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UniProtKB - P20645 (MPRD_HUMAN)

Entry version 196 (07 Apr 2021)
Sequence version 1 (01 Feb 1991)
Previous versions | rss
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Protein

Cation-dependent mannose-6-phosphate receptor

Gene

M6PR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P20645

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

SIGNOR Signaling Network Open Resource

More...SIGNORi		P20645

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.247.1.1, the mannose 6-phosphate receptor (m6pr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name:
CD Man-6-P receptor
Short name:
CD-MPR
Alternative name(s):
46 kDa mannose 6-phosphate receptor
Short name:
MPR 46
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:M6PR
Synonyms:MPR46, MPRD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6752, M6PR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		154540, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P20645

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000003056.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 185LumenalSequence analysisAdd BLAST159
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei186 – 210HelicalSequence analysisAdd BLAST25
Topological domaini211 – 277CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4074

Open Targets

More...OpenTargetsi		ENSG00000003056

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30513

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P20645, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5788

Drug and drug target database

More...DrugBanki		DB02755, 1-3 Sugar Ring of Pentamannosyl 6-Phosphate
DB15874, Agalsidase alfa
DB00103, Agalsidase beta
DB01272, Alglucosidase alfa
DB02900, alpha-D-mannose 6-phosphate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		M6PR

Domain mapping of disease mutations (DMDM)

More...DMDMi		127293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Add BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001922627 – 277Cation-dependent mannose-6-phosphate receptorAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 78PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 167PROSITE-ProRule annotation
Disulfide bondi145 ↔ 179PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei267PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1308

Encyclopedia of Proteome Dynamics

More...EPDi		P20645

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P20645

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P20645

MaxQB - The MaxQuant DataBase

More...MaxQBi		P20645

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P20645

PeptideAtlas

More...PeptideAtlasi		P20645

PRoteomics IDEntifications database

More...PRIDEi		P20645

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53769

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1083, 20 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P20645, 6 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20645

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P20645

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P20645

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P20645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000003056, Expressed in small intestine Peyer's patch and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P20645, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20645, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000003056, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds GGA1, GGA2 and GGA3.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110251, 43 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P20645

Protein interaction database and analysis system

More...IntActi		P20645, 16 interactors

Molecular INTeraction database

More...MINTi		P20645

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000000412

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P20645

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P20645, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20645

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 181MRHPROSITE-ProRule annotationAdd BLAST152

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTJ5, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_058440_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20645

Identification of Orthologs from Complete Genome Data

More...OMAi		RVCREVN

Database of Orthologous Groups

More...OrthoDBi		1214298at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20645

TreeFam database of animal gene trees

More...TreeFami		TF328910

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.70.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028927, Man-6-P_rcpt
IPR000296, Man-6-P_rcpt_cation_dep
IPR009011, Man6P_isomerase_rcpt-bd_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02157, Man-6-P_recep, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00715, MAN6PRECEPTR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51914, MRH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P20645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK 
        60         70         80         90        100
RLKPLFNKSF ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE 
       110        120        130        140        150
TVVGRLNETH IFNGSNWIML IYKGGDEYDN HCGKEQRRAV VMISCNRHTL 
       160        170        180        190        200
ADNFNPVSEE RGKVQDCFYL FEMDSSLACS PEISHLSVGS ILLVTFASLV 
       210        220        230        240        250
AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC DFVCRSKPRN 
       260        270 
VPAAYRGVGD DQLGEESEER DDHLLPM
Length:277
Mass (Da):30,993
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1093FE25DEB6C8E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX30F5GX30_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
191Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF90H0YF90_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXE0F5GXE0_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXU0F5GXU0_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H883F5H883_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGT2H0YGT2_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGE9H0YGE9_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFY9H0YFY9_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4U1F5H4U1_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFL0H0YFL0_HUMAN
Cation-dependent mannose-6-phosphat...
M6PR
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M16985 mRNA Translation: AAA59542.1
X56254 X56257 Genomic DNA Translation: CAB94715.1
AK291143 mRNA Translation: BAF83832.1
CH471116 Genomic DNA Translation: EAW88596.1
CH471116 Genomic DNA Translation: EAW88597.1
CH471116 Genomic DNA Translation: EAW88598.1
CH471116 Genomic DNA Translation: EAW88599.1
BC024206 mRNA Translation: AAH24206.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8598.1

Protein sequence database of the Protein Information Resource

More...PIRi		S15368, A32700

NCBI Reference Sequences

More...RefSeqi		NP_002346.1, NM_002355.3
XP_005253433.1, XM_005253376.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000000412; ENSP00000000412; ENSG00000003056

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4074

UCSC genome browser

More...UCSCi		uc001qvf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16985 mRNA Translation: AAA59542.1
X56254 X56257 Genomic DNA Translation: CAB94715.1
AK291143 mRNA Translation: BAF83832.1
CH471116 Genomic DNA Translation: EAW88596.1
CH471116 Genomic DNA Translation: EAW88597.1
CH471116 Genomic DNA Translation: EAW88598.1
CH471116 Genomic DNA Translation: EAW88599.1
BC024206 mRNA Translation: AAH24206.1
CCDSiCCDS8598.1
PIRiS15368, A32700
RefSeqiNP_002346.1, NM_002355.3
XP_005253433.1, XM_005253376.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JUQX-ray2.20E/F/G/H265-277[»]
SMRiP20645
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110251, 43 interactors
ELMiP20645
IntActiP20645, 16 interactors
MINTiP20645
STRINGi9606.ENSP00000000412

Chemistry databases

BindingDBiP20645
ChEMBLiCHEMBL5788
DrugBankiDB02755, 1-3 Sugar Ring of Pentamannosyl 6-Phosphate
DB15874, Agalsidase alfa
DB00103, Agalsidase beta
DB01272, Alglucosidase alfa
DB02900, alpha-D-mannose 6-phosphate

Protein family/group databases

TCDBi9.B.247.1.1, the mannose 6-phosphate receptor (m6pr) family

PTM databases

GlyConnecti1083, 20 N-Linked glycans (2 sites)
GlyGeniP20645, 6 sites, 1 N-linked glycan (1 site)
iPTMnetiP20645
MetOSiteiP20645
PhosphoSitePlusiP20645
SwissPalmiP20645

Genetic variation databases

BioMutaiM6PR
DMDMi127293

Proteomic databases

CPTACiCPTAC-1308
EPDiP20645
jPOSTiP20645
MassIVEiP20645
MaxQBiP20645
PaxDbiP20645
PeptideAtlasiP20645
PRIDEiP20645
ProteomicsDBi53769

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11573, 260 antibodies

The DNASU plasmid repository

More...DNASUi		4074

Genome annotation databases

EnsembliENST00000000412; ENSP00000000412; ENSG00000003056
GeneIDi4074
KEGGihsa:4074
UCSCiuc001qvf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4074
DisGeNETi4074

GeneCards: human genes, protein and diseases

More...GeneCardsi		M6PR
HGNCiHGNC:6752, M6PR
HPAiENSG00000003056, Low tissue specificity
MIMi154540, gene
neXtProtiNX_P20645
OpenTargetsiENSG00000003056
PharmGKBiPA30513
VEuPathDBiHostDB:ENSG00000003056.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTJ5, Eukaryota
GeneTreeiENSGT00390000002109
HOGENOMiCLU_058440_0_0_1
InParanoidiP20645
OMAiRVCREVN
OrthoDBi1214298at2759
PhylomeDBiP20645
TreeFamiTF328910

Enzyme and pathway databases

PathwayCommonsiP20645
ReactomeiR-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
SIGNORiP20645

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4074, 8 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		M6PR, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cation-dependent_mannose-6-phosphate_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4074
PharosiP20645, Tbio

Protein Ontology

More...PROi		PR:P20645
RNActiP20645, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000003056, Expressed in small intestine Peyer's patch and 245 other tissues
ExpressionAtlasiP20645, baseline and differential
GenevisibleiP20645, HS

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR028927, Man-6-P_rcpt
IPR000296, Man-6-P_rcpt_cation_dep
IPR009011, Man6P_isomerase_rcpt-bd_dom_sf
PfamiView protein in Pfam
PF02157, Man-6-P_recep, 1 hit
PRINTSiPR00715, MAN6PRECEPTR
PROSITEiView protein in PROSITE
PS51914, MRH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPRD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20645
Secondary accession number(s): A8K528, D3DUV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 7, 2021
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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