MX1

Functionⁱ

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.13 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	77 – 84	GTPSequence analysis	8
Nucleotide bindingⁱ	178 – 182	GTPSequence analysis	5
Nucleotide bindingⁱ	247 – 250	GTPSequence analysis	4

GO - Molecular functionⁱ

GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding
Source: ProtInc
Traceable author statementⁱ
- 2154602
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 9389754
defense response
Source: ProtInc
Traceable author statementⁱ
- 2154602
defense response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 21478870
dynamin family protein polymerization involved in mitochondrial fission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
innate immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
membrane fusion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitochondrial fission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of viral genome replication
Source: UniProtKB
Inferred from direct assayⁱ
response to type I interferon
Source: UniProtKB
Traceable author statementⁱ
- 21859714
response to virus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15047845
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9389754
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Antiviral defense, Immunity, Innate immunity
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-909733 Interferon alpha/beta signaling
SIGNORⁱ	P20591

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon-induced GTP-binding protein Mx1 Alternative name(s): Interferon-induced protein p78 Short name: IFI-78K Interferon-regulated resistance GTP-binding protein MxA Myxoma resistance protein 1 Myxovirus resistance protein 1 Cleaved into the following chain: Interferon-induced GTP-binding protein Mx1, N-terminally processed
Gene namesⁱ	Name:MX1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157601.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7532 MX1
MIMⁱ	147150 gene
neXtProtⁱ	NX_P20591

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	81	S → C: No effect on GTP-binding, nor on viral infection. 1 Publication	1
Mutagenesisⁱ	83	K → A: Loss of GTP-binding. Loss of potentiation of TRPC6 activity. Loss of protection against viral infection. 2 Publications	1
Mutagenesisⁱ	83	K → M: Loss of GTP-binding. Loss of protection against viral infection. 2 Publications	1
Mutagenesisⁱ	103	T → A: Loss of GTP-binding. Loss of potentiation of TRPC6 activity. Loss of protection against viral infection. 2 Publications	1
Mutagenesisⁱ	554	K → E: Strong liposome-binding reduction. 1 Publication	1
Mutagenesisⁱ	555	K → E: Strong liposome-binding reduction. 1 Publication	1
Mutagenesisⁱ	556	K → E: Strong liposome-binding reduction. 1 Publication	1
Mutagenesisⁱ	557	K → E: Strong liposome-binding reduction. 1 Publication	1
Mutagenesisⁱ	612	L → K: Loss of GTP-hydrolysis. No effect on GTP-binding, nor on potentiation of TRPC6 activity. 1 Publication	1
Mutagenesisⁱ	632	E → A: Reduced antiviral activity. 1 Publication	1
Mutagenesisⁱ	640	R → A: Fails to sequester viral nucleoproteins, no antiviral activity. 1 Publication	1
Mutagenesisⁱ	645	E → R: Loss of antiviral activity towards CCHFV and LACV. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4599
Open Targets More...OpenTargetsⁱ	ENSG00000157601
PharmGKBⁱ	PA31333

Polymorphism and mutation databases

BioMutaⁱ	MX1
DMDMⁱ	251757499

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000382943	1 – 662	Interferon-induced GTP-binding protein Mx1Add BLAST	662
Initiator methionineⁱ		Removed; alternate2 Publications
ChainⁱPRO_0000206592	2 – 662	Interferon-induced GTP-binding protein Mx1, N-terminally processedAdd BLAST	661

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionine; in Interferon-induced GTP-binding protein Mx1; alternate1 Publication		1

Post-translational modificationⁱ

ISGylated.1 Publication

Keywords - PTMⁱ

Acetylation, Ubl conjugation

Proteomic databases

EPDⁱ	P20591
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P20591
PaxDbⁱ	P20591
PeptideAtlas More...PeptideAtlasⁱ	P20591
PRIDEⁱ	P20591
ProteomicsDBⁱ	53763 53764 [P20591-2]

PTM databases

iPTMnetⁱ	P20591
PhosphoSitePlusⁱ	P20591

Expressionⁱ

Inductionⁱ

By type I and type III interferons. Isoform 2 is induced by HSV-1.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000157601 Expressed in 223 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_MX1
ExpressionAtlasⁱ	P20591 baseline and differential
Genevisibleⁱ	P20591 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030917 HPA030918 HPA049724

HPAⁱ

HPA030917
HPA030918
HPA049724

Interactionⁱ

Subunit structureⁱ

Homotetramer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Interacts with HSPA5. Interacts with DDX39A and DDX39B. Interacts with TUBB/TUBB5 (By similarity). The GTP-bound form interacts (via C-terminus) with THOV P5 protein. The GTP-bound form interacts with LACV protein N. Interacts with CCHFV protein N.By similarity10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		12	EBI-929476,EBI-929476
CAB39L	Q9H9S4	3	EBI-929476,EBI-1047244
SIAH1	Q8IUQ4	3	EBI-929476,EBI-747107
TRPC3	Q13507	2	EBI-929476,EBI-520807
TRPC4	Q9UBN4	2	EBI-929476,EBI-929504
TRPC6	Q9Y210	4	EBI-929476,EBI-929362

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110684, 40 interactors
Database of interacting proteins More...DIPⁱ	DIP-35694N
IntActⁱ	P20591, 15 interactors
STRINGⁱ	9606.ENSP00000381599

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	47 – 49	Combined sources	3
Helixⁱ	50 – 61	Combined sources	12
Helixⁱ	64 – 66	Combined sources	3
Beta strandⁱ	72 – 78	Combined sources	7
Helixⁱ	83 – 91	Combined sources	9
Beta strandⁱ	99 – 101	Combined sources	3
Beta strandⁱ	107 – 113	Combined sources	7
Beta strandⁱ	115 – 117	Combined sources	3
Beta strandⁱ	121 – 126	Combined sources	6
Beta strandⁱ	129 – 133	Combined sources	5
Helixⁱ	136 – 138	Combined sources	3
Helixⁱ	139 – 150	Combined sources	12
Beta strandⁱ	153 – 155	Combined sources	3
Beta strandⁱ	162 – 168	Combined sources	7
Beta strandⁱ	173 – 178	Combined sources	6
Helixⁱ	195 – 206	Combined sources	12
Beta strandⁱ	208 – 210	Combined sources	3
Beta strandⁱ	211 – 218	Combined sources	8
Turnⁱ	223 – 225	Combined sources	3
Helixⁱ	227 – 235	Combined sources	9
Beta strandⁱ	239 – 247	Combined sources	9
Helixⁱ	249 – 251	Combined sources	3
Beta strandⁱ	252 – 256	Combined sources	5
Helixⁱ	257 – 264	Combined sources	8
Beta strandⁱ	275 – 277	Combined sources	3
Helixⁱ	283 – 288	Combined sources	6
Helixⁱ	292 – 305	Combined sources	14
Turnⁱ	307 – 309	Combined sources	3
Helixⁱ	310 – 314	Combined sources	5
Helixⁱ	320 – 358	Combined sources	39
Helixⁱ	367 – 390	Combined sources	24
Helixⁱ	403 – 437	Combined sources	35
Beta strandⁱ	444 – 446	Combined sources	3
Helixⁱ	449 – 452	Combined sources	4
Helixⁱ	454 – 462	Combined sources	9
Helixⁱ	463 – 465	Combined sources	3
Beta strandⁱ	467 – 474	Combined sources	8
Helixⁱ	479 – 481	Combined sources	3
Helixⁱ	483 – 490	Combined sources	8
Beta strandⁱ	495 – 502	Combined sources	8
Helixⁱ	504 – 506	Combined sources	3
Helixⁱ	513 – 520	Combined sources	8
Beta strandⁱ	523 – 525	Combined sources	3
Helixⁱ	543 – 546	Combined sources	4
Helixⁱ	551 – 561	Combined sources	11
Helixⁱ	564 – 566	Combined sources	3
Turnⁱ	568 – 570	Combined sources	3
Helixⁱ	571 – 575	Combined sources	5
Helixⁱ	581 – 596	Combined sources	16
Helixⁱ	599 – 601	Combined sources	3
Turnⁱ	602 – 604	Combined sources	3
Helixⁱ	605 – 621	Combined sources	17
Helixⁱ	623 – 625	Combined sources	3
Helixⁱ	626 – 629	Combined sources	4
Helixⁱ	635 – 658	Combined sources	24
Turnⁱ	659 – 661	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P20591
SMRⁱ	P20591
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P20591

EvolutionaryTraceⁱ

P20591

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	67 – 340	Dynamin-type GPROSITE-ProRule annotationAdd BLAST		274
Domainⁱ	574 – 662	GEDPROSITE-ProRule annotationAdd BLAST		89

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	77 – 84	G1 motifPROSITE-ProRule annotation	8
Regionⁱ	102 – 104	G2 motifPROSITE-ProRule annotation	3
Regionⁱ	178 – 181	G3 motifPROSITE-ProRule annotation	4
Regionⁱ	247 – 250	G4 motifPROSITE-ProRule annotation	4
Regionⁱ	279 – 282	G5 motifPROSITE-ProRule annotation	4
Regionⁱ	341 – 366	Bundle signaling element (BSE)Add BLAST	26
Regionⁱ	366 – 533	Middle domainAdd BLAST	168
Regionⁱ	367 – 632	StalkAdd BLAST	266
Regionⁱ	554 – 557	Critical for lipid-binding	4

Domainⁱ

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.1 Publication

The middle domain mediates self-assembly and oligomerization.1 Publication

Sequence similaritiesⁱ

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0446 Eukaryota COG0699 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119213
HOGENOMⁱ	HOG000063238
HOVERGENⁱ	HBG008788
InParanoidⁱ	P20591
KEGG Orthology (KO) More...KOⁱ	K14754
OMAⁱ	KATIPCL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G080G
PhylomeDBⁱ	P20591
TreeFamⁱ	TF331484

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08771 DLP_1, 1 hit
InterProⁱ	View protein in InterPro IPR000375 Dynamin_central IPR001401 Dynamin_GTPase IPR019762 Dynamin_GTPase_CS IPR022812 Dynamin_SF IPR030381 G_DYNAMIN_dom IPR003130 GED IPR020850 GED_dom IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR11566 PTHR11566, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01031 Dynamin_M, 1 hit PF00350 Dynamin_N, 1 hit PF02212 GED, 1 hit
PRINTSⁱ	PR00195 DYNAMIN
SMARTⁱ	View protein in SMART SM00053 DYNc, 1 hit SM00302 GED, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00410 G_DYNAMIN_1, 1 hit PS51718 G_DYNAMIN_2, 1 hit PS51388 GED, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P20591-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVSEVDIAK ADPAAASHPL LLNGDATVAQ KNPGSVAENN LCSQYEEKVR 
        60         70         80         90        100
PCIDLIDSLR ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG 
       110        120        130        140        150
IVTRCPLVLK LKKLVNEDKW RGKVSYQDYE IEISDASEVE KEINKAQNAI 
       160        170        180        190        200
AGEGMGISHE LITLEISSRD VPDLTLIDLP GITRVAVGNQ PADIGYKIKT 
       210        220        230        240        250
LIKKYIQRQE TISLVVVPSN VDIATTEALS MAQEVDPEGD RTIGILTKPD 
       260        270        280        290        300
LVDKGTEDKV VDVVRNLVFH LKKGYMIVKC RGQQEIQDQL SLSEALQREK 
       310        320        330        340        350
IFFENHPYFR DLLEEGKATV PCLAEKLTSE LITHICKSLP LLENQIKETH 
       360        370        380        390        400
QRITEELQKY GVDIPEDENE KMFFLIDKVN AFNQDITALM QGEETVGEED 
       410        420        430        440        450
IRLFTRLRHE FHKWSTIIEN NFQEGHKILS RKIQKFENQY RGRELPGFVN 
       460        470        480        490        500
YRTFETIVKQ QIKALEEPAV DMLHTVTDMV RLAFTDVSIK NFEEFFNLHR 
       510        520        530        540        550
TAKSKIEDIR AEQEREGEKL IRLHFQMEQI VYCQDQVYRG ALQKVREKEL 
       560        570        580        590        600
EEEKKKKSWD FGAFQSSSAT DSSMEEIFQH LMAYHQEASK RISSHIPLII 
       610        620        630        640        650
QFFMLQTYGQ QLQKAMLQLL QDKDTYSWLL KERSDTSDKR KFLKERLARL 
       660 
TQARRRLAQF PG

Length:662

Mass (Da):75,520

Last modified:July 7, 2009 - v4

Checksum:ⁱ626A7DD946F89384

GO

Isoform 2 (identifier: P20591-2) [UniParc]FASTA Add to basket

Also known as: 56-kda, varMxA

The sequence of this isoform differs from the canonical sequence as follows:
425-662: GHKILSRKIQ...ARRRLAQFPG → GGQQAHLQPH...PRLTTLCPAP

« Hide

        10         20         30         40         50
MVVSEVDIAK ADPAAASHPL LLNGDATVAQ KNPGSVAENN LCSQYEEKVR 
        60         70         80         90        100
PCIDLIDSLR ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG 
       110        120        130        140        150
IVTRCPLVLK LKKLVNEDKW RGKVSYQDYE IEISDASEVE KEINKAQNAI 
       160        170        180        190        200
AGEGMGISHE LITLEISSRD VPDLTLIDLP GITRVAVGNQ PADIGYKIKT 
       210        220        230        240        250
LIKKYIQRQE TISLVVVPSN VDIATTEALS MAQEVDPEGD RTIGILTKPD 
       260        270        280        290        300
LVDKGTEDKV VDVVRNLVFH LKKGYMIVKC RGQQEIQDQL SLSEALQREK 
       310        320        330        340        350
IFFENHPYFR DLLEEGKATV PCLAEKLTSE LITHICKSLP LLENQIKETH 
       360        370        380        390        400
QRITEELQKY GVDIPEDENE KMFFLIDKVN AFNQDITALM QGEETVGEED 
       410        420        430        440        450
IRLFTRLRHE FHKWSTIIEN NFQEGGQQAH LQPHPFDHPV LHAPDVRPAA 
       460        470        480        490        500
SEGHAAAPAG QGHLQLAPEG AERHQRQAEV PEGAACTADA GSAPACPVPR 

LTTLCPAP

Show »

Length:508

Mass (Da):55,661

Checksum:ⁱ4681FED66E2F8C21

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W8T1	F8W8T1_HUMAN	Interferon-induced GTP-binding prot... Interferon-induced GTP-binding protein Mx1	MX1	639	Annotation score:
H9KVC9	H9KVC9_HUMAN	Interferon-induced GTP-binding prot... Interferon-induced GTP-binding protein Mx1	MX1	201	Annotation score:
H9KVC7	H9KVC7_HUMAN	Interferon-induced GTP-binding prot... Interferon-induced GTP-binding protein Mx1	MX1	197	Annotation score:
H9KVC4	H9KVC4_HUMAN	Interferon-induced GTP-binding prot... Interferon-induced GTP-binding protein Mx1	MX1	77	Annotation score:
H9KVD0	H9KVD0_HUMAN	Interferon-induced GTP-binding prot... Interferon-induced GTP-binding protein Mx1	MX1	68	Annotation score:
H9KVD3	H9KVD3_HUMAN	Interferon-induced GTP-binding prot... Interferon-induced GTP-binding protein Mx1	MX1	35	Annotation score:
H9KVC3	H9KVC3_HUMAN	Interferon-induced GTP-binding prot... Interferon-induced GTP-binding protein Mx1	MX1	25	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	164	L → R in AAA36337 (PubMed:2481229).Curated	1
Sequence conflictⁱ	250	D → G in BAG53272 (PubMed:20603636).Curated	1
Sequence conflictⁱ	297	Q → H in BAG37852 (PubMed:20603636).Curated	1
Sequence conflictⁱ	299	E → G in BAG53272 (PubMed:20603636).Curated	1
Sequence conflictⁱ	582	M → I in BAG37852 (PubMed:20603636).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_058010	379	V → I6 PublicationsCorresponds to variant dbSNP:rs469390Ensembl.	1
Natural variantⁱVAR_034116	381	A → V. Corresponds to variant dbSNP:rs34717738Ensembl.	1
Natural variantⁱVAR_034117	611	Q → H. Corresponds to variant dbSNP:rs2230454Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042904	425 – 662	GHKIL…AQFPG → GGQQAHLQPHPFDHPVLHAP DVRPAASEGHAAAPAGQGHL QLAPEGAERHQRQAEVPEGA ACTADAGSAPACPVPRLTTL CPAP in isoform 2. 1 PublicationAdd BLAST		238

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30817 mRNA Translation: AAA36337.1 M33882 mRNA Translation: AAA36458.1 AF135187 Genomic DNA Translation: AAD43063.1 AK096355 mRNA Translation: BAG53272.1 AK315465 mRNA Translation: BAG37852.1 AL163285 Genomic DNA Translation: CAB90556.1 AL773577 Genomic DNA No translation available. AL773578 Genomic DNA No translation available. AP001610 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09600.1 CH471079 Genomic DNA Translation: EAX09601.1 CH471079 Genomic DNA Translation: EAX09602.1 CH471079 Genomic DNA Translation: EAX09603.1 CH471079 Genomic DNA Translation: EAX09604.1 BC014222 mRNA Translation: AAH14222.2 BC032602 mRNA Translation: AAH32602.1 AY186254 mRNA Translation: AAO31807.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13673.1 [P20591-1] CCDS74796.1 [P20591-2]
PIRⁱ	A33481
NCBI Reference Sequences More...RefSeqⁱ	NP_001138397.1, NM_001144925.2 [P20591-1] NP_001171517.1, NM_001178046.2 [P20591-1] NP_001269849.1, NM_001282920.1 [P20591-2] NP_002453.2, NM_002462.4 [P20591-1] XP_005261035.1, XM_005260978.4 [P20591-1] XP_005261036.1, XM_005260979.2 [P20591-1] XP_005261037.1, XM_005260980.2 [P20591-1] XP_005261038.1, XM_005260981.2 [P20591-1] XP_005261039.1, XM_005260982.2 [P20591-1] XP_011527870.1, XM_011529568.2 [P20591-1] XP_016883838.1, XM_017028349.1 [P20591-1] XP_016883839.1, XM_017028350.1 [P20591-1]
UniGeneⁱ	Hs.517307

Genome annotation databases

Ensemblⁱ	ENST00000398598; ENSP00000381599; ENSG00000157601 [P20591-1] ENST00000398600; ENSP00000381601; ENSG00000157601 [P20591-1] ENST00000455164; ENSP00000410523; ENSG00000157601 [P20591-1] ENST00000619682; ENSP00000478441; ENSG00000157601 [P20591-2]
GeneIDⁱ	4599
KEGGⁱ	hsa:4599
UCSC genome browser More...UCSCⁱ	uc002yzh.5 human [P20591-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20591	Interferon-induced GTP-binding protein Mx1 (Fragment)		HUMAN		68	UniRef100_P20591
Interferon-induced GTP-binding protein Mx1 (Fragment)		HUMAN		35
Interferon-induced GTP-binding protein Mx1 (Fragment)		HUMAN		197
Interferon-induced GTP-binding protein Mx1 (Fragment)		HUMAN		201
Interferon-induced GTP-binding protein Mx1 (Fragment)		HUMAN		77
+1

Protein	Similar proteins		Species	Score	Length	Source
P20591	Interferon-induced GTP-binding protein Mx1		PONAB		662	UniRef90_P20591
Interferon-induced GTP-binding protein Mx1 (Fragment)		HUMAN		68
MX dynamin like GTPase 1		PANTR		710
Uncharacterized protein		NOMLE		671
Myxovirus (Influenza virus) resistance 1		PONPY		662
+43
P20591-2	MX dynamin like GTPase 1		PANTR		504	UniRef90_P20591-2
Uncharacterized protein		CALJA		504
Uncharacterized protein		Cebus capucinus imitator		475
UPI00062AAB49		NOMLE		544

Protein	Similar proteins		Species	Score	Length	Source
P20591	Interferon-induced GTP-binding protein Mx1		PONAB		662	UniRef50_P20591
Interferon-induced GTP-binding protein Mx		CHICK		705
Interferon-induced GTP-binding protein Mx2		MACMU		715
Interferon-induced GTP-binding protein Mx2	)	HUMAN		715
Interferon-induced GTP-binding protein Mx		ANAPL		721
+463
P20591-2	Interferon-induced GTP-binding protein MxE		DANRE		625	UniRef50_P20591-2
Uncharacterized protein		CALJA		504
MX dynamin like GTPase 1		PANTR		504
Uncharacterized protein		Cebus capucinus imitator		475
Mx protein		ANGJA		666
+19

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30817 mRNA Translation: AAA36337.1 M33882 mRNA Translation: AAA36458.1 AF135187 Genomic DNA Translation: AAD43063.1 AK096355 mRNA Translation: BAG53272.1 AK315465 mRNA Translation: BAG37852.1 AL163285 Genomic DNA Translation: CAB90556.1 AL773577 Genomic DNA No translation available. AL773578 Genomic DNA No translation available. AP001610 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09600.1 CH471079 Genomic DNA Translation: EAX09601.1 CH471079 Genomic DNA Translation: EAX09602.1 CH471079 Genomic DNA Translation: EAX09603.1 CH471079 Genomic DNA Translation: EAX09604.1 BC014222 mRNA Translation: AAH14222.2 BC032602 mRNA Translation: AAH32602.1 AY186254 mRNA Translation: AAO31807.1
CCDSⁱ	CCDS13673.1 [P20591-1] CCDS74796.1 [P20591-2]
PIRⁱ	A33481
RefSeqⁱ	NP_001138397.1, NM_001144925.2 [P20591-1] NP_001171517.1, NM_001178046.2 [P20591-1] NP_001269849.1, NM_001282920.1 [P20591-2] NP_002453.2, NM_002462.4 [P20591-1] XP_005261035.1, XM_005260978.4 [P20591-1] XP_005261036.1, XM_005260979.2 [P20591-1] XP_005261037.1, XM_005260980.2 [P20591-1] XP_005261038.1, XM_005260981.2 [P20591-1] XP_005261039.1, XM_005260982.2 [P20591-1] XP_011527870.1, XM_011529568.2 [P20591-1] XP_016883838.1, XM_017028349.1 [P20591-1] XP_016883839.1, XM_017028350.1 [P20591-1]
UniGeneⁱ	Hs.517307

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3LJB	X-ray	2.40	A/B	366-636	[»]
	3SZR	X-ray	3.50	A	33-662	[»]
	3ZYS	electron microscopy	12.20	B/E	1-662	[»]
	4P4S	X-ray	3.30	A	70-342	[»]
				B	43-662	[»]
	4P4T	X-ray	2.30	A	37-366	[»]
				A	637-662	[»]
	4P4U	X-ray	1.90	A	37-364	[»]
				A	632-661	[»]
	5GTM	X-ray	2.90	A/B	33-662	[»]
ProteinModelPortalⁱ	P20591
SMRⁱ	P20591
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110684, 40 interactors
DIPⁱ	DIP-35694N
IntActⁱ	P20591, 15 interactors
STRINGⁱ	9606.ENSP00000381599

PTM databases

iPTMnetⁱ	P20591
PhosphoSitePlusⁱ	P20591

Polymorphism and mutation databases

BioMutaⁱ	MX1
DMDMⁱ	251757499

Proteomic databases

EPDⁱ	P20591
MaxQBⁱ	P20591
PaxDbⁱ	P20591
PeptideAtlasⁱ	P20591
PRIDEⁱ	P20591
ProteomicsDBⁱ	53763 53764 [P20591-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4599
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000398598; ENSP00000381599; ENSG00000157601 [P20591-1] ENST00000398600; ENSP00000381601; ENSG00000157601 [P20591-1] ENST00000455164; ENSP00000410523; ENSG00000157601 [P20591-1] ENST00000619682; ENSP00000478441; ENSG00000157601 [P20591-2]
GeneIDⁱ	4599
KEGGⁱ	hsa:4599
UCSCⁱ	uc002yzh.5 human [P20591-1]

Organism-specific databases

CTDⁱ	4599
DisGeNETⁱ	4599
EuPathDBⁱ	HostDB:ENSG00000157601.13
GeneCardsⁱ	MX1
H-InvDBⁱ	HIX0027784
HGNCⁱ	HGNC:7532 MX1
HPAⁱ	HPA030917 HPA030918 HPA049724
MIMⁱ	147150 gene
neXtProtⁱ	NX_P20591
OpenTargetsⁱ	ENSG00000157601
PharmGKBⁱ	PA31333
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0446 Eukaryota COG0699 LUCA
GeneTreeⁱ	ENSGT00760000119213
HOGENOMⁱ	HOG000063238
HOVERGENⁱ	HBG008788
InParanoidⁱ	P20591
KOⁱ	K14754
OMAⁱ	KATIPCL
OrthoDBⁱ	EOG091G080G
PhylomeDBⁱ	P20591
TreeFamⁱ	TF331484

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-909733 Interferon alpha/beta signaling
SIGNORⁱ	P20591

Miscellaneous databases

ChiTaRSⁱ	MX1 human
EvolutionaryTraceⁱ	P20591
GeneWikiⁱ	MX1
GenomeRNAiⁱ	4599
Protein Ontology More...PROⁱ	PR:P20591
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157601 Expressed in 223 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_MX1
ExpressionAtlasⁱ	P20591 baseline and differential
Genevisibleⁱ	P20591 HS

Family and domain databases

CDDⁱ	cd08771 DLP_1, 1 hit
InterProⁱ	View protein in InterPro IPR000375 Dynamin_central IPR001401 Dynamin_GTPase IPR019762 Dynamin_GTPase_CS IPR022812 Dynamin_SF IPR030381 G_DYNAMIN_dom IPR003130 GED IPR020850 GED_dom IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR11566 PTHR11566, 1 hit
Pfamⁱ	View protein in Pfam PF01031 Dynamin_M, 1 hit PF00350 Dynamin_N, 1 hit PF02212 GED, 1 hit
PRINTSⁱ	PR00195 DYNAMIN
SMARTⁱ	View protein in SMART SM00053 DYNc, 1 hit SM00302 GED, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00410 G_DYNAMIN_1, 1 hit PS51718 G_DYNAMIN_2, 1 hit PS51388 GED, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MX1_HUMAN
Accessionⁱ	P20591Primary (citable) accession number: P20591 Secondary accession number(s): B2RDA5 Q96CI3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	July 7, 2009
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P20591 (MX1_HUMAN)

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Interferon-induced GTP-binding protein Mx1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Nucleus

Other locations

Cytosol

Endoplasmic reticulum

Mitochondrion

Nucleus

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Keywords - Cellular componenti

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Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

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Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ