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UniProtKB - P20807 (CAN3_HUMAN)

Entry version 231 (07 Apr 2021)
Sequence version 2 (01 Feb 1996)
Previous versions | rss
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Protein

Calpain-3

Gene

CAPN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by micromolar concentrations of calcium and inhibited by calpastatin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei129PROSITE-ProRule annotation1
Active sitei334PROSITE-ProRule annotation1
Active sitei358PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi662 – 6721Combined sources1 PublicationAdd BLAST11
Calcium bindingi705 – 7162PROSITE-ProRule annotationCombined sources1 PublicationAdd BLAST12
Calcium bindingi735 – 7413PROSITE-ProRule annotationCombined sources1 Publication7
Calcium bindingi800 – 8064Combined sources1 Publication7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.22.54, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P20807

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix

SIGNOR Signaling Network Open Resource

More...SIGNORi		P20807

Protein family/group databases

MEROPS protease database

More...MEROPSi		C02.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-3 (EC:3.4.22.54)
Alternative name(s):
Calcium-activated neutral proteinase 3
Short name:
CANP 3
Calpain L3
Calpain p94
Muscle-specific calcium-activated neutral protease 3
New calpain 1
Short name:
nCL-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPN3
Synonyms:CANP3, CANPL3, NCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1480, CAPN3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114240, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P20807

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000092529.22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Muscular dystrophy, limb-girdle, autosomal recessive 1 (LGMDR1)10 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. The symptoms usually begin during the first two decades of life, and the disease gradually worsens, often resulting in loss of walking ability 10 or 20 years after onset.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0095484V → I in LGMDR1. Corresponds to variant dbSNP:rs140660066EnsemblClinVar.1
Natural variantiVAR_00954926P → L in LGMDR1. Corresponds to variant dbSNP:rs762020512EnsemblClinVar.1
Natural variantiVAR_00955077D → N in LGMDR1. 1
Natural variantiVAR_00955186S → F in LGMDR1; severe. 1 PublicationCorresponds to variant dbSNP:rs121434546EnsemblClinVar.1
Natural variantiVAR_00955293 – 100Missing in LGMDR1. 8
Natural variantiVAR_009554118R → G in LGMDR1. Corresponds to variant dbSNP:rs1566973583Ensembl.1
Natural variantiVAR_009555137C → R in LGMDR1. 1
Natural variantiVAR_009556162I → L in LGMDR1. 1
Natural variantiVAR_001363182L → Q in LGMDR1. 1
Natural variantiVAR_009557183P → L in LGMDR1. 1
Natural variantiVAR_009559189L → P in LGMDR1. Corresponds to variant dbSNP:rs758795961EnsemblClinVar.1
Natural variantiVAR_001364200 – 204Missing in LGMDR1. 1 Publication5
Natural variantiVAR_009560214G → S in LGMDR1. Corresponds to variant dbSNP:rs369784333EnsemblClinVar.1
Natural variantiVAR_009562215 – 221Missing in LGMDR1 and LGMDD4. 3 Publications7
Natural variantiVAR_009561215S → P in LGMDR1. 1 Publication1
Natural variantiVAR_009563217E → K in LGMDR1. Corresponds to variant dbSNP:rs773001194EnsemblClinVar.1
Natural variantiVAR_009564222G → R in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs1345121557EnsemblClinVar.1
Natural variantiVAR_009565226E → K in LGMDR1. 1
Natural variantiVAR_009566232T → I in LGMDR1. 1
Natural variantiVAR_001365234G → E in LGMDR1. Corresponds to variant dbSNP:rs1555420634EnsemblClinVar.1
Natural variantiVAR_009568254Missing in LGMDR1. 1
Natural variantiVAR_076561266 – 267Missing in LGMDR1. 2 Publications2
Natural variantiVAR_009569319P → L in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs121434547EnsemblClinVar.1
Natural variantiVAR_009570334H → Q in LGMDR1. 1 Publication1
Natural variantiVAR_009571336Y → N in LGMDR1. 1 Publication1
Natural variantiVAR_001366354V → G in LGMDR1. Corresponds to variant dbSNP:rs1555421271EnsemblClinVar.1
Natural variantiVAR_009572360W → C in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs267606703EnsemblClinVar.1
Natural variantiVAR_009573437R → C in LGMDR1. Corresponds to variant dbSNP:rs777483913EnsemblClinVar.1
Natural variantiVAR_009574440R → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs777323132EnsemblClinVar.1
Natural variantiVAR_009575441G → D in LGMDR1. 1
Natural variantiVAR_009576445G → R in LGMDR1. Corresponds to variant dbSNP:rs773827877EnsemblClinVar.1
Natural variantiVAR_009577448R → C in LGMDR1. Corresponds to variant dbSNP:rs776043976EnsemblClinVar.1
Natural variantiVAR_009578448R → G in LGMDR1. Corresponds to variant dbSNP:rs776043976EnsemblClinVar.1
Natural variantiVAR_009579448R → H in LGMDR1. Corresponds to variant dbSNP:rs863224956EnsemblClinVar.1
Natural variantiVAR_009580479S → G in LGMDR1. Corresponds to variant dbSNP:rs201736037EnsemblClinVar.1
Natural variantiVAR_009581486Q → E in LGMDR1. 1 Publication1
Natural variantiVAR_009582489R → Q in LGMDR1. Corresponds to variant dbSNP:rs147764579EnsemblClinVar.1
Natural variantiVAR_009583489R → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs863224957EnsemblClinVar.1
Natural variantiVAR_009584490R → Q in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs121434548EnsemblClinVar.1
Natural variantiVAR_001367490R → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs141656719EnsemblClinVar.1
Natural variantiVAR_009585493R → W in LGMDR1. Corresponds to variant dbSNP:rs557164942EnsemblClinVar.1
Natural variantiVAR_009586496G → R in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs761637940Ensembl.1
Natural variantiVAR_009587502I → T in LGMDR1. Corresponds to variant dbSNP:rs148044781EnsemblClinVar.1
Natural variantiVAR_009588541R → Q in LGMDR1. Corresponds to variant dbSNP:rs398123143EnsemblClinVar.1
Natural variantiVAR_009589567G → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs727503839EnsemblClinVar.1
Natural variantiVAR_001368572R → Q in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs121434544EnsemblClinVar.1
Natural variantiVAR_009590572R → W in LGMDR1. 2 PublicationsCorresponds to variant dbSNP:rs863224959EnsemblClinVar.1
Natural variantiVAR_009591606S → L in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs199806879EnsemblClinVar.1
Natural variantiVAR_009592638Q → P in LGMDR1. 1
Natural variantiVAR_009593698R → P in LGMDR1. 1
Natural variantiVAR_009594702A → V in LGMDR1. 3 PublicationsCorresponds to variant dbSNP:rs886042557EnsemblClinVar.1
Natural variantiVAR_009595705D → G in LGMDR1. 1
Natural variantiVAR_009596705D → H in LGMDR1. 1
Natural variantiVAR_009597731F → S in LGMDR1. 1
Natural variantiVAR_001369744S → G in LGMDR1. 2 PublicationsCorresponds to variant dbSNP:rs750083132EnsemblClinVar.1
Natural variantiVAR_009598748R → Q in LGMDR1. 5 PublicationsCorresponds to variant dbSNP:rs587780290EnsemblClinVar.1
Natural variantiVAR_001370769R → Q in LGMDR1. Corresponds to variant dbSNP:rs80338802EnsemblClinVar.1
Natural variantiVAR_009599774H → D in LGMDR1; unknown pathological significance. 1
Natural variantiVAR_009600798A → E in LGMDR1; unknown pathological significance. Corresponds to variant dbSNP:rs149095128EnsemblClinVar.1
Muscular dystrophy, limb-girdle, autosomal dominant 4 (LGMDD4)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of autosomal dominant limb-girdle muscular dystrophy, a myopathy characterized by proximal and/or distal muscle weakness and atrophy. The age at onset is variable and can range from the first to the sixth decade, although later onset is less common. LGMDD4 is characterized by onset of proximal muscle weakness in young adulthood, gait difficulties, increased serum creatine kinase, myalgia, and back pain. Some patients may have upper limb involvement. Disease severity and expressivity are highly variable.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009562215 – 221Missing in LGMDR1 and LGMDD4. 3 Publications7

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi129C → S: Loss of activity. No effect on CMYA5-binding. 1 Publication1

Keywords - Diseasei

Disease variant, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET

More...DisGeNETi		825

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CAPN3

MalaCards human disease database

More...MalaCardsi		CAPN3
MIMi253600, phenotype
618129, phenotype

Open Targets

More...OpenTargetsi		ENSG00000092529

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		267, Calpain-3-related limb-girdle muscular dystrophy R1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26061

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P20807, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB06124, L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAPN3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002077061 – 821Calpain-3Add BLAST821

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P20807

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P20807

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P20807

PeptideAtlas

More...PeptideAtlasi		P20807

PRoteomics IDEntifications database

More...PRIDEi		P20807

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53791 [P20807-1]
53792 [P20807-2]
53793 [P20807-3]
53794 [P20807-4]
78657

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P20807, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20807

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P20807

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform I is skeletal muscle specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000092529, Expressed in muscle of leg and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P20807, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20807, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000092529, Tissue enhanced (brain, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; via EF-hand domain 4 (PubMed:24846670).

Interacts with TTN/titin (PubMed:14583192).

Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis (PubMed:20634290).

Interacts with SIMC1 (PubMed:23707407).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107275, 34 interactors

Protein interaction database and analysis system

More...IntActi		P20807, 44 interactors

Molecular INTeraction database

More...MINTi		P20807

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380349

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P20807, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1821
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20807

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 417Calpain catalyticPROSITE-ProRule annotationAdd BLAST344
Domaini649 – 683EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini692 – 725EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini722 – 757EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini787 – 821EF-hand 4PROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni418 – 586Domain IIIAdd BLAST169
Regioni587 – 649LinkerAdd BLAST63
Regioni650 – 821Domain IVAdd BLAST172

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0045, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156092

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010982_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20807

Identification of Orthologs from Complete Genome Data

More...OMAi		MEIADNP

Database of Orthologous Groups

More...OrthoDBi		704215at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20807

TreeFam database of animal gene trees

More...TreeFami		TF314748

Family and domain databases

Conserved Domains Database

More...CDDi		cd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR029531, CAPN3
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat

The PANTHER Classification System

More...PANTHERi		PTHR10183:SF329, PTHR10183:SF329, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01067, Calpain_III, 1 hit
PF13833, EF-hand_8, 1 hit
PF00648, Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00704, CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit
SM00054, EFh, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 4 hits
PS00139, THIOL_PROTEASE_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform I (identifier: P20807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN 
        60         70         80         90        100
FPIIGVKEKT FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK 
       110        120        130        140        150
RPPEICENPR FIIDGANRTD ICQGELGDCW FLAAIACLTL NQHLLFRVIP 
       160        170        180        190        200
HDQSFIENYA GIFHFQFWRY GEWVDVVIDD CLPTYNNQLV FTKSNHRNEF 
       210        220        230        240        250
WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE IRDAPSDMYK 
       260        270        280        290        300
IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ 
       310        320        330        340        350
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK 
       360        370        380        390        400
VKLVRLRNPW GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS 
       410        420        430        440        450
YEDFIYHFTK LEICNLTADA LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF 
       460        470        480        490        500
PDTFWTNPQY RLKLLEEDDD PDDSEVICSF LVALMQKNRR KDRKLGASLF 
       510        520        530        540        550
TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM REVSQRFRLP 
       560        570        580        590        600
PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK 
       610        620        630        640        650
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE 
       660        670        680        690        700
QQQFRNIFKQ IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM 
       710        720        730        740        750
IALMDTDGSG KLNLQEFHHL WNKIKAWQKI FKHYDTDQSG TINSYEMRNA 
       760        770        780        790        800
VNDAGFHLNN QLYDIITMRY ADKHMNIDFD SFICCFVRLE GMFRAFHAFD 
       810        820 
KDGDGIIKLN VLEWLQLTMY A
Length:821
Mass (Da):94,254
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC608E8B67AA2741
GO
Isoform II (identifier: P20807-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-315: Missing.
     595-638: Missing.

Show »
Length:729
Mass (Da):84,089
Checksum:iDE8265BA362725FD
GO
Isoform III (identifier: P20807-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     595-600: Missing.

Show »
Length:815
Mass (Da):93,512
Checksum:iE51E96C05024617C
GO
Isoform IV (identifier: P20807-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-512: Missing.

Show »
Length:309
Mass (Da):35,930
Checksum:i8F6F0380D4DE8262
GO
Isoform V (identifier: P20807-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-665: Missing.

Show »
Length:156
Mass (Da):18,246
Checksum:i240D1D4F331C4AA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W8F5F8W8F5_HUMAN
Calpain-3
CAPN3
773Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMH1H3BMH1_HUMAN
Calpain-3
CAPN3
255Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KAB9A0A669KAB9_HUMAN
Calpain-3
CAPN3
202Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB08A0A669KB08_HUMAN
Calpain-3
CAPN3
229Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS77H3BS77_HUMAN
Calpain-3
CAPN3
191Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUZ3H3BUZ3_HUMAN
Calpain-3
CAPN3
157Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV08H3BV08_HUMAN
Calpain-3
CAPN3
169Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNN7H3BNN7_HUMAN
Calpain-3
CAPN3
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S2Z3E6A0A0S2Z3E6_HUMAN
Calpain-3
CAPN3
83Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KAU6A0A669KAU6_HUMAN
Calpain-3
CAPN3
184Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0095484V → I in LGMDR1. Corresponds to variant dbSNP:rs140660066EnsemblClinVar.1
Natural variantiVAR_02227221G → E1 PublicationCorresponds to variant dbSNP:rs28364364EnsemblClinVar.1
Natural variantiVAR_00954926P → L in LGMDR1. Corresponds to variant dbSNP:rs762020512EnsemblClinVar.1
Natural variantiVAR_00955077D → N in LGMDR1. 1
Natural variantiVAR_00955186S → F in LGMDR1; severe. 1 PublicationCorresponds to variant dbSNP:rs121434546EnsemblClinVar.1
Natural variantiVAR_00955293 – 100Missing in LGMDR1. 8
Natural variantiVAR_009553107E → K. Corresponds to variant dbSNP:rs1801505EnsemblClinVar.1
Natural variantiVAR_009554118R → G in LGMDR1. Corresponds to variant dbSNP:rs1566973583Ensembl.1
Natural variantiVAR_009555137C → R in LGMDR1. 1
Natural variantiVAR_015389160A → G1 PublicationCorresponds to variant dbSNP:rs17592EnsemblClinVar.1
Natural variantiVAR_009556162I → L in LGMDR1. 1
Natural variantiVAR_001363182L → Q in LGMDR1. 1
Natural variantiVAR_009557183P → L in LGMDR1. 1
Natural variantiVAR_009558184T → M. Corresponds to variant dbSNP:rs35889956EnsemblClinVar.1
Natural variantiVAR_009559189L → P in LGMDR1. Corresponds to variant dbSNP:rs758795961EnsemblClinVar.1
Natural variantiVAR_001364200 – 204Missing in LGMDR1. 1 Publication5
Natural variantiVAR_009560214G → S in LGMDR1. Corresponds to variant dbSNP:rs369784333EnsemblClinVar.1
Natural variantiVAR_009562215 – 221Missing in LGMDR1 and LGMDD4. 3 Publications7
Natural variantiVAR_009561215S → P in LGMDR1. 1 Publication1
Natural variantiVAR_009563217E → K in LGMDR1. Corresponds to variant dbSNP:rs773001194EnsemblClinVar.1
Natural variantiVAR_009564222G → R in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs1345121557EnsemblClinVar.1
Natural variantiVAR_009565226E → K in LGMDR1. 1
Natural variantiVAR_009566232T → I in LGMDR1. 1
Natural variantiVAR_001365234G → E in LGMDR1. Corresponds to variant dbSNP:rs1555420634EnsemblClinVar.1
Natural variantiVAR_009567236A → T1 PublicationCorresponds to variant dbSNP:rs1801449EnsemblClinVar.1
Natural variantiVAR_009568254Missing in LGMDR1. 1
Natural variantiVAR_076561266 – 267Missing in LGMDR1. 2 Publications2
Natural variantiVAR_009569319P → L in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs121434547EnsemblClinVar.1
Natural variantiVAR_009570334H → Q in LGMDR1. 1 Publication1
Natural variantiVAR_009571336Y → N in LGMDR1. 1 Publication1
Natural variantiVAR_001366354V → G in LGMDR1. Corresponds to variant dbSNP:rs1555421271EnsemblClinVar.1
Natural variantiVAR_009572360W → C in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs267606703EnsemblClinVar.1
Natural variantiVAR_009573437R → C in LGMDR1. Corresponds to variant dbSNP:rs777483913EnsemblClinVar.1
Natural variantiVAR_009574440R → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs777323132EnsemblClinVar.1
Natural variantiVAR_009575441G → D in LGMDR1. 1
Natural variantiVAR_009576445G → R in LGMDR1. Corresponds to variant dbSNP:rs773827877EnsemblClinVar.1
Natural variantiVAR_009577448R → C in LGMDR1. Corresponds to variant dbSNP:rs776043976EnsemblClinVar.1
Natural variantiVAR_009578448R → G in LGMDR1. Corresponds to variant dbSNP:rs776043976EnsemblClinVar.1
Natural variantiVAR_009579448R → H in LGMDR1. Corresponds to variant dbSNP:rs863224956EnsemblClinVar.1
Natural variantiVAR_009580479S → G in LGMDR1. Corresponds to variant dbSNP:rs201736037EnsemblClinVar.1
Natural variantiVAR_009581486Q → E in LGMDR1. 1 Publication1
Natural variantiVAR_009582489R → Q in LGMDR1. Corresponds to variant dbSNP:rs147764579EnsemblClinVar.1
Natural variantiVAR_009583489R → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs863224957EnsemblClinVar.1
Natural variantiVAR_009584490R → Q in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs121434548EnsemblClinVar.1
Natural variantiVAR_001367490R → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs141656719EnsemblClinVar.1
Natural variantiVAR_009585493R → W in LGMDR1. Corresponds to variant dbSNP:rs557164942EnsemblClinVar.1
Natural variantiVAR_009586496G → R in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs761637940Ensembl.1
Natural variantiVAR_009587502I → T in LGMDR1. Corresponds to variant dbSNP:rs148044781EnsemblClinVar.1
Natural variantiVAR_009588541R → Q in LGMDR1. Corresponds to variant dbSNP:rs398123143EnsemblClinVar.1
Natural variantiVAR_009589567G → W in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs727503839EnsemblClinVar.1
Natural variantiVAR_001368572R → Q in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs121434544EnsemblClinVar.1
Natural variantiVAR_009590572R → W in LGMDR1. 2 PublicationsCorresponds to variant dbSNP:rs863224959EnsemblClinVar.1
Natural variantiVAR_009591606S → L in LGMDR1. 1 PublicationCorresponds to variant dbSNP:rs199806879EnsemblClinVar.1
Natural variantiVAR_047691622E → A. Corresponds to variant dbSNP:rs11557723Ensembl.1
Natural variantiVAR_009592638Q → P in LGMDR1. 1
Natural variantiVAR_009593698R → P in LGMDR1. 1
Natural variantiVAR_009594702A → V in LGMDR1. 3 PublicationsCorresponds to variant dbSNP:rs886042557EnsemblClinVar.1
Natural variantiVAR_009595705D → G in LGMDR1. 1
Natural variantiVAR_009596705D → H in LGMDR1. 1
Natural variantiVAR_009597731F → S in LGMDR1. 1
Natural variantiVAR_001369744S → G in LGMDR1. 2 PublicationsCorresponds to variant dbSNP:rs750083132EnsemblClinVar.1
Natural variantiVAR_009598748R → Q in LGMDR1. 5 PublicationsCorresponds to variant dbSNP:rs587780290EnsemblClinVar.1
Natural variantiVAR_001370769R → Q in LGMDR1. Corresponds to variant dbSNP:rs80338802EnsemblClinVar.1
Natural variantiVAR_009599774H → D in LGMDR1; unknown pathological significance. 1
Natural variantiVAR_009600798A → E in LGMDR1; unknown pathological significance. Corresponds to variant dbSNP:rs149095128EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0442551 – 665Missing in isoform V. 1 PublicationAdd BLAST665
Alternative sequenceiVSP_0078131 – 512Missing in isoform IV. 2 PublicationsAdd BLAST512
Alternative sequenceiVSP_005227268 – 315Missing in isoform II. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_005228595 – 638Missing in isoform II. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_005229595 – 600Missing in isoform III. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X85030 mRNA Translation: CAA59403.1
AF209502 Genomic DNA Translation: AAL40183.1
AF127764 mRNA Translation: AAD28253.1
AF127765 mRNA Translation: AAD28254.3
BT007322 mRNA Translation: AAP35986.1
AY902237 Genomic DNA Translation: AAW69391.1
AC012651 Genomic DNA No translation available.
BC003169 mRNA Translation: AAH03169.1
BC003521 mRNA Translation: AAH03521.1
BC004883 mRNA Translation: AAH04883.1
BC007810 mRNA Translation: AAH07810.3
BC067126 mRNA Translation: AAH67126.1
BC100782 mRNA Translation: AAI00783.1
BC107791 mRNA Translation: AAI07792.1
BC128605 mRNA Translation: AAI28606.1
BC146649 mRNA Translation: AAI46650.1
BC146672 mRNA Translation: AAI46673.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10085.1 [P20807-2]
CCDS10086.1 [P20807-5]
CCDS32207.1 [P20807-3]
CCDS45245.1 [P20807-1]
CCDS45246.1 [P20807-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A56218, CIHUH3

NCBI Reference Sequences

More...RefSeqi		NP_000061.1, NM_000070.2 [P20807-1]
NP_077320.1, NM_024344.1 [P20807-3]
NP_775110.1, NM_173087.1 [P20807-2]
NP_775111.1, NM_173088.1 [P20807-4]
NP_775112.1, NM_173089.1 [P20807-5]
NP_775113.1, NM_173090.1 [P20807-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337571; ENSP00000336840; ENSG00000092529 [P20807-5]
ENST00000349748; ENSP00000183936; ENSG00000092529 [P20807-2]
ENST00000356316; ENSP00000348667; ENSG00000092529 [P20807-5]
ENST00000357568; ENSP00000350181; ENSG00000092529 [P20807-3]
ENST00000397163; ENSP00000380349; ENSG00000092529 [P20807-1]
ENST00000397200; ENSP00000380384; ENSG00000092529 [P20807-4]
ENST00000397204; ENSP00000380387; ENSG00000092529 [P20807-5]
ENST00000569136; ENSP00000455254; ENSG00000092529 [P20807-5]
ENST00000673692; ENSP00000501138; ENSG00000092529 [P20807-5]
ENST00000673771; ENSP00000501023; ENSG00000092529 [P20807-5]
ENST00000673851; ENSP00000501142; ENSG00000092529 [P20807-5]
ENST00000673886; ENSP00000501155; ENSG00000092529 [P20807-5]
ENST00000673890; ENSP00000501293; ENSG00000092529 [P20807-5]
ENST00000673928; ENSP00000501099; ENSG00000092529 [P20807-5]
ENST00000673936; ENSP00000501189; ENSG00000092529 [P20807-5]
ENST00000674018; ENSP00000501271; ENSG00000092529 [P20807-5]
ENST00000674093; ENSP00000501303; ENSG00000092529 [P20807-5]
ENST00000674119; ENSP00000501217; ENSG00000092529 [P20807-5]
ENST00000674139; ENSP00000501054; ENSG00000092529 [P20807-5]
ENST00000674146; ENSP00000501175; ENSG00000092529 [P20807-5]
ENST00000674149; ENSP00000501112; ENSG00000092529 [P20807-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:825

UCSC genome browser

More...UCSCi		uc001zpn.2, human [P20807-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Leiden Muscular Dystrophy pages

Calpain-3 mutations in LGMD2A

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85030 mRNA Translation: CAA59403.1
AF209502 Genomic DNA Translation: AAL40183.1
AF127764 mRNA Translation: AAD28253.1
AF127765 mRNA Translation: AAD28254.3
BT007322 mRNA Translation: AAP35986.1
AY902237 Genomic DNA Translation: AAW69391.1
AC012651 Genomic DNA No translation available.
BC003169 mRNA Translation: AAH03169.1
BC003521 mRNA Translation: AAH03521.1
BC004883 mRNA Translation: AAH04883.1
BC007810 mRNA Translation: AAH07810.3
BC067126 mRNA Translation: AAH67126.1
BC100782 mRNA Translation: AAI00783.1
BC107791 mRNA Translation: AAI07792.1
BC128605 mRNA Translation: AAI28606.1
BC146649 mRNA Translation: AAI46650.1
BC146672 mRNA Translation: AAI46673.1
CCDSiCCDS10085.1 [P20807-2]
CCDS10086.1 [P20807-5]
CCDS32207.1 [P20807-3]
CCDS45245.1 [P20807-1]
CCDS45246.1 [P20807-4]
PIRiA56218, CIHUH3
RefSeqiNP_000061.1, NM_000070.2 [P20807-1]
NP_077320.1, NM_024344.1 [P20807-3]
NP_775110.1, NM_173087.1 [P20807-2]
NP_775111.1, NM_173088.1 [P20807-4]
NP_775112.1, NM_173089.1 [P20807-5]
NP_775113.1, NM_173090.1 [P20807-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y9Vmodel-A/B649-821[»]
4OKHX-ray2.45A/B/C642-821[»]
6BDTX-ray2.30A/B/C/D46-419[»]
6BGPX-ray2.75A/B/C/D46-419[»]
6BJDX-ray2.80A/B/C/D46-419[»]
6BKJX-ray3.20A/B/C/D46-419[»]
SMRiP20807
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107275, 34 interactors
IntActiP20807, 44 interactors
MINTiP20807
STRINGi9606.ENSP00000380349

Chemistry databases

DrugBankiDB06124, L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal

Protein family/group databases

MEROPSiC02.004

PTM databases

GlyGeniP20807, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP20807
PhosphoSitePlusiP20807

Genetic variation databases

BioMutaiCAPN3

Proteomic databases

jPOSTiP20807
MassIVEiP20807
PaxDbiP20807
PeptideAtlasiP20807
PRIDEiP20807
ProteomicsDBi53791 [P20807-1]
53792 [P20807-2]
53793 [P20807-3]
53794 [P20807-4]
78657

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10719, 188 antibodies

The DNASU plasmid repository

More...DNASUi		825

Genome annotation databases

EnsembliENST00000337571; ENSP00000336840; ENSG00000092529 [P20807-5]
ENST00000349748; ENSP00000183936; ENSG00000092529 [P20807-2]
ENST00000356316; ENSP00000348667; ENSG00000092529 [P20807-5]
ENST00000357568; ENSP00000350181; ENSG00000092529 [P20807-3]
ENST00000397163; ENSP00000380349; ENSG00000092529 [P20807-1]
ENST00000397200; ENSP00000380384; ENSG00000092529 [P20807-4]
ENST00000397204; ENSP00000380387; ENSG00000092529 [P20807-5]
ENST00000569136; ENSP00000455254; ENSG00000092529 [P20807-5]
ENST00000673692; ENSP00000501138; ENSG00000092529 [P20807-5]
ENST00000673771; ENSP00000501023; ENSG00000092529 [P20807-5]
ENST00000673851; ENSP00000501142; ENSG00000092529 [P20807-5]
ENST00000673886; ENSP00000501155; ENSG00000092529 [P20807-5]
ENST00000673890; ENSP00000501293; ENSG00000092529 [P20807-5]
ENST00000673928; ENSP00000501099; ENSG00000092529 [P20807-5]
ENST00000673936; ENSP00000501189; ENSG00000092529 [P20807-5]
ENST00000674018; ENSP00000501271; ENSG00000092529 [P20807-5]
ENST00000674093; ENSP00000501303; ENSG00000092529 [P20807-5]
ENST00000674119; ENSP00000501217; ENSG00000092529 [P20807-5]
ENST00000674139; ENSP00000501054; ENSG00000092529 [P20807-5]
ENST00000674146; ENSP00000501175; ENSG00000092529 [P20807-5]
ENST00000674149; ENSP00000501112; ENSG00000092529 [P20807-5]
GeneIDi825
KEGGihsa:825
UCSCiuc001zpn.2, human [P20807-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		825
DisGeNETi825

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAPN3
GeneReviewsiCAPN3
HGNCiHGNC:1480, CAPN3
HPAiENSG00000092529, Tissue enhanced (brain, skeletal muscle)
MalaCardsiCAPN3
MIMi114240, gene
253600, phenotype
618129, phenotype
neXtProtiNX_P20807
OpenTargetsiENSG00000092529
Orphaneti267, Calpain-3-related limb-girdle muscular dystrophy R1
PharmGKBiPA26061
VEuPathDBiHostDB:ENSG00000092529.22

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0045, Eukaryota
GeneTreeiENSGT00940000156092
HOGENOMiCLU_010982_0_1_1
InParanoidiP20807
OMAiMEIADNP
OrthoDBi704215at2759
PhylomeDBiP20807
TreeFamiTF314748

Enzyme and pathway databases

BRENDAi3.4.22.54, 2681
PathwayCommonsiP20807
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
SIGNORiP20807

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		825, 6 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAPN3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CAPN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		825
PharosiP20807, Tbio

Protein Ontology

More...PROi		PR:P20807
RNActiP20807, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000092529, Expressed in muscle of leg and 114 other tissues
ExpressionAtlasiP20807, baseline and differential
GenevisibleiP20807, HS

Family and domain databases

CDDicd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit
InterProiView protein in InterPro
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR029531, CAPN3
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF329, PTHR10183:SF329, 1 hit
PfamiView protein in Pfam
PF01067, Calpain_III, 1 hit
PF13833, EF-hand_8, 1 hit
PF00648, Peptidase_C2, 1 hit
PRINTSiPR00704, CALPAIN
SMARTiView protein in SMART
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit
SM00054, EFh, 3 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 4 hits
PS00139, THIOL_PROTEASE_CYS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20807
Secondary accession number(s): A6H8K6
, Q7L4R0, Q9BQC8, Q9BTU4, Q9Y5S6, Q9Y5S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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