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Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP20719
SIGNORiP20719

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Alternative name(s):
Homeobox protein Hox-1C
Gene namesi
Name:HOXA5
Synonyms:HOX1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106004.4
HGNCiHGNC:5106 HOXA5
MIMi142952 gene
neXtProtiNX_P20719

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3202
OpenTargetsiENSG00000106004
PharmGKBiPA29383

Polymorphism and mutation databases

BioMutaiHOXA5
DMDMi52788238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000571 – 270Homeobox protein Hox-A5Add BLAST270

Proteomic databases

EPDiP20719
MaxQBiP20719
PaxDbiP20719
PeptideAtlasiP20719
PRIDEiP20719
ProteomicsDBi53780

PTM databases

iPTMnetiP20719
PhosphoSitePlusiP20719

Expressioni

Developmental stagei

Expressed during embryogenesis and in adult kidney.

Gene expression databases

BgeeiENSG00000106004 Expressed in 151 organ(s), highest expression level in right adrenal gland
CleanExiHS_HOXA5
GenevisibleiP20719 HS

Interactioni

Protein-protein interaction databases

BioGridi109442, 37 interactors
IntActiP20719, 6 interactors
MINTiP20719
STRINGi9606.ENSP00000222726

Structurei

3D structure databases

ProteinModelPortaliP20719
SMRiP20719
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 181Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP20719
KOiK09305
OMAiLKSMNMA
OrthoDBiEOG091G09XD
PhylomeDBiP20719
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P20719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN
60 70 80 90 100
GMDLSVGRSG SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP
110 120 130 140 150
LPCSAVAPSP GSDSHHGGKN SLSNSSGASA DAGSTHISSR EGVGTASGAE
160 170 180 190 200
EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART
210 220 230 240 250
AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW
260 270
KKDNKLKSMS MAAAGGAFRP
Length:270
Mass (Da):29,345
Last modified:September 27, 2004 - v2
Checksum:i2093BB73101AFCCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114S → T in AAA58663 (PubMed:2568583).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26679 Genomic DNA Translation: AAA58663.1
BT009744 mRNA Translation: AAP88746.1
CR542256 mRNA Translation: CAG47052.1
AC004080 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24223.1
CH471073 Genomic DNA Translation: EAW93873.1
BC013682 mRNA Translation: AAH13682.1
CCDSiCCDS5406.1
PIRiA24777
A32799 WJHU1C
RefSeqiNP_061975.2, NM_019102.3
UniGeneiHs.655218

Genome annotation databases

EnsembliENST00000222726; ENSP00000222726; ENSG00000106004
GeneIDi3202
KEGGihsa:3202
UCSCiuc003syn.2 human

Similar proteinsi

Entry informationi

Entry nameiHXA5_HUMAN
AccessioniPrimary (citable) accession number: P20719
Secondary accession number(s): A4D179, O43367, Q96CY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: September 27, 2004
Last modified: September 12, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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