UniProtKB - P20749 (BCL3_HUMAN)
B-cell lymphoma 3 protein
BCL3
Functioni
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
By similarity1 PublicationCaution
GO - Molecular functioni
- DNA-binding transcription factor binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- protein-macromolecule adaptor activity Source: UniProtKB
- transcription coactivator activity Source: Ensembl
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- antimicrobial humoral response Source: Ensembl
- cellular response to DNA damage stimulus Source: UniProtKB
- defense response to bacterium Source: Ensembl
- defense response to protozoan Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
- extracellular matrix organization Source: Ensembl
- follicular dendritic cell differentiation Source: Ensembl
- germinal center formation Source: Ensembl
- humoral immune response mediated by circulating immunoglobulin Source: Ensembl
- I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
- marginal zone B cell differentiation Source: Ensembl
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of interleukin-8 production Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-10 production Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of translation Source: UniProtKB
- protein import into nucleus Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
- regulation of DNA binding Source: UniProtKB
- regulation of NIK/NF-kappaB signaling Source: UniProtKB
- response to UV-C Source: UniProtKB
- response to virus Source: UniProtKB
- spleen development Source: Ensembl
- T-helper 1 type immune response Source: Ensembl
- T-helper 2 cell differentiation Source: Ensembl
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P20749 |
SignaLinki | P20749 |
SIGNORi | P20749 |
Names & Taxonomyi
Protein namesi | Recommended name: B-cell lymphoma 3 proteinShort name: BCL-3 Alternative name(s): Proto-oncogene BCL3 |
Gene namesi | Name:BCL3 Synonyms:BCL4, D19S37 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:998, BCL3 |
MIMi | 109560, gene |
neXtProti | NX_P20749 |
VEuPathDBi | HostDB:ENSG00000069399 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
Other locations
- perinuclear region By similarity
Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- Bcl3-Bcl10 complex Source: UniProtKB
- Bcl3/NF-kappaB2 complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- midbody Source: HPA
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 602 |
OpenTargetsi | ENSG00000069399 |
PharmGKBi | PA25310 |
Miscellaneous databases
Pharosi | P20749, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523197 |
Genetic variation databases
BioMutai | BCL3 |
DMDMi | 294862410 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066976 | 1 – 454 | B-cell lymphoma 3 proteinAdd BLAST | 454 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineCombined sources | 1 | |
Modified residuei | 374 | PhosphoserineCombined sources | 1 | |
Modified residuei | 402 | Phosphoserine; by GSK31 Publication | 1 | |
Modified residuei | 406 | Phosphoserine; by GSK31 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P20749 |
jPOSTi | P20749 |
MassIVEi | P20749 |
MaxQBi | P20749 |
PaxDbi | P20749 |
PeptideAtlasi | P20749 |
PRIDEi | P20749 |
ProteomicsDBi | 53783 |
PTM databases
iPTMneti | P20749 |
PhosphoSitePlusi | P20749 |
Expressioni
Gene expression databases
Bgeei | ENSG00000069399, Expressed in left lobe of thyroid gland and 215 other tissues |
ExpressionAtlasi | P20749, baseline and differential |
Genevisiblei | P20749, HS |
Organism-specific databases
HPAi | ENSG00000069399, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3.
Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3.
Interacts with N4BP2, COPS5 and PIR.
Interacts with CYLD (By similarity).
By similarityBinary interactionsi
P20749
With | #Exp. | IntAct |
---|---|---|
BCL10 [O95999] | 3 | EBI-958997,EBI-958922 |
CTBP2 [P56545] | 2 | EBI-958997,EBI-741533 |
LCK [P06239] | 3 | EBI-958997,EBI-1348 |
NUP58 [Q9BVL2] | 3 | EBI-958997,EBI-2811583 |
GO - Molecular functioni
- DNA-binding transcription factor binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107074, 49 interactors |
CORUMi | P20749 |
IntActi | P20749, 11 interactors |
MINTi | P20749 |
STRINGi | 9606.ENSP00000164227 |
Miscellaneous databases
RNActi | P20749, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P20749 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20749 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 134 – 163 | ANK 1Add BLAST | 30 | |
Repeati | 171 – 200 | ANK 2Add BLAST | 30 | |
Repeati | 204 – 235 | ANK 3Add BLAST | 32 | |
Repeati | 241 – 270 | ANK 4Add BLAST | 30 | |
Repeati | 275 – 304 | ANK 5Add BLAST | 30 | |
Repeati | 308 – 337 | ANK 6Add BLAST | 30 | |
Repeati | 338 – 367 | ANK 7Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 360 – 454 | DisorderedSequence analysisAdd BLAST | 95 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 363 – 403 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 404 – 431 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 440 – 454 | Pro residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000161392 |
HOGENOMi | CLU_720685_0_0_1 |
InParanoidi | P20749 |
OMAi | MMCSMEH |
OrthoDBi | 1341288at2759 |
PhylomeDBi | P20749 |
TreeFami | TF320166 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
IDEALi | IID00445 |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA
60 70 80 90 100
AGLVVPLDPL RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP
110 120 130 140 150
FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA
160 170 180 190 200
VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA
210 220 230 240 250
LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV
260 270 280 290 300
NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA
310 320 330 340 350
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR
360 370 380 390 400
SRRVIDILRG KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS
410 420 430 440 450
SSPSQSPPRD PPGFPMAPPN FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA
PGGS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C0A2 | H7C0A2_HUMAN | B-cell lymphoma 3 protein | BCL3 | 308 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31731 Genomic DNA Translation: AAA51816.1 Different initiation. M31732 mRNA Translation: AAA51815.1 Different initiation. AC092066 Genomic DNA No translation available. BC064993 mRNA Translation: AAH64993.1 Different initiation. AH006679 Genomic DNA Translation: AAC51348.1 |
CCDSi | CCDS12642.2 |
PIRi | A34794 |
RefSeqi | NP_005169.2, NM_005178.4 |
Genome annotation databases
Ensembli | ENST00000164227; ENSP00000164227; ENSG00000069399 |
GeneIDi | 602 |
KEGGi | hsa:602 |
MANE-Selecti | ENST00000164227.10; ENSP00000164227.5; NM_005178.5; NP_005169.2 |
UCSCi | uc010xxe.3, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31731 Genomic DNA Translation: AAA51816.1 Different initiation. M31732 mRNA Translation: AAA51815.1 Different initiation. AC092066 Genomic DNA No translation available. BC064993 mRNA Translation: AAH64993.1 Different initiation. AH006679 Genomic DNA Translation: AAC51348.1 |
CCDSi | CCDS12642.2 |
PIRi | A34794 |
RefSeqi | NP_005169.2, NM_005178.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K1A | X-ray | 1.86 | A | 127-367 | [»] | |
1K1B | X-ray | 1.90 | A | 127-367 | [»] | |
SMRi | P20749 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107074, 49 interactors |
CORUMi | P20749 |
IntActi | P20749, 11 interactors |
MINTi | P20749 |
STRINGi | 9606.ENSP00000164227 |
Chemistry databases
ChEMBLi | CHEMBL4523197 |
PTM databases
iPTMneti | P20749 |
PhosphoSitePlusi | P20749 |
Genetic variation databases
BioMutai | BCL3 |
DMDMi | 294862410 |
Proteomic databases
EPDi | P20749 |
jPOSTi | P20749 |
MassIVEi | P20749 |
MaxQBi | P20749 |
PaxDbi | P20749 |
PeptideAtlasi | P20749 |
PRIDEi | P20749 |
ProteomicsDBi | 53783 |
Protocols and materials databases
Antibodypediai | 3672, 391 antibodies from 40 providers |
DNASUi | 602 |
Genome annotation databases
Ensembli | ENST00000164227; ENSP00000164227; ENSG00000069399 |
GeneIDi | 602 |
KEGGi | hsa:602 |
MANE-Selecti | ENST00000164227.10; ENSP00000164227.5; NM_005178.5; NP_005169.2 |
UCSCi | uc010xxe.3, human |
Organism-specific databases
CTDi | 602 |
DisGeNETi | 602 |
GeneCardsi | BCL3 |
HGNCi | HGNC:998, BCL3 |
HPAi | ENSG00000069399, Tissue enhanced (liver) |
MIMi | 109560, gene |
neXtProti | NX_P20749 |
OpenTargetsi | ENSG00000069399 |
PharmGKBi | PA25310 |
VEuPathDBi | HostDB:ENSG00000069399 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000161392 |
HOGENOMi | CLU_720685_0_0_1 |
InParanoidi | P20749 |
OMAi | MMCSMEH |
OrthoDBi | 1341288at2759 |
PhylomeDBi | P20749 |
TreeFami | TF320166 |
Enzyme and pathway databases
PathwayCommonsi | P20749 |
SignaLinki | P20749 |
SIGNORi | P20749 |
Miscellaneous databases
BioGRID-ORCSi | 602, 5 hits in 1044 CRISPR screens |
ChiTaRSi | BCL3, human |
EvolutionaryTracei | P20749 |
GeneWikii | BCL3 |
GenomeRNAii | 602 |
Pharosi | P20749, Tbio |
PROi | PR:P20749 |
RNActi | P20749, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000069399, Expressed in left lobe of thyroid gland and 215 other tissues |
ExpressionAtlasi | P20749, baseline and differential |
Genevisiblei | P20749, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
IDEALi | IID00445 |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BCL3_HUMAN | |
Accessioni | P20749Primary (citable) accession number: P20749 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 23, 2022 | |
This is version 203 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references