UniProtKB - P20648 (ATP4A_HUMAN)
Protein
Potassium-transporting ATPase alpha chain 1
Gene
ATP4A
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.
Catalytic activityi
- EC:7.2.2.19
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 387 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 728 | MagnesiumBy similarity | 1 | |
Metal bindingi | 732 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- magnesium ion binding Source: InterPro
- potassium:proton exchanging ATPase activity Source: GO_Central
- sodium:potassium-exchanging ATPase activity Source: GO_Central
GO - Biological processi
- cellular potassium ion homeostasis Source: GO_Central
- cellular sodium ion homeostasis Source: GO_Central
- ion transmembrane transport Source: Reactome
- potassium ion import across plasma membrane Source: GO_Central
- proton transmembrane transport Source: GO_Central
- sodium ion export across plasma membrane Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Hydrogen ion transport, Ion transport, Potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02790-MONOMER |
BRENDAi | 3.6.3.10, 2681 |
PathwayCommonsi | P20648 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
Protein family/group databases
TCDBi | 3.A.3.1.2, the p-type atpase (p-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium-transporting ATPase alpha chain 1 (EC:7.2.2.19)Alternative name(s): Gastric H(+)/K(+) ATPase subunit alpha Proton pump |
Gene namesi | Name:ATP4A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:819, ATP4A |
MIMi | 137216, gene |
neXtProti | NX_P20648 |
VEuPathDBi | HostDB:ENSG00000105675.8 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- extracellular space Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 98 | CytoplasmicSequence analysisAdd BLAST | 98 | |
Transmembranei | 99 – 119 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 142 | LumenalSequence analysisAdd BLAST | 23 | |
Transmembranei | 143 – 163 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 299 | CytoplasmicSequence analysisAdd BLAST | 136 | |
Transmembranei | 300 – 319 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 320 – 331 | LumenalSequence analysisAdd BLAST | 12 | |
Transmembranei | 332 – 349 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 350 – 783 | CytoplasmicSequence analysisAdd BLAST | 434 | |
Transmembranei | 784 – 803 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 804 – 813 | LumenalSequence analysis | 10 | |
Transmembranei | 814 – 834 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 835 – 854 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 855 – 877 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 878 – 929 | LumenalSequence analysisAdd BLAST | 52 | |
Transmembranei | 930 – 949 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 950 – 963 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 964 – 982 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 983 – 997 | LumenalSequence analysisAdd BLAST | 15 | |
Transmembranei | 998 – 1018 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1019 – 1035 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 495 |
MalaCardsi | ATP4A |
OpenTargetsi | ENSG00000105675 |
Orphaneti | 464756, Familial gastric type 1 neuroendocrine tumor |
PharmGKBi | PA25113 |
Miscellaneous databases
Pharosi | P20648, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2095173 |
DrugBanki | DB05351, Dexlansoprazole DB00736, Esomeprazole DB00448, Lansoprazole DB00338, Omeprazole DB00213, Pantoprazole DB13620, Potassium gluconate DB01129, Rabeprazole |
DrugCentrali | P20648 |
Genetic variation databases
BioMutai | ATP4A |
DMDMi | 148877240 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046253 | 1 – 1035 | Potassium-transporting ATPase alpha chain 1Add BLAST | 1035 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 10 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 463 | PhosphoserineBy similarity | 1 | |
Modified residuei | 601 | PhosphoserineBy similarity | 1 | |
Modified residuei | 840 | PhosphoserineBy similarity | 1 | |
Modified residuei | 954 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P20648 |
jPOSTi | P20648 |
MassIVEi | P20648 |
MaxQBi | P20648 |
PaxDbi | P20648 |
PeptideAtlasi | P20648 |
PRIDEi | P20648 |
ProteomicsDBi | 53770 |
PTM databases
iPTMneti | P20648 |
PhosphoSitePlusi | P20648 |
SwissPalmi | P20648 |
Expressioni
Tissue specificityi
Found in gastric mucosa.
Gene expression databases
Bgeei | ENSG00000105675, Expressed in body of stomach and 87 other tissues |
ExpressionAtlasi | P20648, baseline and differential |
Genevisiblei | P20648, HS |
Organism-specific databases
HPAi | ENSG00000105675, Tissue enriched (stomach) |
Interactioni
Subunit structurei
Composed of two subunits: alpha (catalytic) and beta.
Protein-protein interaction databases
BioGRIDi | 106985, 91 interactors |
ComplexPortali | CPX-2160, Hydrogen:potassium-exchanging ATPase complex |
CORUMi | P20648 |
IntActi | P20648, 12 interactors |
MINTi | P20648 |
STRINGi | 9606.ENSP00000262623 |
Chemistry databases
BindingDBi | P20648 |
Miscellaneous databases
RNActi | P20648, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0203, Eukaryota |
GeneTreei | ENSGT00940000160297 |
HOGENOMi | CLU_002360_4_1_1 |
InParanoidi | P20648 |
OMAi | YRAEKTI |
OrthoDBi | 388324at2759 |
PhylomeDBi | P20648 |
TreeFami | TF312838 |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR015127, ATPase_P-typ_H/K-transp_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit PF09040, H-K_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P20648-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM
60 70 80 90 100
EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY
110 120 130 140 150
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV
160 170 180 190 200
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD
210 220 230 240 250
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET
260 270 280 290 300
RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE
310 320 330 340 350
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT
360 370 380 390 400
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS
410 420 430 440 450
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA
460 470 480 490 500
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ
510 520 530 540 550
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ
560 570 580 590 600
TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV
610 620 630 640 650
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE
660 670 680 690 700
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV
710 720 730 740 750
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS
760 770 780 790 800
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP
810 820 830 840 850
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP
860 870 880 890 900
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ
910 920 930 940 950
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT
960 970 980 990 1000
RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW
1010 1020 1030
LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R249 | M0R249_HUMAN | Potassium-transporting ATPase alpha... | ATP4A | 34 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019428 | 265 | V → A1 PublicationCorresponds to variant dbSNP:rs2733743Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05451 Genomic DNA Translation: AAA51010.1 M63962 Genomic DNA Translation: AAA35988.1 AD000090 Genomic DNA Translation: AAB50172.1 AC002389 Genomic DNA Translation: AAB64182.1 M27575 Genomic DNA Translation: AAA35577.1 |
CCDSi | CCDS12467.1 |
PIRi | A36558, A35292 C27397 |
RefSeqi | NP_000695.2, NM_000704.2 |
Genome annotation databases
Ensembli | ENST00000262623; ENSP00000262623; ENSG00000105675 |
GeneIDi | 495 |
KEGGi | hsa:495 |
UCSCi | uc002oal.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05451 Genomic DNA Translation: AAA51010.1 M63962 Genomic DNA Translation: AAA35988.1 AD000090 Genomic DNA Translation: AAB50172.1 AC002389 Genomic DNA Translation: AAB64182.1 M27575 Genomic DNA Translation: AAA35577.1 |
CCDSi | CCDS12467.1 |
PIRi | A36558, A35292 C27397 |
RefSeqi | NP_000695.2, NM_000704.2 |
3D structure databases
SMRi | P20648 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106985, 91 interactors |
ComplexPortali | CPX-2160, Hydrogen:potassium-exchanging ATPase complex |
CORUMi | P20648 |
IntActi | P20648, 12 interactors |
MINTi | P20648 |
STRINGi | 9606.ENSP00000262623 |
Chemistry databases
BindingDBi | P20648 |
ChEMBLi | CHEMBL2095173 |
DrugBanki | DB05351, Dexlansoprazole DB00736, Esomeprazole DB00448, Lansoprazole DB00338, Omeprazole DB00213, Pantoprazole DB13620, Potassium gluconate DB01129, Rabeprazole |
DrugCentrali | P20648 |
Protein family/group databases
TCDBi | 3.A.3.1.2, the p-type atpase (p-atpase) superfamily |
PTM databases
iPTMneti | P20648 |
PhosphoSitePlusi | P20648 |
SwissPalmi | P20648 |
Genetic variation databases
BioMutai | ATP4A |
DMDMi | 148877240 |
Proteomic databases
EPDi | P20648 |
jPOSTi | P20648 |
MassIVEi | P20648 |
MaxQBi | P20648 |
PaxDbi | P20648 |
PeptideAtlasi | P20648 |
PRIDEi | P20648 |
ProteomicsDBi | 53770 |
Protocols and materials databases
Antibodypediai | 48214, 44 antibodies |
DNASUi | 495 |
Genome annotation databases
Ensembli | ENST00000262623; ENSP00000262623; ENSG00000105675 |
GeneIDi | 495 |
KEGGi | hsa:495 |
UCSCi | uc002oal.2, human |
Organism-specific databases
CTDi | 495 |
DisGeNETi | 495 |
GeneCardsi | ATP4A |
HGNCi | HGNC:819, ATP4A |
HPAi | ENSG00000105675, Tissue enriched (stomach) |
MalaCardsi | ATP4A |
MIMi | 137216, gene |
neXtProti | NX_P20648 |
OpenTargetsi | ENSG00000105675 |
Orphaneti | 464756, Familial gastric type 1 neuroendocrine tumor |
PharmGKBi | PA25113 |
VEuPathDBi | HostDB:ENSG00000105675.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0203, Eukaryota |
GeneTreei | ENSGT00940000160297 |
HOGENOMi | CLU_002360_4_1_1 |
InParanoidi | P20648 |
OMAi | YRAEKTI |
OrthoDBi | 388324at2759 |
PhylomeDBi | P20648 |
TreeFami | TF312838 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02790-MONOMER |
BRENDAi | 3.6.3.10, 2681 |
PathwayCommonsi | P20648 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
Miscellaneous databases
BioGRID-ORCSi | 495, 1 hit in 874 CRISPR screens |
GenomeRNAii | 495 |
Pharosi | P20648, Tclin |
PROi | PR:P20648 |
RNActi | P20648, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105675, Expressed in body of stomach and 87 other tissues |
ExpressionAtlasi | P20648, baseline and differential |
Genevisiblei | P20648, HS |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR015127, ATPase_P-typ_H/K-transp_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit PF09040, H-K_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATP4A_HUMAN | |
Accessioni | P20648Primary (citable) accession number: P20648 Secondary accession number(s): O00738 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | May 29, 2007 | |
Last modified: | February 10, 2021 | |
This is version 210 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants