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Protein

Putative alpha-1-antitrypsin-related protein

Gene

SERPINA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative serine protease inhibitor.

Caution

Has been originally thought to be the product of a pseudogene (PubMed:9383284). New lines of evidence suggest it is a truely active gene (PubMed:23826168).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei384 – 385Reactive bondSequence analysis2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.952

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alpha-1-antitrypsin-related protein
Alternative name(s):
Protease inhibitor 1-like
Serpin A2
Gene namesi
Name:SERPINA2
Synonyms:ARGS, ATR, PIL, SERPINA2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8985 SERPINA2
MIMi107410 gene
neXtProtiNX_P20848

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi390502

Polymorphism and mutation databases

DMDMi112891

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003241022 – 420Putative alpha-1-antitrypsin-related proteinAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP20848
PeptideAtlasiP20848
PRIDEiP20848
ProteomicsDBi53815

PTM databases

iPTMnetiP20848
PhosphoSitePlusiP20848

Expressioni

Tissue specificityi

Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung.2 Publications

Gene expression databases

CleanExiHS_ATR

Interactioni

Subunit structurei

Interacts with CANX AND PDIA3.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP20848
SMRiP20848
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP20848
PhylomeDBiP20848

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFSVSWGVL LLAGLCCLVP SSLVEDPQGD AAQKTDTSHH DQGDWEDLAC
60 70 80 90 100
QKISYNVTDL AFDLYKSWLI YHNQHVLVTP TSVAMAFRML SLGTKADTRT
110 120 130 140 150
EILEGLNVNL TETPEAKIHE CFQQVLQALS RPDTRLQLTT GSSLFVNKSM
160 170 180 190 200
KLVDTFLEDT KKLYHSEASS INFRDTEEAK EQINNYVEKR TGRKVVDLVK
210 220 230 240 250
HLKKDTSLAL VDYISFHGKW KDKFKAERIM VEGFHVDDKT IIRVPMINHL
260 270 280 290 300
GRFDIHRDRE LSSWVLAQHY VGNATAFFIL PDPKKMWQLE EKLTYSHLEN
310 320 330 340 350
IQRAFDIRSI NLHFPKLSIS GTYKLKRVPR NLGITKIFSN EADLSGVSQE
360 370 380 390 400
APLKLSKAVH VAVLTIDEKG TEATGAPHLE EKAWSKYQTV MFNRPFLVII
410 420
KEYITNFPLF IGKVVNPTQK
Length:420
Mass (Da):47,891
Last modified:February 1, 1991 - v1
Checksum:i4A5A7B9BE05BCEAA
GO

Polymorphismi

The sequence shown is that of the V3 allele. Other alleles are: V1 and V2.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070190329P → L in V2. 1 Publication1
Natural variantiVAR_070191341E → K in V1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19684, M19685 Genomic DNA Translation: AAA51544.1
PIRiA28882
UniGeneiHs.525557

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiA1ATR_HUMAN
AccessioniPrimary (citable) accession number: P20848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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