UniProtKB - P20618 (PSB1_HUMAN)
Proteasome subunit beta type-1
PSMB1
Functioni
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- neutrophil degranulation Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasomal protein catabolic process Source: GO_Central
- proteasomal ubiquitin-independent protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P20618 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P20618 |
Protein family/group databases
MEROPSi | T01.986 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit beta type-1Alternative name(s): Macropain subunit C5 Multicatalytic endopeptidase complex subunit C5 Proteasome component C5 Proteasome gamma chain |
Gene namesi | Name:PSMB1 Synonyms:PSC5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9537, PSMB1 |
MIMi | 602017, gene |
neXtProti | NX_P20618 |
VEuPathDBi | HostDB:ENSG00000008018.8 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- ficolin-1-rich granule lumen Source: Reactome
- proteasome complex Source: UniProtKB
- proteasome core complex Source: UniProtKB
- proteasome core complex, beta-subunit complex Source: UniProtKB
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 5689 |
OpenTargetsi | ENSG00000008018 |
PharmGKBi | PA33882 |
Miscellaneous databases
Pharosi | P20618, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4208 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE DB00188, Bortezomib DB08889, Carfilzomib |
DrugCentrali | P20618 |
GuidetoPHARMACOLOGYi | 2404 |
Genetic variation databases
BioMutai | PSMB1 |
DMDMi | 130853 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000259623 | 1 – 28 | 1 PublicationAdd BLAST | 28 | |
ChainiPRO_0000148030 | 29 – 241 | Proteasome subunit beta type-1Add BLAST | 213 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Glycosylationi | 58 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 62 | PhosphoserineCombined sources | 1 | |
Modified residuei | 68 | PhosphoserineCombined sources | 1 | |
Modified residuei | 150 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 162 | PhosphoserineCombined sources | 1 | |
Modified residuei | 204 | N6-acetyllysineCombined sources | 1 | |
Glycosylationi | 209 | O-linked (GlcNAc) serineBy similarity | 1 |
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P20618 |
jPOSTi | P20618 |
MassIVEi | P20618 |
MaxQBi | P20618 |
PaxDbi | P20618 |
PeptideAtlasi | P20618 |
PRIDEi | P20618 |
ProteomicsDBi | 53768 |
TopDownProteomicsi | P20618 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00025019 |
UCD-2DPAGEi | P20618 |
PTM databases
GlyGeni | P20618, 2 sites |
iPTMneti | P20618 |
MetOSitei | P20618 |
PhosphoSitePlusi | P20618 |
SwissPalmi | P20618 |
Expressioni
Gene expression databases
Bgeei | ENSG00000008018, Expressed in endometrium and 247 other tissues |
ExpressionAtlasi | P20618, baseline and differential |
Genevisiblei | P20618, HS |
Organism-specific databases
HPAi | ENSG00000008018, Low tissue specificity |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
Interacts with SERPINB2.
Interacts with RFPL4A (By similarity).
By similarity6 Publications(Microbial infection) Interacts with HIV-1 protein Tat.
1 PublicationBinary interactionsi
P20618
Protein-protein interaction databases
BioGRIDi | 111662, 260 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P20618 |
DIPi | DIP-31193N |
IntActi | P20618, 151 interactors |
MINTi | P20618 |
STRINGi | 9606.ENSP00000262193 |
Chemistry databases
BindingDBi | P20618 |
Miscellaneous databases
RNActi | P20618, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P20618 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0179, Eukaryota |
GeneTreei | ENSGT00550000075035 |
HOGENOMi | CLU_035750_1_1_1 |
InParanoidi | P20618 |
OMAi | YHYTGPV |
OrthoDBi | 1092660at2759 |
PhylomeDBi | P20618 |
TreeFami | TF106218 |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR035202, Proteasome_beta1 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF59, PTHR11599:SF59, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLSSTAMYSA PGRDLGMEPH RAAGPLQLRF SPYVFNGGTI LAIAGEDFAI
60 70 80 90 100
VASDTRLSEG FSIHTRDSPK CYKLTDKTVI GCSGFHGDCL TLTKIIEARL
110 120 130 140 150
KMYKHSNNKA MTTGAIAAML STILYSRRFF PYYVYNIIGG LDEEGKGAVY
160 170 180 190 200
SFDPVGSYQR DSFKAGGSAS AMLQPLLDNQ VGFKNMQNVE HVPLSLDRAM
210 220 230 240
RLVKDVFISA AERDVYTGDA LRICIVTKEG IREETVSLRK D
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051547 | 11 | P → A1 PublicationCorresponds to variant dbSNP:rs12717Ensembl. | 1 | |
Natural variantiVAR_051548 | 208 | I → N. Corresponds to variant dbSNP:rs10541Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00761 mRNA Translation: BAA00658.1 BT019720 mRNA Translation: AAV38525.1 AB451312 mRNA Translation: BAG70126.1 AB451442 mRNA Translation: BAG70256.1 AL031259 Genomic DNA No translation available. BC000508 mRNA Translation: AAH00508.1 BC020807 mRNA Translation: AAH20807.1 |
CCDSi | CCDS34577.1 |
PIRi | S15973, SNHUC5 |
RefSeqi | NP_002784.1, NM_002793.3 |
Genome annotation databases
Ensembli | ENST00000262193; ENSP00000262193; ENSG00000008018 |
GeneIDi | 5689 |
KEGGi | hsa:5689 |
UCSCi | uc011ehe.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00761 mRNA Translation: BAA00658.1 BT019720 mRNA Translation: AAV38525.1 AB451312 mRNA Translation: BAG70126.1 AB451442 mRNA Translation: BAG70256.1 AL031259 Genomic DNA No translation available. BC000508 mRNA Translation: AAH00508.1 BC020807 mRNA Translation: AAH20807.1 |
CCDSi | CCDS34577.1 |
PIRi | S15973, SNHUC5 |
RefSeqi | NP_002784.1, NM_002793.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4R3O | X-ray | 2.60 | 1/M | 29-241 | [»] | |
4R67 | X-ray | 2.89 | 1/M/a/o | 29-241 | [»] | |
5A0Q | electron microscopy | 3.50 | M/a | 29-241 | [»] | |
5GJQ | electron microscopy | 4.50 | f/t | 1-241 | [»] | |
5GJR | electron microscopy | 3.50 | f/t | 1-241 | [»] | |
5L4G | electron microscopy | 4.02 | 1/U | 1-241 | [»] | |
5L5B | X-ray | 2.80 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5D | X-ray | 2.80 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5E | X-ray | 2.90 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5F | X-ray | 2.50 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5H | X-ray | 2.60 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5I | X-ray | 2.90 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5J | X-ray | 2.90 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5O | X-ray | 2.60 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5P | X-ray | 2.80 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5Q | X-ray | 2.80 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5R | X-ray | 2.90 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5S | X-ray | 2.60 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5T | X-ray | 2.90 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5U | X-ray | 2.60 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5V | X-ray | 2.70 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5W | X-ray | 2.80 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5X | X-ray | 2.90 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5Y | X-ray | 2.70 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L5Z | X-ray | 2.70 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L60 | X-ray | 2.70 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L61 | X-ray | 2.80 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L62 | X-ray | 2.80 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L63 | X-ray | 2.70 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5L64 | X-ray | 2.70 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5LE5 | X-ray | 1.80 | L/Z | 29-241 | [»] | |
5LEX | X-ray | 2.20 | L/Z | 29-241 | [»] | |
5LEY | X-ray | 1.90 | L/Z | 29-241 | [»] | |
5LEZ | X-ray | 2.19 | L/Z | 29-241 | [»] | |
5LF0 | X-ray | 2.41 | L/Z | 29-241 | [»] | |
5LF1 | X-ray | 2.00 | L/Z | 29-241 | [»] | |
5LF3 | X-ray | 2.10 | L/Z | 29-241 | [»] | |
5LF4 | X-ray | 1.99 | L/Z | 29-241 | [»] | |
5LF6 | X-ray | 2.07 | L/Z | 29-241 | [»] | |
5LF7 | X-ray | 2.00 | L/Z | 29-241 | [»] | |
5LN3 | electron microscopy | 6.80 | 6 | 1-241 | [»] | |
5M2B | X-ray | 2.70 | L/Z | 124-138 | [»] | |
L/Z | 145-160 | [»] | ||||
5M32 | electron microscopy | 3.80 | L/Z | 1-241 | [»] | |
5T0C | electron microscopy | 3.80 | AS/BS | 2-241 | [»] | |
5T0G | electron microscopy | 4.40 | S | 2-241 | [»] | |
5T0H | electron microscopy | 6.80 | S | 2-241 | [»] | |
5T0I | electron microscopy | 8.00 | S | 2-241 | [»] | |
5T0J | electron microscopy | 8.00 | S | 2-241 | [»] | |
5VFO | electron microscopy | 3.50 | S/s | 29-241 | [»] | |
5VFP | electron microscopy | 4.20 | S/s | 29-241 | [»] | |
5VFQ | electron microscopy | 4.20 | S/s | 29-241 | [»] | |
5VFR | electron microscopy | 4.90 | S/s | 29-241 | [»] | |
5VFS | electron microscopy | 3.60 | S/s | 29-241 | [»] | |
5VFT | electron microscopy | 7.00 | S/s | 29-241 | [»] | |
5VFU | electron microscopy | 5.80 | S/s | 29-241 | [»] | |
6AVO | electron microscopy | 3.80 | S/X | 29-241 | [»] | |
6E5B | X-ray | 2.77 | L/Z | 1-241 | [»] | |
6KWY | electron microscopy | 2.72 | L/Z | 1-241 | [»] | |
6MSB | electron microscopy | 3.00 | S/s | 2-241 | [»] | |
6MSD | electron microscopy | 3.20 | S/s | 2-241 | [»] | |
6MSE | electron microscopy | 3.30 | A | 151-231 | [»] | |
6MSG | electron microscopy | 3.50 | S/s | 2-241 | [»] | |
6MSH | electron microscopy | 3.60 | S/s | 2-241 | [»] | |
6MSJ | electron microscopy | 3.30 | S/s | 2-241 | [»] | |
6MSK | electron microscopy | 3.20 | S/s | 2-241 | [»] | |
6R70 | electron microscopy | 3.50 | L/Z | 29-241 | [»] | |
6REY | electron microscopy | 3.00 | M/a | 29-241 | [»] | |
6RGQ | electron microscopy | 2.60 | M/a | 29-241 | [»] | |
6WJD | electron microscopy | 4.80 | S/s | 2-241 | [»] | |
6WJN | electron microscopy | 5.70 | S/s | 29-241 | [»] | |
6XMJ | electron microscopy | 3.00 | M | 29-241 | [»] | |
SMRi | P20618 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111662, 260 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P20618 |
DIPi | DIP-31193N |
IntActi | P20618, 151 interactors |
MINTi | P20618 |
STRINGi | 9606.ENSP00000262193 |
Chemistry databases
BindingDBi | P20618 |
ChEMBLi | CHEMBL4208 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE DB00188, Bortezomib DB08889, Carfilzomib |
DrugCentrali | P20618 |
GuidetoPHARMACOLOGYi | 2404 |
Protein family/group databases
MEROPSi | T01.986 |
PTM databases
GlyGeni | P20618, 2 sites |
iPTMneti | P20618 |
MetOSitei | P20618 |
PhosphoSitePlusi | P20618 |
SwissPalmi | P20618 |
Genetic variation databases
BioMutai | PSMB1 |
DMDMi | 130853 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00025019 |
UCD-2DPAGEi | P20618 |
Proteomic databases
EPDi | P20618 |
jPOSTi | P20618 |
MassIVEi | P20618 |
MaxQBi | P20618 |
PaxDbi | P20618 |
PeptideAtlasi | P20618 |
PRIDEi | P20618 |
ProteomicsDBi | 53768 |
TopDownProteomicsi | P20618 |
Protocols and materials databases
Antibodypediai | 33582, 221 antibodies |
DNASUi | 5689 |
Genome annotation databases
Ensembli | ENST00000262193; ENSP00000262193; ENSG00000008018 |
GeneIDi | 5689 |
KEGGi | hsa:5689 |
UCSCi | uc011ehe.3, human |
Organism-specific databases
CTDi | 5689 |
DisGeNETi | 5689 |
GeneCardsi | PSMB1 |
HGNCi | HGNC:9537, PSMB1 |
HPAi | ENSG00000008018, Low tissue specificity |
MIMi | 602017, gene |
neXtProti | NX_P20618 |
OpenTargetsi | ENSG00000008018 |
PharmGKBi | PA33882 |
VEuPathDBi | HostDB:ENSG00000008018.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0179, Eukaryota |
GeneTreei | ENSGT00550000075035 |
HOGENOMi | CLU_035750_1_1_1 |
InParanoidi | P20618 |
OMAi | YHYTGPV |
OrthoDBi | 1092660at2759 |
PhylomeDBi | P20618 |
TreeFami | TF106218 |
Enzyme and pathway databases
PathwayCommonsi | P20618 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P20618 |
Miscellaneous databases
BioGRID-ORCSi | 5689, 723 hits in 884 CRISPR screens |
ChiTaRSi | PSMB1, human |
GeneWikii | PSMB1 |
GenomeRNAii | 5689 |
Pharosi | P20618, Tclin |
PROi | PR:P20618 |
RNActi | P20618, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000008018, Expressed in endometrium and 247 other tissues |
ExpressionAtlasi | P20618, baseline and differential |
Genevisiblei | P20618, HS |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR035202, Proteasome_beta1 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF59, PTHR11599:SF59, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSB1_HUMAN | |
Accessioni | P20618Primary (citable) accession number: P20618 Secondary accession number(s): B5BU76, Q9BWA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | May 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 220 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Peptidase families
Classification of peptidase families and list of entries