UniProtKB - P20853 (CP2A7_HUMAN)

BLAST

>sp|P20853|CP2A7_HUMAN Cytochrome P450 2A7 OS=Homo sapiens OX=9606 GN=CYP2A7 PE=2 SV=2
MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK
FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN
GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN
VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL
LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI
AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ
RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK
GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF
ATIPRNYTMSFLPR

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History
Entry version 168 (07 Nov 2018)
Sequence version 2 (25 Nov 2008)
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Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	439	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

arachidonic acid epoxygenase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
aromatase activity Source: UniProtKB-EC
heme binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
iron ion binding Source: InterPro
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxygen binding
Source: ProtInc
Traceable author statementⁱ
- 7864805
steroid hydroxylase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

coumarin metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
epoxygenase P450 pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exogenous drug catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
organic acid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidation-reduction process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
xenobiotic metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions

Reactomeⁱ

R-HSA-211935 Fatty acids
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2A7 (EC:1.14.14.1) Alternative name(s): CYPIIA7 Cytochrome P450 IIA4
Gene namesⁱ	Name:CYP2A7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198077.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2611 CYP2A7
MIMⁱ	608054 gene
neXtProtⁱ	NX_P20853

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1549
Open Targets More...OpenTargetsⁱ	ENSG00000198077
PharmGKBⁱ	PA27102

Polymorphism and mutation databases

BioMutaⁱ	CYP2A7
DMDMⁱ	215273959

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051669	1 – 494	Cytochrome P450 2A7Add BLAST		494

Proteomic databases

PaxDbⁱ	P20853
PeptideAtlas More...PeptideAtlasⁱ	P20853
PRIDEⁱ	P20853
ProteomicsDBⁱ	53821
TopDownProteomicsⁱ	P20853

PTM databases

iPTMnetⁱ	P20853
PhosphoSitePlusⁱ	P20853

Expressionⁱ

Inductionⁱ

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgeeⁱ	ENSG00000198077 Expressed in 76 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	P20853 baseline and differential
Genevisibleⁱ	P20853 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB033510 HPA046713 HPA047262

HPAⁱ

CAB033510
HPA046713
HPA047262

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107928, 2 interactors
STRINGⁱ	9606.ENSP00000301146

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P20853
SMRⁱ	P20853
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG015789
InParanoidⁱ	P20853
KEGG Orthology (KO) More...KOⁱ	K17684
OMAⁱ	FEYEDKQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P20853
TreeFamⁱ	TF352043

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008067 Cyt_P450_E_grp-I_CYP2A-like IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01684 EP450ICYP2A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P20853-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN 
        60         70         80         90        100
TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG 
       110        120        130        140        150
RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ 
       160        170        180        190        200
EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS 
       210        220        230        240        250
LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK 
       260        270        280        290        300
KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI 
       310        320        330        340        350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP 
       360        370        380        390        400
YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR 
       410        420        430        440        450
DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF 
       460        470        480        490 
LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR

Length:494

Mass (Da):56,425

Last modified:November 25, 2008 - v2

Checksum:ⁱ4DA10D0C2714E6AA

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W816	F8W816_HUMAN	Cytochrome P450 2A7 Cytochrome P450 2A7	CYP2A7	443	Annotation score:
M0R020	M0R020_HUMAN	Cytochrome P450 2A7 Cytochrome P450 2A7	CYP2A7	80	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	108	D → E in AAB40520 (PubMed:7668294).Curated	1
Sequence conflictⁱ	163	T → S in AAA52138 (PubMed:2322567).Curated	1
Sequence conflictⁱ	226	V → L in AAB40520 (PubMed:7668294).Curated	1
Sequence conflictⁱ	242	Q → L in AAB40520 (PubMed:7668294).Curated	1
Sequence conflictⁱ	402 – 403	PS → LR in AAB40520 (PubMed:7668294).Curated	2
Sequence conflictⁱ	409	Q → R in AAB40520 (PubMed:7668294).Curated	1
Sequence conflictⁱ	418 – 419	DD → GE in AAB40520 (PubMed:7668294).Curated	2
Sequence conflictⁱ	426	S → R in AAB40520 (PubMed:7668294).Curated	1
Sequence conflictⁱ	435	G → R in AAB40520 (PubMed:7668294).Curated	1
Sequence conflictⁱ	438	N → Y in AAA52138 (PubMed:2322567).Curated	1
Sequence conflictⁱ	475	P → S in AAA52138 (PubMed:2322567).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047815	61	F → I. Corresponds to variant dbSNP:rs10425176Ensembl.	1
Natural variantⁱVAR_047816	64	C → R. Corresponds to variant dbSNP:rs10425169Ensembl.	1
Natural variantⁱVAR_061043	169	D → E. Corresponds to variant dbSNP:rs4142867Ensembl.	1
Natural variantⁱVAR_047817	274	H → R. Corresponds to variant dbSNP:rs4079366Ensembl.	1
Natural variantⁱVAR_047818	301	A → G. Corresponds to variant dbSNP:rs2545754Ensembl.	1
Natural variantⁱVAR_047819	311	R → C. Corresponds to variant dbSNP:rs3869579Ensembl.	1
Natural variantⁱVAR_047820	368	M → T. Corresponds to variant dbSNP:rs2261144Ensembl.	1
Natural variantⁱVAR_061044	479	V → G1 PublicationCorresponds to variant dbSNP:rs12460590Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M33317 mRNA Translation: AAA52138.1 U22029 mRNA Translation: AAB40520.1 AC008537 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12569.1
PIRⁱ	C34271 I38967
NCBI Reference Sequences More...RefSeqⁱ	NP_000755.2, NM_000764.2 NP_085079.2, NM_030589.2
UniGeneⁱ	Hs.719890

Genome annotation databases

Ensemblⁱ	ENST00000301146; ENSP00000301146; ENSG00000198077
GeneIDⁱ	1549
KEGGⁱ	hsa:1549
UCSC genome browser More...UCSCⁱ	uc002opm.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20853	Cytochrome P450		HUMAN		494	UniRef90_P20853
Cytochrome P450 family 2 subfamily A member 7		PANTR		494
Uncharacterized protein		COLAP		494
Cytochrome P450 family 2 subfamily A member 6		GORGO		494
UPI000C2A4422		Ugandan red Colobus		494
+11

Protein	Similar proteins		Species	Score	Length	Source
P20853	Cytochrome P450 2A6	)	HUMAN		494	UniRef50_P11509
Cytochrome P450 2C2		RABIT		490
Cytochrome P450 2A9		MESAU		493
Cytochrome P450 2C55		RAT		490
Cytochrome P450 2C39		MOUSE		490
+1276

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M33317 mRNA Translation: AAA52138.1 U22029 mRNA Translation: AAB40520.1 AC008537 Genomic DNA No translation available.
CCDSⁱ	CCDS12569.1
PIRⁱ	C34271 I38967
RefSeqⁱ	NP_000755.2, NM_000764.2 NP_085079.2, NM_030589.2
UniGeneⁱ	Hs.719890

3D structure databases

ProteinModelPortalⁱ	P20853
SMRⁱ	P20853
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107928, 2 interactors
STRINGⁱ	9606.ENSP00000301146

PTM databases

iPTMnetⁱ	P20853
PhosphoSitePlusⁱ	P20853

Polymorphism and mutation databases

BioMutaⁱ	CYP2A7
DMDMⁱ	215273959

Proteomic databases

PaxDbⁱ	P20853
PeptideAtlasⁱ	P20853
PRIDEⁱ	P20853
ProteomicsDBⁱ	53821
TopDownProteomicsⁱ	P20853

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1549
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301146; ENSP00000301146; ENSG00000198077
GeneIDⁱ	1549
KEGGⁱ	hsa:1549
UCSCⁱ	uc002opm.3 human

Organism-specific databases

CTDⁱ	1549
DisGeNETⁱ	1549
EuPathDBⁱ	HostDB:ENSG00000198077.10
GeneCardsⁱ	CYP2A7
H-InvDBⁱ	HIX0137215
HGNCⁱ	HGNC:2611 CYP2A7
HPAⁱ	CAB033510 HPA046713 HPA047262
MIMⁱ	608054 gene
neXtProtⁱ	NX_P20853
OpenTargetsⁱ	ENSG00000198077
PharmGKBⁱ	PA27102
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG015789
InParanoidⁱ	P20853
KOⁱ	K17684
OMAⁱ	FEYEDKQ
OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P20853
TreeFamⁱ	TF352043

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions

Reactomeⁱ

R-HSA-211935 Fatty acids
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

Miscellaneous databases

ChiTaRSⁱ	CYP2A7 human
GeneWikiⁱ	CYP2A7
GenomeRNAiⁱ	1549
Protein Ontology More...PROⁱ	PR:P20853
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198077 Expressed in 76 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	P20853 baseline and differential
Genevisibleⁱ	P20853 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008067 Cyt_P450_E_grp-I_CYP2A-like IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01684 EP450ICYP2A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2A7_HUMAN
Accessionⁱ	P20853Primary (citable) accession number: P20853 Secondary accession number(s): Q13121
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - P20853 (CP2A7_HUMAN)

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Cytochrome P450 2A7

CYP2A7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ