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Protein

Low affinity immunoglobulin epsilon Fc receptor

Gene

Fcer2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Miscellaneous

There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi272CalciumBy similarity1
Metal bindingi292CalciumBy similarity1
Metal bindingi293CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor
LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin epsilon Fc receptor
Alternative name(s):
Fc-epsilon-RII
Lymphocyte IgE receptor
CD_antigen: CD23
Gene namesi
Name:Fcer2
Synonyms:Fcer2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95497 Fcer2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 49Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST26
Topological domaini50 – 331ExtracellularSequence analysisAdd BLAST282

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466401 – 331Low affinity immunoglobulin epsilon Fc receptorAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi17S-palmitoyl cysteineBy similarity1
Lipidationi18S-palmitoyl cysteineBy similarity1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi183 ↔ 311PROSITE-ProRule annotation
Disulfide bondi186 ↔ 197PROSITE-ProRule annotation
Disulfide bondi214 ↔ 305PROSITE-ProRule annotation
Disulfide bondi282 ↔ 296PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP20693
PRIDEiP20693

PTM databases

iPTMnetiP20693
PhosphoSitePlusiP20693

Expressioni

Gene expression databases

BgeeiENSMUSG00000005540
ExpressionAtlasiP20693 baseline and differential
GenevisibleiP20693 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005678

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLJmodel-A196-308[»]
ProteinModelPortaliP20693
SMRiP20693
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati71 – 91Add BLAST21
Repeati92 – 112Add BLAST21
Repeati113 – 133Add BLAST21
Domaini185 – 298C-type lectinPROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS34 Eukaryota
ENOG410XZ77 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000089951
HOVERGENiHBG051599
InParanoidiP20693
KOiK06468
OMAiGQWNDAF
OrthoDBiEOG091G0KN3
PhylomeDBiP20693
TreeFamiTF333341

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20693-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEENEYSGYW EPPRKRCCCA RRGTQLMLVG LLSTAMWAGL LALLLLWHWE
60 70 80 90 100
TEKNLKQLGD TAIQNVSHVT KDLQKFQSNQ LAQKSQVVQM SQNLQELQAE
110 120 130 140 150
QKQMKAQDSR LSQNLTGLQE DLRNAQSQNS KLSQNLNRLQ DDLVNIKSLG
160 170 180 190 200
LNEKRTASDS LEKLQEEVAK LWIEILISKG TACNICPKNW LHFQQKCYYF
210 220 230 240 250
GKGSKQWIQA RFACSDLQGR LVSIHSQKEQ DFLMQHINKK DSWIGLQDLN
260 270 280 290 300
MEGEFVWSDG SPVGYSNWNP GEPNNGGQGE DCVMMRGSGQ WNDAFCRSYL
310 320 330
DAWVCEQLAT CEISAPLASV TPTRPTPKSE P
Length:331
Mass (Da):37,648
Last modified:February 1, 1991 - v1
Checksum:iB8C6D65F34ACCDB2
GO
Isoform 2 (identifier: P20693-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MNSQNQ

Show »
Length:330
Mass (Da):37,467
Checksum:i61D2B82297CF8D79
GO
Isoform 3 (identifier: P20693-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MDTHHT

Show »
Length:330
Mass (Da):37,487
Checksum:i4DEDD630A27B80F7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0030581 – 7MEENEYS → MNSQNQ in isoform 2. 1 Publication7
Alternative sequenceiVSP_0030591 – 7MEENEYS → MDTHHT in isoform 3. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99371 mRNA Translation: AAA74898.1
M34163 mRNA Translation: AAA37603.1
X64223 mRNA Translation: CAA45532.1
X64224 mRNA Translation: CAA45533.1
CCDSiCCDS22071.1 [P20693-1]
CCDS85491.1 [P20693-3]
CCDS85494.1 [P20693-2]
PIRiA43518 LNMSER
RefSeqiNP_001240666.1, NM_001253737.1 [P20693-2]
NP_001240668.1, NM_001253739.1 [P20693-3]
NP_001240672.1, NM_001253743.1
NP_001240674.1, NM_001253745.1
NP_001240675.1, NM_001253746.1
NP_001240676.1, NM_001253747.1
NP_038545.1, NM_013517.4 [P20693-1]
UniGeneiMm.1233

Genome annotation databases

EnsembliENSMUST00000005678; ENSMUSP00000005678; ENSMUSG00000005540 [P20693-1]
ENSMUST00000208145; ENSMUSP00000146647; ENSMUSG00000005540 [P20693-3]
ENSMUST00000208492; ENSMUSP00000146568; ENSMUSG00000005540 [P20693-2]
GeneIDi14128
KEGGimmu:14128
UCSCiuc009ksl.1 mouse [P20693-3]
uc009ksm.1 mouse [P20693-2]
uc009ksn.1 mouse [P20693-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFCER2_MOUSE
AccessioniPrimary (citable) accession number: P20693
Secondary accession number(s): Q61556, Q61557
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 28, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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