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Protein

Protein-arginine deiminase type-2

Gene

Padi2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein-arginine deiminase activity Source: UniProtKB

GO - Biological processi

  • histone citrullination Source: GO_Central
  • protein citrullination Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

BRENDAi3.5.3.15 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-2 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase II
Protein-arginine deiminase type II
Gene namesi
Name:Padi2
Synonyms:Pad2, Pdi, Pdi2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3288 Padi2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200281 – 665Protein-arginine deiminase type-2Add BLAST665

Proteomic databases

PaxDbiP20717
PRIDEiP20717

PTM databases

iPTMnetiP20717
PhosphoSitePlusiP20717

Expressioni

Tissue specificityi

Spinal cord, submaxillary gland, cerebrum, cerebellum, and skeletal muscle.

Interactioni

Protein-protein interaction databases

CORUMiP20717
STRINGi10116.ENSRNOP00000010183

Structurei

3D structure databases

ProteinModelPortaliP20717
SMRiP20717
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiP20717
KOiK01481
PhylomeDBiP20717

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

P20717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRERTVRLQ YGSRVEAVYV LGTQLWTDVY SAAPAGAKTF SLKHSEGVKV
60 70 80 90 100
EVVRDGEAEE VVTNGKQRWA LSPSTTLRLS MAQASTEASS DKVTVNYYEE
110 120 130 140 150
DGSAPIDQAG LFLTAIEISL DVDADRDGEV EKNNPKKASW TWGPEGQGAI
160 170 180 190 200
LLVNCDRDTP WLPKEDCSDE KVYSKQDLQD MSQMILRTKG PDRLPAGYEI
210 220 230 240 250
VLYISMSDSD KVGVFYVENP FFGQRYIHIL GRQKLYHVVK YTGGSAELLF
260 270 280 290 300
FVEGLRFPDE SFSGLVSIHV SLLEYMAEDI PLTPIFTDTV TFRIAPWIMT
310 320 330 340 350
PNILPPVSVF VCCMKDNYLF LKEVKNLVEK TNCELKVCFQ YMNRGDRWIQ
360 370 380 390 400
DEIEFGYIEA PHKGFPVVLD SPRDGNLKDF PIKQLLGPDF GYVTREPLFE
410 420 430 440 450
TVTSLDSFGN LEVSPPVTVN GKAYPLGRIL IGSSFPLSGG RRMTKVVRDF
460 470 480 490 500
LQAQQVQAPV ELYSDWLTVG HVDEFMTFVP IPGKKEFRLL MASTSACYQL
510 520 530 540 550
FREKQKEGHG EAIMFKGLGG MSSKRITINK ILSNESLTQE NQYFQRCLDW
560 570 580 590 600
NRDILKKELA LTEKDIIDLP ALFKMDEDRQ ARAFFPNMVN MIVLDKDLGI
610 620 630 640 650
PKPFGPQVEE ECCLETHVRG LLEPLGLACT FIDDISAYHK FLGEVHCGTN
660
VRRKPFTFKW WHMVP
Length:665
Mass (Da):75,356
Last modified:February 1, 1991 - v1
Checksum:i96C38C8ECD7A0799
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05022 mRNA Translation: AAA41793.1
D10459 Genomic DNA Translation: BAA01253.1
PIRiA34339 DIRTR1
RefSeqiNP_058922.1, NM_017226.1
UniGeneiRn.98523

Genome annotation databases

GeneIDi29511
KEGGirno:29511
UCSCiRGD:3288 rat

Similar proteinsi

Entry informationi

Entry nameiPADI2_RAT
AccessioniPrimary (citable) accession number: P20717
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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