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Protein

Troponin C, skeletal muscle

Gene

Tnnc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi28 – 391Add BLAST12
Calcium bindingi64 – 752Add BLAST12
Calcium bindingi104 – 1153Add BLAST12
Calcium bindingi140 – 1514Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Alternative name(s):
STNC
Gene namesi
Name:Tnnc2
Synonyms:Tncs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98780 Tnnc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737042 – 160Troponin C, skeletal muscleAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP20801
PaxDbiP20801
PeptideAtlasiP20801
PRIDEiP20801

2D gel databases

SWISS-2DPAGEiP20801

PTM databases

iPTMnetiP20801
PhosphoSitePlusiP20801

Expressioni

Tissue specificityi

Fast skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000017300 Expressed in 150 organ(s), highest expression level in quadriceps femoris
CleanExiMM_TNNC2
GenevisibleiP20801 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204239, 1 interactor
STRINGi10090.ENSMUSP00000099384

Structurei

3D structure databases

ProteinModelPortaliP20801
SMRiP20801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 50EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini91 – 126EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 160EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP20801
KOiK12042
OMAiVETWEVD
OrthoDBiEOG091G0QHM
PhylomeDBiP20801
TreeFamiTF318191

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20801-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT
60 70 80 90 100
PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF
110 120 130 140 150
RIFDRNADGY IDAEELAEIF RASGEHVTEE EIESLMKDGD KNNDGRIDFD
160
EFLKMMEGVQ
Length:160
Mass (Da):18,110
Last modified:January 23, 2007 - v2
Checksum:i9AE469E732A0F903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57590 Genomic DNA Translation: AAA37642.1
BC024390 mRNA Translation: AAH24390.1
CCDSiCCDS17056.1
PIRiA38383
RefSeqiNP_033420.1, NM_009394.2
UniGeneiMm.1716

Genome annotation databases

EnsembliENSMUST00000103095; ENSMUSP00000099384; ENSMUSG00000017300
GeneIDi21925
KEGGimmu:21925
UCSCiuc008nvz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57590 Genomic DNA Translation: AAA37642.1
BC024390 mRNA Translation: AAH24390.1
CCDSiCCDS17056.1
PIRiA38383
RefSeqiNP_033420.1, NM_009394.2
UniGeneiMm.1716

3D structure databases

ProteinModelPortaliP20801
SMRiP20801
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204239, 1 interactor
STRINGi10090.ENSMUSP00000099384

PTM databases

iPTMnetiP20801
PhosphoSitePlusiP20801

2D gel databases

SWISS-2DPAGEiP20801

Proteomic databases

MaxQBiP20801
PaxDbiP20801
PeptideAtlasiP20801
PRIDEiP20801

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103095; ENSMUSP00000099384; ENSMUSG00000017300
GeneIDi21925
KEGGimmu:21925
UCSCiuc008nvz.1 mouse

Organism-specific databases

CTDi7125
MGIiMGI:98780 Tnnc2

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP20801
KOiK12042
OMAiVETWEVD
OrthoDBiEOG091G0QHM
PhylomeDBiP20801
TreeFamiTF318191

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRSiTnnc2 mouse
PROiPR:P20801
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017300 Expressed in 150 organ(s), highest expression level in quadriceps femoris
CleanExiMM_TNNC2
GenevisibleiP20801 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC2_MOUSE
AccessioniPrimary (citable) accession number: P20801
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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