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UniProtKB - P20760 (IGG2A_RAT)
Protein
Ig gamma-2A chain C region
Gene
Igg-2a
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- antigen binding Source: GO_Central
- immunoglobulin receptor binding Source: GO_Central
GO - Biological processi
- B cell receptor signaling pathway Source: GO_Central
- complement activation, classical pathway Source: GO_Central
- defense response to bacterium Source: GO_Central
- innate immune response Source: GO_Central
- phagocytosis, engulfment Source: GO_Central
- phagocytosis, recognition Source: GO_Central
- positive regulation of B cell activation Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Ig gamma-2A chain C region |
Gene namesi | Name:Igg-2a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359626, Igg-2a |
Subcellular locationi
Extracellular region or secreted
- immunoglobulin complex, circulating Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153592 | ‹1 – 322 | Ig gamma-2A chain C regionAdd BLAST | ›322 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 82 | |||
Disulfide bondi | 102 | Interchain (with a heavy chain) | ||
Disulfide bondi | 105 | Interchain (with a heavy chain) | ||
Disulfide bondi | 107 | Interchain (with a heavy chain) | ||
Disulfide bondi | 136 ↔ 196 | |||
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 242 ↔ 300 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P20760 |
PRIDEi | P20760 |
PTM databases
CarbonylDBi | P20760 |
GlyGeni | P20760, 1 site |
Interactioni
GO - Molecular functioni
- immunoglobulin receptor binding Source: GO_Central
Protein-protein interaction databases
IntActi | P20760, 2 interactors |
STRINGi | 10116.ENSRNOP00000062949 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P20760 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20760 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 98 | Ig-like 1Add BLAST | 93 | |
Domaini | 115 – 212 | Ig-like 2Add BLAST | 98 | |
Domaini | 221 – 317 | Ig-like 3Add BLAST | 97 |
Keywords - Domaini
Immunoglobulin domain, RepeatPhylogenomic databases
eggNOGi | ENOG502R54U, Eukaryota |
InParanoidi | P20760 |
PhylomeDBi | P20760 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 2 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
i Sequence
Sequence statusi: Complete.
P20760-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTV PSSTWSSQAV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
ECNPCGCTGS EVSSVFIFPP KTKDVLTITL TPKVTCVVVD ISQNDPEVRF
160 170 180 190 200
SWFIDDVEVH TAQTHAPEKQ SNSTLRSVSE LPIVHRDWLN GKTFKCKVNS
210 220 230 240 250
GAFPAPIEKS ISKPEGTPRG PQVYTMAPPK EEMTQSQVSI TCMVKGFYPP
260 270 280 290 300
DIYTEWKMNG QPQENYKNTP PTMDTDGSYF LYSKLNVKKE TWQQGNTFTC
310 320
SVLHEGLHNH HTEKSLSHSP GK
Sequence cautioni
The sequence AAA41376 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13804 Genomic DNA Translation: AAA41376.1 Different initiation. |
PIRi | PS0019 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13804 Genomic DNA Translation: AAA41376.1 Different initiation. |
PIRi | PS0019 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FN4 | X-ray | 2.80 | B/D | 4-102 | [»] | |
1I1A | X-ray | 2.80 | C/D | 98-322 | [»] | |
1I1C | X-ray | 2.70 | A/B | 98-322 | [»] | |
4UAO | X-ray | 3.10 | C | 1-102 | [»] | |
SMRi | P20760 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P20760, 2 interactors |
STRINGi | 10116.ENSRNOP00000062949 |
PTM databases
CarbonylDBi | P20760 |
GlyGeni | P20760, 1 site |
Proteomic databases
PaxDbi | P20760 |
PRIDEi | P20760 |
Organism-specific databases
RGDi | 1359626, Igg-2a |
Phylogenomic databases
eggNOGi | ENOG502R54U, Eukaryota |
InParanoidi | P20760 |
PhylomeDBi | P20760 |
Miscellaneous databases
EvolutionaryTracei | P20760 |
PROi | PR:P20760 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 2 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | IGG2A_RAT | |
Accessioni | P20760Primary (citable) accession number: P20760 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | June 2, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references