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Protein

Ig gamma-2B chain C region

Gene

Igh-1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-166663 Initial triggering of complement
R-RNO-173623 Classical antibody-mediated complement activation
R-RNO-2029481 FCGR activation
R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-2029485 Role of phospholipids in phagocytosis
R-RNO-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2B chain C region
Alternative name(s):
Immunoglobulin heavy chain 1a
Gene namesi
Name:Igh-1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1305720 Igh-1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153593‹1 – 333Ig gamma-2B chain C regionAdd BLAST›333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi15Interchain (with a light chain)PROSITE-ProRule annotation
Disulfide bondi27 ↔ 80PROSITE-ProRule annotation
Disulfide bondi106Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi109Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi112Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi115Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
Disulfide bondi253 ↔ 311PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP20761
PRIDEiP20761

Expressioni

Gene expression databases

BgeeiENSRNOG00000048402 Expressed in 8 organ(s), highest expression level in spleen
GenevisibleiP20761 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20761, 1 interactor
STRINGi10116.ENSRNOP00000044037

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20761
SMRiP20761
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20761

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 96Ig-like 1Add BLAST91
Domaini124 – 223Ig-like 2Add BLAST100
Domaini232 – 328Ig-like 3Add BLAST97

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J Eukaryota
ENOG410YNB1 LUCA
GeneTreeiENSGT00530000063726
HOGENOMiHOG000168559
HOVERGENiHBG005814
InParanoidiP20761
OMAiCSVVHEG
OrthoDBiEOG091G0D3U

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

P20761-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AQTTAPSVYP LAPGCGDTTS STVTLGCLVK GYFPEPVTVT WNSGALSSDV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTS STWPSQTVTC NVAHPASSTK VDKKVERRNG
110 120 130 140 150
GIGHKCPTCP TCHKCPVPEL LGGPSVFIFP PKPKDILLIS QNAKVTCVVV
160 170 180 190 200
DVSEEEPDVQ FSWFVNNVEV HTAQTQPREE QYNSTFRVVS ALPIQHQDWM
210 220 230 240 250
SGKEFKCKVN NKALPSPIEK TISKPKGLVR KPQVYVMGPP TEQLTEQTVS
260 270 280 290 300
LTCLTSGFLP NDIGVEWTSN GHIEKNYKNT EPVMDSDGSF FMYSKLNVER
310 320 330
SRWDSRAPFV CSVVHEGLHN HHVEKSISRP PGK
Length:333
Mass (Da):36,497
Last modified:February 1, 1991 - v1
Checksum:i55F8B64D48D460A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

PIRiPS0018
UniGeneiRn.2255

Genome annotation databases

EnsembliENSRNOT00000045874; ENSRNOP00000044037; ENSRNOG00000048402

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiPS0018
UniGeneiRn.2255

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BFOX-ray2.60B/D/F/H1-95[»]
1C5DX-ray2.40B/H1-98[»]
2ARJX-ray2.88B/H1-98[»]
3B9KX-ray2.70D/H1-96[»]
ProteinModelPortaliP20761
SMRiP20761
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP20761, 1 interactor
STRINGi10116.ENSRNOP00000044037

Proteomic databases

PaxDbiP20761
PRIDEiP20761

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045874; ENSRNOP00000044037; ENSRNOG00000048402

Organism-specific databases

RGDi1305720 Igh-1a

Phylogenomic databases

eggNOGiENOG410IJ6J Eukaryota
ENOG410YNB1 LUCA
GeneTreeiENSGT00530000063726
HOGENOMiHOG000168559
HOVERGENiHBG005814
InParanoidiP20761
OMAiCSVVHEG
OrthoDBiEOG091G0D3U

Enzyme and pathway databases

ReactomeiR-RNO-166663 Initial triggering of complement
R-RNO-173623 Classical antibody-mediated complement activation
R-RNO-2029481 FCGR activation
R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-2029485 Role of phospholipids in phagocytosis
R-RNO-977606 Regulation of Complement cascade

Miscellaneous databases

EvolutionaryTraceiP20761
PROiPR:P20761

Gene expression databases

BgeeiENSRNOG00000048402 Expressed in 8 organ(s), highest expression level in spleen
GenevisibleiP20761 RN

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIGG2B_RAT
AccessioniPrimary (citable) accession number: P20761
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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