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Protein

Cytochrome P450 3A5

Gene

CYP3A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Miscellaneous

Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi441Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aromatase activity Source: UniProtKB-EC
  • estrogen 16-alpha-hydroxylase activity Source: BHF-UCL
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: UniProtKB
  • oxidoreductase activity Source: BHF-UCL
  • oxygen binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.14.14.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-211981 Xenobiotics
R-HSA-5423646 Aflatoxin activation and detoxification

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P20815

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001325

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 3A5 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA5
Cytochrome P450 HLp2
Cytochrome P450-PCN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP3A5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106258.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2638 CYP3A5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605325 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20815

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1577

MalaCards human disease database

More...
MalaCardsi
CYP3A5

Open Targets

More...
OpenTargetsi
ENSG00000106258

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
241043 Tacrolimus dose selection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA131

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3019

Drug and drug target database

More...
DrugBanki
DB00802 Alfentanil
DB00404 Alprazolam
DB06403 Ambrisentan
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00701 Amprenavir
DB06605 Apixaban
DB00673 Aprepitant
DB00278 Argatroban
DB01238 Aripiprazole
DB06413 Armodafinil
DB06697 Artemether
DB00637 Astemizole
DB01076 Atorvastatin
DB06626 Axitinib
DB00972 Azelastine
DB04957 Azimilide
DB00394 Beclomethasone dipropionate
DB08873 Boceprevir
DB08870 Brentuximab vedotin
DB00921 Buprenorphine
DB00490 Buspirone
DB06772 Cabazitaxel
DB00201 Caffeine
DB00564 Carbamazepine
DB00439 Cerivastatin
DB06419 Cethromycin
DB00446 Chloramphenicol
DB00608 Chloroquine
DB01114 Chlorphenamine
DB01166 Cilostazol
DB00501 Cimetidine
DB00537 Ciprofloxacin
DB00604 Cisapride
DB01211 Clarithromycin
DB00575 Clonidine
DB00758 Clopidogrel
DB05239 Cobimetinib
DB00907 Cocaine
DB00318 Codeine
DB08865 Crizotinib
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB09102 Daclatasvir
DB00250 Dapsone
DB01254 Dasatinib
DB00694 Daunorubicin
DB00705 Delavirdine
DB01234 Dexamethasone
DB04856 Dexloxiglumide
DB00514 Dextromethorphan
DB00829 Diazepam
DB00343 Diltiazem
DB00822 Disulfiram
DB01248 Docetaxel
DB08930 Dolutegravir
DB01184 Domperidone
DB01126 Dutasteride
DB08899 Enzalutamide
DB00700 Eplerenone
DB00530 Erlotinib
DB00783 Estradiol
DB00655 Estrone
DB00593 Ethosuximide
DB00773 Etoposide
DB01023 Felodipine
DB00813 Fentanyl
DB01216 Finasteride
DB00196 Fluconazole
DB00472 Fluoxetine
DB00499 Flutamide
DB00588 Fluticasone Propionate
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB00317 Gefitinib
DB06730 Gestodene
DB00889 Granisetron
DB01218 Halofantrine
DB00502 Haloperidol
DB00741 Hydrocortisone
DB06789 Hydroxyprogesterone caproate
DB09053 Ibrutinib
DB01181 Ifosfamide
DB04946 Iloperidone
DB00619 Imatinib
DB00224 Indinavir
DB00762 Irinotecan
DB01167 Itraconazole
DB01026 Ketoconazole
DB01259 Lapatinib
DB00528 Lercanidipine
DB01227 Levomethadyl Acetate
DB00281 Lidocaine
DB00678 Losartan
DB00227 Lovastatin
DB00333 Methadone
DB01388 Mibefradil
DB00683 Midazolam
DB00834 Mifepristone
DB00745 Modafinil
DB00688 Mycophenolate mofetil
DB00731 Nateglinide
DB01149 Nefazodone
DB00220 Nelfinavir
DB00238 Nevirapine
DB00622 Nicardipine
DB01115 Nifedipine
DB00393 Nimodipine
DB00401 Nisoldipine
DB01054 Nitrendipine
DB00717 Norethisterone
DB01059 Norfloxacin
DB00540 Nortriptyline
DB00904 Ondansetron
DB00842 Oxazepam
DB00776 Oxcarbazepine
DB01062 Oxybutynin
DB00497 Oxycodone
DB01229 Paclitaxel
DB01267 Paliperidone
DB09297 Paritaprevir
DB00738 Pentamidine
DB08883 Perampanel
DB00780 Phenelzine
DB01174 Phenobarbital
DB00252 Phenytoin
DB01100 Pimozide
DB08901 Ponatinib
DB00175 Pravastatin
DB01058 Praziquantel
DB00396 Progesterone
DB00571 Propranolol
DB01224 Quetiapine
DB01103 Quinacrine
DB00468 Quinine
DB00863 Ranitidine
DB00206 Reserpine
DB01045 Rifampicin
DB01201 Rifapentine
DB00734 Risperidone
DB00503 Ritonavir
DB06228 Rivaroxaban
DB06176 Romidepsin
DB01098 Rosuvastatin
DB00938 Salmeterol
DB01232 Saquinavir
DB06335 Saxagliptin
DB06731 Seproxetine
DB00203 Sildenafil
DB00641 Simvastatin
DB00877 Sirolimus
DB00398 Sorafenib
DB00795 Sulfasalazine
DB01268 Sunitinib
DB00864 Tacrolimus
DB00675 Tamoxifen
DB00976 Telithromycin
DB06287 Temsirolimus
DB00444 Teniposide
DB00342 Terfenadine
DB00624 Testosterone
DB01041 Thalidomide
DB05773 Trastuzumab emtansine
DB00656 Trazodone
DB00755 Tretinoin
DB00897 Triazolam
DB00197 Troglitazone
DB01361 Troleandomycin
DB06267 Udenafil
DB00313 Valproic Acid
DB00862 Vardenafil
DB00661 Verapamil
DB00541 Vincristine
DB00582 Voriconazole
DB09068 Vortioxetine
DB00943 Zalcitabine
DB00962 Zaleplon
DB00246 Ziprasidone
DB00425 Zolpidem

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1338

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CYP3A5

Domain mapping of disease mutations (DMDM)

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DMDMi
117157

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000517871 – 502Cytochrome P450 3A5Add BLAST502

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P20815

PeptideAtlas

More...
PeptideAtlasi
P20815

PRoteomics IDEntifications database

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PRIDEi
P20815

ProteomicsDB human proteome resource

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ProteomicsDBi
53804
53805 [P20815-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20815

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20815

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000106258 Expressed in 182 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_CYP3A5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P20815 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P20815 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA072245

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107949, 7 interactors

Protein interaction database and analysis system

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IntActi
P20815, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000222982

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P20815

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P20815

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P20815

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0158 Eukaryota
COG2124 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000039127

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108567

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P20815

KEGG Orthology (KO)

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KOi
K17690

Identification of Orthologs from Complete Genome Data

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OMAi
PAIAKHI

Database of Orthologous Groups

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OrthoDBi
EOG091G0JNC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20815

TreeFam database of animal gene trees

More...
TreeFami
TF105087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P20815-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV
60 70 80 90 100
LSYRQGLWKF DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS
110 120 130 140 150
VFTNRRSLGP VGFMKSAISL AEDEEWKRIR SLLSPTFTSG KLKEMFPIIA
160 170 180 190 200
QYGDVLVRNL RREAEKGKPV TLKDIFGAYS MDVITGTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL FPKDTINFLS
260 270 280 290 300
KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV
360 370 380 390 400
VQMEYLDMVV NETLRLFPVA IRLERTCKKD VEINGVFIPK GSMVVIPTYA
410 420 430 440 450
LHHDPKYWTE PEEFRPERFS KKKDSIDPYI YTPFGTGPRN CIGMRFALMN
460 470 480 490 500
MKLALIRVLQ NFSFKPCKET QIPLKLDTQG LLQPEKPIVL KVDSRDGTLS

GE
Length:502
Mass (Da):57,109
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5A2302E2633E717
GO
Isoform 2 (identifier: P20815-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-140: SLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG → ICATTSTIKMQTHSVTMWLPPAVLQSQHGVCLFL
     141-502: Missing.

Note: No experimental confirmation available.
Show »
Length:140
Mass (Da):15,846
Checksum:iF40CE9C9DAE2CAC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z3N0Q7Z3N0_HUMAN
Cytochrome P450 3A5
CYP3A5 DKFZp686I18188
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti305A → P no nucleotide entry (PubMed:2802615).Curated1
Sequence conflicti318L → F no nucleotide entry (PubMed:2802615).Curated1
Sequence conflicti324H → D no nucleotide entry (PubMed:2802615).Curated1
Sequence conflicti377C → G no nucleotide entry (PubMed:2802615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02473128R → C in allele CYP3A5*8. 1 PublicationCorresponds to variant dbSNP:rs55817950Ensembl.1
Natural variantiVAR_02472830H → Y1 PublicationCorresponds to variant dbSNP:rs28383468Ensembl.1
Natural variantiVAR_024732200Q → R in allele CYP3A5*4. 1 PublicationCorresponds to variant dbSNP:rs56411402Ensembl.1
Natural variantiVAR_024729277D → E1 PublicationCorresponds to variant dbSNP:rs28383477Ensembl.1
Natural variantiVAR_024730337A → T in allele CYP3A5*9. 2 PublicationsCorresponds to variant dbSNP:rs28383479Ensembl.1
Natural variantiVAR_029161371I → V. Corresponds to variant dbSNP:rs28365092Ensembl.1
Natural variantiVAR_008365398T → N in allele CYP3A5*2. 2 PublicationsCorresponds to variant dbSNP:rs28365083Ensembl.1
Natural variantiVAR_024733446F → S1 PublicationCorresponds to variant dbSNP:rs41279854Ensembl.1
Natural variantiVAR_029162488I → T. Corresponds to variant dbSNP:rs28365085Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042734107 – 140SLGPV…TFTSG → ICATTSTIKMQTHSVTMWLP PAVLQSQHGVCLFL in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_042735141 – 502Missing in isoform 2. 1 PublicationAdd BLAST362

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04813 mRNA Translation: AAA02993.1
AK299002 mRNA Translation: BAH12923.1
AC005020 Genomic DNA Translation: AAS02016.1
CH236956 Genomic DNA Translation: EAL23868.1
CH471091 Genomic DNA Translation: EAW76638.1
CH471091 Genomic DNA Translation: EAW76642.1
BC033862 mRNA Translation: AAH33862.1
AF280107 Genomic DNA Translation: AAG32288.1
L35912 Genomic DNA Translation: AAB00083.1
S74699 Genomic DNA Translation: AAD14157.1
S74700 Genomic DNA Translation: AAD14158.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55134.1 [P20815-2]
CCDS5672.1 [P20815-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A34101
A60558

NCBI Reference Sequences

More...
RefSeqi
NP_000768.1, NM_000777.4 [P20815-1]
NP_001177413.1, NM_001190484.2 [P20815-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.571258

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222982; ENSP00000222982; ENSG00000106258 [P20815-1]
ENST00000439761; ENSP00000401269; ENSG00000106258 [P20815-2]
ENST00000646887; ENSP00000496704; ENSG00000106258 [P20815-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1577

UCSC genome browser

More...
UCSCi
uc003urq.4 human [P20815-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP3A5 alleles

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04813 mRNA Translation: AAA02993.1
AK299002 mRNA Translation: BAH12923.1
AC005020 Genomic DNA Translation: AAS02016.1
CH236956 Genomic DNA Translation: EAL23868.1
CH471091 Genomic DNA Translation: EAW76638.1
CH471091 Genomic DNA Translation: EAW76642.1
BC033862 mRNA Translation: AAH33862.1
AF280107 Genomic DNA Translation: AAG32288.1
L35912 Genomic DNA Translation: AAB00083.1
S74699 Genomic DNA Translation: AAD14157.1
S74700 Genomic DNA Translation: AAD14158.1
CCDSiCCDS55134.1 [P20815-2]
CCDS5672.1 [P20815-1]
PIRiA34101
A60558
RefSeqiNP_000768.1, NM_000777.4 [P20815-1]
NP_001177413.1, NM_001190484.2 [P20815-2]
UniGeneiHs.571258

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VEUX-ray2.91A/B/C/D/E/F/G/H/I/J/K/L24-497[»]
ProteinModelPortaliP20815
SMRiP20815
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107949, 7 interactors
IntActiP20815, 4 interactors
STRINGi9606.ENSP00000222982

Chemistry databases

BindingDBiP20815
ChEMBLiCHEMBL3019
DrugBankiDB00802 Alfentanil
DB00404 Alprazolam
DB06403 Ambrisentan
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00701 Amprenavir
DB06605 Apixaban
DB00673 Aprepitant
DB00278 Argatroban
DB01238 Aripiprazole
DB06413 Armodafinil
DB06697 Artemether
DB00637 Astemizole
DB01076 Atorvastatin
DB06626 Axitinib
DB00972 Azelastine
DB04957 Azimilide
DB00394 Beclomethasone dipropionate
DB08873 Boceprevir
DB08870 Brentuximab vedotin
DB00921 Buprenorphine
DB00490 Buspirone
DB06772 Cabazitaxel
DB00201 Caffeine
DB00564 Carbamazepine
DB00439 Cerivastatin
DB06419 Cethromycin
DB00446 Chloramphenicol
DB00608 Chloroquine
DB01114 Chlorphenamine
DB01166 Cilostazol
DB00501 Cimetidine
DB00537 Ciprofloxacin
DB00604 Cisapride
DB01211 Clarithromycin
DB00575 Clonidine
DB00758 Clopidogrel
DB05239 Cobimetinib
DB00907 Cocaine
DB00318 Codeine
DB08865 Crizotinib
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB09102 Daclatasvir
DB00250 Dapsone
DB01254 Dasatinib
DB00694 Daunorubicin
DB00705 Delavirdine
DB01234 Dexamethasone
DB04856 Dexloxiglumide
DB00514 Dextromethorphan
DB00829 Diazepam
DB00343 Diltiazem
DB00822 Disulfiram
DB01248 Docetaxel
DB08930 Dolutegravir
DB01184 Domperidone
DB01126 Dutasteride
DB08899 Enzalutamide
DB00700 Eplerenone
DB00530 Erlotinib
DB00783 Estradiol
DB00655 Estrone
DB00593 Ethosuximide
DB00773 Etoposide
DB01023 Felodipine
DB00813 Fentanyl
DB01216 Finasteride
DB00196 Fluconazole
DB00472 Fluoxetine
DB00499 Flutamide
DB00588 Fluticasone Propionate
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB00317 Gefitinib
DB06730 Gestodene
DB00889 Granisetron
DB01218 Halofantrine
DB00502 Haloperidol
DB00741 Hydrocortisone
DB06789 Hydroxyprogesterone caproate
DB09053 Ibrutinib
DB01181 Ifosfamide
DB04946 Iloperidone
DB00619 Imatinib
DB00224 Indinavir
DB00762 Irinotecan
DB01167 Itraconazole
DB01026 Ketoconazole
DB01259 Lapatinib
DB00528 Lercanidipine
DB01227 Levomethadyl Acetate
DB00281 Lidocaine
DB00678 Losartan
DB00227 Lovastatin
DB00333 Methadone
DB01388 Mibefradil
DB00683 Midazolam
DB00834 Mifepristone
DB00745 Modafinil
DB00688 Mycophenolate mofetil
DB00731 Nateglinide
DB01149 Nefazodone
DB00220 Nelfinavir
DB00238 Nevirapine
DB00622 Nicardipine
DB01115 Nifedipine
DB00393 Nimodipine
DB00401 Nisoldipine
DB01054 Nitrendipine
DB00717 Norethisterone
DB01059 Norfloxacin
DB00540 Nortriptyline
DB00904 Ondansetron
DB00842 Oxazepam
DB00776 Oxcarbazepine
DB01062 Oxybutynin
DB00497 Oxycodone
DB01229 Paclitaxel
DB01267 Paliperidone
DB09297 Paritaprevir
DB00738 Pentamidine
DB08883 Perampanel
DB00780 Phenelzine
DB01174 Phenobarbital
DB00252 Phenytoin
DB01100 Pimozide
DB08901 Ponatinib
DB00175 Pravastatin
DB01058 Praziquantel
DB00396 Progesterone
DB00571 Propranolol
DB01224 Quetiapine
DB01103 Quinacrine
DB00468 Quinine
DB00863 Ranitidine
DB00206 Reserpine
DB01045 Rifampicin
DB01201 Rifapentine
DB00734 Risperidone
DB00503 Ritonavir
DB06228 Rivaroxaban
DB06176 Romidepsin
DB01098 Rosuvastatin
DB00938 Salmeterol
DB01232 Saquinavir
DB06335 Saxagliptin
DB06731 Seproxetine
DB00203 Sildenafil
DB00641 Simvastatin
DB00877 Sirolimus
DB00398 Sorafenib
DB00795 Sulfasalazine
DB01268 Sunitinib
DB00864 Tacrolimus
DB00675 Tamoxifen
DB00976 Telithromycin
DB06287 Temsirolimus
DB00444 Teniposide
DB00342 Terfenadine
DB00624 Testosterone
DB01041 Thalidomide
DB05773 Trastuzumab emtansine
DB00656 Trazodone
DB00755 Tretinoin
DB00897 Triazolam
DB00197 Troglitazone
DB01361 Troleandomycin
DB06267 Udenafil
DB00313 Valproic Acid
DB00862 Vardenafil
DB00661 Verapamil
DB00541 Vincristine
DB00582 Voriconazole
DB09068 Vortioxetine
DB00943 Zalcitabine
DB00962 Zaleplon
DB00246 Ziprasidone
DB00425 Zolpidem
GuidetoPHARMACOLOGYi1338
SwissLipidsiSLP:000001325

PTM databases

iPTMnetiP20815
PhosphoSitePlusiP20815

Polymorphism and mutation databases

BioMutaiCYP3A5
DMDMi117157

Proteomic databases

PaxDbiP20815
PeptideAtlasiP20815
PRIDEiP20815
ProteomicsDBi53804
53805 [P20815-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1577
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222982; ENSP00000222982; ENSG00000106258 [P20815-1]
ENST00000439761; ENSP00000401269; ENSG00000106258 [P20815-2]
ENST00000646887; ENSP00000496704; ENSG00000106258 [P20815-2]
GeneIDi1577
KEGGihsa:1577
UCSCiuc003urq.4 human [P20815-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1577
DisGeNETi1577
EuPathDBiHostDB:ENSG00000106258.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP3A5
HGNCiHGNC:2638 CYP3A5
HPAiHPA072245
MalaCardsiCYP3A5
MIMi605325 gene
neXtProtiNX_P20815
OpenTargetsiENSG00000106258
Orphaneti241043 Tacrolimus dose selection
PharmGKBiPA131

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00940000153111
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiP20815
KOiK17690
OMAiPAIAKHI
OrthoDBiEOG091G0JNC
PhylomeDBiP20815
TreeFamiTF105087

Enzyme and pathway databases

BRENDAi1.14.14.1 2681
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-5423646 Aflatoxin activation and detoxification
SABIO-RKiP20815

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP3A5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYP3A5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1577

Protein Ontology

More...
PROi
PR:P20815

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106258 Expressed in 182 organ(s), highest expression level in liver
CleanExiHS_CYP3A5
ExpressionAtlasiP20815 baseline and differential
GenevisibleiP20815 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP3A5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20815
Secondary accession number(s): A4D289
, B7Z5I7, Q53WY8, Q75MV0, Q9HB56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: December 5, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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