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UniProtKB - P20648 (ATP4A_HUMAN)

Entry version 212 (02 Jun 2021)
Sequence version 5 (29 May 2007)
Previous versions | rss
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Protein

Potassium-transporting ATPase alpha chain 1

Gene

ATP4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The catalytic subunit of the gastric H+/K+ ATPase pump which transports H+ ions in exchange for K+ ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H+ ions to the gastric lumen while transporting K+ ion from the lumen into the cell (By similarity).

Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity).

Within a transport cycle, the transfer of a H+ ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H+ ion in the stomach lumen is followed by binding of K+ ion converting the pump conformation back to the E1 state (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi340Potassium; via carbonyl oxygenBy similarity1
Metal bindingi341Potassium; via carbonyl oxygenBy similarity1
Metal bindingi343Potassium; via carbonyl oxygenBy similarity1
Metal bindingi345PotassiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3874-aspartylphosphate intermediateBy similarity1
Metal bindingi387MagnesiumBy similarity1
Metal bindingi389MagnesiumBy similarity1
Metal bindingi728MagnesiumBy similarity1
Metal bindingi732MagnesiumBy similarity1
Metal bindingi797PotassiumBy similarity1
Metal bindingi822PotassiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processHydrogen ion transport, Ion transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS02790-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		7.2.2.19, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P20648

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-936837, Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.3.1.2, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:7.2.2.19By similarity)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP4AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:819, ATP4A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		137216, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P20648

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105675.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 142LumenalSequence analysisAdd BLAST23
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 299CytoplasmicSequence analysisAdd BLAST136
Transmembranei300 – 319HelicalSequence analysisAdd BLAST20
Topological domaini320 – 331LumenalSequence analysisAdd BLAST12
Transmembranei332 – 349HelicalSequence analysisAdd BLAST18
Topological domaini350 – 783CytoplasmicSequence analysisAdd BLAST434
Transmembranei784 – 803HelicalSequence analysisAdd BLAST20
Topological domaini804 – 813LumenalSequence analysis10
Transmembranei814 – 834HelicalSequence analysisAdd BLAST21
Topological domaini835 – 854CytoplasmicSequence analysisAdd BLAST20
Transmembranei855 – 877HelicalSequence analysisAdd BLAST23
Topological domaini878 – 929LumenalSequence analysisAdd BLAST52
Transmembranei930 – 949HelicalSequence analysisAdd BLAST20
Topological domaini950 – 963CytoplasmicSequence analysisAdd BLAST14
Transmembranei964 – 982HelicalSequence analysisAdd BLAST19
Topological domaini983 – 997LumenalSequence analysisAdd BLAST15
Transmembranei998 – 1018HelicalSequence analysisAdd BLAST21
Topological domaini1019 – 1035CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		495

MalaCards human disease database

More...MalaCardsi		ATP4A

Open Targets

More...OpenTargetsi		ENSG00000105675

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		464756, Familial gastric type 1 neuroendocrine tumor

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25113

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P20648, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2095173

Drug and drug target database

More...DrugBanki		DB05351, Dexlansoprazole
DB00736, Esomeprazole
DB00448, Lansoprazole
DB00338, Omeprazole
DB00213, Pantoprazole
DB13620, Potassium gluconate
DB01129, Rabeprazole

DrugCentral

More...DrugCentrali		P20648

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP4A

Domain mapping of disease mutations (DMDM)

More...DMDMi		148877240

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000462531 – 1035Potassium-transporting ATPase alpha chain 1Add BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphotyrosineBy similarity1
Modified residuei10PhosphotyrosineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei463PhosphoserineBy similarity1
Modified residuei601PhosphoserineBy similarity1
Modified residuei840PhosphoserineBy similarity1
Modified residuei954Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P20648

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P20648

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P20648

MaxQB - The MaxQuant DataBase

More...MaxQBi		P20648

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P20648

PeptideAtlas

More...PeptideAtlasi		P20648

PRoteomics IDEntifications database

More...PRIDEi		P20648

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53770

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20648

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P20648

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P20648

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in gastric parietal cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105675, Expressed in body of stomach and 87 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P20648, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20648, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105675, Tissue enriched (stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The gastric H+/K+ ATPase pump is composed of the catalytic alpha subunit ATP4A and the regulatory beta subunit ATP4B.

Interacts (via the P-domain) with ATP4B (via N-terminus); this interaction stabilizes the lumenal-open E2 conformation state and prevents the reverse reaction of the transport cycle.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106985, 91 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2160, Hydrogen:potassium-exchanging ATPase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P20648

Protein interaction database and analysis system

More...IntActi		P20648, 13 interactors

Molecular INTeraction database

More...MINTi		P20648

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262623

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P20648

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P20648, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20648

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0203, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160297

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002360_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20648

Identification of Orthologs from Complete Genome Data

More...OMAi		YRAEKTI

Database of Orthologous Groups

More...OrthoDBi		388324at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20648

TreeFam database of animal gene trees

More...TreeFami		TF312838

Family and domain databases

Conserved Domains Database

More...CDDi		cd02608, P-type_ATPase_Na-K_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR015127, ATPase_P-typ_H/K-transp_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR005775, P-type_ATPase_IIC
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00689, Cation_ATPase_C, 1 hit
PF00690, Cation_ATPase_N, 1 hit
PF09040, H-K_ATPase_N, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDF00027, p-type_atpase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00831, Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01106, ATPase-IIC_X-K, 1 hit
TIGR01494, ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P20648-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM 
        60         70         80         90        100
EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY 
       110        120        130        140        150
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV 
       160        170        180        190        200
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD 
       210        220        230        240        250
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET 
       260        270        280        290        300
RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 
       310        320        330        340        350
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT 
       360        370        380        390        400
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS 
       410        420        430        440        450
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA 
       460        470        480        490        500
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ 
       510        520        530        540        550
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ 
       560        570        580        590        600
TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 
       610        620        630        640        650
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE 
       660        670        680        690        700
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV 
       710        720        730        740        750
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS 
       760        770        780        790        800
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP 
       810        820        830        840        850
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP 
       860        870        880        890        900
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 
       910        920        930        940        950
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT 
       960        970        980        990       1000
RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW 
      1010       1020       1030 
LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY
Length:1,035
Mass (Da):114,119
Last modified:May 29, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE320595E7D9E0E28
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R249M0R249_HUMAN
Potassium-transporting ATPase alpha...
ATP4A
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019428265V → A1 PublicationCorresponds to variant dbSNP:rs2733743Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J05451 Genomic DNA Translation: AAA51010.1
M63962 Genomic DNA Translation: AAA35988.1
AD000090 Genomic DNA Translation: AAB50172.1
AC002389 Genomic DNA Translation: AAB64182.1
M27575 Genomic DNA Translation: AAA35577.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12467.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36558, A35292
C27397

NCBI Reference Sequences

More...RefSeqi		NP_000695.2, NM_000704.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262623; ENSP00000262623; ENSG00000105675

Database of genes from NCBI RefSeq genomes

More...GeneIDi		495

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:495

UCSC genome browser

More...UCSCi		uc002oal.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05451 Genomic DNA Translation: AAA51010.1
M63962 Genomic DNA Translation: AAA35988.1
AD000090 Genomic DNA Translation: AAB50172.1
AC002389 Genomic DNA Translation: AAB64182.1
M27575 Genomic DNA Translation: AAA35577.1
CCDSiCCDS12467.1
PIRiA36558, A35292
C27397
RefSeqiNP_000695.2, NM_000704.2

3D structure databases

SMRiP20648
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106985, 91 interactors
ComplexPortaliCPX-2160, Hydrogen:potassium-exchanging ATPase complex
CORUMiP20648
IntActiP20648, 13 interactors
MINTiP20648
STRINGi9606.ENSP00000262623

Chemistry databases

BindingDBiP20648
ChEMBLiCHEMBL2095173
DrugBankiDB05351, Dexlansoprazole
DB00736, Esomeprazole
DB00448, Lansoprazole
DB00338, Omeprazole
DB00213, Pantoprazole
DB13620, Potassium gluconate
DB01129, Rabeprazole
DrugCentraliP20648

Protein family/group databases

TCDBi3.A.3.1.2, the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiP20648
PhosphoSitePlusiP20648
SwissPalmiP20648

Genetic variation databases

BioMutaiATP4A
DMDMi148877240

Proteomic databases

EPDiP20648
jPOSTiP20648
MassIVEiP20648
MaxQBiP20648
PaxDbiP20648
PeptideAtlasiP20648
PRIDEiP20648
ProteomicsDBi53770

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48214, 45 antibodies

The DNASU plasmid repository

More...DNASUi		495

Genome annotation databases

EnsembliENST00000262623; ENSP00000262623; ENSG00000105675
GeneIDi495
KEGGihsa:495
UCSCiuc002oal.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		495
DisGeNETi495

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP4A
HGNCiHGNC:819, ATP4A
HPAiENSG00000105675, Tissue enriched (stomach)
MalaCardsiATP4A
MIMi137216, gene
neXtProtiNX_P20648
OpenTargetsiENSG00000105675
Orphaneti464756, Familial gastric type 1 neuroendocrine tumor
PharmGKBiPA25113
VEuPathDBiHostDB:ENSG00000105675.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0203, Eukaryota
GeneTreeiENSGT00940000160297
HOGENOMiCLU_002360_4_1_1
InParanoidiP20648
OMAiYRAEKTI
OrthoDBi388324at2759
PhylomeDBiP20648
TreeFamiTF312838

Enzyme and pathway databases

BioCyciMetaCyc:HS02790-MONOMER
BRENDAi7.2.2.19, 2681
PathwayCommonsiP20648
ReactomeiR-HSA-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		495, 1 hit in 987 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		495
PharosiP20648, Tclin

Protein Ontology

More...PROi		PR:P20648
RNActiP20648, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105675, Expressed in body of stomach and 87 other tissues
ExpressionAtlasiP20648, baseline and differential
GenevisibleiP20648, HS

Family and domain databases

CDDicd02608, P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR015127, ATPase_P-typ_H/K-transp_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR005775, P-type_ATPase_IIC
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00689, Cation_ATPase_C, 1 hit
PF00690, Cation_ATPase_N, 1 hit
PF09040, H-K_ATPase_N, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SMARTiView protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01106, ATPase-IIC_X-K, 1 hit
TIGR01494, ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATP4A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20648
Secondary accession number(s): O00738
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 29, 2007
Last modified: June 2, 2021
This is version 212 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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