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Protein

Ig gamma-2A chain C region

Gene

Igg-2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • immunoglobulin receptor binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region
Gene namesi
Name:Igg-2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359626 Igg-2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153592‹1 – 322Ig gamma-2A chain C regionAdd BLAST›322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82
Disulfide bondi102Interchain (with a heavy chain)
Disulfide bondi105Interchain (with a heavy chain)
Disulfide bondi107Interchain (with a heavy chain)
Disulfide bondi136 ↔ 196
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi242 ↔ 300

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20760
PRIDEiP20760

PTM databases

CarbonylDBiP20760

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20760, 2 interactors
STRINGi10116.ENSRNOP00000062949

Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20760
SMRiP20760
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20760

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 98Ig-like 1Add BLAST93
Domaini115 – 212Ig-like 2Add BLAST98
Domaini221 – 317Ig-like 3Add BLAST97

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J Eukaryota
ENOG410YNB1 LUCA
HOVERGENiHBG005814
InParanoidiP20760
PhylomeDBiP20760

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequencei

Sequence statusi: Complete.

P20760-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTV PSSTWSSQAV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
ECNPCGCTGS EVSSVFIFPP KTKDVLTITL TPKVTCVVVD ISQNDPEVRF
160 170 180 190 200
SWFIDDVEVH TAQTHAPEKQ SNSTLRSVSE LPIVHRDWLN GKTFKCKVNS
210 220 230 240 250
GAFPAPIEKS ISKPEGTPRG PQVYTMAPPK EEMTQSQVSI TCMVKGFYPP
260 270 280 290 300
DIYTEWKMNG QPQENYKNTP PTMDTDGSYF LYSKLNVKKE TWQQGNTFTC
310 320
SVLHEGLHNH HTEKSLSHSP GK
Length:322
Mass (Da):35,186
Last modified:February 1, 1991 - v1
Checksum:iE8EA136A9DE01EDB
GO

Sequence cautioni

The sequence AAA41376 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13804 Genomic DNA Translation: AAA41376.1 Different initiation.
PIRiPS0019
UniGeneiRn.106192
Rn.10956

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13804 Genomic DNA Translation: AAA41376.1 Different initiation.
PIRiPS0019
UniGeneiRn.106192
Rn.10956

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FN4X-ray2.80B/D4-102[»]
1I1AX-ray2.80C/D98-322[»]
1I1CX-ray2.70A/B98-322[»]
4UAOX-ray3.10C1-102[»]
ProteinModelPortaliP20760
SMRiP20760
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP20760, 2 interactors
STRINGi10116.ENSRNOP00000062949

PTM databases

CarbonylDBiP20760

Proteomic databases

PaxDbiP20760
PRIDEiP20760

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1359626 Igg-2a

Phylogenomic databases

eggNOGiENOG410IJ6J Eukaryota
ENOG410YNB1 LUCA
HOVERGENiHBG005814
InParanoidiP20760
PhylomeDBiP20760

Miscellaneous databases

EvolutionaryTraceiP20760
PROiPR:P20760

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGG2A_RAT
AccessioniPrimary (citable) accession number: P20760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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