UniProtKB - P20813 (CP2B6_HUMAN)
Protein
Cytochrome P450 2B6
Gene
CYP2B6
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:21289075, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:21289075, PubMed:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850).4 Publications
Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.1 Publication
Catalytic activityi
- N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- O2 + reduced [NADPH—hemoprotein reductase] + testosterone = 16α,17β-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- O2 + reduced [NADPH—hemoprotein reductase] + testosterone = 16β,17β-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,4-cineole + O2 + reduced [NADPH—hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
heme3 Publications
Kineticsi
- KM=360 µM for 1,4-cineole1 Publication
- KM=13.3 µM for testosterone (16-alpha-hydroxylation)1 Publication
- KM=27.7 µM for testosterone (16-beta-hydroxylation)1 Publication
- KM=3.6 µM for N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (14,15-epoxidation)1 Publication
- KM=1.32 µM for N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (11,12-epoxidation)1 Publication
- KM=1.21 µM for N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (8,9-epoxidation)1 Publication
- Vmax=3.4 nmol/min/nmol enzyme toward 1,4-cineole1 Publication
- Vmax=2.04 pmol/min/pmol enzyme toward N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (14,15-epoxidation)1 Publication
- Vmax=7.56 pmol/min/pmol enzyme toward N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (11,12-epoxidation)1 Publication
- Vmax=3.12 pmol/min/pmol enzyme toward N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (8,9-epoxidation)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 436 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- anandamide 11,12 epoxidase activity Source: UniProtKB
- anandamide 14,15 epoxidase activity Source: UniProtKB
- anandamide 8,9 epoxidase activity Source: UniProtKB
- arachidonic acid epoxygenase activity Source: GO_Central
- estrogen 2-hydroxylase activity Source: UniProtKB
- heme binding Source: UniProtKB
- iron ion binding Source: InterPro
- monooxygenase activity Source: BHF-UCL
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- steroid hydroxylase activity Source: GO_Central
- testosterone 16-alpha-hydroxylase activity Source: UniProtKB
- testosterone 16-beta-hydroxylase activity Source: UniProtKB
GO - Biological processi
- cellular ketone metabolic process Source: BHF-UCL
- drug metabolic process Source: BHF-UCL
- epoxygenase P450 pathway Source: GO_Central
- exogenous drug catabolic process Source: BHF-UCL
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: BHF-UCL
- steroid metabolic process Source: BHF-UCL
- xenobiotic metabolic process Source: UniProtKB
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding, NADP |
Enzyme and pathway databases
BioCyci | MetaCyc:HS09587-MONOMER |
BRENDAi | 1.14.14.1, 2681 |
PathwayCommonsi | P20813 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions |
SABIO-RKi | P20813 |
SIGNORi | P20813 |
Chemistry databases
SwissLipidsi | SLP:000001346 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2B6 (EC:1.14.13.-2 Publications)Alternative name(s): 1,4-cineole 2-exo-monooxygenase1 Publication CYPIIB6 Cytochrome P450 IIB11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197408.8 |
HGNCi | HGNC:2615, CYP2B6 |
MIMi | 123930, gene |
neXtProti | NX_P20813 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1555 |
MalaCardsi | CYP2B6 |
MIMi | 614546, phenotype |
OpenTargetsi | ENSG00000197408 |
Orphaneti | 240869, Efavirenz toxicity |
PharmGKBi | PA123 |
Miscellaneous databases
Pharosi | P20813, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4729 |
DrugBanki | DB08369, 1-(biphenyl-4-ylmethyl)-1H-imidazole DB02974, 4-(4-Chlorophenyl)Imidazole DB12001, Abemaciclib DB00321, Amitriptyline DB00381, Amlodipine DB00701, Amprenavir DB01435, Antipyrine DB00714, Apomorphine DB06413, Armodafinil DB06697, Artemether DB13132, Artemisinin DB11586, Asunaprevir DB01076, Atorvastatin DB00972, Azelastine DB04975, Banoxantrone DB00865, Benzphetamine DB00443, Betamethasone DB04794, Bifonazole DB05541, Brivaracetam DB01222, Budesonide DB01156, Bupropion DB00564, Carbamazepine DB06119, Cenobamate DB00439, Cerivastatin DB00568, Cinnarizine DB00604, Cisapride DB00515, Cisplatin DB00349, Clobazam DB06470, Clomethiazole DB00758, Clopidogrel DB01559, Clotiazepam DB00257, Clotrimazole DB01394, Colchicine DB05219, Crisaborole DB08865, Crizotinib DB11672, Curcumin DB14635, Curcumin sulfate DB04664, Cyclohexyl-pentyl-maltoside DB00531, Cyclophosphamide DB08912, Dabrafenib DB01151, Desipramine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB04856, Dexloxiglumide DB00514, Dextromethorphan DB00829, Diazepam DB00586, Diclofenac DB01184, Domperidone DB00997, Doxorubicin DB00625, Efavirenz DB15444, Elexacaftor DB13874, Enasidenib DB08899, Enzalutamide DB00751, Epinastine DB11823, Esketamine DB00655, Estrone DB00898, Ethanol DB01466, Ethylmorphine DB01544, Flunitrazepam DB00472, Fluoxetine DB01095, Fluvastatin DB00176, Fluvoxamine DB01320, Fosphenytoin DB01159, Halothane DB00956, Hydrocodone DB00741, Hydrocortisone DB09054, Idelalisib DB01181, Ifosfamide DB00458, Imipramine DB00762, Irinotecan DB11633, Isavuconazole DB00753, Isoflurane DB11757, Istradefylline DB01167, Itraconazole DB14568, Ivosidenib DB09570, Ixazomib DB01221, Ketamine DB06738, Ketobemidone DB01026, Ketoconazole DB11951, Lemborexant DB09078, Lenvatinib DB12070, Letermovir DB00281, Lidocaine DB00836, Loperamide DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB12130, Lorlatinib DB09280, Lumacaftor DB00772, Malathion DB09238, Manidipine DB01043, Memantine DB00454, Meperidine DB00532, Mephenytoin DB04817, Metamizole DB00333, Methadone DB00763, Methimazole DB01028, Methoxyflurane DB09241, Methylene blue DB00849, Methylphenobarbital DB00959, Methylprednisolone DB06710, Methyltestosterone DB00379, Mexiletine DB06148, Mianserin DB01110, Miconazole DB06595, Midostaurin DB00745, Modafinil DB00220, Nelfinavir DB00238, Nevirapine DB00622, Nicardipine DB00184, Nicotine DB01115, Nifedipine DB04868, Nilotinib DB00435, Nitric Oxide DB00957, Norgestimate DB09074, Olaparib DB01173, Orphenadrine DB11837, Osilodrostat DB04938, Ospemifene DB00715, Paroxetine DB08883, Perampanel DB01074, Perhexiline DB04930, Permethrin DB12978, Pexidartinib DB03575, Phencyclidine DB01174, Phenobarbital DB00252, Phenytoin DB13941, Piperaquine DB11642, Pitolisant DB06209, Prasugrel DB14631, Prednisolone phosphate DB00635, Prednisone DB01069, Promethazine DB00818, Propofol DB01589, Quazepam DB00908, Quinidine DB00481, Raloxifene DB08896, Regorafenib DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB01201, Rifapentine DB08864, Rilpivirine DB00503, Ritonavir DB06176, Romidepsin DB00296, Ropivacaine DB00778, Roxithromycin DB06654, Safinamide DB01037, Selegiline DB06739, Seratrodast DB01104, Sertraline DB01236, Sevoflurane DB00641, Simvastatin DB00398, Sorafenib DB06729, Sulfaphenazole DB01138, Sulfinpyrazone DB00675, Tamoxifen DB00231, Temazepam DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB04572, Thiotepa DB00208, Ticlopidine DB00193, Tramadol DB00755, Tretinoin DB12245, Triclabendazole DB12808, Trifarotene DB00197, Troglitazone DB00313, Valproic acid DB11613, Velpatasvir DB08881, Vemurafenib DB00661, Verapamil DB00582, Voriconazole DB09068, Vortioxetine DB14975, Voxelotor DB15035, Zanubrutinib |
DrugCentrali | P20813 |
GuidetoPHARMACOLOGYi | 1324 |
Polymorphism and mutation databases
BioMutai | CYP2B6 |
DMDMi | 117205 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051683 | 1 – 491 | Cytochrome P450 2B6Add BLAST | 491 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 128 | Phosphoserine; by PKABy similarity | 1 |
Post-translational modificationi
Phosphorylation is accompanied by a decrease in enzyme activity.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P20813 |
MassIVEi | P20813 |
PaxDbi | P20813 |
PeptideAtlasi | P20813 |
PRIDEi | P20813 |
ProteomicsDBi | 5366 53803 [P20813-1] |
PTM databases
iPTMneti | P20813 |
PhosphoSitePlusi | P20813 |
Expressioni
Tissue specificityi
Expressed in liver, lung and heart right ventricle.1 Publication
Inductioni
By phenobarbital.
Gene expression databases
Bgeei | ENSG00000197408, Expressed in liver and 92 other tissues |
ExpressionAtlasi | P20813, baseline and differential |
Genevisiblei | P20813, HS |
Organism-specific databases
HPAi | ENSG00000197408, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107933, 4 interactors |
IntActi | P20813, 5 interactors |
STRINGi | 9606.ENSP00000324648 |
Chemistry databases
BindingDBi | P20813 |
Miscellaneous databases
RNActi | P20813, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P20813 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20813 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000157162 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P20813 |
OMAi | HICLGMK |
OrthoDBi | 702827at2759 |
PhylomeDBi | P20813 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008068, Cyt_P450_E_grp-I_CYP2B-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01685, EP450ICYP2B PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P20813-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELSVLLFLA LLTGLLLLLV QRHPNTHDRL PPGPRPLPLL GNLLQMDRRG
60 70 80 90 100
LLKSFLRFRE KYGDVFTVHL GPRPVVMLCG VEAIREALVD KAEAFSGRGK
110 120 130 140 150
IAMVDPFFRG YGVIFANGNR WKVLRRFSVT TMRDFGMGKR SVEERIQEEA
160 170 180 190 200
QCLIEELRKS KGALMDPTFL FQSITANIIC SIVFGKRFHY QDQEFLKMLN
210 220 230 240 250
LFYQTFSLIS SVFGQLFELF SGFLKYFPGA HRQVYKNLQE INAYIGHSVE
260 270 280 290 300
KHRETLDPSA PKDLIDTYLL HMEKEKSNAH SEFSHQNLNL NTLSLFFAGT
310 320 330 340 350
ETTSTTLRYG FLLMLKYPHV AERVYREIEQ VIGPHRPPEL HDRAKMPYTE
360 370 380 390 400
AVIYEIQRFS DLLPMGVPHI VTQHTSFRGY IIPKDTEVFL ILSTALHDPH
410 420 430 440 450
YFEKPDAFNP DHFLDANGAL KKTEAFIPFS LGKRICLGEG IARAELFLFF
460 470 480 490
TTILQNFSMA SPVAPEDIDL TPQECGVGKI PPTYQIRFLP R
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZJ2 | M0QZJ2_HUMAN | Cytochrome P450 2B6 | CYP2B6 | 255 | Annotation score: | ||
A0A2R8YFA4 | A0A2R8YFA4_HUMAN | Cytochrome P450 2B6 | CYP2B6 | 194 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 | I → T in AAF13602 (Ref. 2) Curated | 1 | |
Sequence conflicti | 238 | L → P in AAF13602 (Ref. 2) Curated | 1 |
Polymorphismi
Variability among CYP2B6 alleles may account for differential metabolism of endogenous steroids and endocannabinoids among individuals. For 16-alpha hydroxylation of testosterone, Vmax/Km values between alleles decrease in the following order: 2B6*1 > 2B6*6 > 2B6*9 > 2B7*4. For 16-beta hydroxylation of testosterone, 2B6*6 has the highest catalytic efficiency. For anandamide metabolism, 2B6*6 and 2B6*9 alleles show significantly lower rates of epoxidation (PubMed:21289075). Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIMi:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma. Patients homozygous for 2B6*6 have significantly higher plasma efavirenz levels when compared to 2B6*6 heterozygous ones (PubMed:15622315, PubMed:15194512, PubMed:20639527).4 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023563 | 21 | Q → L in allele CYP2B6*10. 1 PublicationCorresponds to variant dbSNP:rs34883432Ensembl. | 1 | |
Natural variantiVAR_016927 | 22 | R → C in allele CYP2B6*2 and allele CYP2B6*10. 6 PublicationsCorresponds to variant dbSNP:rs8192709Ensembl. | 1 | |
Natural variantiVAR_025206 | 26 | T → S1 PublicationCorresponds to variant dbSNP:rs33973337Ensembl. | 1 | |
Natural variantiVAR_025207 | 28 | D → G1 PublicationCorresponds to variant dbSNP:rs33980385Ensembl. | 1 | |
Natural variantiVAR_033819 | 29 | R → P. Corresponds to variant dbSNP:rs34284776Ensembl. | 1 | |
Natural variantiVAR_025208 | 29 | R → S1 PublicationCorresponds to variant dbSNP:rs33926104Ensembl. | 1 | |
Natural variantiVAR_023564 | 46 | M → V in allele CYP2B6*11. 1 PublicationCorresponds to variant dbSNP:rs35303484Ensembl. | 1 | |
Natural variantiVAR_023565 | 99 | G → E in allele CYP2B6*12. 1 PublicationCorresponds to variant dbSNP:rs36060847Ensembl. | 1 | |
Natural variantiVAR_016948 | 139 | K → E in allele CYP2B6*8 and allele CYP2B6*13. 2 PublicationsCorresponds to variant dbSNP:rs12721655Ensembl. | 1 | |
Natural variantiVAR_023566 | 140 | R → Q in allele CYP2B6*14. 1 PublicationCorresponds to variant dbSNP:rs35773040Ensembl. | 1 | |
Natural variantiVAR_016924 | 167 | P → A2 PublicationsCorresponds to variant dbSNP:rs3826711Ensembl. | 1 | |
Natural variantiVAR_016925 | 172 | Q → H in allele CYP2B6*6, allele CYP2B6*7, allele CYP2B6*9 and allele CYP2B6*13. 8 PublicationsCorresponds to variant dbSNP:rs3745274EnsemblClinVar. | 1 | |
Natural variantiVAR_016928 | 259 | S → R in allele CYP2B6*3. 2 PublicationsCorresponds to variant dbSNP:rs45482602Ensembl. | 1 | |
Natural variantiVAR_016926 | 262 | K → R in allele CYP2B6*4, allele CYP2B6*6, allele CYP2B6*7 and allele CYP2B6*13; slight decrease in activity. 5 PublicationsCorresponds to variant dbSNP:rs2279343EnsemblClinVar. | 1 | |
Natural variantiVAR_025209 | 289 | N → K1 PublicationCorresponds to variant dbSNP:rs34277950Ensembl. | 1 | |
Natural variantiVAR_025210 | 306 | T → S1 PublicationCorresponds to variant dbSNP:rs34698757Ensembl. | 1 | |
Natural variantiVAR_024716 | 328 | I → T2 PublicationsCorresponds to variant dbSNP:rs28399499EnsemblClinVar. | 1 | |
Natural variantiVAR_023567 | 391 | I → N in allele CYP2B6*15. 1 PublicationCorresponds to variant dbSNP:rs35979566Ensembl. | 1 | |
Natural variantiVAR_016929 | 487 | R → C in allele CYP2B6*5 and allele CYP2B6*7. 6 PublicationsCorresponds to variant dbSNP:rs3211371Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055571 | 1 – 57 | MELSV…KSFLR → MRCMLTNSHPWCGCDWQ in isoform 2. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_055572 | 162 – 321 | Missing in isoform 2. 1 PublicationAdd BLAST | 160 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29874 mRNA Translation: AAA52144.1 AF182277 mRNA Translation: AAF13602.1 AK301620 mRNA Translation: BAG63105.1 DQ298753 Genomic DNA Translation: ABB84469.1 AC023172 Genomic DNA Translation: AAF32444.1 AC011541 Genomic DNA No translation available. X13494 mRNA No translation available. |
CCDSi | CCDS12570.1 [P20813-1] |
PIRi | A32969 |
RefSeqi | NP_000758.1, NM_000767.4 [P20813-1] XP_011524852.1, XM_011526550.2 |
Genome annotation databases
Ensembli | ENST00000324071; ENSP00000324648; ENSG00000197408 [P20813-1] |
GeneIDi | 1555 |
KEGGi | hsa:1555 |
UCSCi | uc002opr.2, human [P20813-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP2B6 alleles |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29874 mRNA Translation: AAA52144.1 AF182277 mRNA Translation: AAF13602.1 AK301620 mRNA Translation: BAG63105.1 DQ298753 Genomic DNA Translation: ABB84469.1 AC023172 Genomic DNA Translation: AAF32444.1 AC011541 Genomic DNA No translation available. X13494 mRNA No translation available. |
CCDSi | CCDS12570.1 [P20813-1] |
PIRi | A32969 |
RefSeqi | NP_000758.1, NM_000767.4 [P20813-1] XP_011524852.1, XM_011526550.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3IBD | X-ray | 2.00 | A | 30-491 | [»] | |
3QOA | X-ray | 2.10 | A | 27-491 | [»] | |
3QU8 | X-ray | 2.80 | A/B/C/D/E/F | 27-491 | [»] | |
3UA5 | X-ray | 2.80 | A/B | 27-491 | [»] | |
4I91 | X-ray | 2.00 | A | 27-491 | [»] | |
4RQL | X-ray | 2.10 | A/B | 27-491 | [»] | |
4RRT | X-ray | 2.20 | A/B | 27-491 | [»] | |
4ZV8 | X-ray | 2.24 | A | 30-491 | [»] | |
5UAP | X-ray | 2.03 | A/B | 20-491 | [»] | |
5UDA | X-ray | 1.93 | A/B | 20-491 | [»] | |
5UEC | X-ray | 2.27 | A | 20-491 | [»] | |
5UFG | X-ray | 1.76 | A | 20-491 | [»] | |
5WBG | X-ray | 2.99 | A/B/C/D/E/F | 20-491 | [»] | |
SMRi | P20813 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107933, 4 interactors |
IntActi | P20813, 5 interactors |
STRINGi | 9606.ENSP00000324648 |
Chemistry databases
BindingDBi | P20813 |
ChEMBLi | CHEMBL4729 |
DrugBanki | DB08369, 1-(biphenyl-4-ylmethyl)-1H-imidazole DB02974, 4-(4-Chlorophenyl)Imidazole DB12001, Abemaciclib DB00321, Amitriptyline DB00381, Amlodipine DB00701, Amprenavir DB01435, Antipyrine DB00714, Apomorphine DB06413, Armodafinil DB06697, Artemether DB13132, Artemisinin DB11586, Asunaprevir DB01076, Atorvastatin DB00972, Azelastine DB04975, Banoxantrone DB00865, Benzphetamine DB00443, Betamethasone DB04794, Bifonazole DB05541, Brivaracetam DB01222, Budesonide DB01156, Bupropion DB00564, Carbamazepine DB06119, Cenobamate DB00439, Cerivastatin DB00568, Cinnarizine DB00604, Cisapride DB00515, Cisplatin DB00349, Clobazam DB06470, Clomethiazole DB00758, Clopidogrel DB01559, Clotiazepam DB00257, Clotrimazole DB01394, Colchicine DB05219, Crisaborole DB08865, Crizotinib DB11672, Curcumin DB14635, Curcumin sulfate DB04664, Cyclohexyl-pentyl-maltoside DB00531, Cyclophosphamide DB08912, Dabrafenib DB01151, Desipramine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB04856, Dexloxiglumide DB00514, Dextromethorphan DB00829, Diazepam DB00586, Diclofenac DB01184, Domperidone DB00997, Doxorubicin DB00625, Efavirenz DB15444, Elexacaftor DB13874, Enasidenib DB08899, Enzalutamide DB00751, Epinastine DB11823, Esketamine DB00655, Estrone DB00898, Ethanol DB01466, Ethylmorphine DB01544, Flunitrazepam DB00472, Fluoxetine DB01095, Fluvastatin DB00176, Fluvoxamine DB01320, Fosphenytoin DB01159, Halothane DB00956, Hydrocodone DB00741, Hydrocortisone DB09054, Idelalisib DB01181, Ifosfamide DB00458, Imipramine DB00762, Irinotecan DB11633, Isavuconazole DB00753, Isoflurane DB11757, Istradefylline DB01167, Itraconazole DB14568, Ivosidenib DB09570, Ixazomib DB01221, Ketamine DB06738, Ketobemidone DB01026, Ketoconazole DB11951, Lemborexant DB09078, Lenvatinib DB12070, Letermovir DB00281, Lidocaine DB00836, Loperamide DB01601, Lopinavir DB00455, Loratadine DB04871, Lorcaserin DB12130, Lorlatinib DB09280, Lumacaftor DB00772, Malathion DB09238, Manidipine DB01043, Memantine DB00454, Meperidine DB00532, Mephenytoin DB04817, Metamizole DB00333, Methadone DB00763, Methimazole DB01028, Methoxyflurane DB09241, Methylene blue DB00849, Methylphenobarbital DB00959, Methylprednisolone DB06710, Methyltestosterone DB00379, Mexiletine DB06148, Mianserin DB01110, Miconazole DB06595, Midostaurin DB00745, Modafinil DB00220, Nelfinavir DB00238, Nevirapine DB00622, Nicardipine DB00184, Nicotine DB01115, Nifedipine DB04868, Nilotinib DB00435, Nitric Oxide DB00957, Norgestimate DB09074, Olaparib DB01173, Orphenadrine DB11837, Osilodrostat DB04938, Ospemifene DB00715, Paroxetine DB08883, Perampanel DB01074, Perhexiline DB04930, Permethrin DB12978, Pexidartinib DB03575, Phencyclidine DB01174, Phenobarbital DB00252, Phenytoin DB13941, Piperaquine DB11642, Pitolisant DB06209, Prasugrel DB14631, Prednisolone phosphate DB00635, Prednisone DB01069, Promethazine DB00818, Propofol DB01589, Quazepam DB00908, Quinidine DB00481, Raloxifene DB08896, Regorafenib DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB01201, Rifapentine DB08864, Rilpivirine DB00503, Ritonavir DB06176, Romidepsin DB00296, Ropivacaine DB00778, Roxithromycin DB06654, Safinamide DB01037, Selegiline DB06739, Seratrodast DB01104, Sertraline DB01236, Sevoflurane DB00641, Simvastatin DB00398, Sorafenib DB06729, Sulfaphenazole DB01138, Sulfinpyrazone DB00675, Tamoxifen DB00231, Temazepam DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB04572, Thiotepa DB00208, Ticlopidine DB00193, Tramadol DB00755, Tretinoin DB12245, Triclabendazole DB12808, Trifarotene DB00197, Troglitazone DB00313, Valproic acid DB11613, Velpatasvir DB08881, Vemurafenib DB00661, Verapamil DB00582, Voriconazole DB09068, Vortioxetine DB14975, Voxelotor DB15035, Zanubrutinib |
DrugCentrali | P20813 |
GuidetoPHARMACOLOGYi | 1324 |
SwissLipidsi | SLP:000001346 |
PTM databases
iPTMneti | P20813 |
PhosphoSitePlusi | P20813 |
Polymorphism and mutation databases
BioMutai | CYP2B6 |
DMDMi | 117205 |
Proteomic databases
EPDi | P20813 |
MassIVEi | P20813 |
PaxDbi | P20813 |
PeptideAtlasi | P20813 |
PRIDEi | P20813 |
ProteomicsDBi | 5366 53803 [P20813-1] |
Protocols and materials databases
Antibodypediai | 30684, 334 antibodies |
Genome annotation databases
Ensembli | ENST00000324071; ENSP00000324648; ENSG00000197408 [P20813-1] |
GeneIDi | 1555 |
KEGGi | hsa:1555 |
UCSCi | uc002opr.2, human [P20813-1] |
Organism-specific databases
CTDi | 1555 |
DisGeNETi | 1555 |
EuPathDBi | HostDB:ENSG00000197408.8 |
GeneCardsi | CYP2B6 |
HGNCi | HGNC:2615, CYP2B6 |
HPAi | ENSG00000197408, Tissue enriched (liver) |
MalaCardsi | CYP2B6 |
MIMi | 123930, gene 614546, phenotype |
neXtProti | NX_P20813 |
OpenTargetsi | ENSG00000197408 |
Orphaneti | 240869, Efavirenz toxicity |
PharmGKBi | PA123 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000157162 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P20813 |
OMAi | HICLGMK |
OrthoDBi | 702827at2759 |
PhylomeDBi | P20813 |
TreeFami | TF352043 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS09587-MONOMER |
BRENDAi | 1.14.14.1, 2681 |
PathwayCommonsi | P20813 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions |
SABIO-RKi | P20813 |
SIGNORi | P20813 |
Miscellaneous databases
BioGRID-ORCSi | 1555, 4 hits in 840 CRISPR screens |
EvolutionaryTracei | P20813 |
GeneWikii | CYP2B6 |
GenomeRNAii | 1555 |
Pharosi | P20813, Tchem |
PROi | PR:P20813 |
RNActi | P20813, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197408, Expressed in liver and 92 other tissues |
ExpressionAtlasi | P20813, baseline and differential |
Genevisiblei | P20813, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008068, Cyt_P450_E_grp-I_CYP2B-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01685, EP450ICYP2B PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2B6_HUMAN | |
Accessioni | P20813Primary (citable) accession number: P20813 Secondary accession number(s): B4DWP3, Q2V565, Q9UK46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 213 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations