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Protein

Cation-dependent mannose-6-phosphate receptor

Gene

M6PR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.

GO - Molecular functioni

  • mannose binding Source: InterPro
  • mannose transmembrane transporter activity Source: InterPro
  • retromer complex binding Source: ParkinsonsUK-UCL
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiP20645

Protein family/group databases

TCDBi9.B.247.1.1 the mannose 6-phosphate receptor (m6pr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name:
CD Man-6-P receptor
Short name:
CD-MPR
Alternative name(s):
46 kDa mannose 6-phosphate receptor
Short name:
MPR 46
Gene namesi
Name:M6PR
Synonyms:MPR46, MPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000003056.7
HGNCiHGNC:6752 M6PR
MIMi154540 gene
neXtProtiNX_P20645

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 185LumenalSequence analysisAdd BLAST159
Transmembranei186 – 210HelicalSequence analysisAdd BLAST25
Topological domaini211 – 277CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4074
OpenTargetsiENSG00000003056
PharmGKBiPA30513

Chemistry databases

ChEMBLiCHEMBL5788
DrugBankiDB02755 1-3 Sugar Ring of Pentamannosyl 6-Phosphate
DB01272 Alglucosidase alfa
DB02900 alpha-D-mannose 6-phosphate

Polymorphism and mutation databases

BioMutaiM6PR
DMDMi127293

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001922627 – 277Cation-dependent mannose-6-phosphate receptorAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei267PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP20645
MaxQBiP20645
PaxDbiP20645
PeptideAtlasiP20645
PRIDEiP20645
ProteomicsDBi53769

PTM databases

GlyConnecti1083
iPTMnetiP20645
PhosphoSitePlusiP20645
SwissPalmiP20645

Expressioni

Gene expression databases

BgeeiENSG00000003056 Expressed in 234 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_M6PR
ExpressionAtlasiP20645 baseline and differential
GenevisibleiP20645 HS

Organism-specific databases

HPAiCAB034464
HPA040445

Interactioni

Subunit structurei

Homodimer. Binds GGA1, GGA2 and GGA3.

Protein-protein interaction databases

BioGridi110251, 26 interactors
ELMiP20645
IntActiP20645, 9 interactors
MINTiP20645
STRINGi9606.ENSP00000000412

Chemistry databases

BindingDBiP20645

Structurei

3D structure databases

ProteinModelPortaliP20645
SMRiP20645
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK0D Eukaryota
ENOG4111GED LUCA
GeneTreeiENSGT00390000002109
HOGENOMiHOG000013085
HOVERGENiHBG006395
InParanoidiP20645
KOiK10089
OMAiSDWIMLI
OrthoDBiEOG091G0WP5
PhylomeDBiP20645
TreeFamiTF328910

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR028927 Man-6-P_rcpt
IPR000296 Man-6-P_rcpt_cation_dep
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
PANTHERiPTHR15071:SF9 PTHR15071:SF9, 1 hit
PfamiView protein in Pfam
PF02157 Man-6-P_recep, 1 hit
PRINTSiPR00715 MAN6PRECEPTR

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P20645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK
60 70 80 90 100
RLKPLFNKSF ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE
110 120 130 140 150
TVVGRLNETH IFNGSNWIML IYKGGDEYDN HCGKEQRRAV VMISCNRHTL
160 170 180 190 200
ADNFNPVSEE RGKVQDCFYL FEMDSSLACS PEISHLSVGS ILLVTFASLV
210 220 230 240 250
AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC DFVCRSKPRN
260 270
VPAAYRGVGD DQLGEESEER DDHLLPM
Length:277
Mass (Da):30,993
Last modified:February 1, 1991 - v1
Checksum:i1093FE25DEB6C8E8
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX30F5GX30_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
191Annotation score:
F5GXU0F5GXU0_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
109Annotation score:
F5GXE0F5GXE0_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
92Annotation score:
F5H883F5H883_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
133Annotation score:
H0YGT2H0YGT2_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
122Annotation score:
H0YF90H0YF90_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
148Annotation score:
H0YFY9H0YFY9_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
85Annotation score:
H0YGE9H0YGE9_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
104Annotation score:
H0YFL0H0YFL0_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
96Annotation score:
F5H4U1F5H4U1_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
25Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16985 mRNA Translation: AAA59542.1
X56254
, X56255, X56256, X56257 Genomic DNA Translation: CAB94715.1
AK291143 mRNA Translation: BAF83832.1
CH471116 Genomic DNA Translation: EAW88596.1
CH471116 Genomic DNA Translation: EAW88597.1
CH471116 Genomic DNA Translation: EAW88598.1
CH471116 Genomic DNA Translation: EAW88599.1
BC024206 mRNA Translation: AAH24206.1
CCDSiCCDS8598.1
PIRiS15368 A32700
RefSeqiNP_002346.1, NM_002355.3
XP_005253433.1, XM_005253376.2
UniGeneiHs.134084
Hs.744902

Genome annotation databases

EnsembliENST00000000412; ENSP00000000412; ENSG00000003056
GeneIDi4074
KEGGihsa:4074
UCSCiuc001qvf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16985 mRNA Translation: AAA59542.1
X56254
, X56255, X56256, X56257 Genomic DNA Translation: CAB94715.1
AK291143 mRNA Translation: BAF83832.1
CH471116 Genomic DNA Translation: EAW88596.1
CH471116 Genomic DNA Translation: EAW88597.1
CH471116 Genomic DNA Translation: EAW88598.1
CH471116 Genomic DNA Translation: EAW88599.1
BC024206 mRNA Translation: AAH24206.1
CCDSiCCDS8598.1
PIRiS15368 A32700
RefSeqiNP_002346.1, NM_002355.3
XP_005253433.1, XM_005253376.2
UniGeneiHs.134084
Hs.744902

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JUQX-ray2.20E/F/G/H265-277[»]
ProteinModelPortaliP20645
SMRiP20645
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110251, 26 interactors
ELMiP20645
IntActiP20645, 9 interactors
MINTiP20645
STRINGi9606.ENSP00000000412

Chemistry databases

BindingDBiP20645
ChEMBLiCHEMBL5788
DrugBankiDB02755 1-3 Sugar Ring of Pentamannosyl 6-Phosphate
DB01272 Alglucosidase alfa
DB02900 alpha-D-mannose 6-phosphate

Protein family/group databases

TCDBi9.B.247.1.1 the mannose 6-phosphate receptor (m6pr) family

PTM databases

GlyConnecti1083
iPTMnetiP20645
PhosphoSitePlusiP20645
SwissPalmiP20645

Polymorphism and mutation databases

BioMutaiM6PR
DMDMi127293

Proteomic databases

EPDiP20645
MaxQBiP20645
PaxDbiP20645
PeptideAtlasiP20645
PRIDEiP20645
ProteomicsDBi53769

Protocols and materials databases

DNASUi4074
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000000412; ENSP00000000412; ENSG00000003056
GeneIDi4074
KEGGihsa:4074
UCSCiuc001qvf.4 human

Organism-specific databases

CTDi4074
DisGeNETi4074
EuPathDBiHostDB:ENSG00000003056.7
GeneCardsiM6PR
HGNCiHGNC:6752 M6PR
HPAiCAB034464
HPA040445
MIMi154540 gene
neXtProtiNX_P20645
OpenTargetsiENSG00000003056
PharmGKBiPA30513
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK0D Eukaryota
ENOG4111GED LUCA
GeneTreeiENSGT00390000002109
HOGENOMiHOG000013085
HOVERGENiHBG006395
InParanoidiP20645
KOiK10089
OMAiSDWIMLI
OrthoDBiEOG091G0WP5
PhylomeDBiP20645
TreeFamiTF328910

Enzyme and pathway databases

ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiP20645

Miscellaneous databases

ChiTaRSiM6PR human
GeneWikiiCation-dependent_mannose-6-phosphate_receptor
GenomeRNAii4074
PROiPR:P20645
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000003056 Expressed in 234 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_M6PR
ExpressionAtlasiP20645 baseline and differential
GenevisibleiP20645 HS

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR028927 Man-6-P_rcpt
IPR000296 Man-6-P_rcpt_cation_dep
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
PANTHERiPTHR15071:SF9 PTHR15071:SF9, 1 hit
PfamiView protein in Pfam
PF02157 Man-6-P_recep, 1 hit
PRINTSiPR00715 MAN6PRECEPTR
ProtoNetiSearch...

Entry informationi

Entry nameiMPRD_HUMAN
AccessioniPrimary (citable) accession number: P20645
Secondary accession number(s): A8K528, D3DUV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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