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Protein

Potassium-transporting ATPase alpha chain 1

Gene

ATP4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3874-aspartylphosphate intermediateBy similarity1
Metal bindingi728MagnesiumBy similarity1
Metal bindingi732MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciMetaCyc:HS02790-MONOMER
BRENDAi3.6.3.10 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.1.2 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105675.8
HGNCiHGNC:819 ATP4A
MIMi137216 gene
neXtProtiNX_P20648

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 142LumenalSequence analysisAdd BLAST23
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 299CytoplasmicSequence analysisAdd BLAST136
Transmembranei300 – 319HelicalSequence analysisAdd BLAST20
Topological domaini320 – 331LumenalSequence analysisAdd BLAST12
Transmembranei332 – 349HelicalSequence analysisAdd BLAST18
Topological domaini350 – 783CytoplasmicSequence analysisAdd BLAST434
Transmembranei784 – 803HelicalSequence analysisAdd BLAST20
Topological domaini804 – 813LumenalSequence analysis10
Transmembranei814 – 834HelicalSequence analysisAdd BLAST21
Topological domaini835 – 854CytoplasmicSequence analysisAdd BLAST20
Transmembranei855 – 877HelicalSequence analysisAdd BLAST23
Topological domaini878 – 929LumenalSequence analysisAdd BLAST52
Transmembranei930 – 949HelicalSequence analysisAdd BLAST20
Topological domaini950 – 963CytoplasmicSequence analysisAdd BLAST14
Transmembranei964 – 982HelicalSequence analysisAdd BLAST19
Topological domaini983 – 997LumenalSequence analysisAdd BLAST15
Transmembranei998 – 1018HelicalSequence analysisAdd BLAST21
Topological domaini1019 – 1035CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi495
MalaCardsiATP4A
OpenTargetsiENSG00000105675
PharmGKBiPA25113

Chemistry databases

ChEMBLiCHEMBL2095173
DrugBankiDB00736 Esomeprazole
DB00448 Lansoprazole
DB00338 Omeprazole
DB00213 Pantoprazole
DB01129 Rabeprazole
DB05351 TAK-390MR

Polymorphism and mutation databases

BioMutaiATP4A
DMDMi148877240

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462531 – 1035Potassium-transporting ATPase alpha chain 1Add BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphotyrosineBy similarity1
Modified residuei10PhosphotyrosineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei463PhosphoserineBy similarity1
Modified residuei601PhosphoserineBy similarity1
Modified residuei840PhosphoserineBy similarity1
Modified residuei954Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP20648
MaxQBiP20648
PaxDbiP20648
PeptideAtlasiP20648
PRIDEiP20648
ProteomicsDBi53770

PTM databases

iPTMnetiP20648
PhosphoSitePlusiP20648
SwissPalmiP20648

Expressioni

Tissue specificityi

Found in gastric mucosa.

Gene expression databases

BgeeiENSG00000105675 Expressed in 71 organ(s), highest expression level in body of stomach
CleanExiHS_ATP4A
ExpressionAtlasiP20648 baseline and differential
GenevisibleiP20648 HS

Organism-specific databases

HPAiHPA039154

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridi106985, 89 interactors
ComplexPortaliCPX-2160 Hydrogen:potassium-exchanging ATPase complex
CORUMiP20648
STRINGi9606.ENSP00000262623

Chemistry databases

BindingDBiP20648

Structurei

3D structure databases

ProteinModelPortaliP20648
SMRiP20648
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265622
HOVERGENiHBG004298
InParanoidiP20648
KOiK01542
OMAiNHIHTAD
OrthoDBiEOG091G01BB
PhylomeDBiP20648
TreeFamiTF312838

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR015127 ATPase_P-typ_H/K-transp_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PF09040 H-K_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P20648-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM
60 70 80 90 100
EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY
110 120 130 140 150
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV
160 170 180 190 200
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD
210 220 230 240 250
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET
260 270 280 290 300
RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE
310 320 330 340 350
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT
360 370 380 390 400
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS
410 420 430 440 450
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA
460 470 480 490 500
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ
510 520 530 540 550
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ
560 570 580 590 600
TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV
610 620 630 640 650
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE
660 670 680 690 700
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV
710 720 730 740 750
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS
760 770 780 790 800
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP
810 820 830 840 850
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP
860 870 880 890 900
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ
910 920 930 940 950
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT
960 970 980 990 1000
RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW
1010 1020 1030
LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY
Length:1,035
Mass (Da):114,119
Last modified:May 29, 2007 - v5
Checksum:iE320595E7D9E0E28
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R249M0R249_HUMAN
Potassium-transporting ATPase alpha...
ATP4A
34Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019428265V → A1 PublicationCorresponds to variant dbSNP:rs2733743Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05451 Genomic DNA Translation: AAA51010.1
M63962 Genomic DNA Translation: AAA35988.1
AD000090 Genomic DNA Translation: AAB50172.1
AC002389 Genomic DNA Translation: AAB64182.1
M27575 Genomic DNA Translation: AAA35577.1
CCDSiCCDS12467.1
PIRiA36558 A35292
C27397
RefSeqiNP_000695.2, NM_000704.2
UniGeneiHs.36992

Genome annotation databases

EnsembliENST00000262623; ENSP00000262623; ENSG00000105675
GeneIDi495
KEGGihsa:495
UCSCiuc002oal.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05451 Genomic DNA Translation: AAA51010.1
M63962 Genomic DNA Translation: AAA35988.1
AD000090 Genomic DNA Translation: AAB50172.1
AC002389 Genomic DNA Translation: AAB64182.1
M27575 Genomic DNA Translation: AAA35577.1
CCDSiCCDS12467.1
PIRiA36558 A35292
C27397
RefSeqiNP_000695.2, NM_000704.2
UniGeneiHs.36992

3D structure databases

ProteinModelPortaliP20648
SMRiP20648
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106985, 89 interactors
ComplexPortaliCPX-2160 Hydrogen:potassium-exchanging ATPase complex
CORUMiP20648
STRINGi9606.ENSP00000262623

Chemistry databases

BindingDBiP20648
ChEMBLiCHEMBL2095173
DrugBankiDB00736 Esomeprazole
DB00448 Lansoprazole
DB00338 Omeprazole
DB00213 Pantoprazole
DB01129 Rabeprazole
DB05351 TAK-390MR

Protein family/group databases

TCDBi3.A.3.1.2 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiP20648
PhosphoSitePlusiP20648
SwissPalmiP20648

Polymorphism and mutation databases

BioMutaiATP4A
DMDMi148877240

Proteomic databases

EPDiP20648
MaxQBiP20648
PaxDbiP20648
PeptideAtlasiP20648
PRIDEiP20648
ProteomicsDBi53770

Protocols and materials databases

DNASUi495
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262623; ENSP00000262623; ENSG00000105675
GeneIDi495
KEGGihsa:495
UCSCiuc002oal.2 human

Organism-specific databases

CTDi495
DisGeNETi495
EuPathDBiHostDB:ENSG00000105675.8
GeneCardsiATP4A
HGNCiHGNC:819 ATP4A
HPAiHPA039154
MalaCardsiATP4A
MIMi137216 gene
neXtProtiNX_P20648
OpenTargetsiENSG00000105675
PharmGKBiPA25113
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265622
HOVERGENiHBG004298
InParanoidiP20648
KOiK01542
OMAiNHIHTAD
OrthoDBiEOG091G01BB
PhylomeDBiP20648
TreeFamiTF312838

Enzyme and pathway databases

BioCyciMetaCyc:HS02790-MONOMER
BRENDAi3.6.3.10 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

GenomeRNAii495
PROiPR:P20648
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105675 Expressed in 71 organ(s), highest expression level in body of stomach
CleanExiHS_ATP4A
ExpressionAtlasiP20648 baseline and differential
GenevisibleiP20648 HS

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR015127 ATPase_P-typ_H/K-transp_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PF09040 H-K_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATP4A_HUMAN
AccessioniPrimary (citable) accession number: P20648
Secondary accession number(s): O00738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 29, 2007
Last modified: September 12, 2018
This is version 192 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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