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Protein

Integrin alpha-X

Gene

ITGAX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi157Magnesium1
Metal bindingi159Magnesium1
Metal bindingi161Magnesium1
Metal bindingi259Magnesium1
Metal bindingi466Calcium 21
Metal bindingi468Calcium 21
Metal bindingi470Calcium 21
Metal bindingi472Calcium 2; via carbonyl oxygen1
Metal bindingi532Calcium 31
Metal bindingi534Calcium 31
Metal bindingi536Calcium 3; via carbonyl oxygen1
Metal bindingi593Calcium 11
Metal bindingi595Calcium 11
Metal bindingi597Calcium 11
Metal bindingi599Calcium 1; via carbonyl oxygen1
Metal bindingi601Calcium 11

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi466 – 4749
Calcium bindingi530 – 5389
Calcium bindingi593 – 6019

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P20702

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P20702

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-X
Alternative name(s):
CD11 antigen-like family member C
Leu M5
Leukocyte adhesion glycoprotein p150,95 alpha chain
Leukocyte adhesion receptor p150,95
CD_antigen: CD11c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGAX
Synonyms:CD11C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140678.16

Human Gene Nomenclature Database

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HGNCi
HGNC:6152 ITGAX

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
151510 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P20702

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1107ExtracellularSequence analysisAdd BLAST1088
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1108 – 1128HelicalSequence analysisAdd BLAST21
Topological domaini1129 – 1163CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3687

Open Targets

More...
OpenTargetsi
ENSG00000140678

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29952

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITGAX

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146345441

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001629420 – 1163Integrin alpha-XAdd BLAST1144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69 ↔ 761 Publication
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 1261 Publication
Disulfide bondi116 ↔ 1451 Publication
Glycosylationi392N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi495 ↔ 5061 Publication
Disulfide bondi639 ↔ 7221 Publication
Disulfide bondi655 ↔ 7121 Publication
Glycosylationi697N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi735N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi771 ↔ 7771 Publication
Disulfide bondi848 ↔ 8631 Publication
Glycosylationi899N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi939N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi998 ↔ 10221 Publication
Disulfide bondi1027 ↔ 10321 Publication
Glycosylationi1050N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P20702

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20702

PeptideAtlas

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PeptideAtlasi
P20702

PRoteomics IDEntifications database

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PRIDEi
P20702

ProteomicsDB human proteome resource

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ProteomicsDBi
53777

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1413

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20702

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20702

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in monocytes and granulocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140678 Expressed in 119 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_ITGAX

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P20702 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P20702 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB004458
CAB072871
HPA004723

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB2P051073EBI-2568308,EBI-300173

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109893, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1827 Integrin alphaX-beta2 complex

Database of interacting proteins

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DIPi
DIP-59369N

Protein interaction database and analysis system

More...
IntActi
P20702, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000268296

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N3YX-ray1.65A147-338[»]
2LUVNMR-A1129-1163[»]
3K6SX-ray3.50A/C/E/G20-1103[»]
3K71X-ray3.95A/C/E/G20-1103[»]
3K72X-ray3.70A/C20-1103[»]
4NEHX-ray2.75A20-1101[»]
4NENX-ray2.90A20-1101[»]
5ES4X-ray3.30A/C/E/G20-1103[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P20702

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P20702

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P20702

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 78FG-GAP 1PROSITE-ProRule annotationAdd BLAST56
Repeati79 – 138FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 339VWFAPROSITE-ProRule annotationAdd BLAST175
Repeati340 – 391FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati392 – 443FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati444 – 504FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati507 – 565FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati570 – 630FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1131 – 1135GFFKR motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPBA Eukaryota
ENOG410ZFBE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154838

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113114

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG100530

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P20702

KEGG Orthology (KO)

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KOi
K06462

Database of Orthologous Groups

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OrthoDBi
73876at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P20702

TreeFam database of animal gene trees

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TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.130, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P20702-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRTRAALLL FTALATSLGF NLDTEELTAF RVDSAGFGDS VVQYANSWVV
60 70 80 90 100
VGAPQKITAA NQTGGLYQCG YSTGACEPIG LQVPPEAVNM SLGLSLASTT
110 120 130 140 150
SPSQLLACGP TVHHECGRNM YLTGLCFLLG PTQLTQRLPV SRQECPRQEQ
160 170 180 190 200
DIVFLIDGSG SISSRNFATM MNFVRAVISQ FQRPSTQFSL MQFSNKFQTH
210 220 230 240 250
FTFEEFRRSS NPLSLLASVH QLQGFTYTAT AIQNVVHRLF HASYGARRDA
260 270 280 290 300
AKILIVITDG KKEGDSLDYK DVIPMADAAG IIRYAIGVGL AFQNRNSWKE
310 320 330 340 350
LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE
360 370 380 390 400
MAQEGFSAVF TPDGPVLGAV GSFTWSGGAF LYPPNMSPTF INMSQENVDM
410 420 430 440 450
RDSYLGYSTE LALWKGVQSL VLGAPRYQHT GKAVIFTQVS RQWRMKAEVT
460 470 480 490 500
GTQIGSYFGA SLCSVDVDSD GSTDLVLIGA PHYYEQTRGG QVSVCPLPRG
510 520 530 540 550
WRRWWCDAVL YGEQGHPWGR FGAALTVLGD VNGDKLTDVV IGAPGEEENR
560 570 580 590 600
GAVYLFHGVL GPSISPSHSQ RIAGSQLSSR LQYFGQALSG GQDLTQDGLV
610 620 630 640 650
DLAVGARGQV LLLRTRPVLW VGVSMQFIPA EIPRSAFECR EQVVSEQTLV
660 670 680 690 700
QSNICLYIDK RSKNLLGSRD LQSSVTLDLA LDPGRLSPRA TFQETKNRSL
710 720 730 740 750
SRVRVLGLKA HCENFNLLLP SCVEDSVTPI TLRLNFTLVG KPLLAFRNLR
760 770 780 790 800
PMLAADAQRY FTASLPFEKN CGADHICQDN LGISFSFPGL KSLLVGSNLE
810 820 830 840 850
LNAEVMVWND GEDSYGTTIT FSHPAGLSYR YVAEGQKQGQ LRSLHLTCDS
860 870 880 890 900
APVGSQGTWS TSCRINHLIF RGGAQITFLA TFDVSPKAVL GDRLLLTANV
910 920 930 940 950
SSENNTPRTS KTTFQLELPV KYAVYTVVSS HEQFTKYLNF SESEEKESHV
960 970 980 990 1000
AMHRYQVNNL GQRDLPVSIN FWVPVELNQE AVWMDVEVSH PQNPSLRCSS
1010 1020 1030 1040 1050
EKIAPPASDF LAHIQKNPVL DCSIAGCLRF RCDVPSFSVQ EELDFTLKGN
1060 1070 1080 1090 1100
LSFGWVRQIL QKKVSVVSVA EITFDTSVYS QLPGQEAFMR AQTTTVLEKY
1110 1120 1130 1140 1150
KVHNPTPLIV GSSIGGLLLL ALITAVLYKV GFFKRQYKEM MEEANGQIAP
1160
ENGTQTPSPP SEK
Length:1,163
Mass (Da):127,829
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8947288C43E76BE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BN02H3BN02_HUMAN
Integrin alpha-X
ITGAX
1,169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X131A0A087X131_HUMAN
Integrin alpha-X
ITGAX
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti209S → T in AAA59180 (PubMed:3327687).Curated1
Sequence conflicti209S → T in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti266S → T in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti327N → T in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti330K → R in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti335A → P in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti460A → P in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti469S → T in AAA59180 (PubMed:3327687).Curated1
Sequence conflicti480A → P in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti490G → A in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti756D → L in AAA59180 (PubMed:3327687).Curated1
Sequence conflicti819I → V in AAH38237 (PubMed:15489334).Curated1
Sequence conflicti990H → L in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti1005P → G in AAA51620 (PubMed:2303426).Curated1
Sequence conflicti1161 – 1163SEK → TPHYPQDNV in AAH38237 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01867248W → R. Corresponds to variant dbSNP:rs2230424Ensembl.1
Natural variantiVAR_049632201F → L1 PublicationCorresponds to variant dbSNP:rs1574566Ensembl.1
Natural variantiVAR_031925251A → T2 PublicationsCorresponds to variant dbSNP:rs2230428Ensembl.1
Natural variantiVAR_031926517P → R. Corresponds to variant dbSNP:rs2230429Ensembl.1
Natural variantiVAR_031927547E → K1 PublicationCorresponds to variant dbSNP:rs17853815Ensembl.1
Natural variantiVAR_059363564I → V. Corresponds to variant dbSNP:rs189592567Ensembl.1
Natural variantiVAR_031928971F → L. Corresponds to variant dbSNP:rs2230427Ensembl.1
Natural variantiVAR_0666621012A → V1 PublicationCorresponds to variant dbSNP:rs181404376Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M81695 mRNA Translation: AAA59180.1
M29165 mRNA No translation available.
M29487
, M29482, M29483, M29484, M29485, M29486 Genomic DNA Translation: AAA51620.1 Sequence problems.
BC038237 mRNA Translation: AAH38237.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10711.1

Protein sequence database of the Protein Information Resource

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PIRi
A36584 RWHU1C

NCBI Reference Sequences

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RefSeqi
NP_000878.2, NM_000887.4
NP_001273304.1, NM_001286375.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.248472

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000268296; ENSP00000268296; ENSG00000140678

Database of genes from NCBI RefSeq genomes

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GeneIDi
3687

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3687

UCSC genome browser

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UCSCi
uc002ebu.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81695 mRNA Translation: AAA59180.1
M29165 mRNA No translation available.
M29487
, M29482, M29483, M29484, M29485, M29486 Genomic DNA Translation: AAA51620.1 Sequence problems.
BC038237 mRNA Translation: AAH38237.1
CCDSiCCDS10711.1
PIRiA36584 RWHU1C
RefSeqiNP_000878.2, NM_000887.4
NP_001273304.1, NM_001286375.1
UniGeneiHs.248472

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N3YX-ray1.65A147-338[»]
2LUVNMR-A1129-1163[»]
3K6SX-ray3.50A/C/E/G20-1103[»]
3K71X-ray3.95A/C/E/G20-1103[»]
3K72X-ray3.70A/C20-1103[»]
4NEHX-ray2.75A20-1101[»]
4NENX-ray2.90A20-1101[»]
5ES4X-ray3.30A/C/E/G20-1103[»]
ProteinModelPortaliP20702
SMRiP20702
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109893, 1 interactor
ComplexPortaliCPX-1827 Integrin alphaX-beta2 complex
DIPiDIP-59369N
IntActiP20702, 2 interactors
STRINGi9606.ENSP00000268296

PTM databases

GlyConnecti1413
iPTMnetiP20702
PhosphoSitePlusiP20702

Polymorphism and mutation databases

BioMutaiITGAX
DMDMi146345441

Proteomic databases

jPOSTiP20702
PaxDbiP20702
PeptideAtlasiP20702
PRIDEiP20702
ProteomicsDBi53777

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3687
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268296; ENSP00000268296; ENSG00000140678
GeneIDi3687
KEGGihsa:3687
UCSCiuc002ebu.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3687
DisGeNETi3687
EuPathDBiHostDB:ENSG00000140678.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ITGAX

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0012988
HGNCiHGNC:6152 ITGAX
HPAiCAB004458
CAB072871
HPA004723
MIMi151510 gene
neXtProtiNX_P20702
OpenTargetsiENSG00000140678
PharmGKBiPA29952

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00940000154838
HOGENOMiHOG000113114
HOVERGENiHBG100530
InParanoidiP20702
KOiK06462
OrthoDBi73876at2759
PhylomeDBiP20702
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP20702
SIGNORiP20702

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITGAX human
EvolutionaryTraceiP20702

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD11c

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3687

Protein Ontology

More...
PROi
PR:P20702

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140678 Expressed in 119 organ(s), highest expression level in blood
CleanExiHS_ITGAX
ExpressionAtlasiP20702 baseline and differential
GenevisibleiP20702 HS

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITAX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20702
Secondary accession number(s): Q8IVA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 2007
Last modified: January 16, 2019
This is version 184 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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