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Entry version 179 (12 Aug 2020)
Sequence version 2 (25 Nov 2008)
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Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi439Iron (heme axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P20853

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211935, Fatty acids
R-HSA-211981, Xenobiotics
R-HSA-211999, CYP2E1 reactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2A7 (EC:1.14.14.1)
Alternative name(s):
CYPIIA7
Cytochrome P450 IIA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2A7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198077.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2611, CYP2A7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608054, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20853

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1549

Open Targets

More...
OpenTargetsi
ENSG00000198077

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27102

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P20853, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP2A7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273959

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516691 – 494Cytochrome P450 2A7Add BLAST494

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P20853

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20853

PeptideAtlas

More...
PeptideAtlasi
P20853

PRoteomics IDEntifications database

More...
PRIDEi
P20853

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53821

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P20853

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20853

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20853

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198077, Expressed in right lobe of liver and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P20853, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20853, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198077, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107928, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P20853, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301146

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P20853, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20853

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0156, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154117

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001570_22_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20853

KEGG Orthology (KO)

More...
KOi
K17684

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTFIMAM

Database of Orthologous Groups

More...
OrthoDBi
702827at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20853

TreeFam database of animal gene trees

More...
TreeFami
TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008067, Cyt_P450_E_grp-I_CYP2A-like
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463, EP450I
PR01684, EP450ICYP2A
PR00385, P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P20853-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN
60 70 80 90 100
TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG
110 120 130 140 150
RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ
160 170 180 190 200
EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS
210 220 230 240 250
LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK
260 270 280 290 300
KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI
310 320 330 340 350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP
360 370 380 390 400
YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR
410 420 430 440 450
DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF
460 470 480 490
LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR
Length:494
Mass (Da):56,425
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DA10D0C2714E6AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W816F8W816_HUMAN
Cytochrome P450 2A7
CYP2A7
443Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R020M0R020_HUMAN
Cytochrome P450 2A7
CYP2A7
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108D → E in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti163T → S in AAA52138 (PubMed:2322567).Curated1
Sequence conflicti226V → L in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti242Q → L in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti402 – 403PS → LR in AAB40520 (PubMed:7668294).Curated2
Sequence conflicti409Q → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti418 – 419DD → GE in AAB40520 (PubMed:7668294).Curated2
Sequence conflicti426S → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti435G → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti438N → Y in AAA52138 (PubMed:2322567).Curated1
Sequence conflicti475P → S in AAA52138 (PubMed:2322567).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04781561F → I. Corresponds to variant dbSNP:rs10425176Ensembl.1
Natural variantiVAR_04781664C → R. Corresponds to variant dbSNP:rs10425169Ensembl.1
Natural variantiVAR_061043169D → E. Corresponds to variant dbSNP:rs4142867Ensembl.1
Natural variantiVAR_047817274H → R. Corresponds to variant dbSNP:rs4079366Ensembl.1
Natural variantiVAR_047818301A → G. Corresponds to variant dbSNP:rs2545754Ensembl.1
Natural variantiVAR_047819311R → C. Corresponds to variant dbSNP:rs3869579Ensembl.1
Natural variantiVAR_047820368M → T. Corresponds to variant dbSNP:rs2261144Ensembl.1
Natural variantiVAR_061044479V → G1 PublicationCorresponds to variant dbSNP:rs12460590EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M33317 mRNA Translation: AAA52138.1
U22029 mRNA Translation: AAB40520.1
AC008537 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12569.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C34271
I38967

NCBI Reference Sequences

More...
RefSeqi
NP_000755.2, NM_000764.2
NP_085079.2, NM_030589.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301146; ENSP00000301146; ENSG00000198077

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1549

UCSC genome browser

More...
UCSCi
uc002opm.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33317 mRNA Translation: AAA52138.1
U22029 mRNA Translation: AAB40520.1
AC008537 Genomic DNA No translation available.
CCDSiCCDS12569.1
PIRiC34271
I38967
RefSeqiNP_000755.2, NM_000764.2
NP_085079.2, NM_030589.2

3D structure databases

SMRiP20853
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107928, 2 interactors
IntActiP20853, 2 interactors
STRINGi9606.ENSP00000301146

PTM databases

iPTMnetiP20853
PhosphoSitePlusiP20853

Polymorphism and mutation databases

BioMutaiCYP2A7
DMDMi215273959

Proteomic databases

MassIVEiP20853
PaxDbiP20853
PeptideAtlasiP20853
PRIDEiP20853
ProteomicsDBi53821
TopDownProteomicsiP20853

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30661, 197 antibodies

The DNASU plasmid repository

More...
DNASUi
1549

Genome annotation databases

EnsembliENST00000301146; ENSP00000301146; ENSG00000198077
GeneIDi1549
KEGGihsa:1549
UCSCiuc002opm.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1549
DisGeNETi1549
EuPathDBiHostDB:ENSG00000198077.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP2A7
HGNCiHGNC:2611, CYP2A7
HPAiENSG00000198077, Tissue enriched (liver)
MIMi608054, gene
neXtProtiNX_P20853
OpenTargetsiENSG00000198077
PharmGKBiPA27102

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0156, Eukaryota
GeneTreeiENSGT00940000154117
HOGENOMiCLU_001570_22_3_1
InParanoidiP20853
KOiK17684
OMAiNTFIMAM
OrthoDBi702827at2759
PhylomeDBiP20853
TreeFamiTF352043

Enzyme and pathway databases

PathwayCommonsiP20853
ReactomeiR-HSA-211935, Fatty acids
R-HSA-211981, Xenobiotics
R-HSA-211999, CYP2E1 reactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1549, 10 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP2A7, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYP2A7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1549
PharosiP20853, Tbio

Protein Ontology

More...
PROi
PR:P20853
RNActiP20853, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198077, Expressed in right lobe of liver and 93 other tissues
ExpressionAtlasiP20853, baseline and differential
GenevisibleiP20853, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008067, Cyt_P450_E_grp-I_CYP2A-like
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR01684, EP450ICYP2A
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2A7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20853
Secondary accession number(s): Q13121
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: August 12, 2020
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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