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Protein

B-cell lymphoma 3 protein

Gene

BCL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • DNA binding transcription factor activity Source: Ensembl
  • protein binding, bridging Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral response Source: Ensembl
  • cellular response to DNA damage stimulus Source: UniProtKB
  • defense response to bacterium Source: Ensembl
  • defense response to protozoan Source: Ensembl
  • DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  • extracellular matrix organization Source: Ensembl
  • follicular dendritic cell differentiation Source: Ensembl
  • germinal center formation Source: Ensembl
  • humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • maintenance of protein location in nucleus Source: UniProtKB
  • marginal zone B cell differentiation Source: Ensembl
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of interleukin-8 biosynthetic process Source: UniProtKB
  • negative regulation of JAK-STAT cascade Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  • positive regulation of interferon-gamma production Source: Ensembl
  • positive regulation of interleukin-10 biosynthetic process Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • positive regulation of translation Source: UniProtKB
  • protein import into nucleus, translocation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of DNA binding Source: UniProtKB
  • regulation of NIK/NF-kappaB signaling Source: UniProtKB
  • response to UV-C Source: UniProtKB
  • response to virus Source: UniProtKB
  • spleen development Source: Ensembl
  • T-helper 1 type immune response Source: Ensembl
  • T-helper 2 cell differentiation Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP20749

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma 3 protein
Short name:
BCL-3
Alternative name(s):
Proto-oncogene BCL3
Gene namesi
Name:BCL3
Synonyms:BCL4, D19S37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000069399.12
HGNCiHGNC:998 BCL3
MIMi109560 gene
neXtProtiNX_P20749

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.2 Publications

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi602
OpenTargetsiENSG00000069399
PharmGKBiPA25310

Polymorphism and mutation databases

BioMutaiBCL3
DMDMi294862410

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669761 – 454B-cell lymphoma 3 proteinAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei402Phosphoserine; by GSK31 Publication1
Modified residuei406Phosphoserine; by GSK31 Publication1

Post-translational modificationi

Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).By similarity
Activated by phosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP20749
MaxQBiP20749
PaxDbiP20749
PeptideAtlasiP20749
PRIDEiP20749
ProteomicsDBi53783

PTM databases

iPTMnetiP20749
PhosphoSitePlusiP20749

Expressioni

Gene expression databases

BgeeiENSG00000069399
CleanExiHS_BCL3
ExpressionAtlasiP20749 baseline and differential
GenevisibleiP20749 HS

Organism-specific databases

HPAiCAB002051
HPA047514

Interactioni

Subunit structurei

Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107074, 42 interactors
CORUMiP20749
IntActiP20749, 6 interactors
MINTiP20749
STRINGi9606.ENSP00000164227

Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi138 – 144Combined sources7
Helixi148 – 160Combined sources13
Helixi175 – 181Combined sources7
Helixi185 – 193Combined sources9
Helixi208 – 214Combined sources7
Helixi218 – 227Combined sources10
Helixi245 – 252Combined sources8
Helixi255 – 263Combined sources9
Turni273 – 275Combined sources3
Helixi279 – 285Combined sources7
Helixi289 – 297Combined sources9
Helixi312 – 319Combined sources8
Helixi322 – 330Combined sources9
Turni345 – 348Combined sources4
Helixi352 – 358Combined sources7

3D structure databases

ProteinModelPortaliP20749
SMRiP20749
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20749

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati134 – 163ANK 1Add BLAST30
Repeati171 – 200ANK 2Add BLAST30
Repeati204 – 235ANK 3Add BLAST32
Repeati241 – 270ANK 4Add BLAST30
Repeati275 – 304ANK 5Add BLAST30
Repeati308 – 337ANK 6Add BLAST30
Repeati338 – 367ANK 7Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 120Pro-richAdd BLAST112
Compositional biasi365 – 454Pro/Ser-richAdd BLAST90

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOGENOMiHOG000095189
HOVERGENiHBG108320
InParanoidiP20749
KOiK09258
OMAiDPPGFPM
OrthoDBiEOG091G092R
PhylomeDBiP20749
TreeFamiTF320166

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

Sequencei

Sequence statusi: Complete.

P20749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA
60 70 80 90 100
AGLVVPLDPL RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP
110 120 130 140 150
FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA
160 170 180 190 200
VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA
210 220 230 240 250
LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV
260 270 280 290 300
NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA
310 320 330 340 350
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR
360 370 380 390 400
SRRVIDILRG KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS
410 420 430 440 450
SSPSQSPPRD PPGFPMAPPN FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA

PGGS
Length:454
Mass (Da):47,584
Last modified:April 20, 2010 - v2
Checksum:i385F5320DB72C0E0
GO

Sequence cautioni

The sequence AAA51815 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA51816 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH64993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31731 Genomic DNA Translation: AAA51816.1 Different initiation.
M31732 mRNA Translation: AAA51815.1 Different initiation.
AC092066 Genomic DNA No translation available.
BC064993 mRNA Translation: AAH64993.1 Different initiation.
AH006679 Genomic DNA Translation: AAC51348.1
CCDSiCCDS12642.2
PIRiA34794
RefSeqiNP_005169.2, NM_005178.4
UniGeneiHs.31210

Genome annotation databases

EnsembliENST00000164227; ENSP00000164227; ENSG00000069399
GeneIDi602
KEGGihsa:602
UCSCiuc010xxe.3 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiBCL3_HUMAN
AccessioniPrimary (citable) accession number: P20749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 20, 2010
Last modified: July 18, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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