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Protein

Interleukin-11

Gene

IL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168Important for interaction with IL6ST and for the stimulation of cell proliferationBy similarity1

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB
  • interleukin-11 receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiP20809
SIGNORiP20809

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-11
Short name:
IL-11
Alternative name(s):
Adipogenesis inhibitory factor1 Publication
Short name:
AGIF1 Publication
INN: Oprelvekin
Gene namesi
Name:IL11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000095752.6
HGNCiHGNC:5966 IL11
MIMi147681 gene
neXtProtiNX_P20809

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi182H → V: Increases affinity for IL11RA and stimulation of cell proliferation. 1 Publication1
Mutagenesisi186D → A: Strongly increases affinity for IL11RA and stimulation of cell proliferation. 1 Publication1
Mutagenesisi186D → V: Increases affinity for IL11RA and stimulation of cell proliferation. 1 Publication1

Organism-specific databases

DisGeNETi3589
OpenTargetsiENSG00000095752
PharmGKBiPA29781

Polymorphism and mutation databases

BioMutaiIL11
DMDMi124294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001561822 – 199Interleukin-11Add BLAST178

Proteomic databases

PaxDbiP20809
PeptideAtlasiP20809
PRIDEiP20809
ProteomicsDBi53795

PTM databases

iPTMnetiP20809
PhosphoSitePlusiP20809

Expressioni

Gene expression databases

BgeeiENSG00000095752 Expressed in 86 organ(s), highest expression level in adenohypophysis
CleanExiHS_IL11
ExpressionAtlasiP20809 baseline and differential
GenevisibleiP20809 HS

Organism-specific databases

HPAiHPA044955

Interactioni

Subunit structurei

Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex.1 Publication1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109803, 2 interactors
DIPiDIP-3775N
IntActiP20809, 4 interactors
STRINGi9606.ENSP00000264563

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20809
SMRiP20809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 190Important for interaction with IL11RA and for the stimulation of cell proliferationCurated9

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWMH Eukaryota
ENOG411181Z LUCA
GeneTreeiENSGT00390000007165
HOGENOMiHOG000013057
HOVERGENiHBG003999
InParanoidiP20809
KOiK05417
OMAiMNSVCCL
OrthoDBiEOG091G0V1V
PhylomeDBiP20809
TreeFamiTF337294

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020438 IL-11
IPR020412 IL-11_mml
PfamiView protein in Pfam
PF07400 IL11, 1 hit
PRINTSiPR01943 INTLKN11MAML
PR01927 INTRLEUKIN11
SUPFAMiSSF47266 SSF47266, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P20809-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL
60 70 80 90 100
ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD
110 120 130 140 150
LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP
160 170 180 190
QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Length:199
Mass (Da):21,429
Last modified:February 1, 1991 - v1
Checksum:iF292BF8B34F4096D
GO
Isoform 2 (identifier: P20809-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:120
Mass (Da):12,994
Checksum:i780FBDAA475370D2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESD5K7ESD5_HUMAN
Interleukin-11
IL11
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175H → L in AAH12506 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016313108V → M1 PublicationCorresponds to variant dbSNP:rs4252576Ensembl.1
Natural variantiVAR_016314112R → H1 PublicationCorresponds to variant dbSNP:rs4252548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469361 – 79Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57765 mRNA Translation: AAA59132.1
X58377 mRNA Translation: CAA41266.1
AY207429 Genomic DNA Translation: AAO13493.1
AK298973 mRNA Translation: BAG61067.1
AC020922 Genomic DNA No translation available.
BC012506 mRNA Translation: AAH12506.1
CCDSiCCDS12923.1 [P20809-1]
CCDS59423.1 [P20809-2]
PIRiA42830 B38285
RefSeqiNP_000632.1, NM_000641.3 [P20809-1]
NP_001254647.1, NM_001267718.1 [P20809-2]
UniGeneiHs.467304

Genome annotation databases

EnsembliENST00000264563; ENSP00000264563; ENSG00000095752 [P20809-1]
ENST00000585513; ENSP00000467355; ENSG00000095752 [P20809-1]
ENST00000590625; ENSP00000465705; ENSG00000095752 [P20809-2]
GeneIDi3589
KEGGihsa:3589
UCSCiuc002qks.3 human [P20809-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Neumega

Clinical information on Neumega

Wikipedia

Interleukin-11 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57765 mRNA Translation: AAA59132.1
X58377 mRNA Translation: CAA41266.1
AY207429 Genomic DNA Translation: AAO13493.1
AK298973 mRNA Translation: BAG61067.1
AC020922 Genomic DNA No translation available.
BC012506 mRNA Translation: AAH12506.1
CCDSiCCDS12923.1 [P20809-1]
CCDS59423.1 [P20809-2]
PIRiA42830 B38285
RefSeqiNP_000632.1, NM_000641.3 [P20809-1]
NP_001254647.1, NM_001267718.1 [P20809-2]
UniGeneiHs.467304

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MHLX-ray2.09A23-199[»]
ProteinModelPortaliP20809
SMRiP20809
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109803, 2 interactors
DIPiDIP-3775N
IntActiP20809, 4 interactors
STRINGi9606.ENSP00000264563

PTM databases

iPTMnetiP20809
PhosphoSitePlusiP20809

Polymorphism and mutation databases

BioMutaiIL11
DMDMi124294

Proteomic databases

PaxDbiP20809
PeptideAtlasiP20809
PRIDEiP20809
ProteomicsDBi53795

Protocols and materials databases

DNASUi3589
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264563; ENSP00000264563; ENSG00000095752 [P20809-1]
ENST00000585513; ENSP00000467355; ENSG00000095752 [P20809-1]
ENST00000590625; ENSP00000465705; ENSG00000095752 [P20809-2]
GeneIDi3589
KEGGihsa:3589
UCSCiuc002qks.3 human [P20809-1]

Organism-specific databases

CTDi3589
DisGeNETi3589
EuPathDBiHostDB:ENSG00000095752.6
GeneCardsiIL11
HGNCiHGNC:5966 IL11
HPAiHPA044955
MIMi147681 gene
neXtProtiNX_P20809
OpenTargetsiENSG00000095752
PharmGKBiPA29781
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWMH Eukaryota
ENOG411181Z LUCA
GeneTreeiENSGT00390000007165
HOGENOMiHOG000013057
HOVERGENiHBG003999
InParanoidiP20809
KOiK05417
OMAiMNSVCCL
OrthoDBiEOG091G0V1V
PhylomeDBiP20809
TreeFamiTF337294

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiP20809
SIGNORiP20809

Miscellaneous databases

ChiTaRSiIL11 human
GeneWikiiInterleukin_11
GenomeRNAii3589
PROiPR:P20809
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095752 Expressed in 86 organ(s), highest expression level in adenohypophysis
CleanExiHS_IL11
ExpressionAtlasiP20809 baseline and differential
GenevisibleiP20809 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020438 IL-11
IPR020412 IL-11_mml
PfamiView protein in Pfam
PF07400 IL11, 1 hit
PRINTSiPR01943 INTLKN11MAML
PR01927 INTRLEUKIN11
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL11_HUMAN
AccessioniPrimary (citable) accession number: P20809
Secondary accession number(s): B4DQV5, Q96EB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 12, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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