UniProtKB - P20592 (MX2_HUMAN)
Protein
Interferon-induced GTP-binding protein Mx2
Gene
MX2
Organism
Homo sapiens (Human)
Status
Functioni
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 125 – 132 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 225 – 229 | GTPSequence analysis | 5 | |
Nucleotide bindingi | 294 – 297 | GTPSequence analysis | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB
- microtubule binding Source: GO_Central
GO - Biological processi
- defense response Source: ProtInc
- defense response to virus Source: UniProtKB
- dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
- membrane fusion Source: GO_Central
- mitochondrial fission Source: GO_Central
- mRNA transport Source: UniProtKB-KW
- organelle fission Source: GO_Central
- postsynaptic neurotransmitter receptor internalization Source: GO_Central
- receptor internalization Source: GO_Central
- regulation of cell cycle Source: UniProtKB
- regulation of nucleocytoplasmic transport Source: UniProtKB
- regulation of synapse structure or activity Source: GO_Central
- response to interferon-alpha Source: UniProtKB
- response to virus Source: UniProtKB
- synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central
- type I interferon signaling pathway Source: Reactome
Keywordsi
Biological process | Antiviral defense, Immunity, Innate immunity, mRNA transport, Protein transport, Translocation, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P20592 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-909733, Interferon alpha/beta signaling |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon-induced GTP-binding protein Mx2Alternative name(s): Interferon-regulated resistance GTP-binding protein MxB Myxovirus resistance protein 2 p78-related protein |
Gene namesi | Name:MX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183486.12 |
HGNCi | HGNC:7533, MX2 |
MIMi | 147890, gene |
neXtProti | NX_P20592 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- nuclear pore complex 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Localization to nuclear pores requires GTP-binding.
Cytoskeleton
- microtubule cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial membrane Source: GO_Central
Nucleus
- nuclear pore Source: UniProtKB
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic endocytic zone membrane Source: GO_Central
- postsynaptic membrane Source: GO_Central
Other locations
- axon Source: GO_Central
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: GO_Central
- dendritic spine Source: GO_Central
- dendritic spine head Source: GO_Central
- membrane Source: GO_Central
- postsynaptic density Source: GO_Central
- presynapse Source: GOC
- synapse Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nuclear pore complex, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 131 | K → A: Loss of GTP-binding and localization to nuclear pore. Disruption of nuclear import. 1 Publication | 1 | |
Mutagenesisi | 151 | T → A: Defective GTP-hydrolysis. Disruption of nuclear import and cell-cycle progression. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4600 |
OpenTargetsi | ENSG00000183486 |
PharmGKBi | PA31334 |
Miscellaneous databases
Pharosi | P20592, Tbio |
Polymorphism and mutation databases
BioMutai | MX2 |
DMDMi | 127571 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206598 | 1 – 715 | Interferon-induced GTP-binding protein Mx2Add BLAST | 715 |
Proteomic databases
EPDi | P20592 |
jPOSTi | P20592 |
MassIVEi | P20592 |
MaxQBi | P20592 |
PaxDbi | P20592 |
PeptideAtlasi | P20592 |
PRIDEi | P20592 |
ProteomicsDBi | 53765 [P20592-1] 6679 |
PTM databases
iPTMneti | P20592 |
PhosphoSitePlusi | P20592 |
SwissPalmi | P20592 |
Expressioni
Inductioni
By type I and type III interferons.1 Publication
Gene expression databases
Bgeei | ENSG00000183486, Expressed in epithelium of bronchus and 183 other tissues |
ExpressionAtlasi | P20592, baseline and differential |
Genevisiblei | P20592, HS |
Organism-specific databases
HPAi | ENSG00000183486, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Binary interactionsi
Hide detailsP20592
With | #Exp. | IntAct |
---|---|---|
ATRIP [Q8WXE1] | 3 | EBI-10200618,EBI-747353 |
EHMT2 [A2ABF9] | 3 | EBI-10200618,EBI-10174566 |
EHMT2 [Q96KQ7] | 3 | EBI-10200618,EBI-744366 |
PIAS2 [O75928] | 3 | EBI-10200618,EBI-348555 |
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 110685, 13 interactors |
DIPi | DIP-59212N |
IntActi | P20592, 5 interactors |
STRINGi | 9606.ENSP00000333657 |
Miscellaneous databases
RNActi | P20592, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P20592 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 115 – 387 | Dynamin-type GPROSITE-ProRule annotationAdd BLAST | 273 | |
Domaini | 623 – 714 | GEDPROSITE-ProRule annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 125 – 132 | G1 motifPROSITE-ProRule annotation | 8 | |
Regioni | 150 – 152 | G2 motifPROSITE-ProRule annotation | 3 | |
Regioni | 225 – 228 | G3 motifPROSITE-ProRule annotation | 4 | |
Regioni | 294 – 297 | G4 motifPROSITE-ProRule annotation | 4 | |
Regioni | 326 – 329 | G5 motifPROSITE-ProRule annotation | 4 |
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
GeneTreei | ENSGT00940000163266 |
HOGENOMi | CLU_008964_8_0_1 |
InParanoidi | P20592 |
OMAi | DNQPRDI |
OrthoDBi | 494748at2759 |
PhylomeDBi | P20592 |
TreeFami | TF331484 |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
InterProi | View protein in InterPro IPR000375, Dynamin_central IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P20592-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ
60 70 80 90 100
GAEKDAAFLA KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC
110 120 130 140 150
IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV
160 170 180 190 200
TRCPLVLKLK KQPCEAWAGR ISYRNTELEL QDPGQVEKEI HKAQNVMAGN
210 220 230 240 250
GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD IGLQIKALIK
260 270 280 290 300
KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD
310 320 330 340 350
RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF
360 370 380 390 400
QTHPYFRVLL EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA
410 420 430 440 450
TEELRRCGAD IPSQEADKMF FLIEKIKMFN QDIEKLVEGE EVVRENETRL
460 470 480 490 500
YNKIREDFKN WVGILATNTQ KVKNIIHEEV EKYEKQYRGK ELLGFVNYKT
510 520 530 540 550
FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG EFFNLNQTVQ
560 570 580 590 600
STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL
610 620 630 640 650
GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ
660 670 680 690 700
YFMLRENGDS LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT
710
QARHALCQFS SKEIH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JEL4 | C9JEL4_HUMAN | Interferon-induced GTP-binding prot... | MX2 | 133 | Annotation score: | ||
C9JS04 | C9JS04_HUMAN | Interferon-induced GTP-binding prot... | MX2 | 125 | Annotation score: | ||
C9JZQ9 | C9JZQ9_HUMAN | Interferon-induced GTP-binding prot... | MX2 | 129 | Annotation score: | ||
C9J9T4 | C9J9T4_HUMAN | Interferon-induced GTP-binding prot... | MX2 | 14 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056443 | 148 – 192 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_056444 | 245 – 246 | IK → VS in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_056445 | 247 – 715 | Missing in isoform 2. 1 PublicationAdd BLAST | 469 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30818 mRNA Translation: AAA36338.1 M33883 mRNA Translation: AAA36459.1 AK298780 mRNA Translation: BAH12869.1 AL163285 Genomic DNA Translation: CAB90555.1 AL773578 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09605.1 CH471079 Genomic DNA Translation: EAX09606.1 BC035293 mRNA Translation: AAH35293.1 |
CCDSi | CCDS13672.1 [P20592-1] |
PIRi | B33481 |
RefSeqi | NP_002454.1, NM_002463.1 [P20592-1] XP_005261040.1, XM_005260983.4 [P20592-1] XP_005261041.1, XM_005260984.1 [P20592-1] XP_011527873.1, XM_011529571.1 [P20592-1] XP_011527874.1, XM_011529572.1 [P20592-1] |
Genome annotation databases
Ensembli | ENST00000330714; ENSP00000333657; ENSG00000183486 [P20592-1] |
GeneIDi | 4600 |
KEGGi | hsa:4600 |
UCSCi | uc002yzf.2, human [P20592-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30818 mRNA Translation: AAA36338.1 M33883 mRNA Translation: AAA36459.1 AK298780 mRNA Translation: BAH12869.1 AL163285 Genomic DNA Translation: CAB90555.1 AL773578 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09605.1 CH471079 Genomic DNA Translation: EAX09606.1 BC035293 mRNA Translation: AAH35293.1 |
CCDSi | CCDS13672.1 [P20592-1] |
PIRi | B33481 |
RefSeqi | NP_002454.1, NM_002463.1 [P20592-1] XP_005261040.1, XM_005260983.4 [P20592-1] XP_005261041.1, XM_005260984.1 [P20592-1] XP_011527873.1, XM_011529571.1 [P20592-1] XP_011527874.1, XM_011529572.1 [P20592-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4WHJ | X-ray | 3.20 | A/B | 84-715 | [»] | |
4X0R | X-ray | 2.90 | A/B | 413-678 | [»] | |
5UOT | electron microscopy | 4.60 | 0/1/2/3/4/5/6/7/8/9/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T | 93-711 | [»] | |
SMRi | P20592 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110685, 13 interactors |
DIPi | DIP-59212N |
IntActi | P20592, 5 interactors |
STRINGi | 9606.ENSP00000333657 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | P20592 |
PhosphoSitePlusi | P20592 |
SwissPalmi | P20592 |
Polymorphism and mutation databases
BioMutai | MX2 |
DMDMi | 127571 |
Proteomic databases
EPDi | P20592 |
jPOSTi | P20592 |
MassIVEi | P20592 |
MaxQBi | P20592 |
PaxDbi | P20592 |
PeptideAtlasi | P20592 |
PRIDEi | P20592 |
ProteomicsDBi | 53765 [P20592-1] 6679 |
Protocols and materials databases
Antibodypediai | 23558, 125 antibodies |
DNASUi | 4600 |
Genome annotation databases
Ensembli | ENST00000330714; ENSP00000333657; ENSG00000183486 [P20592-1] |
GeneIDi | 4600 |
KEGGi | hsa:4600 |
UCSCi | uc002yzf.2, human [P20592-1] |
Organism-specific databases
CTDi | 4600 |
DisGeNETi | 4600 |
EuPathDBi | HostDB:ENSG00000183486.12 |
GeneCardsi | MX2 |
HGNCi | HGNC:7533, MX2 |
HPAi | ENSG00000183486, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 147890, gene |
neXtProti | NX_P20592 |
OpenTargetsi | ENSG00000183486 |
PharmGKBi | PA31334 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
GeneTreei | ENSGT00940000163266 |
HOGENOMi | CLU_008964_8_0_1 |
InParanoidi | P20592 |
OMAi | DNQPRDI |
OrthoDBi | 494748at2759 |
PhylomeDBi | P20592 |
TreeFami | TF331484 |
Enzyme and pathway databases
PathwayCommonsi | P20592 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-909733, Interferon alpha/beta signaling |
Miscellaneous databases
BioGRID-ORCSi | 4600, 2 hits in 847 CRISPR screens |
ChiTaRSi | MX2, human |
GeneWikii | MX2 |
GenomeRNAii | 4600 |
Pharosi | P20592, Tbio |
PROi | PR:P20592 |
RNActi | P20592, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183486, Expressed in epithelium of bronchus and 183 other tissues |
ExpressionAtlasi | P20592, baseline and differential |
Genevisiblei | P20592, HS |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
InterProi | View protein in InterPro IPR000375, Dynamin_central IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MX2_HUMAN | |
Accessioni | P20592Primary (citable) accession number: P20592 Secondary accession number(s): B7Z5D3, D3DSI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM