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UniProtKB - P20800 (EDN2_HUMAN)
Protein
Endothelin-2
Gene
EDN2
Organism
Homo sapiens (Human)
Status
Functioni
Endothelins are endothelium-derived vasoconstrictor peptides.
GO - Molecular functioni
- endothelin B receptor binding Source: BHF-UCL
- hormone activity Source: BHF-UCL
GO - Biological processi
- angiogenesis Source: Ensembl
- artery smooth muscle contraction Source: BHF-UCL
- axon extension Source: Ensembl
- calcium-mediated signaling Source: BHF-UCL
- cell surface receptor signaling pathway Source: BHF-UCL
- cell tip growth Source: Ensembl
- cellular calcium ion homeostasis Source: GO_Central
- cytokine-mediated signaling pathway Source: BHF-UCL
- endothelial cell migration Source: Ensembl
- energy homeostasis Source: Ensembl
- hormonal regulation of the force of heart contraction Source: BHF-UCL
- inositol phosphate-mediated signaling Source: BHF-UCL
- lung alveolus development Source: Ensembl
- macrophage activation Source: BHF-UCL
- macrophage chemotaxis Source: BHF-UCL
- neutrophil chemotaxis Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
- positive regulation of heart rate Source: BHF-UCL
- positive regulation of leukocyte chemotaxis Source: BHF-UCL
- positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
- positive regulation of smooth muscle contraction Source: Ensembl
- positive regulation of the force of heart contraction by chemical signal Source: BHF-UCL
- prostaglandin biosynthetic process Source: BHF-UCL
- regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
- regulation of vasoconstriction Source: InterPro
- temperature homeostasis Source: Ensembl
- vasoconstriction Source: BHF-UCL
- vein smooth muscle contraction Source: BHF-UCL
Keywordsi
Molecular function | Vasoactive, Vasoconstrictor |
Enzyme and pathway databases
PathwayCommonsi | P20800 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P20800 |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin-2Short name: ET-2 Alternative name(s): Preproendothelin-2 Short name: PPET2 |
Gene namesi | Name:EDN2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3177, EDN2 |
MIMi | 131241, gene |
neXtProti | NX_P20800 |
VEuPathDBi | HostDB:ENSG00000127129 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1907 |
OpenTargetsi | ENSG00000127129 |
PharmGKBi | PA27615 |
Miscellaneous databases
Pharosi | P20800, Tbio |
Genetic variation databases
BioMutai | EDN2 |
DMDMi | 119615 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000008093 | 25 – 46 | Add BLAST | 22 | |
PeptideiPRO_0000008094 | 49 – 69 | Endothelin-2Add BLAST | 21 | |
PropeptideiPRO_0000008095 | 70 – 178 | Add BLAST | 109 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 63 | By similarity | ||
Disulfide bondi | 51 ↔ 59 | By similarity |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 69 – 70 | Cleavage; by KEL | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
MassIVEi | P20800 |
PaxDbi | P20800 |
PeptideAtlasi | P20800 |
PRIDEi | P20800 |
PTM databases
iPTMneti | P20800 |
PhosphoSitePlusi | P20800 |
Expressioni
Tissue specificityi
Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.1 Publication
Gene expression databases
Bgeei | ENSG00000127129, Expressed in ectocervix and 132 other tissues |
Genevisiblei | P20800, HS |
Organism-specific databases
HPAi | ENSG00000127129, Tissue enhanced (esophagus, intestine, vagina) |
Interactioni
GO - Molecular functioni
- endothelin B receptor binding Source: BHF-UCL
- hormone activity Source: BHF-UCL
Protein-protein interaction databases
STRINGi | 9606.ENSP00000361668 |
Miscellaneous databases
RNActi | P20800, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 96 – 111 | Endothelin-likeAdd BLAST | 16 | |
Regioni | 159 – 178 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the endothelin/sarafotoxin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S5KM, Eukaryota |
GeneTreei | ENSGT00950000183053 |
HOGENOMi | CLU_090013_2_1_1 |
InParanoidi | P20800 |
OMAi | PTAWCSV |
OrthoDBi | 1264335at2759 |
PhylomeDBi | P20800 |
TreeFami | TF333184 |
Family and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin IPR015658, ET-2 |
PANTHERi | PTHR13874, PTHR13874, 1 hit PTHR13874:SF9, PTHR13874:SF9, 1 hit |
Pfami | View protein in Pfam PF00322, Endothelin, 1 hit |
PRINTSi | PR00365, ENDOTHELIN |
SMARTi | View protein in SMART SM00272, END, 2 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P20800-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS
60 70 80 90 100
CSSWLDKECV YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS
110 120 130 140 150
ARDPACATFC LRRPWTEAGA VPSRKSPADV FQTGKTGATT GELLQRLRDI
160 170
STVKSLFAKR QQEAMREPRS THSRWRKR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033914 | 131 | F → L. Corresponds to variant dbSNP:rs5798Ensembl. | 1 | |
Natural variantiVAR_018817 | 168 | P → L1 PublicationCorresponds to variant dbSNP:rs11572371Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55177 mRNA Translation: CAA38962.1 M65199 mRNA Translation: AAA52404.1 AY518541 Genomic DNA Translation: AAR89914.1 AL445933 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07175.1 BC034393 mRNA Translation: AAH34393.1 M25550 Genomic DNA Translation: AAA52340.1 |
CCDSi | CCDS462.1 |
PIRi | A39070 |
RefSeqi | NP_001289198.1, NM_001302269.1 NP_001947.1, NM_001956.4 |
Genome annotation databases
Ensembli | ENST00000372587; ENSP00000361668; ENSG00000127129 |
GeneIDi | 1907 |
KEGGi | hsa:1907 |
MANE-Selecti | ENST00000372587.5; ENSP00000361668.4; NM_001956.5; NP_001947.1 |
UCSCi | uc001cgx.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55177 mRNA Translation: CAA38962.1 M65199 mRNA Translation: AAA52404.1 AY518541 Genomic DNA Translation: AAR89914.1 AL445933 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07175.1 BC034393 mRNA Translation: AAH34393.1 M25550 Genomic DNA Translation: AAA52340.1 |
CCDSi | CCDS462.1 |
PIRi | A39070 |
RefSeqi | NP_001289198.1, NM_001302269.1 NP_001947.1, NM_001956.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000361668 |
PTM databases
iPTMneti | P20800 |
PhosphoSitePlusi | P20800 |
Genetic variation databases
BioMutai | EDN2 |
DMDMi | 119615 |
Proteomic databases
MassIVEi | P20800 |
PaxDbi | P20800 |
PeptideAtlasi | P20800 |
PRIDEi | P20800 |
Protocols and materials databases
Antibodypediai | 32186, 198 antibodies from 25 providers |
DNASUi | 1907 |
Genome annotation databases
Ensembli | ENST00000372587; ENSP00000361668; ENSG00000127129 |
GeneIDi | 1907 |
KEGGi | hsa:1907 |
MANE-Selecti | ENST00000372587.5; ENSP00000361668.4; NM_001956.5; NP_001947.1 |
UCSCi | uc001cgx.4, human |
Organism-specific databases
CTDi | 1907 |
DisGeNETi | 1907 |
GeneCardsi | EDN2 |
HGNCi | HGNC:3177, EDN2 |
HPAi | ENSG00000127129, Tissue enhanced (esophagus, intestine, vagina) |
MIMi | 131241, gene |
neXtProti | NX_P20800 |
OpenTargetsi | ENSG00000127129 |
PharmGKBi | PA27615 |
VEuPathDBi | HostDB:ENSG00000127129 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5KM, Eukaryota |
GeneTreei | ENSGT00950000183053 |
HOGENOMi | CLU_090013_2_1_1 |
InParanoidi | P20800 |
OMAi | PTAWCSV |
OrthoDBi | 1264335at2759 |
PhylomeDBi | P20800 |
TreeFami | TF333184 |
Enzyme and pathway databases
PathwayCommonsi | P20800 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P20800 |
Miscellaneous databases
BioGRID-ORCSi | 1907, 4 hits in 1035 CRISPR screens |
GeneWikii | Endothelin_2 |
GenomeRNAii | 1907 |
Pharosi | P20800, Tbio |
PROi | PR:P20800 |
RNActi | P20800, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127129, Expressed in ectocervix and 132 other tissues |
Genevisiblei | P20800, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin IPR015658, ET-2 |
PANTHERi | PTHR13874, PTHR13874, 1 hit PTHR13874:SF9, PTHR13874:SF9, 1 hit |
Pfami | View protein in Pfam PF00322, Endothelin, 1 hit |
PRINTSi | PR00365, ENDOTHELIN |
SMARTi | View protein in SMART SM00272, END, 2 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | EDN2_HUMAN | |
Accessioni | P20800Primary (citable) accession number: P20800 Secondary accession number(s): Q5T1R3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families