UniProtKB - P20853 (CP2A7_HUMAN)
Protein
Cytochrome P450 2A7
Gene
CYP2A7
Organism
Homo sapiens (Human)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 439 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- arachidonic acid epoxygenase activity Source: GO_Central
- aromatase activity Source: UniProtKB-EC
- heme binding Source: GO_Central
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- oxygen binding Source: ProtInc
- steroid hydroxylase activity Source: GO_Central
GO - Biological processi
- coumarin metabolic process Source: GO_Central
- epoxygenase P450 pathway Source: GO_Central
- exogenous drug catabolic process Source: GO_Central
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: GO_Central
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P20853 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CYP2A7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198077.10 |
HGNCi | HGNC:2611, CYP2A7 |
MIMi | 608054, gene |
neXtProti | NX_P20853 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1549 |
OpenTargetsi | ENSG00000198077 |
PharmGKBi | PA27102 |
Miscellaneous databases
Pharosi | P20853, Tbio |
Polymorphism and mutation databases
BioMutai | CYP2A7 |
DMDMi | 215273959 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051669 | 1 – 494 | Cytochrome P450 2A7Add BLAST | 494 |
Proteomic databases
MassIVEi | P20853 |
PaxDbi | P20853 |
PeptideAtlasi | P20853 |
PRIDEi | P20853 |
ProteomicsDBi | 53821 |
TopDownProteomicsi | P20853 |
PTM databases
iPTMneti | P20853 |
PhosphoSitePlusi | P20853 |
Expressioni
Inductioni
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Gene expression databases
Bgeei | ENSG00000198077, Expressed in right lobe of liver and 93 other tissues |
ExpressionAtlasi | P20853, baseline and differential |
Genevisiblei | P20853, HS |
Organism-specific databases
HPAi | ENSG00000198077, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107928, 2 interactors |
IntActi | P20853, 2 interactors |
STRINGi | 9606.ENSP00000301146 |
Miscellaneous databases
RNActi | P20853, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000154117 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P20853 |
OMAi | NTFIMAM |
OrthoDBi | 702827at2759 |
PhylomeDBi | P20853 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008067, Cyt_P450_E_grp-I_CYP2A-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01684, EP450ICYP2A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P20853-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN
60 70 80 90 100
TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG
110 120 130 140 150
RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ
160 170 180 190 200
EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS
210 220 230 240 250
LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK
260 270 280 290 300
KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI
310 320 330 340 350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP
360 370 380 390 400
YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR
410 420 430 440 450
DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF
460 470 480 490
LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W816 | F8W816_HUMAN | Cytochrome P450 2A7 | CYP2A7 | 443 | Annotation score: | ||
M0R020 | M0R020_HUMAN | Cytochrome P450 2A7 | CYP2A7 | 80 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 108 | D → E in AAB40520 (PubMed:7668294).Curated | 1 | |
Sequence conflicti | 163 | T → S in AAA52138 (PubMed:2322567).Curated | 1 | |
Sequence conflicti | 226 | V → L in AAB40520 (PubMed:7668294).Curated | 1 | |
Sequence conflicti | 242 | Q → L in AAB40520 (PubMed:7668294).Curated | 1 | |
Sequence conflicti | 402 – 403 | PS → LR in AAB40520 (PubMed:7668294).Curated | 2 | |
Sequence conflicti | 409 | Q → R in AAB40520 (PubMed:7668294).Curated | 1 | |
Sequence conflicti | 418 – 419 | DD → GE in AAB40520 (PubMed:7668294).Curated | 2 | |
Sequence conflicti | 426 | S → R in AAB40520 (PubMed:7668294).Curated | 1 | |
Sequence conflicti | 435 | G → R in AAB40520 (PubMed:7668294).Curated | 1 | |
Sequence conflicti | 438 | N → Y in AAA52138 (PubMed:2322567).Curated | 1 | |
Sequence conflicti | 475 | P → S in AAA52138 (PubMed:2322567).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047815 | 61 | F → I. Corresponds to variant dbSNP:rs10425176Ensembl. | 1 | |
Natural variantiVAR_047816 | 64 | C → R. Corresponds to variant dbSNP:rs10425169Ensembl. | 1 | |
Natural variantiVAR_061043 | 169 | D → E. Corresponds to variant dbSNP:rs4142867Ensembl. | 1 | |
Natural variantiVAR_047817 | 274 | H → R. Corresponds to variant dbSNP:rs4079366Ensembl. | 1 | |
Natural variantiVAR_047818 | 301 | A → G. Corresponds to variant dbSNP:rs2545754Ensembl. | 1 | |
Natural variantiVAR_047819 | 311 | R → C. Corresponds to variant dbSNP:rs3869579Ensembl. | 1 | |
Natural variantiVAR_047820 | 368 | M → T. Corresponds to variant dbSNP:rs2261144Ensembl. | 1 | |
Natural variantiVAR_061044 | 479 | V → G1 PublicationCorresponds to variant dbSNP:rs12460590EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33317 mRNA Translation: AAA52138.1 U22029 mRNA Translation: AAB40520.1 AC008537 Genomic DNA No translation available. |
CCDSi | CCDS12569.1 |
PIRi | C34271 I38967 |
RefSeqi | NP_000755.2, NM_000764.2 NP_085079.2, NM_030589.2 |
Genome annotation databases
Ensembli | ENST00000301146; ENSP00000301146; ENSG00000198077 |
GeneIDi | 1549 |
KEGGi | hsa:1549 |
UCSCi | uc002opm.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33317 mRNA Translation: AAA52138.1 U22029 mRNA Translation: AAB40520.1 AC008537 Genomic DNA No translation available. |
CCDSi | CCDS12569.1 |
PIRi | C34271 I38967 |
RefSeqi | NP_000755.2, NM_000764.2 NP_085079.2, NM_030589.2 |
3D structure databases
SMRi | P20853 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107928, 2 interactors |
IntActi | P20853, 2 interactors |
STRINGi | 9606.ENSP00000301146 |
PTM databases
iPTMneti | P20853 |
PhosphoSitePlusi | P20853 |
Polymorphism and mutation databases
BioMutai | CYP2A7 |
DMDMi | 215273959 |
Proteomic databases
MassIVEi | P20853 |
PaxDbi | P20853 |
PeptideAtlasi | P20853 |
PRIDEi | P20853 |
ProteomicsDBi | 53821 |
TopDownProteomicsi | P20853 |
Protocols and materials databases
Antibodypediai | 30661, 197 antibodies |
DNASUi | 1549 |
Genome annotation databases
Ensembli | ENST00000301146; ENSP00000301146; ENSG00000198077 |
GeneIDi | 1549 |
KEGGi | hsa:1549 |
UCSCi | uc002opm.3, human |
Organism-specific databases
CTDi | 1549 |
DisGeNETi | 1549 |
EuPathDBi | HostDB:ENSG00000198077.10 |
GeneCardsi | CYP2A7 |
HGNCi | HGNC:2611, CYP2A7 |
HPAi | ENSG00000198077, Tissue enriched (liver) |
MIMi | 608054, gene |
neXtProti | NX_P20853 |
OpenTargetsi | ENSG00000198077 |
PharmGKBi | PA27102 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000154117 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P20853 |
OMAi | NTFIMAM |
OrthoDBi | 702827at2759 |
PhylomeDBi | P20853 |
TreeFami | TF352043 |
Enzyme and pathway databases
PathwayCommonsi | P20853 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions |
Miscellaneous databases
BioGRID-ORCSi | 1549, 10 hits in 842 CRISPR screens |
ChiTaRSi | CYP2A7, human |
GeneWikii | CYP2A7 |
GenomeRNAii | 1549 |
Pharosi | P20853, Tbio |
PROi | PR:P20853 |
RNActi | P20853, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198077, Expressed in right lobe of liver and 93 other tissues |
ExpressionAtlasi | P20853, baseline and differential |
Genevisiblei | P20853, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008067, Cyt_P450_E_grp-I_CYP2A-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01684, EP450ICYP2A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2A7_HUMAN | |
Accessioni | P20853Primary (citable) accession number: P20853 Secondary accession number(s): Q13121 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations