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Protein

Mimecan

Gene

OGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-2022857 Keratan sulfate degradation
R-HSA-3656225 Defective CHST6 causes MCDC1
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Osteoinductive factor
Short name:
OIF
Gene namesi
Name:OGN
Synonyms:OIF, SLRR3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106809.10
HGNCiHGNC:8126 OGN
MIMi602383 gene
neXtProtiNX_P20774

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4969
OpenTargetsiENSG00000106809
PharmGKBiPA31913

Polymorphism and mutation databases

BioMutaiOGN
DMDMi129078

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003276021 – 298MimecanAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80O-linked (GalNAc...) threonine1 Publication1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 288By similarity
Glycosylationi258N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP20774
PaxDbiP20774
PeptideAtlasiP20774
PRIDEiP20774
ProteomicsDBi53784

2D gel databases

REPRODUCTION-2DPAGEiIPI00025465

PTM databases

GlyConnecti767
iPTMnetiP20774
PhosphoSitePlusiP20774
UniCarbKBiP20774

Miscellaneous databases

PMAP-CutDBiP20774

Expressioni

Tissue specificityi

Bone.

Gene expression databases

BgeeiENSG00000106809
CleanExiHS_OGN
ExpressionAtlasiP20774 baseline and differential
GenevisibleiP20774 HS

Organism-specific databases

HPAiHPA013132

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRKP461082EBI-1753690,EBI-886

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111019, 7 interactors
IntActiP20774, 3 interactors
STRINGi9606.ENSP00000262551

Structurei

3D structure databases

ProteinModelPortaliP20774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati112 – 131LRR 1Add BLAST20
Repeati132 – 155LRR 2Add BLAST24
Repeati156 – 179LRR 3Add BLAST24
Repeati180 – 199LRR 4Add BLAST20
Repeati200 – 225LRR 5Add BLAST26
Repeati226 – 246LRR 6Add BLAST21
Repeati247 – 277LRR 7Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 106Cys-richAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00730000110781
HOVERGENiHBG006850
InParanoidiP20774
KOiK08126
OMAiCKANDTR
OrthoDBiEOG091G0E49
PhylomeDBiP20774
TreeFamiTF351924

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027211 Mimecan
PANTHERiPTHR24373:SF122 PTHR24373:SF122, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK
60 70 80 90 100
YLDGKNIKEK ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DIPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELSLAENQLL KLPVLPPKLT LFNAKYNKIK
210 220 230 240 250
SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH LQFNNIASIT
260 270 280 290
DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF
Length:298
Mass (Da):33,922
Last modified:February 1, 1991 - v1
Checksum:iF4590785C3849F83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192483
, AF192478, AF192479, AF192480, AF192481, AF192482 Genomic DNA Translation: AAF19364.1
AF202167 mRNA Translation: AAF69109.1
AF100758 mRNA Translation: AAD43022.1
AL110267 mRNA Translation: CAB53706.1
CR533516 mRNA Translation: CAG38547.1
AL137848 Genomic DNA No translation available.
BC037273 mRNA Translation: AAH37273.1
BC095443 mRNA Translation: AAH95443.1
AF112465 Genomic DNA Translation: AAD40453.1
AL133114 mRNA Translation: CAB61417.2
CCDSiCCDS6695.1
PIRiB35272
RefSeqiNP_054776.1, NM_014057.4
NP_077727.3, NM_024416.4
NP_148935.1, NM_033014.3
UniGeneiHs.109439
Hs.617761

Genome annotation databases

EnsembliENST00000262551; ENSP00000262551; ENSG00000106809
ENST00000375561; ENSP00000364711; ENSG00000106809
GeneIDi4969
KEGGihsa:4969
UCSCiuc004asa.4 human

Similar proteinsi

Entry informationi

Entry nameiMIME_HUMAN
AccessioniPrimary (citable) accession number: P20774
Secondary accession number(s): Q6FIB0, Q9UF90, Q9UNK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 18, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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