ATP4A

Functionⁱ

Catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityⁱ

ATP + H₂O + H⁺(In) + K⁺(Out) = ADP + phosphate + H⁺(Out) + K⁺(In).

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	387	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	728	MagnesiumBy similarity	1
Metal bindingⁱ	732	MagnesiumBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
magnesium ion binding Source: InterPro
potassium:proton exchanging ATPase activity
Source: ProtInc
Traceable author statementⁱ
- 2160952
sodium:potassium-exchanging ATPase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP hydrolysis coupled proton transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Hydrogen ion transport, Ion transport, Potassium transport, Transport
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02790-MONOMER
BRENDAⁱ	3.6.3.10 2681
Reactomeⁱ	R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBⁱ	3.A.3.1.2 the p-type atpase (p-atpase) superfamily

TCDBⁱ

3.A.3.1.2 the p-type atpase (p-atpase) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10) Alternative name(s): Gastric H(+)/K(+) ATPase subunit alpha Proton pump
Gene namesⁱ	Name:ATP4A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105675.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:819 ATP4A
MIMⁱ	137216 gene
neXtProtⁱ	NX_P20648

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 98	CytoplasmicSequence analysisAdd BLAST	98
Transmembraneⁱ	99 – 119	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	120 – 142	LumenalSequence analysisAdd BLAST	23
Transmembraneⁱ	143 – 163	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	164 – 299	CytoplasmicSequence analysisAdd BLAST	136
Transmembraneⁱ	300 – 319	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	320 – 331	LumenalSequence analysisAdd BLAST	12
Transmembraneⁱ	332 – 349	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	350 – 783	CytoplasmicSequence analysisAdd BLAST	434
Transmembraneⁱ	784 – 803	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	804 – 813	LumenalSequence analysis	10
Transmembraneⁱ	814 – 834	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	835 – 854	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	855 – 877	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	878 – 929	LumenalSequence analysisAdd BLAST	52
Transmembraneⁱ	930 – 949	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	950 – 963	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	964 – 982	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	983 – 997	LumenalSequence analysisAdd BLAST	15
Transmembraneⁱ	998 – 1018	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1019 – 1035	CytoplasmicSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	495
MalaCards human disease database More...MalaCardsⁱ	ATP4A
Open Targets More...OpenTargetsⁱ	ENSG00000105675
PharmGKBⁱ	PA25113

Chemistry databases

ChEMBLⁱ	CHEMBL2095173
Drug and drug target database More...DrugBankⁱ	DB00736 Esomeprazole DB00448 Lansoprazole DB00338 Omeprazole DB00213 Pantoprazole DB01129 Rabeprazole DB05351 TAK-390MR

Polymorphism and mutation databases

BioMutaⁱ	ATP4A
DMDMⁱ	148877240

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046253	1 – 1035	Potassium-transporting ATPase alpha chain 1Add BLAST		1035

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	7	PhosphotyrosineBy similarity	1
Modified residueⁱ	10	PhosphotyrosineBy similarity	1
Modified residueⁱ	27	PhosphoserineBy similarity	1
Modified residueⁱ	463	PhosphoserineBy similarity	1
Modified residueⁱ	601	PhosphoserineBy similarity	1
Modified residueⁱ	840	PhosphoserineBy similarity	1
Modified residueⁱ	954	Phosphoserine; by PKABy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P20648
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P20648
PaxDbⁱ	P20648
PeptideAtlas More...PeptideAtlasⁱ	P20648
PRIDEⁱ	P20648
ProteomicsDBⁱ	53770

PTM databases

iPTMnetⁱ	P20648
PhosphoSitePlusⁱ	P20648
SwissPalmⁱ	P20648

Expressionⁱ

Tissue specificityⁱ

Found in gastric mucosa.

Gene expression databases

Bgeeⁱ	ENSG00000105675 Expressed in 71 organ(s), highest expression level in body of stomach
CleanExⁱ	HS_ATP4A
ExpressionAtlasⁱ	P20648 baseline and differential
Genevisibleⁱ	P20648 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039154

HPAⁱ

HPA039154

Interactionⁱ

Subunit structureⁱ

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridⁱ	106985, 89 interactors
ComplexPortalⁱ	CPX-2160 Hydrogen:potassium-exchanging ATPase complex
CORUMⁱ	P20648
STRINGⁱ	9606.ENSP00000262623

Chemistry databases

BindingDBⁱ

P20648

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P20648
SMRⁱ	P20648
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0203 Eukaryota COG0474 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139334
HOGENOMⁱ	HOG000265622
HOVERGENⁱ	HBG004298
InParanoidⁱ	P20648
KEGG Orthology (KO) More...KOⁱ	K01542
OMAⁱ	NHIHTAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01BB
PhylomeDBⁱ	P20648
TreeFamⁱ	TF312838

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR006068 ATPase_P-typ_cation-transptr_C IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR015127 ATPase_P-typ_H/K-transp_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR005775 P-type_ATPase_IIC IPR001757 P_typ_ATPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00689 Cation_ATPase_C, 1 hit PF00690 Cation_ATPase_N, 1 hit PF09040 H-K_ATPase_N, 1 hit
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 3 hits SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 3 hits
TIGRFAMsⁱ	TIGR01106 ATPase-IIC_X-K, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P20648-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM 
        60         70         80         90        100
EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY 
       110        120        130        140        150
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV 
       160        170        180        190        200
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD 
       210        220        230        240        250
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET 
       260        270        280        290        300
RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 
       310        320        330        340        350
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT 
       360        370        380        390        400
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS 
       410        420        430        440        450
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA 
       460        470        480        490        500
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ 
       510        520        530        540        550
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ 
       560        570        580        590        600
TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 
       610        620        630        640        650
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE 
       660        670        680        690        700
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV 
       710        720        730        740        750
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS 
       760        770        780        790        800
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP 
       810        820        830        840        850
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP 
       860        870        880        890        900
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 
       910        920        930        940        950
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT 
       960        970        980        990       1000
RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW 
      1010       1020       1030 
LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY

Length:1,035

Mass (Da):114,119

Last modified:May 29, 2007 - v5

Checksum:ⁱE320595E7D9E0E28

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0R249	M0R249_HUMAN		Potassium-transporting ATPase alpha... Potassium-transporting ATPase alpha chain 1	ATP4A	34	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019428	265	V → A1 PublicationCorresponds to variant dbSNP:rs2733743Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05451 Genomic DNA Translation: AAA51010.1 M63962 Genomic DNA Translation: AAA35988.1 AD000090 Genomic DNA Translation: AAB50172.1 AC002389 Genomic DNA Translation: AAB64182.1 M27575 Genomic DNA Translation: AAA35577.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12467.1
PIRⁱ	A36558 A35292 C27397
NCBI Reference Sequences More...RefSeqⁱ	NP_000695.2, NM_000704.2
UniGeneⁱ	Hs.36992

Genome annotation databases

Ensemblⁱ	ENST00000262623; ENSP00000262623; ENSG00000105675
GeneIDⁱ	495
KEGGⁱ	hsa:495
UCSC genome browser More...UCSCⁱ	uc002oal.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20648	Potassium-transporting ATPase alpha chain 1		MOUSE		1033	UniRef90_Q64436
Potassium-transporting ATPase alpha chain 1		RABIT		1035
Potassium-transporting ATPase alpha chain 1	)	PIG		1034
Potassium-transporting ATPase alpha chain 1		CANLF		1034
Potassium-transporting ATPase alpha chain 1		RAT		1033
+172

Protein	Similar proteins		Species	Score	Length	Source
P20648	Sodium/potassium-transporting ATPase subunit alpha-3		HUMAN		1013	UniRef50_P13637
Sodium/potassium-transporting ATPase subunit alpha-3		MOUSE		1013
Sodium/potassium-transporting ATPase subunit alpha-3		RAT		1013
Sodium/potassium-transporting ATPase subunit alpha-3		CHICK		1010
Sodium/potassium-transporting ATPase subunit alpha-2		PONAB		1020
+1034

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05451 Genomic DNA Translation: AAA51010.1 M63962 Genomic DNA Translation: AAA35988.1 AD000090 Genomic DNA Translation: AAB50172.1 AC002389 Genomic DNA Translation: AAB64182.1 M27575 Genomic DNA Translation: AAA35577.1
CCDSⁱ	CCDS12467.1
PIRⁱ	A36558 A35292 C27397
RefSeqⁱ	NP_000695.2, NM_000704.2
UniGeneⁱ	Hs.36992

3D structure databases

ProteinModelPortalⁱ	P20648
SMRⁱ	P20648
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106985, 89 interactors
ComplexPortalⁱ	CPX-2160 Hydrogen:potassium-exchanging ATPase complex
CORUMⁱ	P20648
STRINGⁱ	9606.ENSP00000262623

Chemistry databases

BindingDBⁱ	P20648
ChEMBLⁱ	CHEMBL2095173
DrugBankⁱ	DB00736 Esomeprazole DB00448 Lansoprazole DB00338 Omeprazole DB00213 Pantoprazole DB01129 Rabeprazole DB05351 TAK-390MR

Protein family/group databases

TCDBⁱ	3.A.3.1.2 the p-type atpase (p-atpase) superfamily

TCDBⁱ

3.A.3.1.2 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetⁱ	P20648
PhosphoSitePlusⁱ	P20648
SwissPalmⁱ	P20648

Polymorphism and mutation databases

BioMutaⁱ	ATP4A
DMDMⁱ	148877240

Proteomic databases

EPDⁱ	P20648
MaxQBⁱ	P20648
PaxDbⁱ	P20648
PeptideAtlasⁱ	P20648
PRIDEⁱ	P20648
ProteomicsDBⁱ	53770

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	495
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262623; ENSP00000262623; ENSG00000105675
GeneIDⁱ	495
KEGGⁱ	hsa:495
UCSCⁱ	uc002oal.2 human

Organism-specific databases

CTDⁱ	495
DisGeNETⁱ	495
EuPathDBⁱ	HostDB:ENSG00000105675.8
GeneCardsⁱ	ATP4A
HGNCⁱ	HGNC:819 ATP4A
HPAⁱ	HPA039154
MalaCardsⁱ	ATP4A
MIMⁱ	137216 gene
neXtProtⁱ	NX_P20648
OpenTargetsⁱ	ENSG00000105675
PharmGKBⁱ	PA25113
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0203 Eukaryota COG0474 LUCA
GeneTreeⁱ	ENSGT00890000139334
HOGENOMⁱ	HOG000265622
HOVERGENⁱ	HBG004298
InParanoidⁱ	P20648
KOⁱ	K01542
OMAⁱ	NHIHTAD
OrthoDBⁱ	EOG091G01BB
PhylomeDBⁱ	P20648
TreeFamⁱ	TF312838

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02790-MONOMER
BRENDAⁱ	3.6.3.10 2681
Reactomeⁱ	R-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

GenomeRNAiⁱ	495
Protein Ontology More...PROⁱ	PR:P20648
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105675 Expressed in 71 organ(s), highest expression level in body of stomach
CleanExⁱ	HS_ATP4A
ExpressionAtlasⁱ	P20648 baseline and differential
Genevisibleⁱ	P20648 HS

Family and domain databases

CDDⁱ	cd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR006068 ATPase_P-typ_cation-transptr_C IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR015127 ATPase_P-typ_H/K-transp_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR005775 P-type_ATPase_IIC IPR001757 P_typ_ATPase
Pfamⁱ	View protein in Pfam PF00689 Cation_ATPase_C, 1 hit PF00690 Cation_ATPase_N, 1 hit PF09040 H-K_ATPase_N, 1 hit
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 3 hits SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 3 hits
TIGRFAMsⁱ	TIGR01106 ATPase-IIC_X-K, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATP4A_HUMAN
Accessionⁱ	P20648Primary (citable) accession number: P20648 Secondary accession number(s): O00738
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	May 29, 2007
	Last modified:	September 12, 2018
	This is version 192 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - P20648 (ATP4A_HUMAN)

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Potassium-transporting ATPase alpha chain 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ