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UniProtKB - P20810 (ICAL_HUMAN)

Entry version 195 (02 Jun 2021)
Sequence version 4 (20 Feb 2007)
Previous versions | rss
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Protein

Calpastatin

Gene

CAST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P20810

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

SIGNOR Signaling Network Open Resource

More...SIGNORi		P20810

Protein family/group databases

MEROPS protease database

More...MEROPSi		I27.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpastatin
Alternative name(s):
Calpain inhibitor
Sperm BS-17 component
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAST
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1515, CAST

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114090, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P20810

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000153113.23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma.
Related information in OMIM

Keywords - Diseasei

Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...DisGeNETi		831

MalaCards human disease database

More...MalaCardsi		CAST
MIMi616295, phenotype

Open Targets

More...OpenTargetsi		ENSG00000153113

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		444138, Peeling skin-leukonychia-acral punctate keratoses-cheilitis-knuckle pads syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26098

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P20810, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11638, Artenimol
DB01373, Calcium

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAST

Domain mapping of disease mutations (DMDM)

More...DMDMi		126302556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001476321 – 708CalpastatinAdd BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50N6-acetyllysineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei133PhosphoserineCombined sources1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei243PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Isoform 5 (identifier: P20810-5)
Modified residuei11PhosphoserineCombined sources1
Isoform 6 (identifier: P20810-6)
Modified residuei11PhosphoserineCombined sources1
Isoform 7 (identifier: P20810-7)
Modified residuei11PhosphoserineCombined sources1
Isoform 9 (identifier: P20810-9)
Modified residuei11PhosphoserineCombined sources1
Isoform 10 (identifier: P20810-10)
Modified residuei11PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1023
CPTAC-1024

Encyclopedia of Proteome Dynamics

More...EPDi		P20810

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P20810

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P20810

MaxQB - The MaxQuant DataBase

More...MaxQBi		P20810

PeptideAtlas

More...PeptideAtlasi		P20810

PRoteomics IDEntifications database

More...PRIDEi		P20810

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33826
33906
53796 [P20810-1]
53797 [P20810-2]
53798 [P20810-3]
53799 [P20810-4]
53800 [P20810-5]
53801 [P20810-6]
53802 [P20810-7]
6573

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P20810-5 [P20810-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20810

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P20810

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P20810

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000153113, Expressed in calcaneal tendon and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P20810, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20810, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000153113, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107281, 49 interactors

Protein interaction database and analysis system

More...IntActi		P20810, 29 interactors

Molecular INTeraction database

More...MINTi		P20810

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379157

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P20810, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20810

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati170 – 222Inhibitory domain 1Add BLAST53
Repeati304 – 356Inhibitory domain 2Add BLAST53
Repeati446 – 499Inhibitory domain 3Add BLAST54
Repeati583 – 636Inhibitory domain 4Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 187DisorderedSequence analysisAdd BLAST187
Regioni212 – 404DisorderedSequence analysisAdd BLAST193
Regioni416 – 527DisorderedSequence analysisAdd BLAST112
Regioni543 – 708DisorderedSequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 66Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi67 – 92Polar residuesSequence analysisAdd BLAST26
Compositional biasi170 – 185Polar residuesSequence analysisAdd BLAST16
Compositional biasi273 – 287Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi306 – 394Basic and acidic residuesSequence analysisAdd BLAST89
Compositional biasi437 – 497Basic and acidic residuesSequence analysisAdd BLAST61
Compositional biasi543 – 559Polar residuesSequence analysisAdd BLAST17
Compositional biasi561 – 650Basic and acidic residuesSequence analysisAdd BLAST90
Compositional biasi690 – 708Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protease inhibitor I27 (calpastatin) family. [View classification]Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RHIZ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002993

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20810

Identification of Orthologs from Complete Genome Data

More...OMAi		IKEKDHT

Database of Orthologous Groups

More...OrthoDBi		203890at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20810

TreeFam database of animal gene trees

More...TreeFami		TF332525

Family and domain databases

Database of protein disorder

More...DisProti		DP00196

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026998, Calpastatin
IPR001259, Prot_inh_calpain

The PANTHER Classification System

More...PANTHERi		PTHR10077, PTHR10077, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00748, Calpain_inhib, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 10 described isoforms and 33 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P20810-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPTETKAIP VSQQMEGPHL PNKKKHKKQA VKTEPEKKSQ STKLSVVHEK 
        60         70         80         90        100
KSQEGKPKEH TEPKSLPKQA SDTGSNDAHN KKAVSRSAEQ QPSEKSTEPK 
       110        120        130        140        150
TKPQDMISAG GESVAGITAI SGKPGDKKKE KKSLTPAVPV ESKPDKPSGK 
       160        170        180        190        200
SGMDAALDDL IDTLGGPEET EEENTTYTGP EVSDPMSSTY IEELGKREVT 
       210        220        230        240        250
IPPKYRELLA KKEGITGPPA DSSKPIGPDD AIDALSSDFT CGSPTAAGKK 
       260        270        280        290        300
TEKEESTEVL KAQSAGTVRS AAPPQEKKRK VEKDTMSDQA LEALSASLGT 
       310        320        330        340        350
RQAEPELDLR SIKEVDEAKA KEEKLEKCGE DDETIPSEYR LKPATDKDGK 
       360        370        380        390        400
PLLPEPEEKP KPRSESELID ELSEDFDRSE CKEKPSKPTE KTEESKAAAP 
       410        420        430        440        450
APVSEAVCRT SMCSIQSAPP EPATLKGTVP DDAVEALADS LGKKEADPED 
       460        470        480        490        500
GKPVMDKVKE KAKEEDREKL GEKEETIPPD YRLEEVKDKD GKPLLPKESK 
       510        520        530        540        550
EQLPPMSEDF LLDALSEDFS GPQNASSLKF EDAKLAAAIS EVVSQTPAST 
       560        570        580        590        600
TQAGAPPRDT SQSDKDLDDA LDKLSDSLGQ RQPDPDENKP MEDKVKEKAK 
       610        620        630        640        650
AEHRDKLGER DDTIPPEYRH LLDDNGQDKP VKPPTKKSED SKKPADDQDP 
       660        670        680        690        700
IDALSGDLDS CPSTTETSQN TAKDKCKKAA SSSKAPKNGG KAKDSAKTTE 

ETSKPKDD
Length:708
Mass (Da):76,573
Last modified:February 20, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DB0C14B860E89C7
GO
Isoform 2 (identifier: P20810-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-224: Missing.

Show »
Length:695
Mass (Da):75,304
Checksum:i9DBFF022F785D117
GO
Isoform 3 (identifier: P20810-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     212-224: Missing.

Show »
Length:590
Mass (Da):63,665
Checksum:iDB776EDB8EC13005
GO
Isoform 4 (identifier: P20810-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.
     44-62: Missing.

Show »
Length:667
Mass (Da):71,894
Checksum:i47831647A417E024
GO
Isoform 5 (identifier: P20810-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MNPTETKAIPVSQQMEGPHLPNKKKHKKQ → MSQPGQKPAA...SSSMNPTETK
     212-224: Missing.

Show »
Length:756
Mass (Da):81,169
Checksum:i18BA3EAB0A9989D3
GO
Isoform 6 (identifier: P20810-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM

Show »
Length:791
Mass (Da):84,943
Checksum:iDC3DC0A4FC0F0825
GO
Isoform 7 (identifier: P20810-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM
     44-62: Missing.

Show »
Length:772
Mass (Da):82,771
Checksum:i1B147E0CE4CD15E9
GO
Isoform 8 (identifier: P20810-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.

Show »
Length:686
Mass (Da):74,067
Checksum:i3B383857507798D3
GO
Isoform 9 (identifier: P20810-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MNPTETKAIP...QEGKPKEHTE → MSQPGQKPAA...EPEKKSQSTK

Show »
Length:750
Mass (Da):80,265
Checksum:i41EF9956565188AD
GO
Isoform 10 (identifier: P20810-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MNPTETKAIPVSQQMEGPHLPNKKKHKKQ → MSQPGQKPAA...SSSMNPTETK

Show »
Length:769
Mass (Da):82,437
Checksum:iB29C93684805FE0B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 33 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCH5E9PCH5_HUMAN
Calpain inhibitor
CAST
673Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDE4E9PDE4_HUMAN
Calpain inhibitor
CAST
636Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGB5A0A0C4DGB5_HUMAN
Calpain inhibitor
CAST
741Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7E0F8W7E0_HUMAN
Calpain inhibitor
CAST
393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVY3E7EVY3_HUMAN
Calpain inhibitor
CAST
693Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA91H0YA91_HUMAN
Calpain inhibitor
CAST
301Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ES10E7ES10_HUMAN
Calpain inhibitor
CAST
642Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z574B7Z574_HUMAN
Calpain inhibitor
CAST
694Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQ12E7EQ12_HUMAN
Calpain inhibitor
CAST
423Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQA0E7EQA0_HUMAN
Calpain inhibitor
CAST
431Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16066 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti467R → L in AAC50136 (Ref. 12) Curated1
Sequence conflicti486 – 488VKD → GKE in AAC50136 (Ref. 12) Curated3
Sequence conflicti543V → L in AAC50136 (Ref. 12) Curated1
Sequence conflicti562Missing in AAB60371 (Ref. 15) Curated1
Sequence conflicti651I → V in AAD09102 (Ref. 16) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030741380E → K. Corresponds to variant dbSNP:rs1643702Ensembl.1
Natural variantiVAR_022686408C → S4 PublicationsCorresponds to variant dbSNP:rs754615Ensembl.1
Natural variantiVAR_030742537A → V. Corresponds to variant dbSNP:rs4948Ensembl.1
Natural variantiVAR_005298592E → G1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0007411 – 105Missing in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0473931 – 62MNPTE…KEHTE → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETKAVKTEPEKKS QSTK in isoform 9. CuratedAdd BLAST62
Alternative sequenceiVSP_0380371 – 29MNPTE…KHKKQ → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETK in isoform 5 and isoform 10. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0380381M → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSM in isoform 6 and isoform 7. Curated1
Alternative sequenceiVSP_0007429 – 30Missing in isoform 4 and isoform 8. 3 PublicationsAdd BLAST22
Alternative sequenceiVSP_00074344 – 62Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_000744212 – 224Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D16217 mRNA Translation: BAA03747.1
D50827 mRNA Translation: BAA09438.1
AF327443 mRNA Translation: AAG48151.1
BT009783 mRNA Translation: AAP88785.1
AK296919 mRNA Translation: BAH12454.1
AC008906 Genomic DNA No translation available.
AC020900 Genomic DNA No translation available.
AC104125 Genomic DNA No translation available.
KC877037 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW96068.1
CH471084 Genomic DNA Translation: EAW96071.1
CH471084 Genomic DNA Translation: EAW96075.1
BC013579 mRNA Translation: AAH13579.1
BC016066 mRNA Translation: AAH16066.1 Sequence problems.
AL832349 mRNA No translation available.
M86258 mRNA Translation: AAB59398.1
M28230 M28229 Genomic DNA Translation: AAA52066.1
M33328 mRNA Translation: AAA52296.1
U26724 mRNA Translation: AAC50136.2
S73329 mRNA Translation: AAB32311.1
U38525 mRNA Translation: AAA80684.1
U31345 mRNA Translation: AAB60371.1
U31346 mRNA Translation: AAB60372.1
AF095891 mRNA Translation: AAD09102.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4082.1 [P20810-8]
CCDS43344.1 [P20810-10]
CCDS54882.1 [P20810-9]
CCDS54883.1 [P20810-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A38091

NCBI Reference Sequences

More...RefSeqi		NP_001035905.1, NM_001042440.4 [P20810-9]
NP_001035906.1, NM_001042441.2 [P20810-7]
NP_001035907.1, NM_001042442.2 [P20810-10]
NP_001035908.1, NM_001042443.2 [P20810-1]
NP_001035909.1, NM_001042444.2 [P20810-4]
NP_001271141.1, NM_001284212.3
NP_001317560.1, NM_001330631.1 [P20810-2]
NP_001741.4, NM_001750.6 [P20810-6]
NP_775083.1, NM_173060.4 [P20810-8]
XP_006714759.1, XM_006714696.3
XP_006714764.1, XM_006714701.3
XP_006714766.1, XM_006714703.3
XP_006714767.1, XM_006714704.3
XP_016865402.1, XM_017009913.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309190; ENSP00000312523; ENSG00000153113 [P20810-8]
ENST00000338252; ENSP00000343421; ENSG00000153113 [P20810-2]
ENST00000341926; ENSP00000339914; ENSG00000153113 [P20810-1]
ENST00000395812; ENSP00000379157; ENSG00000153113 [P20810-9]
ENST00000395813; ENSP00000379158; ENSG00000153113 [P20810-1]
ENST00000508830; ENSP00000425721; ENSG00000153113 [P20810-6]
ENST00000510756; ENSP00000422176; ENSG00000153113 [P20810-4]
ENST00000674984; ENSP00000501713; ENSG00000153113 [P20810-10]
ENST00000675033; ENSP00000501659; ENSG00000153113 [P20810-4]
ENST00000675179; ENSP00000501872; ENSG00000153113 [P20810-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:831

UCSC genome browser

More...UCSCi		uc003klt.4, human [P20810-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16217 mRNA Translation: BAA03747.1
D50827 mRNA Translation: BAA09438.1
AF327443 mRNA Translation: AAG48151.1
BT009783 mRNA Translation: AAP88785.1
AK296919 mRNA Translation: BAH12454.1
AC008906 Genomic DNA No translation available.
AC020900 Genomic DNA No translation available.
AC104125 Genomic DNA No translation available.
KC877037 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW96068.1
CH471084 Genomic DNA Translation: EAW96071.1
CH471084 Genomic DNA Translation: EAW96075.1
BC013579 mRNA Translation: AAH13579.1
BC016066 mRNA Translation: AAH16066.1 Sequence problems.
AL832349 mRNA No translation available.
M86258 mRNA Translation: AAB59398.1
M28230 M28229 Genomic DNA Translation: AAA52066.1
M33328 mRNA Translation: AAA52296.1
U26724 mRNA Translation: AAC50136.2
S73329 mRNA Translation: AAB32311.1
U38525 mRNA Translation: AAA80684.1
U31345 mRNA Translation: AAB60371.1
U31346 mRNA Translation: AAB60372.1
AF095891 mRNA Translation: AAD09102.1
CCDSiCCDS4082.1 [P20810-8]
CCDS43344.1 [P20810-10]
CCDS54882.1 [P20810-9]
CCDS54883.1 [P20810-2]
PIRiA38091
RefSeqiNP_001035905.1, NM_001042440.4 [P20810-9]
NP_001035906.1, NM_001042441.2 [P20810-7]
NP_001035907.1, NM_001042442.2 [P20810-10]
NP_001035908.1, NM_001042443.2 [P20810-1]
NP_001035909.1, NM_001042444.2 [P20810-4]
NP_001271141.1, NM_001284212.3
NP_001317560.1, NM_001330631.1 [P20810-2]
NP_001741.4, NM_001750.6 [P20810-6]
NP_775083.1, NM_173060.4 [P20810-8]
XP_006714759.1, XM_006714696.3
XP_006714764.1, XM_006714701.3
XP_006714766.1, XM_006714703.3
XP_006714767.1, XM_006714704.3
XP_016865402.1, XM_017009913.1

3D structure databases

SMRiP20810
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107281, 49 interactors
IntActiP20810, 29 interactors
MINTiP20810
STRINGi9606.ENSP00000379157

Chemistry databases

DrugBankiDB11638, Artenimol
DB01373, Calcium

Protein family/group databases

MEROPSiI27.001

PTM databases

iPTMnetiP20810
MetOSiteiP20810
PhosphoSitePlusiP20810

Genetic variation databases

BioMutaiCAST
DMDMi126302556

Proteomic databases

CPTACiCPTAC-1023
CPTAC-1024
EPDiP20810
jPOSTiP20810
MassIVEiP20810
MaxQBiP20810
PeptideAtlasiP20810
PRIDEiP20810
ProteomicsDBi33826
33906
53796 [P20810-1]
53797 [P20810-2]
53798 [P20810-3]
53799 [P20810-4]
53800 [P20810-5]
53801 [P20810-6]
53802 [P20810-7]
6573
TopDownProteomicsiP20810-5 [P20810-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4008, 400 antibodies

The DNASU plasmid repository

More...DNASUi		831

Genome annotation databases

EnsembliENST00000309190; ENSP00000312523; ENSG00000153113 [P20810-8]
ENST00000338252; ENSP00000343421; ENSG00000153113 [P20810-2]
ENST00000341926; ENSP00000339914; ENSG00000153113 [P20810-1]
ENST00000395812; ENSP00000379157; ENSG00000153113 [P20810-9]
ENST00000395813; ENSP00000379158; ENSG00000153113 [P20810-1]
ENST00000508830; ENSP00000425721; ENSG00000153113 [P20810-6]
ENST00000510756; ENSP00000422176; ENSG00000153113 [P20810-4]
ENST00000674984; ENSP00000501713; ENSG00000153113 [P20810-10]
ENST00000675033; ENSP00000501659; ENSG00000153113 [P20810-4]
ENST00000675179; ENSP00000501872; ENSG00000153113 [P20810-6]
GeneIDi831
KEGGihsa:831
UCSCiuc003klt.4, human [P20810-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		831
DisGeNETi831

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAST
HGNCiHGNC:1515, CAST
HPAiENSG00000153113, Tissue enhanced (skeletal)
MalaCardsiCAST
MIMi114090, gene
616295, phenotype
neXtProtiNX_P20810
OpenTargetsiENSG00000153113
Orphaneti444138, Peeling skin-leukonychia-acral punctate keratoses-cheilitis-knuckle pads syndrome
PharmGKBiPA26098
VEuPathDBiHostDB:ENSG00000153113.23

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RHIZ, Eukaryota
GeneTreeiENSGT00390000002993
InParanoidiP20810
OMAiIKEKDHT
OrthoDBi203890at2759
PhylomeDBiP20810
TreeFamiTF332525

Enzyme and pathway databases

PathwayCommonsiP20810
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORiP20810

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		831, 13 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAST, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Calpastatin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		831
PharosiP20810, Tbio

Protein Ontology

More...PROi		PR:P20810
RNActiP20810, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000153113, Expressed in calcaneal tendon and 251 other tissues
ExpressionAtlasiP20810, baseline and differential
GenevisibleiP20810, HS

Family and domain databases

DisProtiDP00196
InterProiView protein in InterPro
IPR026998, Calpastatin
IPR001259, Prot_inh_calpain
PANTHERiPTHR10077, PTHR10077, 1 hit
PfamiView protein in Pfam
PF00748, Calpain_inhib, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICAL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20810
Secondary accession number(s): B7Z468
, G5E946, G5E9D3, O95360, Q05DE8, Q7Z4K0, Q96D08, Q9H1Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 20, 2007
Last modified: June 2, 2021
This is version 195 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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