UniProtKB - P20766 (LAC1_RAT)
Protein
Ig lambda-1 chain C region
Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- antigen binding Source: GO_Central
- immunoglobulin receptor binding Source: GO_Central
GO - Biological processi
- B cell receptor signaling pathway Source: GO_Central
- complement activation, classical pathway Source: GO_Central
- defense response to bacterium Source: GO_Central
- innate immune response Source: GO_Central
- phagocytosis, engulfment Source: GO_Central
- phagocytosis, recognition Source: GO_Central
- positive regulation of B cell activation Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Ig lambda-1 chain C region |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1564318, RGD1564318 |
Subcellular locationi
Extracellular region or secreted
- immunoglobulin complex, circulating Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153615 | ‹1 – 104 | Ig lambda-1 chain C regionAdd BLAST | ›104 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 85 | PROSITE-ProRule annotation | ||
Disulfide bondi | 103 | Interchain (with heavy chain)PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P20766 |
Interactioni
GO - Molecular functioni
- immunoglobulin receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000054780 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 99 | Ig-likeAdd BLAST | 94 |
Keywords - Domaini
Immunoglobulin domainPhylogenomic databases
eggNOGi | ENOG502TFGC, Eukaryota |
HOGENOMi | CLU_077975_6_3_1 |
InParanoidi | P20766 |
OMAi | TDFYPGV |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
P20766-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
QPKATPSVTL FPPSSEELKT DKATLVCMVT DFYPGVMTVV WKADGTPITQ
60 70 80 90 100
GVETTQPFKQ NNKYMATSYL LLTAKAWETH SNYSCQVTHE ENTVEKSLSR
AECS
Sequence cautioni
The sequence AAA41419 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22520 Genomic DNA Translation: AAA41419.1 Different initiation. |
PIRi | A27390 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22520 Genomic DNA Translation: AAA41419.1 Different initiation. |
PIRi | A27390 |
3D structure databases
SMRi | P20766 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000054780 |
Proteomic databases
PaxDbi | P20766 |
Protocols and materials databases
ABCDi | P20766, 1 sequenced antibody |
Organism-specific databases
RGDi | 1564318, RGD1564318 |
Phylogenomic databases
eggNOGi | ENOG502TFGC, Eukaryota |
HOGENOMi | CLU_077975_6_3_1 |
InParanoidi | P20766 |
OMAi | TDFYPGV |
Miscellaneous databases
PROi | PR:P20766 |
Gene expression databases
Genevisiblei | P20766, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAC1_RAT | |
Accessioni | P20766Primary (citable) accession number: P20766 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |