853

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSG00000198077 Expressed in 76 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP20853 baseline and differential
GenevisibleiP20853 HS

Organism-specific databases

HPAiCAB033510
HPA046713
HPA047262

Interactioni

Protein-protein interaction databases

BioGridi107928, 2 interactors
STRINGi9606.ENSP00000301146

Structurei

3D structure databases

ProteinModelPortaliP20853
SMRiP20853
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP20853
KOiK17684
OMAiFEYEDKQ
OrthoDBiEOG091G0BT8
PhylomeDBiP20853
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P20853-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN
60 70 80 90 100
TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG
110 120 130 140 150
RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ
160 170 180 190 200
EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS
210 220 230 240 250
LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK
260 270 280 290 300
KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI
310 320 330 340 350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP
360 370 380 390 400
YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR
410 420 430 440 450
DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF
460 470 480 490
LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR
Length:494
Mass (Da):56,425
Last modified:November 25, 2008 - v2
Checksum:i4DA10D0C2714E6AA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W816F8W816_HUMAN
Cytochrome P450 2A7
CYP2A7
443Annotation score:
M0R020M0R020_HUMAN
Cytochrome P450 2A7
CYP2A7
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108D → E in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti163T → S in AAA52138 (PubMed:2322567).Curated1
Sequence conflicti226V → L in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti242Q → L in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti402 – 403PS → LR in AAB40520 (PubMed:7668294).Curated2
Sequence conflicti409Q → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti418 – 419DD → GE in AAB40520 (PubMed:7668294).Curated2
Sequence conflicti426S → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti435G → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti438N → Y in AAA52138 (PubMed:2322567).Curated1
Sequence conflicti475P → S in AAA52138 (PubMed:2322567).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04781561F → I. Corresponds to variant dbSNP:rs10425176Ensembl.1
Natural variantiVAR_04781664C → R. Corresponds to variant dbSNP:rs10425169Ensembl.1
Natural variantiVAR_061043169D → E. Corresponds to variant dbSNP:rs4142867Ensembl.1
Natural variantiVAR_047817274H → R. Corresponds to variant dbSNP:rs4079366Ensembl.1
Natural variantiVAR_047818301A → G. Corresponds to variant dbSNP:rs2545754Ensembl.1
Natural variantiVAR_047819311R → C. Corresponds to variant dbSNP:rs3869579Ensembl.1
Natural variantiVAR_047820368M → T. Corresponds to variant dbSNP:rs2261144Ensembl.1
Natural variantiVAR_061044479V → G1 PublicationCorresponds to variant dbSNP:rs12460590Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33317 mRNA Translation: AAA52138.1
U22029 mRNA Translation: AAB40520.1
AC008537 Genomic DNA No translation available.
CCDSiCCDS12569.1
PIRiC34271
I38967
RefSeqiNP_000755.2, NM_000764.2
NP_085079.2, NM_030589.2
UniGeneiHs.719890

Genome annotation databases

EnsembliENST00000301146; ENSP00000301146; ENSG00000198077
GeneIDi1549
KEGGihsa:1549
UCSCiuc002opm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33317 mRNA Translation: AAA52138.1
U22029 mRNA Translation: AAB40520.1
AC008537 Genomic DNA No translation available.
CCDSiCCDS12569.1
PIRiC34271
I38967
RefSeqiNP_000755.2, NM_000764.2
NP_085079.2, NM_030589.2
UniGeneiHs.719890

3D structure databases

ProteinModelPortaliP20853
SMRiP20853
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107928, 2 interactors
STRINGi9606.ENSP00000301146

PTM databases

iPTMnetiP20853
PhosphoSitePlusiP20853

Polymorphism and mutation databases

BioMutaiCYP2A7
DMDMi215273959

Proteomic databases

PaxDbiP20853
PeptideAtlasiP20853
PRIDEiP20853
ProteomicsDBi53821
TopDownProteomicsiP20853

Protocols and materials databases

DNASUi1549
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301146; ENSP00000301146; ENSG00000198077
GeneIDi1549
KEGGihsa:1549
UCSCiuc002opm.3 human

Organism-specific databases

CTDi1549
DisGeNETi1549
EuPathDBiHostDB:ENSG00000198077.10
GeneCardsiCYP2A7
H-InvDBiHIX0137215
HGNCiHGNC:2611 CYP2A7
HPAiCAB033510
HPA046713
HPA047262
MIMi608054 gene
neXtProtiNX_P20853
OpenTargetsiENSG00000198077
PharmGKBiPA27102
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP20853
KOiK17684
OMAiFEYEDKQ
OrthoDBiEOG091G0BT8
PhylomeDBiP20853
TreeFamiTF352043

Enzyme and pathway databases

ReactomeiR-HSA-211935 Fatty acids
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

Miscellaneous databases

ChiTaRSiCYP2A7 human
GeneWikiiCYP2A7
GenomeRNAii1549
PROiPR:P20853
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198077 Expressed in 76 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP20853 baseline and differential
GenevisibleiP20853 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2A7_HUMAN
AccessioniPrimary (citable) accession number: P20853
Secondary accession number(s): Q13121
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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