UniProtKB - P20786 (PGFRA_RAT)
Platelet-derived growth factor receptor alpha
Pdgfra
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 626 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 817 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 598 – 606 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- growth factor binding Source: GO_Central
- phosphatidylinositol 3-kinase binding Source: RGD
- platelet-derived growth factor alpha-receptor activity Source: RGD
- platelet-derived growth factor binding Source: RGD
- platelet-derived growth factor receptor binding Source: RGD
- protein-containing complex binding Source: RGD
- protein homodimerization activity Source: UniProtKB
- protein kinase activity Source: RGD
- transmembrane receptor protein tyrosine kinase activity Source: RGD
- vascular endothelial growth factor-activated receptor activity Source: UniProtKB
- vascular endothelial growth factor binding Source: RGD
GO - Biological processi
- adrenal gland development Source: RGD
- aging Source: RGD
- anatomical structure morphogenesis Source: RGD
- animal organ morphogenesis Source: RGD
- brain development Source: RGD
- cardiac myofibril assembly Source: UniProtKB
- cell chemotaxis Source: UniProtKB
- cell migration Source: RGD
- cellular response to amino acid stimulus Source: RGD
- cellular response to fibroblast growth factor stimulus Source: RGD
- cellular response to interleukin-1 Source: RGD
- cellular response to reactive oxygen species Source: RGD
- embryonic cranial skeleton morphogenesis Source: UniProtKB
- embryonic digestive tract morphogenesis Source: UniProtKB
- embryonic skeletal system morphogenesis Source: UniProtKB
- estrogen metabolic process Source: RGD
- extracellular matrix organization Source: RGD
- face morphogenesis Source: RGD
- female gonad development Source: RGD
- hematopoietic progenitor cell differentiation Source: RGD
- inner ear development Source: RGD
- in utero embryonic development Source: RGD
- Leydig cell differentiation Source: RGD
- lung development Source: RGD
- lung growth Source: RGD
- luteinization Source: UniProtKB
- male genitalia development Source: RGD
- male gonad development Source: RGD
- metanephric glomerular capillary formation Source: UniProtKB
- multicellular organism development Source: GO_Central
- negative regulation of platelet activation Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: RGD
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- phosphatidylinositol-mediated signaling Source: UniProtKB
- platelet aggregation Source: UniProtKB
- platelet-derived growth factor receptor-alpha signaling pathway Source: RGD
- platelet-derived growth factor receptor signaling pathway Source: UniProtKB
- positive regulation of branching involved in lung morphogenesis Source: RGD
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phospholipase C activity Source: RGD
- protein autophosphorylation Source: UniProtKB
- regulation of chemotaxis Source: RGD
- regulation of mesenchymal stem cell differentiation Source: UniProtKB
- response to cytokine Source: RGD
- response to estradiol Source: RGD
- response to estrogen Source: RGD
- response to formaldehyde Source: RGD
- response to hormone Source: RGD
- response to hyperoxia Source: RGD
- response to inorganic substance Source: RGD
- response to organic substance Source: RGD
- retina vasculature development in camera-type eye Source: UniProtKB
- roof of mouth development Source: RGD
- signal transduction involved in regulation of gene expression Source: RGD
- skeletal system morphogenesis Source: RGD
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- white fat cell differentiation Source: RGD
- wound healing Source: RGD
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Chemotaxis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 5301 |
Reactomei | R-RNO-1257604, PIP3 activates AKT signaling R-RNO-186763, Downstream signal transduction R-RNO-186797, Signaling by PDGF R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-derived growth factor receptor alpha (EC:2.7.10.1)Short name: PDGF-R-alpha Short name: PDGFR-alpha Alternative name(s): Alpha platelet-derived growth factor receptor Alpha-type platelet-derived growth factor receptor CD140 antigen-like family member A Platelet-derived growth factor alpha receptor CD_antigen: CD140a |
Gene namesi | Name:Pdgfra |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3284, Pdgfra |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Golgi apparatus
- Golgi apparatus By similarity
Other locations
- cilium By similarity
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: RGD
- integral component of plasma membrane Source: UniProtKB
- intrinsic component of plasma membrane Source: RGD
- plasma membrane Source: UniProtKB
Other locations
- axon Source: RGD
- cell surface Source: RGD
- cilium Source: UniProtKB
- cytoplasm Source: UniProtKB
- microvillus Source: RGD
- protein-containing complex Source: RGD
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 527 | ExtracellularSequence analysisAdd BLAST | 504 | |
Transmembranei | 528 – 548 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 549 – 1088 | CytoplasmicSequence analysisAdd BLAST | 540 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Add BLAST | 23 | |
ChainiPRO_0000016762 | 24 – 1088 | Platelet-derived growth factor receptor alphaAdd BLAST | 1065 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 99 | PROSITE-ProRule annotation | ||
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 149 ↔ 188 | PROSITE-ProRule annotation | ||
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 234 ↔ 289 | PROSITE-ProRule annotation | ||
Glycosylationi | 352 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 358 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 434 ↔ 500 | PROSITE-ProRule annotation | ||
Glycosylationi | 457 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 467 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 571 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 573 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 719 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 730 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 741 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 753 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 761 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 767 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 848 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 987 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1017 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P20786 |
PaxDbi | P20786 |
PRIDEi | P20786 |
PTM databases
GlyGeni | P20786, 7 sites |
iPTMneti | P20786 |
PhosphoSitePlusi | P20786 |
Interactioni
Subunit structurei
Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed.
Interacts (tyrosine phosphorylated) with SHB (via SH2 domain).
Interacts (tyrosine phosphorylated) with SHF (via SH2 domain).
Interacts (tyrosine phosphorylated) with SRC (via SH2 domain).
Interacts (tyrosine phosphorylated) with PIK3R1.
Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain).
Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7 (By similarity).
By similarityGO - Molecular functioni
- growth factor binding Source: GO_Central
- phosphatidylinositol 3-kinase binding Source: RGD
- platelet-derived growth factor binding Source: RGD
- platelet-derived growth factor receptor binding Source: RGD
- protein homodimerization activity Source: UniProtKB
- vascular endothelial growth factor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247307, 1 interactor |
IntActi | P20786, 1 interactor |
MINTi | P20786 |
STRINGi | 10116.ENSRNOP00000003077 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 112 | Ig-like C2-type 1Add BLAST | 89 | |
Domaini | 116 – 200 | Ig-like C2-type 2Add BLAST | 85 | |
Domaini | 201 – 305 | Ig-like C2-type 3Add BLAST | 105 | |
Domaini | 318 – 409 | Ig-like C2-type 4Add BLAST | 92 | |
Domaini | 413 – 516 | Ig-like C2-type 5Add BLAST | 104 | |
Domaini | 592 – 953 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 362 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | P20786 |
OrthoDBi | 236292at2759 |
PhylomeDBi | P20786 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR027290, PDGFRA IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF500950, Alpha-PDGF_receptor, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits SM00220, S_TKc, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGTSQAFLVL SCLLTGPSLI VCQLLLPSIL PNENEKIVPL SSSFSLRCFG
60 70 80 90 100
ESEVSWQHPM SEEEDPNVEI RTEENNSSLF VTVLEVVNAS AAHTGWYTCY
110 120 130 140 150
YNHTQTEESE IEGRHIYIYV PDPDMAFVPL GMTDSLVIVE EDDSAIIPCL
160 170 180 190 200
TTDPDTEVTL HNNGRLVPAS YDSRQGFNGT FSVGPYICEA TVRGRTFKTS
210 220 230 240 250
EFNVYALKAT SELNLEMDTR QTVYKAGETI VVTCAVFNNE VVDLQWTYPG
260 270 280 290 300
EVRNKGITML EEIKLPSIKL VYTLTVPKAT VKDSGDYECA ARQATKEVKE
310 320 330 340 350
MKTVTISVHE KGFVQIRPTF GHLETVNLHQ VREFVVEVQA YPTPRISWLK
360 370 380 390 400
DNLTLIENLT EITTDVQRSQ ETRYQSKLKL IRAKEEDSGH YTIIVQNDDD
410 420 430 440 450
MKSYTFELST LVPASILELV DDHHGSGGGQ TVRCTAEGTP LPNIEWMICK
460 470 480 490 500
DIKKCNNDTS WTVLASNVSN IITEFHQRGR STVEGRVSFA KVEETIAVRC
510 520 530 540 550
LAKNDLGIGN RELKLVAPSL RSELTVAAAV LVLLVIVIVS LIVLVVIWKQ
560 570 580 590 600
KPRYEIRWRV IESISPDGHE YIYVDPMQLP YDSRWEFPRD GLVLGRILGS
610 620 630 640 650
GAFGKVVEGT AYGLSRSQPV MKVAVKMLKP TARSSEKQAL MSELKIMTHL
660 670 680 690 700
GPHLNIVNLL GACTKSGPIY IITEYCFYGD LVNYLHKNRD SFMSRHPEKP
710 720 730 740 750
KKDLDIFGLN PADESTRSYV ILSFENNGDY VDMKQADTTQ YVPMLERKEV
760 770 780 790 800
SKYSDIQRSL YDRPASYKKK SMLDSEAKNL LSDDDSEGLT LLDLLSFTYQ
810 820 830 840 850
VARGMEFLAS KNCVHRDLAA RNVLLAQGKI VKICDFGLAR DIMHDSNYVS
860 870 880 890 900
KGSTFLPVKW MAPESIFDNL YTTLSDVWSY GVLLWEIFSL GGTPYPGMMV
910 920 930 940 950
DSTFYNKIKS GYRMAKPDHA TSEVYEIMVQ CWNSEPEKRP SFYHLSEIVE
960 970 980 990 1000
NLLPGQYKKS YEKIHLDFLK SDHPAVARMR VDSDNAYIGV TYKNEEDKLK
1010 1020 1030 1040 1050
EWEGGLDEQR LSADSGYIIP LPDIDPVPEE EDLGKRNRHS SQTSEESAIE
1060 1070 1080
TGSSSSTFIK REDETIEDID MMDDIGIDSS DLVEDSFL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6A0 | G3V6A0_RAT | Platelet-derived growth factor rece... | Pdgfra rCG_57147 | 1,088 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | L → R in CAA78488 (PubMed:8318539).Curated | 1 | |
Sequence conflicti | 519 | S → T in CAA78488 (PubMed:8318539).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63837 mRNA Translation: AAA40743.1 Different initiation. Z14118 mRNA Translation: CAA78488.1 |
PIRi | A34710, PFRTGA |
RefSeqi | NP_036934.1, NM_012802.1 |
Genome annotation databases
GeneIDi | 25267 |
KEGGi | rno:25267 |
UCSCi | RGD:3284, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63837 mRNA Translation: AAA40743.1 Different initiation. Z14118 mRNA Translation: CAA78488.1 |
PIRi | A34710, PFRTGA |
RefSeqi | NP_036934.1, NM_012802.1 |
3D structure databases
SMRi | P20786 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247307, 1 interactor |
IntActi | P20786, 1 interactor |
MINTi | P20786 |
STRINGi | 10116.ENSRNOP00000003077 |
Chemistry databases
ChEMBLi | CHEMBL2111344 |
PTM databases
GlyGeni | P20786, 7 sites |
iPTMneti | P20786 |
PhosphoSitePlusi | P20786 |
Proteomic databases
jPOSTi | P20786 |
PaxDbi | P20786 |
PRIDEi | P20786 |
Genome annotation databases
GeneIDi | 25267 |
KEGGi | rno:25267 |
UCSCi | RGD:3284, rat |
Organism-specific databases
CTDi | 5156 |
RGDi | 3284, Pdgfra |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | P20786 |
OrthoDBi | 236292at2759 |
PhylomeDBi | P20786 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 5301 |
Reactomei | R-RNO-1257604, PIP3 activates AKT signaling R-RNO-186763, Downstream signal transduction R-RNO-186797, Signaling by PDGF R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Miscellaneous databases
PROi | PR:P20786 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR027290, PDGFRA IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF500950, Alpha-PDGF_receptor, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits SM00220, S_TKc, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGFRA_RAT | |
Accessioni | P20786Primary (citable) accession number: P20786 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | May 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families