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Protein

Zinc finger Y-chromosomal protein 2

Gene

Zfy2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 514C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri520 – 542C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 571C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri577 – 599C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 628C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri634 – 656C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 685C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri691 – 713C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 742C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri748 – 770C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Y-chromosomal protein 2
Gene namesi
Name:Zfy2
Synonyms:Zfy-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome Y

Organism-specific databases

MGIiMGI:99213 Zfy2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472641 – 777Zinc finger Y-chromosomal protein 2Add BLAST777

Proteomic databases

MaxQBiP20662
PaxDbiP20662
PRIDEiP20662

PTM databases

iPTMnetiP20662
PhosphoSitePlusiP20662

Expressioni

Gene expression databases

BgeeiENSMUSG00000000103 Expressed in 40 organ(s), highest expression level in testis
CleanExiMM_ZFY2
GenevisibleiP20662 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111557

Structurei

3D structure databases

ProteinModelPortaliP20662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi372 – 382Nuclear localization signalSequence analysisAdd BLAST11

Domaini

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 514C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri520 – 542C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 571C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri577 – 599C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 628C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri634 – 656C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 685C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri691 – 713C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 742C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri748 – 770C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP20662
OMAiHIKNHPE
OrthoDBiEOG091G02CA
PhylomeDBiP20662
TreeFamiTF335557

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

P20662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDEIELTP EEEKSLFDGI GADAVHMDSD QISVEVQETV FLSNSDVTVH
60 70 80 90 100
NFVPDDPDSV IIQDVIENVL IEDVHCSHIL EETDISDNVI IPEQVLDLDT
110 120 130 140 150
AEEVSLAQFL IPDILTSSIT STSLTMPEHV LMSEAIHVSN VGHFEQVIHD
160 170 180 190 200
SLVEREIITD PLTADISDIL VADWASEAVL DSSGMPLEQQ DDARINCEDY
210 220 230 240 250
LMMSLDEPSK TDHEGSSEVT MNAESETDSS KLDEASPEVI KVCILKADSE
260 270 280 290 300
VDDVGETIQA VESETDNGNE AEVTDQRTSI HVPRVNIYML ASDSQKEEED
310 320 330 340 350
TKVIVGDEDA GGTAADTPEH EQQMDVSEIK AAFLPIAWTA AYDNNSDEIE
360 370 380 390 400
VQNATASAML HHDESGGLDR VPKQKSKKKK RPESKQYQSA IFVAPDGQTL
410 420 430 440 450
RVYPCMFCGK KFKTKRFLKR HIKNHPEYLA NKKYHCTECD YSTNKKISLH
460 470 480 490 500
NHMESHKLTI KTEKTTECDD CRKNLSHAGT MHTEKGVNKT CKCKFCDYET
510 520 530 540 550
AEQTLLNHHL LVVHRKKFPH ICGECGKGFR HPSALKKHIR VHTGEKPYEC
560 570 580 590 600
QYCEYKSADS SNLKTHIKSK HSKEIPLKCG ICLLTFSDTK EAQQHAVLHQ
610 620 630 640 650
ESRTHQCSHC NHKSSNSSDL KRHIISVHTK AYPHKCDMCS KGFHRPSELK
660 670 680 690 700
KHVATHKSKK MHQCRHCDFK SPDPFLLSHH ILSAHTKNVP FKCKRCKKEF
710 720 730 740 750
QQQCELQTHM KTHSSRKVYQ CEYCEYSTKD ASGFKRHVIS IHTKDYPHRC
760 770
DFCKKGFRRP SEKNQHIMRH HKEVGLA
Length:777
Mass (Da):88,127
Last modified:February 26, 2008 - v2
Checksum:i0523462C0380E4DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158I → T in AAA56845 (PubMed:2493989).Curated1
Sequence conflicti284R → K in AAA56845 (PubMed:2493989).Curated1
Sequence conflicti480T → TLCTHKT in AAA56845 (PubMed:2493989).Curated1
Sequence conflicti580G → D in AAA56845 (PubMed:2493989).Curated1
Sequence conflicti670K → N in AAA56845 (PubMed:2493989).Curated1
Sequence conflicti777A → L in AAA56845 (PubMed:2493989).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24401 mRNA Translation: AAA56845.1
AK133222 mRNA Translation: BAE21566.1
CCDSiCCDS41217.1
PIRiA31491
RefSeqiNP_033597.2, NM_009571.2
UniGeneiMm.411381

Genome annotation databases

EnsembliENSMUST00000115891; ENSMUSP00000111557; ENSMUSG00000000103
ENSMUST00000187148; ENSMUSP00000139591; ENSMUSG00000000103
GeneIDi22768
KEGGimmu:22768
UCSCiuc009uzp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24401 mRNA Translation: AAA56845.1
AK133222 mRNA Translation: BAE21566.1
CCDSiCCDS41217.1
PIRiA31491
RefSeqiNP_033597.2, NM_009571.2
UniGeneiMm.411381

3D structure databases

ProteinModelPortaliP20662
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111557

PTM databases

iPTMnetiP20662
PhosphoSitePlusiP20662

Proteomic databases

MaxQBiP20662
PaxDbiP20662
PRIDEiP20662

Protocols and materials databases

DNASUi22768
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115891; ENSMUSP00000111557; ENSMUSG00000000103
ENSMUST00000187148; ENSMUSP00000139591; ENSMUSG00000000103
GeneIDi22768
KEGGimmu:22768
UCSCiuc009uzp.1 mouse

Organism-specific databases

CTDi22768
MGIiMGI:99213 Zfy2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP20662
OMAiHIKNHPE
OrthoDBiEOG091G02CA
PhylomeDBiP20662
TreeFamiTF335557

Miscellaneous databases

PROiPR:P20662
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000103 Expressed in 40 organ(s), highest expression level in testis
CleanExiMM_ZFY2
GenevisibleiP20662 MM

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFY2_MOUSE
AccessioniPrimary (citable) accession number: P20662
Secondary accession number(s): Q3V0D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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