B-cell lymphoma 3 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence."
    Brasier A.R., Lu M., Hai T., Lu Y., Boldogh I.
    J Biol Chem 276:32080-32093(2001) [PubMed] [Europe PMC] [Abstract]
  • "Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3."
    Nishikori M., Ohno H., Haga H., Uchiyama T.
    Cancer Sci 96:487-497(2005) [PubMed] [Europe PMC] [Abstract]
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
  • "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins."
    Zhang Q., Didonato J.A., Karin M., McKeithan T.W.
    Mol Cell Biol 14:3915-3926(1994) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
• protein-macromolecule adaptor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: Ensembl
• transcription corepressor activity Source: UniProtKBInferred from direct assayⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antimicrobial humoral response Source: Ensembl
• cellular response to DNA damage stimulus Source: UniProtKBInferred from direct assayⁱ
  • "Expression of the Bcl-3 proto-oncogene suppresses p53 activation."
    Kashatus D., Cogswell P., Baldwin A.S.
    Genes Dev 20:225-235(2006) [PubMed] [Europe PMC] [Abstract]
• defense response to bacterium Source: Ensembl
• defense response to protozoan Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Expression of the Bcl-3 proto-oncogene suppresses p53 activation."
    Kashatus D., Cogswell P., Baldwin A.S.
    Genes Dev 20:225-235(2006) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix organization Source: Ensembl
• follicular dendritic cell differentiation Source: Ensembl
• germinal center formation Source: Ensembl
• humoral immune response mediated by circulating immunoglobulin Source: Ensembl
• I-kappaB kinase/NF-kappaB signaling Source: UniProtKBInferred from direct assayⁱ
  • "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins."
    Zhang Q., Didonato J.A., Karin M., McKeithan T.W.
    Mol Cell Biol 14:3915-3926(1994) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGIInferred from mutant phenotypeⁱ
  • "Expression of the Bcl-3 proto-oncogene suppresses p53 activation."
    Kashatus D., Cogswell P., Baldwin A.S.
    Genes Dev 20:225-235(2006) [PubMed] [Europe PMC] [Abstract]
• marginal zone B cell differentiation Source: Ensembl
• negative regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "Expression of the Bcl-3 proto-oncogene suppresses p53 activation."
    Kashatus D., Cogswell P., Baldwin A.S.
    Genes Dev 20:225-235(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interleukin-8 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of NF-kappaB transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of receptor signaling pathway via JAK-STAT Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of tumor necrosis factor production Source: Ensembl
• positive regulation of interferon-gamma production Source: Ensembl
• positive regulation of interleukin-10 production Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Expression of the Bcl-3 proto-oncogene suppresses p53 activation."
    Kashatus D., Cogswell P., Baldwin A.S.
    Genes Dev 20:225-235(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of translation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Expression of the Bcl-3 proto-oncogene suppresses p53 activation."
    Kashatus D., Cogswell P., Baldwin A.S.
    Genes Dev 20:225-235(2006) [PubMed] [Europe PMC] [Abstract]
• protein import into nucleus Source: UniProtKBInferred from direct assayⁱ
  • "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins."
    Zhang Q., Didonato J.A., Karin M., McKeithan T.W.
    Mol Cell Biol 14:3915-3926(1994) [PubMed] [Europe PMC] [Abstract]
• regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription."
    Brocke-Heidrich K., Ge B., Cvijic H., Pfeifer G., Loffler D., Henze C., McKeithan T.W., Horn F.
    Oncogene 25:7297-7304(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of DNA binding Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA."
    Bundy D.L., McKeithan T.W.
    J Biol Chem 272:33132-33139(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of NIK/NF-kappaB signaling Source: UniProtKBInferred from expression patternⁱ
  • "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins."
    Zhang Q., Didonato J.A., Karin M., McKeithan T.W.
    Mol Cell Biol 14:3915-3926(1994) [PubMed] [Europe PMC] [Abstract]
• response to UV-C Source: UniProtKBInferred from direct assayⁱ
  • "Expression of the Bcl-3 proto-oncogene suppresses p53 activation."
    Kashatus D., Cogswell P., Baldwin A.S.
    Genes Dev 20:225-235(2006) [PubMed] [Europe PMC] [Abstract]
• response to virus Source: UniProtKBInferred from direct assayⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
• spleen development Source: Ensembl
• T-helper 1 type immune response Source: Ensembl
• T-helper 2 cell differentiation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• DNA-binding transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence."
    Brasier A.R., Lu M., Hai T., Lu Y., Boldogh I.
    J Biol Chem 276:32080-32093(2001) [PubMed] [Europe PMC] [Abstract]
  • "Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3."
    Nishikori M., Ohno H., Haga H., Uchiyama T.
    Cancer Sci 96:487-497(2005) [PubMed] [Europe PMC] [Abstract]
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]
  • "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins."
    Zhang Q., Didonato J.A., Karin M., McKeithan T.W.
    Mol Cell Biol 14:3915-3926(1994) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter."
    Jamaluddin M., Choudhary S., Wang S., Casola A., Huda R., Garofalo R.P., Ray S., Brasier A.R.
    J Virol 79:15302-15313(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA 
        60         70         80         90        100
AGLVVPLDPL RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP 
       110        120        130        140        150
FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA 
       160        170        180        190        200
VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA 
       210        220        230        240        250
LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV 
       260        270        280        290        300
NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA 
       310        320        330        340        350
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR 
       360        370        380        390        400
SRRVIDILRG KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS 
       410        420        430        440        450
SSPSQSPPRD PPGFPMAPPN FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA 

PGGS                                                   

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 19
   Human chromosome 19: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references