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Protein

Endothelin-2

Gene

EDN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functioni

  • endothelin B receptor binding Source: BHF-UCL
  • hormone activity Source: BHF-UCL

GO - Biological processi

  • artery smooth muscle contraction Source: BHF-UCL
  • calcium-mediated signaling Source: BHF-UCL
  • cell surface receptor signaling pathway Source: BHF-UCL
  • cytokine-mediated signaling pathway Source: BHF-UCL
  • energy homeostasis Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: Reactome
  • hormonal regulation of the force of heart contraction Source: BHF-UCL
  • inositol phosphate-mediated signaling Source: BHF-UCL
  • lung alveolus development Source: Ensembl
  • macrophage activation Source: BHF-UCL
  • macrophage chemotaxis Source: BHF-UCL
  • neutrophil chemotaxis Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of heart rate Source: BHF-UCL
  • positive regulation of leukocyte chemotaxis Source: BHF-UCL
  • positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
  • positive regulation of smooth muscle contraction Source: Ensembl
  • positive regulation of the force of heart contraction by chemical signal Source: BHF-UCL
  • prostaglandin biosynthetic process Source: BHF-UCL
  • regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
  • regulation of vasoconstriction Source: InterPro
  • temperature homeostasis Source: Ensembl
  • vasoconstriction Source: BHF-UCL
  • vein smooth muscle contraction Source: BHF-UCL

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Gene namesi
Name:EDN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000127129.9
HGNCiHGNC:3177 EDN2
MIMi131241 gene
neXtProtiNX_P20800

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1907
OpenTargetsiENSG00000127129
PharmGKBiPA27615

Polymorphism and mutation databases

BioMutaiEDN2
DMDMi119615

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000809325 – 46Add BLAST22
PeptideiPRO_000000809449 – 69Endothelin-2Add BLAST21
PropeptideiPRO_000000809570 – 178Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 63By similarity
Disulfide bondi51 ↔ 59By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69 – 70Cleavage; by KEL2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP20800
PeptideAtlasiP20800
PRIDEiP20800
ProteomicsDBi53790

PTM databases

iPTMnetiP20800
PhosphoSitePlusiP20800

Miscellaneous databases

PMAP-CutDBiP20800

Expressioni

Tissue specificityi

Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.1 Publication

Gene expression databases

BgeeiENSG00000127129
CleanExiHS_EDN2
GenevisibleiP20800 HS

Organism-specific databases

HPAiHPA028459

Interactioni

GO - Molecular functioni

  • endothelin B receptor binding Source: BHF-UCL
  • hormone activity Source: BHF-UCL

Protein-protein interaction databases

STRINGi9606.ENSP00000361668

Structurei

3D structure databases

ProteinModelPortaliP20800
SMRiP20800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 111Endothelin-likeAdd BLAST16

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XQ Eukaryota
ENOG410YUMW LUCA
GeneTreeiENSGT00530000063310
HOGENOMiHOG000231110
HOVERGENiHBG051441
InParanoidiP20800
KOiK16367
OMAiPTAWCSV
OrthoDBiEOG091G0WW5
PhylomeDBiP20800
TreeFamiTF333184

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
IPR015658 ET-2
PANTHERiPTHR13874:SF9 PTHR13874:SF9, 1 hit
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS
60 70 80 90 100
CSSWLDKECV YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS
110 120 130 140 150
ARDPACATFC LRRPWTEAGA VPSRKSPADV FQTGKTGATT GELLQRLRDI
160 170
STVKSLFAKR QQEAMREPRS THSRWRKR
Length:178
Mass (Da):19,960
Last modified:November 1, 1991 - v2
Checksum:i7711B2B6F075CFB4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033914131F → L. Corresponds to variant dbSNP:rs5798Ensembl.1
Natural variantiVAR_018817168P → L1 PublicationCorresponds to variant dbSNP:rs11572371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55177 mRNA Translation: CAA38962.1
M65199 mRNA Translation: AAA52404.1
AY518541 Genomic DNA Translation: AAR89914.1
AL445933 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07175.1
BC034393 mRNA Translation: AAH34393.1
M25550 Genomic DNA Translation: AAA52340.1
CCDSiCCDS462.1
PIRiA39070
RefSeqiNP_001289198.1, NM_001302269.1
NP_001947.1, NM_001956.4
UniGeneiHs.1407

Genome annotation databases

EnsembliENST00000372587; ENSP00000361668; ENSG00000127129
GeneIDi1907
KEGGihsa:1907
UCSCiuc001cgx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEDN2_HUMAN
AccessioniPrimary (citable) accession number: P20800
Secondary accession number(s): Q5T1R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1991
Last modified: June 20, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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