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Protein

Neurotrophin-3

Gene

NTF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  • chemoattractant activity Source: BHF-UCL
  • growth factor activity Source: BHF-UCL
  • neurotrophin receptor binding Source: InterPro
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-9025046 NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K
SignaLinkiP20783
SIGNORiP20783

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:NTF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185652.11
HGNCiHGNC:8023 NTF3
MIMi162660 gene
neXtProtiNX_P20783

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4908
OpenTargetsiENSG00000185652
PharmGKBiPA31806

Chemistry databases

DrugBankiDB05066 AV411

Polymorphism and mutation databases

BioMutaiNTF3
DMDMi128581

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001965919 – 138Add BLAST120
ChainiPRO_0000019660139 – 257Neurotrophin-3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 217
Disulfide bondi195 ↔ 246
Disulfide bondi205 ↔ 248

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP20783
PaxDbiP20783
PRIDEiP20783
ProteomicsDBi53785
53786 [P20783-2]

PTM databases

iPTMnetiP20783
PhosphoSitePlusiP20783

Miscellaneous databases

PMAP-CutDBiP20783

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

BgeeiENSG00000185652 Expressed in 132 organ(s), highest expression level in thoracic aorta
CleanExiHS_NTF3
GenevisibleiP20783 HS

Organism-specific databases

HPAiHPA032001

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110963, 13 interactors
CORUMiP20783
DIPiDIP-346N
IntActiP20783, 6 interactors
STRINGi9606.ENSP00000397297

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20783
SMRiP20783
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20783

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHMM Eukaryota
ENOG410XRRK LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP20783
KOiK04356
OMAiSKQMVDI
OrthoDBiEOG091G0GHL
PhylomeDBiP20783
TreeFamiTF106463

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR015578 Neurotrophin-3
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF4 PTHR11589:SF4, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01914 NEUROTROPHN3
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P20783-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS
160 170 180 190 200
VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP
210 220 230 240 250
VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL

SRKIGRT
Length:257
Mass (Da):29,355
Last modified:February 1, 1991 - v1
Checksum:i39A5BB3B28E25E03
GO
Isoform 2 (identifier: P20783-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVTFATILQVNKVM

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,800
Checksum:i43B3342B32424E97
GO

Polymorphismi

Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01208476G → E2 PublicationsCorresponds to variant dbSNP:rs1805149Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0433531M → MVTFATILQVNKVM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53655 mRNA Translation: CAA37703.1
M37763 Genomic DNA Translation: AAA59953.1
M61180 Genomic DNA Translation: AAA63231.1
AK293895 mRNA Translation: BAH11621.1
CR541906 mRNA Translation: CAG46704.1
CH471116 Genomic DNA Translation: EAW88824.1
CH471116 Genomic DNA Translation: EAW88825.1
BC069773 mRNA Translation: AAH69773.1
BC107075 mRNA Translation: AAI07076.1
CCDSiCCDS44806.1 [P20783-2]
CCDS8538.1 [P20783-1]
PIRiA36208 C40304
RefSeqiNP_001096124.1, NM_001102654.1 [P20783-2]
NP_002518.1, NM_002527.4 [P20783-1]
XP_011519265.1, XM_011520963.2 [P20783-1]
UniGeneiHs.99171

Genome annotation databases

EnsembliENST00000331010; ENSP00000328738; ENSG00000185652 [P20783-1]
ENST00000423158; ENSP00000397297; ENSG00000185652 [P20783-2]
GeneIDi4908
KEGGihsa:4908
UCSCiuc001qnk.5 human [P20783-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53655 mRNA Translation: CAA37703.1
M37763 Genomic DNA Translation: AAA59953.1
M61180 Genomic DNA Translation: AAA63231.1
AK293895 mRNA Translation: BAH11621.1
CR541906 mRNA Translation: CAG46704.1
CH471116 Genomic DNA Translation: EAW88824.1
CH471116 Genomic DNA Translation: EAW88825.1
BC069773 mRNA Translation: AAH69773.1
BC107075 mRNA Translation: AAI07076.1
CCDSiCCDS44806.1 [P20783-2]
CCDS8538.1 [P20783-1]
PIRiA36208 C40304
RefSeqiNP_001096124.1, NM_001102654.1 [P20783-2]
NP_002518.1, NM_002527.4 [P20783-1]
XP_011519265.1, XM_011520963.2 [P20783-1]
UniGeneiHs.99171

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8KX-ray2.15A139-257[»]
1BNDX-ray2.30B139-257[»]
1NT3X-ray2.40A139-257[»]
3BUKX-ray2.60A/B139-257[»]
ProteinModelPortaliP20783
SMRiP20783
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110963, 13 interactors
CORUMiP20783
DIPiDIP-346N
IntActiP20783, 6 interactors
STRINGi9606.ENSP00000397297

Chemistry databases

DrugBankiDB05066 AV411

PTM databases

iPTMnetiP20783
PhosphoSitePlusiP20783

Polymorphism and mutation databases

BioMutaiNTF3
DMDMi128581

Proteomic databases

EPDiP20783
PaxDbiP20783
PRIDEiP20783
ProteomicsDBi53785
53786 [P20783-2]

Protocols and materials databases

DNASUi4908
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331010; ENSP00000328738; ENSG00000185652 [P20783-1]
ENST00000423158; ENSP00000397297; ENSG00000185652 [P20783-2]
GeneIDi4908
KEGGihsa:4908
UCSCiuc001qnk.5 human [P20783-1]

Organism-specific databases

CTDi4908
DisGeNETi4908
EuPathDBiHostDB:ENSG00000185652.11
GeneCardsiNTF3
HGNCiHGNC:8023 NTF3
HPAiHPA032001
MIMi162660 gene
neXtProtiNX_P20783
OpenTargetsiENSG00000185652
PharmGKBiPA31806
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMM Eukaryota
ENOG410XRRK LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP20783
KOiK04356
OMAiSKQMVDI
OrthoDBiEOG091G0GHL
PhylomeDBiP20783
TreeFamiTF106463

Enzyme and pathway databases

ReactomeiR-HSA-9025046 NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K
SignaLinkiP20783
SIGNORiP20783

Miscellaneous databases

EvolutionaryTraceiP20783
GeneWikiiNeurotrophin-3
GenomeRNAii4908
PMAP-CutDBiP20783
PROiPR:P20783
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185652 Expressed in 132 organ(s), highest expression level in thoracic aorta
CleanExiHS_NTF3
GenevisibleiP20783 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR015578 Neurotrophin-3
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF4 PTHR11589:SF4, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01914 NEUROTROPHN3
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTF3_HUMAN
AccessioniPrimary (citable) accession number: P20783
Secondary accession number(s): B7Z1T5, Q6FH50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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