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Protein

Neurotrophin-3

Gene

NTF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chemoattractant activity Source: BHF-UCL
  • growth factor activity Source: BHF-UCL
  • neurotrophin receptor binding Source: InterPro
  • signaling receptor binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9025046 NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P20783

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P20783

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185652.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8023 NTF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
162660 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20783

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4908

Open Targets

More...
OpenTargetsi
ENSG00000185652

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31806

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB05066 AV411

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NTF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
128581

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001965919 – 138Add BLAST120
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000019660139 – 257Neurotrophin-3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi152 ↔ 217
Disulfide bondi195 ↔ 246
Disulfide bondi205 ↔ 248

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P20783

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20783

PRoteomics IDEntifications database

More...
PRIDEi
P20783

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53785
53786 [P20783-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20783

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20783

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P20783

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185652 Expressed in 132 organ(s), highest expression level in thoracic aorta

CleanEx database of gene expression profiles

More...
CleanExi
HS_NTF3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20783 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA032001

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110963, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P20783

Database of interacting proteins

More...
DIPi
DIP-346N

Protein interaction database and analysis system

More...
IntActi
P20783, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000397297

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P20783

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20783

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P20783

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHMM Eukaryota
ENOG410XRRK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007725

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231516

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006494

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20783

KEGG Orthology (KO)

More...
KOi
K04356

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKQMVDI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GHL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20783

TreeFam database of animal gene trees

More...
TreeFami
TF106463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR015578 Neurotrophin-3

The PANTHER Classification System

More...
PANTHERi
PTHR11589 PTHR11589, 1 hit
PTHR11589:SF4 PTHR11589:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00243 NGF, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001789 NGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01914 NEUROTROPHN3
PR00268 NGF

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00140 NGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P20783-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS
160 170 180 190 200
VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP
210 220 230 240 250
VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL

SRKIGRT
Length:257
Mass (Da):29,355
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39A5BB3B28E25E03
GO
Isoform 2 (identifier: P20783-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVTFATILQVNKVM

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,800
Checksum:i43B3342B32424E97
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01208476G → E2 PublicationsCorresponds to variant dbSNP:rs1805149Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0433531M → MVTFATILQVNKVM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53655 mRNA Translation: CAA37703.1
M37763 Genomic DNA Translation: AAA59953.1
M61180 Genomic DNA Translation: AAA63231.1
AK293895 mRNA Translation: BAH11621.1
CR541906 mRNA Translation: CAG46704.1
CH471116 Genomic DNA Translation: EAW88824.1
CH471116 Genomic DNA Translation: EAW88825.1
BC069773 mRNA Translation: AAH69773.1
BC107075 mRNA Translation: AAI07076.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44806.1 [P20783-2]
CCDS8538.1 [P20783-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A36208 C40304

NCBI Reference Sequences

More...
RefSeqi
NP_001096124.1, NM_001102654.1 [P20783-2]
NP_002518.1, NM_002527.4 [P20783-1]
XP_011519265.1, XM_011520963.2 [P20783-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.99171

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331010; ENSP00000328738; ENSG00000185652 [P20783-1]
ENST00000423158; ENSP00000397297; ENSG00000185652 [P20783-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4908

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4908

UCSC genome browser

More...
UCSCi
uc001qnk.5 human [P20783-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53655 mRNA Translation: CAA37703.1
M37763 Genomic DNA Translation: AAA59953.1
M61180 Genomic DNA Translation: AAA63231.1
AK293895 mRNA Translation: BAH11621.1
CR541906 mRNA Translation: CAG46704.1
CH471116 Genomic DNA Translation: EAW88824.1
CH471116 Genomic DNA Translation: EAW88825.1
BC069773 mRNA Translation: AAH69773.1
BC107075 mRNA Translation: AAI07076.1
CCDSiCCDS44806.1 [P20783-2]
CCDS8538.1 [P20783-1]
PIRiA36208 C40304
RefSeqiNP_001096124.1, NM_001102654.1 [P20783-2]
NP_002518.1, NM_002527.4 [P20783-1]
XP_011519265.1, XM_011520963.2 [P20783-1]
UniGeneiHs.99171

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8KX-ray2.15A139-257[»]
1BNDX-ray2.30B139-257[»]
1NT3X-ray2.40A139-257[»]
3BUKX-ray2.60A/B139-257[»]
ProteinModelPortaliP20783
SMRiP20783
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110963, 13 interactors
CORUMiP20783
DIPiDIP-346N
IntActiP20783, 6 interactors
STRINGi9606.ENSP00000397297

Chemistry databases

DrugBankiDB05066 AV411

PTM databases

iPTMnetiP20783
PhosphoSitePlusiP20783

Polymorphism and mutation databases

BioMutaiNTF3
DMDMi128581

Proteomic databases

EPDiP20783
PaxDbiP20783
PRIDEiP20783
ProteomicsDBi53785
53786 [P20783-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4908
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331010; ENSP00000328738; ENSG00000185652 [P20783-1]
ENST00000423158; ENSP00000397297; ENSG00000185652 [P20783-2]
GeneIDi4908
KEGGihsa:4908
UCSCiuc001qnk.5 human [P20783-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4908
DisGeNETi4908
EuPathDBiHostDB:ENSG00000185652.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NTF3
HGNCiHGNC:8023 NTF3
HPAiHPA032001
MIMi162660 gene
neXtProtiNX_P20783
OpenTargetsiENSG00000185652
PharmGKBiPA31806

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHMM Eukaryota
ENOG410XRRK LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP20783
KOiK04356
OMAiSKQMVDI
OrthoDBiEOG091G0GHL
PhylomeDBiP20783
TreeFamiTF106463

Enzyme and pathway databases

ReactomeiR-HSA-9025046 NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K
SignaLinkiP20783
SIGNORiP20783

Miscellaneous databases

EvolutionaryTraceiP20783

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Neurotrophin-3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4908
PMAP-CutDBiP20783

Protein Ontology

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PROi
PR:P20783

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000185652 Expressed in 132 organ(s), highest expression level in thoracic aorta
CleanExiHS_NTF3
GenevisibleiP20783 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR015578 Neurotrophin-3
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF4 PTHR11589:SF4, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01914 NEUROTROPHN3
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20783
Secondary accession number(s): B7Z1T5, Q6FH50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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