UniProtKB - P20703 (UVSW_BPT4)
Protein
ATP-dependent DNA helicase uvsW
Gene
uvsW
Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Functioni
Plays important roles in recombination-dependent DNA repair and the reorganization of stalled replication forks during viral DNA synthesis.2 Publications
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 135 – 142 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: InterPro
- DNA helicase activity Source: UniProtKB-EC
- helicase activity Source: CACAO
Keywordsi
Molecular function | Helicase, Hydrolase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:uvsW Synonyms:dar |
Organismi | Enterobacteria phage T4 (Bacteriophage T4) |
Taxonomic identifieri | 10665 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Myoviridae › Tevenvirinae › Tequatrovirus |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 141 | K → R: Loss of activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164988 | 1 – 587 | ATP-dependent DNA helicase uvsWAdd BLAST | 587 |
Proteomic databases
PRIDEi | P20703 |
Interactioni
Subunit structurei
Interacts with gp32.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P20703 |
SMRi | P20703 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20703 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 122 – 280 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 159 | |
Domaini | 335 – 501 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 167 |
Family and domain databases
Gene3Di | 1.20.1280.210, 1 hit |
InterProi | View protein in InterPro IPR020975, DNA-helicase_ATP-dep_UvsW IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038341, UvsW_sf |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF04851, ResIII, 1 hit PF11637, UvsW, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
i Sequence
Sequence statusi: Complete.
P20703-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIKVHFHDF SHVRIDCEES TFHELRDFFS FEADGYRFNP RFRYGNWDGR
60 70 80 90 100
IRLLDYNRLL PFGLVGQIKK FCDNFGYKAW IDPQINEKEE LSRKDFDEWL
110 120 130 140 150
SKLEIYSGNK RIEPHWYQKD AVFEGLVNRR RILNLPTSAG KSLIQALLAR
160 170 180 190 200
YYLENYEGKI LIIVPTTALT TQMADDFVDY RLFSHAMIKK IGGGASKDDK
210 220 230 240 250
YKNDAPVVVG TWQTVVKQPK EWFSQFGMMM NDECHLATGK SISSIISGLN
260 270 280 290 300
NCMFKFGLSG SLRDGKANIM QYVGMFGEIF KPVTTSKLME DGQVTELKIN
310 320 330 340 350
SIFLRYPDEF TTKLKGKTYQ EEIKIITGLS KRNKWIAKLA IKLAQKDENA
360 370 380 390 400
FVMFKHVSHG KAIFDLIKNE YDKVYYVSGE VDTETRNIMK TLAENGKGII
410 420 430 440 450
IVASYGVFST GISVKNLHHV VLAHGVKSKI IVLQTIGRVL RKHGSKTIAT
460 470 480 490 500
VWDLIDSAGV KPKSANTKKK YVHLNYLLKH GIDRIQRYAD EKFNYVMKTV
510 520 530 540 550
NLISFGPLEK KMLLEFKQFL YEASIDEFMG KIASCQTLEG LEELEAYYKK
560 570 580
RVKETELKDT DDISVRDALA GKRAELEDSD DEVEESF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF158101 Genomic DNA Translation: AAD42668.1 X56097 Genomic DNA Translation: CAA39576.1 X14869 Genomic DNA Translation: CAA33014.1 |
PIRi | PQ0097, S10498 |
RefSeqi | NP_049796.1, NC_000866.4 |
Genome annotation databases
GeneIDi | 1258733 |
KEGGi | vg:1258733 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF158101 Genomic DNA Translation: AAD42668.1 X56097 Genomic DNA Translation: CAA39576.1 X14869 Genomic DNA Translation: CAA33014.1 |
PIRi | PQ0097, S10498 |
RefSeqi | NP_049796.1, NC_000866.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RIF | X-ray | 2.00 | A/B | 1-282 | [»] | |
2JPN | NMR | - | A | 512-587 | [»] | |
2OCA | X-ray | 2.70 | A | 1-502 | [»] | |
BMRBi | P20703 | |||||
SMRi | P20703 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | P20703 |
Genome annotation databases
GeneIDi | 1258733 |
KEGGi | vg:1258733 |
Miscellaneous databases
EvolutionaryTracei | P20703 |
Family and domain databases
Gene3Di | 1.20.1280.210, 1 hit |
InterProi | View protein in InterPro IPR020975, DNA-helicase_ATP-dep_UvsW IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038341, UvsW_sf |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF04851, ResIII, 1 hit PF11637, UvsW, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UVSW_BPT4 | |
Accessioni | P20703Primary (citable) accession number: P20703 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references