EDN2

Protein namesⁱ	Recommended name: Endothelin-2 Short name: ET-2 Alternative name(s): Preproendothelin-2 Short name: PPET2
Gene namesⁱ	Name:EDN2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127129.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3177 EDN2
MIMⁱ	131241 gene
neXtProtⁱ	NX_P20800

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1907
Open Targets More...OpenTargetsⁱ	ENSG00000127129
PharmGKBⁱ	PA27615

Polymorphism and mutation databases

BioMutaⁱ	EDN2
DMDMⁱ	119615

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST	24
PropeptideⁱPRO_0000008093	25 – 46	Add BLAST	22
PeptideⁱPRO_0000008094	49 – 69	Endothelin-2Add BLAST	21
PropeptideⁱPRO_0000008095	70 – 178	Add BLAST	109

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	49 ↔ 63	By similarity
Disulfide bondⁱ	51 ↔ 59	By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	69 – 70	Cleavage; by KEL		2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	P20800
PeptideAtlas More...PeptideAtlasⁱ	P20800
PRIDEⁱ	P20800
ProteomicsDBⁱ	53790

PTM databases

iPTMnetⁱ	P20800
PhosphoSitePlusⁱ	P20800

Miscellaneous databases

PMAP-CutDBⁱ	P20800

PMAP-CutDBⁱ

P20800

Expressionⁱ

Tissue specificityⁱ

Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000127129 Expressed in 109 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_EDN2
Genevisibleⁱ	P20800 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028459

HPAⁱ

HPA028459

Interactionⁱ

GO - Molecular functionⁱ

endothelin B receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1713452
hormone activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 2649896

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000361668

STRINGⁱ

9606.ENSP00000361668

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P20800
SMRⁱ	P20800
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	96 – 111	Endothelin-likeAdd BLAST		16

Sequence similaritiesⁱ

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1XQ Eukaryota ENOG410YUMW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063310
HOGENOMⁱ	HOG000231110
HOVERGENⁱ	HBG051441
InParanoidⁱ	P20800
KEGG Orthology (KO) More...KOⁱ	K16367
OMAⁱ	PTAWCSV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WW5
PhylomeDBⁱ	P20800
TreeFamⁱ	TF333184

Family and domain databases

InterProⁱ	View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin IPR015658 ET-2
PANTHERⁱ	PTHR13874:SF9 PTHR13874:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00322 Endothelin, 1 hit
PRINTSⁱ	PR00365 ENDOTHELIN
SMARTⁱ	View protein in SMART SM00272 END, 2 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P20800-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS 
        60         70         80         90        100
CSSWLDKECV YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS 
       110        120        130        140        150
ARDPACATFC LRRPWTEAGA VPSRKSPADV FQTGKTGATT GELLQRLRDI 
       160        170 
STVKSLFAKR QQEAMREPRS THSRWRKR

Length:178

Mass (Da):19,960

Last modified:November 1, 1991 - v2

Checksum:ⁱ7711B2B6F075CFB4

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033914	131	F → L. Corresponds to variant dbSNP:rs5798Ensembl.		1
Natural variantⁱVAR_018817	168	P → L1 PublicationCorresponds to variant dbSNP:rs11572371Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55177 mRNA Translation: CAA38962.1 M65199 mRNA Translation: AAA52404.1 AY518541 Genomic DNA Translation: AAR89914.1 AL445933 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07175.1 BC034393 mRNA Translation: AAH34393.1 M25550 Genomic DNA Translation: AAA52340.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS462.1
PIRⁱ	A39070
NCBI Reference Sequences More...RefSeqⁱ	NP_001289198.1, NM_001302269.1 NP_001947.1, NM_001956.4
UniGeneⁱ	Hs.1407

Genome annotation databases

Ensemblⁱ	ENST00000372587; ENSP00000361668; ENSG00000127129
GeneIDⁱ	1907
KEGGⁱ	hsa:1907
UCSC genome browser More...UCSCⁱ	uc001cgx.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20800	Uncharacterized protein		PANPA		178	UniRef100_P20800

Protein	Similar proteins		Species	Score	Length	Source
P20800	Uncharacterized protein		PANPA		178	UniRef90_P20800
Uncharacterized protein		Cebus capucinus imitator		178
Uncharacterized protein		COLAP		178
EDN2 isoform 2		PONAB		178
Uncharacterized protein		CERAT		178
+12

Protein	Similar proteins		Species	Score	Length	Source
P20800	Endothelin-2		CANLF		178	UniRef50_P20800
Endothelin-2		BOVIN		177
Endothelin-2		ATEAB		180
Uncharacterized protein		PANPA		178
EDN2 isoform 2		PONAB		178
+66

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55177 mRNA Translation: CAA38962.1 M65199 mRNA Translation: AAA52404.1 AY518541 Genomic DNA Translation: AAR89914.1 AL445933 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07175.1 BC034393 mRNA Translation: AAH34393.1 M25550 Genomic DNA Translation: AAA52340.1
CCDSⁱ	CCDS462.1
PIRⁱ	A39070
RefSeqⁱ	NP_001289198.1, NM_001302269.1 NP_001947.1, NM_001956.4
UniGeneⁱ	Hs.1407

3D structure databases

ProteinModelPortalⁱ	P20800
SMRⁱ	P20800
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000361668

STRINGⁱ

9606.ENSP00000361668

PTM databases

iPTMnetⁱ	P20800
PhosphoSitePlusⁱ	P20800

Polymorphism and mutation databases

BioMutaⁱ	EDN2
DMDMⁱ	119615

Proteomic databases

PaxDbⁱ	P20800
PeptideAtlasⁱ	P20800
PRIDEⁱ	P20800
ProteomicsDBⁱ	53790

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1907
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000372587; ENSP00000361668; ENSG00000127129
GeneIDⁱ	1907
KEGGⁱ	hsa:1907
UCSCⁱ	uc001cgx.4 human

Organism-specific databases

CTDⁱ	1907
DisGeNETⁱ	1907
EuPathDBⁱ	HostDB:ENSG00000127129.9
GeneCardsⁱ	EDN2
HGNCⁱ	HGNC:3177 EDN2
HPAⁱ	HPA028459
MIMⁱ	131241 gene
neXtProtⁱ	NX_P20800
OpenTargetsⁱ	ENSG00000127129
PharmGKBⁱ	PA27615
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1XQ Eukaryota ENOG410YUMW LUCA
GeneTreeⁱ	ENSGT00530000063310
HOGENOMⁱ	HOG000231110
HOVERGENⁱ	HBG051441
InParanoidⁱ	P20800
KOⁱ	K16367
OMAⁱ	PTAWCSV
OrthoDBⁱ	EOG091G0WW5
PhylomeDBⁱ	P20800
TreeFamⁱ	TF333184

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events

Reactomeⁱ

R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiⁱ	Endothelin_2
GenomeRNAiⁱ	1907
PMAP-CutDBⁱ	P20800
Protein Ontology More...PROⁱ	PR:P20800
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127129 Expressed in 109 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_EDN2
Genevisibleⁱ	P20800 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR020475 Endothelin IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin IPR015658 ET-2
PANTHERⁱ	PTHR13874:SF9 PTHR13874:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF00322 Endothelin, 1 hit
PRINTSⁱ	PR00365 ENDOTHELIN
SMARTⁱ	View protein in SMART SM00272 END, 2 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EDN2_HUMAN
Accessionⁱ	P20800Primary (citable) accession number: P20800 Secondary accession number(s): Q5T1R3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	November 1, 1991
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P20800 (EDN2_HUMAN)

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Endothelin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ