UniProtKB - P20760 (IGG2A_RAT)

BLAST

>sp|P20760|IGG2A_RAT Ig gamma-2A chain C region OS=Rattus norvegicus OX=10116 GN=Igg-2a PE=1 SV=1
AETTAPSVYPLAPGTALKSNSMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLQSG
LYTLTSSVTVPSSTWSSQAVTCNVAHPASSTKVDKKIVPRECNPCGCTGSEVSSVFIFPP
KTKDVLTITLTPKVTCVVVDISQNDPEVRFSWFIDDVEVHTAQTHAPEKQSNSTLRSVSE
LPIVHRDWLNGKTFKCKVNSGAFPAPIEKSISKPEGTPRGPQVYTMAPPKEEMTQSQVSI
TCMVKGFYPPDIYTEWKMNGQPQENYKNTPPTMDTDGSYFLYSKLNVKKETWQQGNTFTC
SVLHEGLHNHHTEKSLSHSPGK

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History
Entry version 126 (07 Nov 2018)
Sequence version 1 (01 Feb 1991)
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Protein

Ig gamma-2A chain C region

Gene

Igg-2a

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

antigen binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
complement activation, classical pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to bacterium
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
innate immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phagocytosis, engulfment
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phagocytosis, recognition
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of B cell activation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ig gamma-2A chain C region
Gene namesⁱ	Name:Igg-2a
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	1359626 Igg-2a

RGDⁱ

1359626 Igg-2a

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000153592	‹1 – 322	Ig gamma-2A chain C regionAdd BLAST		›322

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	27 ↔ 82
Disulfide bondⁱ	102	Interchain (with a heavy chain)
Disulfide bondⁱ	105	Interchain (with a heavy chain)
Disulfide bondⁱ	107	Interchain (with a heavy chain)
Disulfide bondⁱ	136 ↔ 196
Glycosylationⁱ	172	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	242 ↔ 300

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P20760
PRIDEⁱ	P20760

PTM databases

CarbonylDBⁱ	P20760

CarbonylDBⁱ

P20760

Interactionⁱ

GO - Molecular functionⁱ

immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P20760, 2 interactors
STRINGⁱ	10116.ENSRNOP00000062949

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	7 – 11	Combined sources	5
Beta strandⁱ	19 – 22	Combined sources	4
Beta strandⁱ	25 – 32	Combined sources	8
Beta strandⁱ	38 – 41	Combined sources	4
Helixⁱ	42 – 44	Combined sources	3
Beta strandⁱ	50 – 52	Combined sources	3
Beta strandⁱ	56 – 58	Combined sources	3
Beta strandⁱ	66 – 68	Combined sources	3
Helixⁱ	72 – 77	Combined sources	6
Beta strandⁱ	81 – 85	Combined sources	5
Turnⁱ	87 – 90	Combined sources	4
Beta strandⁱ	93 – 96	Combined sources	4
Beta strandⁱ	115 – 118	Combined sources	4
Helixⁱ	122 – 125	Combined sources	4
Beta strandⁱ	128 – 130	Combined sources	3
Beta strandⁱ	133 – 141	Combined sources	9
Beta strandⁱ	142 – 144	Combined sources	3
Beta strandⁱ	149 – 156	Combined sources	8
Beta strandⁱ	163 – 169	Combined sources	7
Turnⁱ	171 – 173	Combined sources	3
Beta strandⁱ	175 – 182	Combined sources	8
Helixⁱ	185 – 189	Combined sources	5
Beta strandⁱ	194 – 199	Combined sources	6
Beta strandⁱ	201 – 205	Combined sources	5
Beta strandⁱ	207 – 211	Combined sources	5
Beta strandⁱ	222 – 226	Combined sources	5
Helixⁱ	230 – 234	Combined sources	5
Beta strandⁱ	235 – 250	Combined sources	16
Beta strandⁱ	253 – 258	Combined sources	6
Beta strandⁱ	264 – 268	Combined sources	5
Beta strandⁱ	279 – 288	Combined sources	10
Helixⁱ	289 – 293	Combined sources	5
Beta strandⁱ	298 – 303	Combined sources	6
Helixⁱ	308 – 310	Combined sources	3
Beta strandⁱ	311 – 316	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P20760
SMRⁱ	P20760
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P20760

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	6 – 98	Ig-like 1Add BLAST	93
Domainⁱ	115 – 212	Ig-like 2Add BLAST	98
Domainⁱ	221 – 317	Ig-like 3Add BLAST	97

Keywords - Domainⁱ

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IJ6J Eukaryota ENOG410YNB1 LUCA
HOVERGENⁱ	HBG005814
InParanoidⁱ	P20760
PhylomeDBⁱ	P20760

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003597 Ig_C1-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 3 hits
SMARTⁱ	View protein in SMART SM00407 IGc1, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P20760-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV 
        60         70         80         90        100
HTFPAVLQSG LYTLTSSVTV PSSTWSSQAV TCNVAHPASS TKVDKKIVPR 
       110        120        130        140        150
ECNPCGCTGS EVSSVFIFPP KTKDVLTITL TPKVTCVVVD ISQNDPEVRF 
       160        170        180        190        200
SWFIDDVEVH TAQTHAPEKQ SNSTLRSVSE LPIVHRDWLN GKTFKCKVNS 
       210        220        230        240        250
GAFPAPIEKS ISKPEGTPRG PQVYTMAPPK EEMTQSQVSI TCMVKGFYPP 
       260        270        280        290        300
DIYTEWKMNG QPQENYKNTP PTMDTDGSYF LYSKLNVKKE TWQQGNTFTC 
       310        320 
SVLHEGLHNH HTEKSLSHSP GK

Length:322

Mass (Da):35,186

Last modified:February 1, 1991 - v1

Checksum:ⁱE8EA136A9DE01EDB

Sequence cautionⁱ

The sequence AAA41376 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1			1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13804 Genomic DNA Translation: AAA41376.1 Different initiation.
PIRⁱ	PS0019
UniGeneⁱ	Rn.106192 Rn.10956

Protein	Similar proteins		Species	Score	Length	Source
P20760	LOC367586 protein		RAT		461	UniRef100_P20760
UPI0000111CCD		RAT		225

Protein	Similar proteins		Species	Score	Length	Source
P20760	LOC367586 protein		RAT		461	UniRef90_P20760
UPI0000111CCD		RAT		225

Protein	Similar proteins		Species	Score	Length	Source
P20760	Ig gamma-2A chain C region, membrane-bound form	)	MOUSE		398	UniRef50_P01865
Ig gamma-1 chain C region	)	RAT		326
Ig gamma-3 chain C region		FUKDA		385
Uncharacterized protein		MACMU		391
IgG heavy chain (Fragment)		PIG		392
+62

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13804 Genomic DNA Translation: AAA41376.1 Different initiation.
PIRⁱ	PS0019
UniGeneⁱ	Rn.106192 Rn.10956

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1FN4	X-ray	2.80	B/D	4-102	[»]
	1I1A	X-ray	2.80	C/D	98-322	[»]
	1I1C	X-ray	2.70	A/B	98-322	[»]
	4UAO	X-ray	3.10	C	1-102	[»]
ProteinModelPortalⁱ	P20760
SMRⁱ	P20760
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P20760, 2 interactors
STRINGⁱ	10116.ENSRNOP00000062949

PTM databases

CarbonylDBⁱ	P20760

CarbonylDBⁱ

P20760

Proteomic databases

PaxDbⁱ	P20760
PRIDEⁱ	P20760

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

RGDⁱ	1359626 Igg-2a

Phylogenomic databases

eggNOGⁱ	ENOG410IJ6J Eukaryota ENOG410YNB1 LUCA
HOVERGENⁱ	HBG005814
InParanoidⁱ	P20760
PhylomeDBⁱ	P20760

Miscellaneous databases

EvolutionaryTraceⁱ	P20760
Protein Ontology More...PROⁱ	PR:P20760

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003597 Ig_C1-set
Pfamⁱ	View protein in Pfam PF07654 C1-set, 3 hits
SMARTⁱ	View protein in SMART SM00407 IGc1, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IGG2A_RAT
Accessionⁱ	P20760Primary (citable) accession number: P20760
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	February 1, 1991
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P20760 (IGG2A_RAT)

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Ig gamma-2A chain C region

Igg-2a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ