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Entry version 206 (18 Sep 2019)
Sequence version 4 (02 Mar 2010)
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Protein

Histone-lysine N-methyltransferase trithorax

Gene

trx

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12408863). Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes (PubMed:2107543, PubMed:7958911). Acts as an activator of BX-C (PubMed:7924996). Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo (PubMed:7924996, PubMed:25310983).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3598S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei3600S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei3642S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3668ZincBy similarity1
Metal bindingi3714ZincBy similarity1
Metal bindingi3716ZincBy similarity1
Metal bindingi3721ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi759 – 884Nuclear receptorPROSITE-ProRule annotationAdd BLAST126
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1266 – 1347PHD-type 1PROSITE-ProRule annotationAdd BLAST82
Zinc fingeri1348 – 1393PHD-type 2PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1421 – 1482PHD-type 3PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1734 – 1774C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1795 – 1842PHD-type 4PROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P20659

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase trithorax (EC:2.1.1.431 Publication)
Alternative name(s):
Lysine N-methyltransferase 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trx
Synonyms:KMT2A
ORF Names:CG8651
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003862 trx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knock-down in the larva results in decreased expression of Hox genes such as Ubx and Antp.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001248741 – 3726Histone-lysine N-methyltransferase trithoraxAdd BLAST3726

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20659

PRoteomics IDEntifications database

More...
PRIDEi
P20659

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Maternal isoforms are expressed in syncytial blastoderm, confined to the ventral region fated to become mesoderm. An additional broad domain of expression arises during cellularization and is quickly resolved into four pair-rule-like stripes in the posterior half of the embryo.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003862 Expressed in 49 organ(s), highest expression level in eye disc (Drosophila)

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20659 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SET domain) with ash1 (via SET domain) (PubMed:10454589, PubMed:10656681).

Interacts with Nup98 (PubMed:25310983).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66813, 45 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P20659

Protein interaction database and analysis system

More...
IntActi
P20659, 14 interactors

Molecular INTeraction database

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MINTi
P20659

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082406

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20659

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1884 – 1941FYR N-terminalPROSITE-ProRule annotationAdd BLAST58
Domaini3386 – 3470FYR C-terminalPROSITE-ProRule annotationAdd BLAST85
Domaini3588 – 3704SETPROSITE-ProRule annotationAdd BLAST117
Domaini3710 – 3726Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3665 – 3666S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi512 – 516Poly-Ser5
Compositional biasi565 – 570Poly-Asp6
Compositional biasi661 – 664Poly-Ser4
Compositional biasi905 – 910Poly-Ser6
Compositional biasi1576 – 1582Poly-Gln7
Compositional biasi2298 – 3027Gln-richAdd BLAST730
Compositional biasi3032 – 3040Poly-Ser9
Compositional biasi3181 – 3184Poly-Gln4
Compositional biasi3220 – 3225Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1266 – 1347PHD-type 1PROSITE-ProRule annotationAdd BLAST82
Zinc fingeri1348 – 1393PHD-type 2PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1421 – 1482PHD-type 3PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1734 – 1774C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1795 – 1842PHD-type 4PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1084 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20659

KEGG Orthology (KO)

More...
KOi
K09186

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVMYFEQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20659

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR011011 Znf_FYVE_PHD
IPR001628 Znf_hrmn_rcpt
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 1 hit
PF00856 SET, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354 Methyltransferase_trithorax, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 2 hits
SM00184 RING, 4 hits
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 4 hits
PS50016 ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: P20659-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRSKFPGKP SKSINRKRIS VLQLEDDAAN PAEPQQPAPE SQQPSGSGSG
60 70 80 90 100
SSAAREKGNN CDNDEDDNAP GGASISGNTA SSSAGSGNSG NGSSSGSSTG
110 120 130 140 150
SGSSGSGSTN GGSVNGGTHH KSAANLDKEA VTKDQNGDGD KTRGNVSSAP
160 170 180 190 200
SGKLSAAASG KALSKSSRTF SASTSVTSSG RSSGSSPDGN SGASSDGASS
210 220 230 240 250
GISCGKSTAK STEASSGKLA KTTGAGTCSS AKSSKASSGT TSEATTSGLS
260 270 280 290 300
GACLKALFVA TPATSTGLAC ALVSPGGSSQ GGTFPISAAL LRARKNSNKK
310 320 330 340 350
FKNLNLARGE VMLPSTSKLK QLNSPVVDNP SPSPPIASGS TPSVEGGIGV
360 370 380 390 400
GGVVSPGEDA ALKRVLTEMP NEVARDPSPS SCTAAANGAA SGKGSASNGP
410 420 430 440 450
PAMASSGDGS SPKSGADTGP STSSTTAKQK KTVTFRNVLE TSDDKSVVKR
460 470 480 490 500
FYNPDIRIPI VSIMKKDSLN RPLNYSRGGE CIVRPSILSK ILNKNSNIDK
510 520 530 540 550
LNSLKFRSAG ASSSSSNQES GSSSNVFGLS RAFGAPMDED DEGGVTFRRN
560 570 580 590 600
DSPEDQNNAE DDEMDDDDDD EEAEEDDENE DDNDEAVSEK SAETEKSAGA
610 620 630 640 650
DERDPDEKQL VMDSHFVLPK RSTRSSRIIK PNKRLLEEGA ISTKKPLSLG
660 670 680 690 700
DSKGKNVFGT SSSSAGSTAS TFSASTNLKL GKETFFNFGT LKPNSSAAGN
710 720 730 740 750
FVLRQPRLQF QADNQQATFT APKACPTSPS AIPKPANSLA TSSFGSLAST
760 770 780 790 800
NSSTVTPTPS ACSICSAVVS SKEVTQARKY GVVACDVCRK FFSKMTKKSI
810 820 830 840 850
SANSSTANTS SGSQQYLQCK GNEGSPCSIH SAKSQLKNFK KFYKDRCTAC
860 870 880 890 900
WLKKCMISFQ LPAAHRSRLS AILPPGMRGE AAAREEKSAE LLSPTGSLRF
910 920 930 940 950
TSTASSSSPS VVASTSVKWK SSGDSTSALT SIKPNPLAEN NVTFGSTPLL
960 970 980 990 1000
RPAILENPLF LKISNAADQK LAAAEAISPS LTKKNSKQEK EKVKESEQSE
1010 1020 1030 1040 1050
KLLSPTQAGT KKSGAAEAQV EEVQPQKEEA PQTSTTTQPS ASNGASHGVP
1060 1070 1080 1090 1100
QAELAGETNA TGDTLKRQRI DLKGPRVKHV CRSASIVLGQ PLATFGEDQQ
1110 1120 1130 1140 1150
PEDAADMQQE IAAPVPSAIM EPSPEKPTHI VTDENDNCAS CKTSPVGDES
1160 1170 1180 1190 1200
KPSKSSGSAQ AEVKKATALG KEGTASAAGG SSAKVTTRNA AVASNLIVAA
1210 1220 1230 1240 1250
SKKQRNGDIA TSSSVTQSSN QTQGRKTKEH RQQRTLISID FWENYDPAEV
1260 1270 1280 1290 1300
CQTGFGLIVT ETVAQRALCF LCGSTGLDPL IFCACCCEPY HQYCVQDEYN
1310 1320 1330 1340 1350
LKHGSFEDTT LMGSLLETTV NASTGPSSSL NQLTQRLNWL CPRCTVCYTC
1360 1370 1380 1390 1400
NMSSGSKVKC QKCQKNYHST CLGTSKRLLG ADRPLICVNC LKCKSCSTTK
1410 1420 1430 1440 1450
VSKFVGNLPM CTGCFKLRKK GNFCPICQRC YDDNDFDLKM MECGDCGQWV
1460 1470 1480 1490 1500
HSKCEGLSDE QYNLLSTLPE SIEFICKKCA RRNESSKIKA EEWRQAVMEE
1510 1520 1530 1540 1550
FKASLYSVLK LLSKSRQACA LLKLSPRKKL RCTCGASSNQ GKLQPKALQF
1560 1570 1580 1590 1600
SSGSDNGLGS DGESQNSDDV YEFKDQQQQQ QQRNANMNKP RVKSLPCSCQ
1610 1620 1630 1640 1650
QHISHSQSFS LVDIKQKIAG NSYVSLAEFN YDMSQVIQQS NCDELDIAYK
1660 1670 1680 1690 1700
ELLSEQFPWF QNETKACTDA LEEDMFESCS GGNYEDLQDT GGVSASVYNE
1710 1720 1730 1740 1750
HSTSQAESRS GVLDIPLEEV DDFGSCGIKM RLDTRMCLFC RKSGEGLSGE
1760 1770 1780 1790 1800
EARLLYCGHD CWVHTNCAMW SAEVFEEIDG SLQNVHSAVA RGRMIKCTVC
1810 1820 1830 1840 1850
GNRGATVGCN VRSCGEHYHY PCARSIDCAF LTDKSMYCPA HAKNGNALKA
1860 1870 1880 1890 1900
NGSPSVTYES NFEVSRPVYV ELDRKRKKLI EPARVQFHIG SLEVRQLGAI
1910 1920 1930 1940 1950
VPRFSDSYEA VVPINFLCSR LYWSSKEPWK IVEYTVRTTI QNSSSTLTAL
1960 1970 1980 1990 2000
DVGRNYTVDH TNPNSKEVQL GMAQIARWHT SLARSEFLEN GGTDWSGEFP
2010 2020 2030 2040 2050
NPNSCVPPDE NTEEEPQQQA DLLPPELKDA IFEDLPHELL DGISMLDIFL
2060 2070 2080 2090 2100
YDDKTDLFAI SEQSKDGTQA MTSNQAQNQN QQAGGANSVS ICDEDTRNSN
2110 2120 2130 2140 2150
TSLGNGWPAS NPVEDAMLSA ARNSSQVQML KTLAWPKLDG NSAMATAIKR
2160 2170 2180 2190 2200
RKLSKNLAEG VFLTLSSQQR NKKEMATVAG VSRRQSISET SVEGVATTSG
2210 2220 2230 2240 2250
SVRSKSFTWS AAKRYFEKSE GREEAAKMRI MQMDGVDDSI TEFRIISGDG
2260 2270 2280 2290 2300
NLSTAQFSGQ VKCDRCQCTY RNYDAFQRHL PSCSPTMSSN ETESDVSGQG
2310 2320 2330 2340 2350
MTNNATQISA ESLNELQKQL LANAGGLNYL QSATSFPQVQ SLGSLGQFGL
2360 2370 2380 2390 2400
QGLQQLQLQP QSLGSGFFLS QPNPATQANT DDLQIYANSL QSLAANLGGG
2410 2420 2430 2440 2450
FTLAQPTVTA PAQPQLIAVS TNPDGTQQFI QIPQTMQATT TPTATYQTLQ
2460 2470 2480 2490 2500
ATNTDKKIML PLTAAGKPLK TVATKAAQQA AVKQRQLKSG HQVKPIQAKL
2510 2520 2530 2540 2550
QPHPQQHQQQ QQTQVQQPIT VMGQNLLQPQ LLFQSSTQTQ APQIILPQAQ
2560 2570 2580 2590 2600
PQNIISFVTG DGSQGQPLQY ISIPTAGEYK PQPQPTATPT FLTTAPGAGA
2610 2620 2630 2640 2650
TYLQTDASGN LVLTTTPSNS GLQMLTAQSL QAQPQVIGTL IQPQTIQLGG
2660 2670 2680 2690 2700
GADGNQPGSN QQPLILGGTG GGSSGLEFAT TSPQVILATQ PMYYGLETIV
2710 2720 2730 2740 2750
QNTVMSSQQF VSTAMPGMLS QNASFSATTT QVFQASKIEP IVDLPAGYVV
2760 2770 2780 2790 2800
LNNTGDASSA GTFLNAASVL QQQTQDDTTT QILQNANFQF QSVPTSSGAS
2810 2820 2830 2840 2850
TSMDYTSPVM VTAKIPPVTQ IKRTNAQAKA AGISGVGKVP PQPQVVNKVL
2860 2870 2880 2890 2900
PTSIVTQQSQ VQVKNSNLKQ SQVKGKAASG TGTTCGAPPS IASKPLQKKT
2910 2920 2930 2940 2950
NMIRPIHKLE VKPKVMKPTP KVQNQNHSLL QQQQQQQPQL QQQIPAVVVN
2960 2970 2980 2990 3000
QVPKVTISQQ RIPAQTQQQQ LQQAQMIHIP QQQQPLQQQQ VQVQPSMPII
3010 3020 3030 3040 3050
TLAEAPVVQS QFVMEPQALE QQELANRVQH FSTSSSSSSS NCSLPTNVVN
3060 3070 3080 3090 3100
PMQQQAPSTT SSSTTRPTNR VLPMQQRQEP APLSNECPVV SSPTPPKPVE
3110 3120 3130 3140 3150
QPIIHQMTSA SVSKCYAQKS TLPSPVYEAE LKVSSVLESI VPDVTMDAIL
3160 3170 3180 3190 3200
EEQPVTESIY TEGLYEKNSP GESKTEQLLL QQQQREQLNQ QLVNNGYLLD
3210 3220 3230 3240 3250
KHTFQVEPMD TDVYREEDLE EEEDEDDDFS LKMATSACND HEMSDSEEPA
3260 3270 3280 3290 3300
VKDKISKILD NLTNDDCADS IATATTMEVD ASAGYQQMVE DVLATTAAQS
3310 3320 3330 3340 3350
APTEEFEGAL ETAAVEAAAT YINEMADAHV LDLKQLQNGV ELELRRRKEE
3360 3370 3380 3390 3400
QRTVSQEQEQ SKAAIVPTAA APEPPQPIQE PKKMTGPHLL YEIQSEDGFT
3410 3420 3430 3440 3450
YKSSSITEIW EKVFEAVQVA RRAHGLTPLP EGPLADMGGI QMIGLKTNAL
3460 3470 3480 3490 3500
KYLIEQLPGV EKCSKYTPKY HKRNGNVSTA ANGAHGGNLG GSSASAALSV
3510 3520 3530 3540 3550
SGGDSHGLLD YGSDQDELEE NAYDCARCEP YSNRSEYDMF SWLASRHRKQ
3560 3570 3580 3590 3600
PIQVFVQPSD NELVPRRGTG SNLPMAMKYR TLKETYKDYV GVFRSHIHGR
3610 3620 3630 3640 3650
GLYCTKDIEA GEMVIEYAGE LIRSTLTDKR ERYYDSRGIG CYMFKIDDNL
3660 3670 3680 3690 3700
VVDATMRGNA ARFINHCCEP NCYSKVVDIL GHKHIIIFAL RRIVQGEELT
3710 3720
YDYKFPFEDE KIPCSCGSKR CRKYLN
Length:3,726
Mass (Da):400,098
Last modified:March 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3DDB8F062BD7796
GO
Isoform B (identifier: P20659-2) [UniParc]FASTAAdd to basket
Also known as: C, E

The sequence of this isoform differs from the canonical sequence as follows:
     1-368: Missing.

Show »
Length:3,358
Mass (Da):364,664
Checksum:i1382F25255A47E5B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK93328 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239 – 249GTTSEATTSGL → LEQLVKQQPLV in AAA29025 (PubMed:2107543).CuratedAdd BLAST11
Sequence conflicti239 – 249GTTSEATTSGL → LEQLVKQQPLV in CAA90513 (PubMed:7924996).CuratedAdd BLAST11
Sequence conflicti239 – 249GTTSEATTSGL → LEQLVKQQPLV in CAA83516 (PubMed:8555104).CuratedAdd BLAST11
Sequence conflicti303N → K in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti303N → K in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti303N → K in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti337A → L in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti337A → L in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti337A → L in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti521G → R in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti521G → R in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti521G → R in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti521G → R in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti521G → R in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti578E → Q in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti578E → Q in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti578E → Q in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti578E → Q in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti578E → Q in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti587V → A in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti587V → A in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti587V → A in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti587V → A in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti587V → A in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti700N → I in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti700N → I in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti700N → I in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti700N → I in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti700N → I in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti720T → A in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti720T → A in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti720T → A in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti720T → A in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti720T → A in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti1073K → P in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti1073K → P in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti1073K → P in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti1073K → P in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti1073K → P in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti1529 – 1530KL → NV in AAA29025 (PubMed:2107543).Curated2
Sequence conflicti1529 – 1530KL → NV in CAA90513 (PubMed:7924996).Curated2
Sequence conflicti1529 – 1530KL → NV in CAA90514 (PubMed:7924996).Curated2
Sequence conflicti1529 – 1530KL → NV in CAA83515 (PubMed:8555104).Curated2
Sequence conflicti1529 – 1530KL → NV in CAA83516 (PubMed:8555104).Curated2
Sequence conflicti1594S → P in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti1594S → P in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti1594S → P in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti1594S → P in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti1594S → P in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti1627A → E in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti1627A → E in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti1627A → E in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti1627A → E in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti1627A → E in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti1690T → A in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti1690T → A in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti1690T → A in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti1690T → A in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti1690T → A in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti2010E → Q in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti2010E → Q in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti2010E → Q in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti2010E → Q in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti2010E → Q in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti2025P → PWLTSPLKFLGLSTHGGLLL WLLLGVVVRLKQGG in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti2341S → R in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti2341S → R in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti2341S → R in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti2341S → R in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti2365S → N in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti2365S → N in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti2365S → N in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti2365S → N in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti2365S → N in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti2392S → G in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti2392S → G in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti2392S → G in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti2392S → G in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti3157E → Q in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti3157E → Q in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti3157E → Q in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti3157E → Q in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti3157E → Q in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti3234A → R in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti3234A → R in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti3234A → R in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti3234A → R in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti3234A → R in CAA83516 (PubMed:8555104).Curated1
Sequence conflicti3690L → V in AAA29025 (PubMed:2107543).Curated1
Sequence conflicti3690L → V in CAA90513 (PubMed:7924996).Curated1
Sequence conflicti3690L → V in CAA90514 (PubMed:7924996).Curated1
Sequence conflicti3690L → V in CAA83515 (PubMed:8555104).Curated1
Sequence conflicti3690L → V in CAA83516 (PubMed:8555104).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0066651 – 368Missing in isoform B. CuratedAdd BLAST368

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M31617 mRNA Translation: AAA29025.1
Z50152 Genomic DNA Translation: CAA90514.1
Z50152 Genomic DNA Translation: CAA90513.1
Z31725 Genomic DNA Translation: CAA83516.1
Z31725 Genomic DNA Translation: CAA83515.1
AE014297 Genomic DNA Translation: AAF55041.2
AE014297 Genomic DNA Translation: AAN13599.1
AE014297 Genomic DNA Translation: AAN13600.1
AE014297 Genomic DNA Translation: AAN13601.1
AE014297 Genomic DNA Translation: AAX52951.1
AY051904 mRNA Translation: AAK93328.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
A35085

NCBI Reference Sequences

More...
RefSeqi
NP_001014621.1, NM_001014621.2 [P20659-2]
NP_476769.1, NM_057421.3 [P20659-1]
NP_476770.1, NM_057422.3 [P20659-2]
NP_599108.1, NM_134281.2 [P20659-2]
NP_599109.1, NM_134282.2 [P20659-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082947; FBpp0082406; FBgn0003862 [P20659-1]
FBtr0082948; FBpp0082407; FBgn0003862 [P20659-2]
FBtr0082949; FBpp0082408; FBgn0003862 [P20659-2]
FBtr0082950; FBpp0082409; FBgn0003862 [P20659-1]
FBtr0100277; FBpp0099668; FBgn0003862 [P20659-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41737

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8651

UCSC genome browser

More...
UCSCi
CG8651-RC d. melanogaster
CG8651-RD d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31617 mRNA Translation: AAA29025.1
Z50152 Genomic DNA Translation: CAA90514.1
Z50152 Genomic DNA Translation: CAA90513.1
Z31725 Genomic DNA Translation: CAA83516.1
Z31725 Genomic DNA Translation: CAA83515.1
AE014297 Genomic DNA Translation: AAF55041.2
AE014297 Genomic DNA Translation: AAN13599.1
AE014297 Genomic DNA Translation: AAN13600.1
AE014297 Genomic DNA Translation: AAN13601.1
AE014297 Genomic DNA Translation: AAX52951.1
AY051904 mRNA Translation: AAK93328.1 Different initiation.
PIRiA35085
RefSeqiNP_001014621.1, NM_001014621.2 [P20659-2]
NP_476769.1, NM_057421.3 [P20659-1]
NP_476770.1, NM_057422.3 [P20659-2]
NP_599108.1, NM_134281.2 [P20659-2]
NP_599109.1, NM_134282.2 [P20659-1]

3D structure databases

SMRiP20659
ModBaseiSearch...

Protein-protein interaction databases

BioGridi66813, 45 interactors
ELMiP20659
IntActiP20659, 14 interactors
MINTiP20659
STRINGi7227.FBpp0082406

Proteomic databases

PaxDbiP20659
PRIDEiP20659

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082947; FBpp0082406; FBgn0003862 [P20659-1]
FBtr0082948; FBpp0082407; FBgn0003862 [P20659-2]
FBtr0082949; FBpp0082408; FBgn0003862 [P20659-2]
FBtr0082950; FBpp0082409; FBgn0003862 [P20659-1]
FBtr0100277; FBpp0099668; FBgn0003862 [P20659-2]
GeneIDi41737
KEGGidme:Dmel_CG8651
UCSCiCG8651-RC d. melanogaster
CG8651-RD d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41737
FlyBaseiFBgn0003862 trx

Phylogenomic databases

eggNOGiKOG1084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000163756
InParanoidiP20659
KOiK09186
OMAiGVMYFEQ
PhylomeDBiP20659

Enzyme and pathway databases

ReactomeiR-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiP20659

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
trx fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41737

Protein Ontology

More...
PROi
PR:P20659

Gene expression databases

BgeeiFBgn0003862 Expressed in 49 organ(s), highest expression level in eye disc (Drosophila)
GenevisibleiP20659 DM

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR011011 Znf_FYVE_PHD
IPR001628 Znf_hrmn_rcpt
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 1 hit
PF00856 SET, 1 hit
PIRSFiPIRSF010354 Methyltransferase_trithorax, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 2 hits
SM00184 RING, 4 hits
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 4 hits
PS50016 ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRX_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20659
Secondary accession number(s): A4V2V9
, A4V2W0, Q27255, Q27327, Q8INF9, Q960R2, Q9VFL1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 2, 2010
Last modified: September 18, 2019
This is version 206 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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