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Protein

Cytochrome P450 4A2

Gene

Cyp4a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).1 Publication

Catalytic activityi

A long-chain fatty acid + [reduced NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315Heme (covalent; via 1 link)1 Publication1
Metal bindingi451Iron (heme axial ligand)1 Publication1

GO - Molecular functioni

  • alkane 1-monooxygenase activity Source: RGD
  • arachidonic acid 11,12-epoxygenase activity Source: RGD
  • arachidonic acid binding Source: RGD
  • arachidonic acid monooxygenase activity Source: RGD
  • fatty acid binding Source: RGD
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro

GO - Biological processi

  • arachidonic acid metabolic process Source: RGD
  • icosanoid biosynthetic process Source: RGD
  • kidney development Source: RGD
  • lauric acid metabolic process Source: RGD
  • linoleic acid metabolic process Source: RGD
  • response to drug Source: RGD
  • response to hormone Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-RNO-211935 Fatty acids
R-RNO-211958 Miscellaneous substrates
R-RNO-211979 Eicosanoids
R-RNO-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-RNO-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Chemistry databases

SwissLipidsiSLP:000000743

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4A2
Alternative name(s):
CYPIVA2
Cytochrome P-450 K-2
Cytochrome P450 K-5
Cytochrome P450-LA-omega 2
Lauric acid omega-hydroxylase
Long-chain fatty acid omega-monooxygenase (EC:1.14.14.801 Publication)
Gene namesi
Name:Cyp4a2
Synonyms:Cyp4a-2, Cyp4a11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2479 Cyp4a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000035671 – 42 Publications4
ChainiPRO_00000035685 – 504Cytochrome P450 4A2Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei434PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP20816
PRIDEiP20816

PTM databases

iPTMnetiP20816

Expressioni

Inductioni

By clofibrate.

Gene expression databases

BgeeiENSRNOG00000030154
GenevisibleiP20816 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042072

Structurei

3D structure databases

ProteinModelPortaliP20816
SMRiP20816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOVERGENiHBG000182
InParanoidiP20816
KOiK07425
OMAiLLCRETY

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSVFSPTR SLDGVSGFFQ GAFLLSLFLV LFKAVQFYLR RQWLLKALEK
60 70 80 90 100
FPSTPSHWLW GHNLKDREFQ QVLTWVEKFP GACLQWLSGS TARVLLYDPD
110 120 130 140 150
YVKVVLGRSD PKPYQSLAPW IGYGLLLLNG KKWFQHRRML TPAFHYDILK
160 170 180 190 200
PYVKIMADSV SIMLDKWEKL DDQDHPLEIF HYVSLMTLDT VMKCAFSHQG
210 220 230 240 250
SVQLDVNSRS YTKAVEDLNN LIFFRVRSAF YGNSIIYNMS SDGRLSRRAC
260 270 280 290 300
QIAHEHTDGV IKTRKAQLQN EEELQKARKK RHLDFLDILL FAKMEDGKSL
310 320 330 340 350
SDEDLRAEVD TFMFEGHDTT ASGISWVFYA LATHPEHQER CREEVQSILG
360 370 380 390 400
DGTSVTWDHL DQMPYTTMCI KEALRLYSPV PSVSRELSSP VTFPDGRSIP
410 420 430 440 450
KGIRVTILIY GLHHNPSYWP NPKVFDPSRF SPDSPRHSHA YLPFSGGARN
460 470 480 490 500
CIGKQFAMNE LKVAVALTLL RFELLPDPTR IPVPMPRLVL KSKNGIHLRL

KKLR
Length:504
Mass (Da):57,969
Last modified:August 1, 1991 - v2
Checksum:i8A795DD454125287
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57719 Genomic DNA Translation: AAA41039.1
BC078684 mRNA Translation: AAH78684.1
BC098705 mRNA Translation: AAH98705.1
PIRiA32965
PC4350
RefSeqiNP_001038235.1, NM_001044770.2
XP_017448632.1, XM_017593143.1
UniGeneiRn.214991

Genome annotation databases

EnsembliENSRNOT00000051252; ENSRNOP00000042072; ENSRNOG00000030154
ENSRNOT00000083686; ENSRNOP00000072485; ENSRNOG00000030154
ENSRNOT00000088209; ENSRNOP00000074484; ENSRNOG00000030154
GeneIDi24306
KEGGirno:24306

Similar proteinsi

Entry informationi

Entry nameiCP4A2_RAT
AccessioniPrimary (citable) accession number: P20816
Secondary accession number(s): Q4G071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 1, 1991
Last modified: July 18, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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