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UniProtKB - P20585 (MSH3_HUMAN)

Entry version 193 (02 Dec 2020)
Sequence version 4 (11 Jan 2011)
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Protein

DNA mismatch repair protein Msh3

Gene

MSH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi896 – 903ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P20585

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5358606, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5632927, Defective Mismatch Repair Associated With MSH3
R-HSA-5632928, Defective Mismatch Repair Associated With MSH2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA mismatch repair protein Msh3
Short name:
hMSH3
Alternative name(s):
Divergent upstream protein
Short name:
DUP
Mismatch repair protein 1
Short name:
MRP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSH3
Synonyms:DUC1, DUG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000113318.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:7326, MSH3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600887, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P20585

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Endometrial cancer (ENDMC)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids.
Related information in OMIM
Familial adenomatous polyposis 4 (FAP4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of familial adenomatous polyposis, a condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma. FAP4 inheritance is autosomal recessive.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		4437

MalaCards human disease database

More...MalaCardsi		MSH3
MIMi608089, phenotype
617100, phenotype

Open Targets

More...OpenTargetsi		ENSG00000113318

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		480536, MSH3-related attenuated familial adenomatous polyposis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31134

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P20585, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MSH3

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001151921 – 1137DNA mismatch repair protein Msh3Add BLAST1137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33PhosphoserineCombined sources1
Modified residuei1099PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P20585

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P20585

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P20585

MaxQB - The MaxQuant DataBase

More...MaxQBi		P20585

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P20585

PeptideAtlas

More...PeptideAtlasi		P20585

PRoteomics IDEntifications database

More...PRIDEi		P20585

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53762

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20585

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P20585

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113318, Expressed in bronchial epithelial cell and 248 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20585, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000113318, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (PubMed:26300262). Heterodimer consisting of MSH2-MSH3 (MutS beta) (PubMed:8942985).

Forms a ternary complex with MutL alpha (MLH1-PMS1).

Interacts with EXO1 (PubMed:11427529).

Interacts with MCM9 (PubMed:26300262).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110574, 54 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-77, DNA mismatch repair MutSbeta complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P20585

Database of interacting proteins

More...DIPi		DIP-35127N

Protein interaction database and analysis system

More...IntActi		P20585, 22 interactors

Molecular INTeraction database

More...MINTi		P20585

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265081

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P20585, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20585

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 297Interaction with EXO11 PublicationAdd BLAST223

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 62Poly-AlaAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0218, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074949

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002472_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20585

Identification of Orthologs from Complete Genome Data

More...OMAi		LHIAPCE

Database of Orthologous Groups

More...OrthoDBi		138168at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20585

TreeFam database of animal gene trees

More...TreeFami		TF300525

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.110, 1 hit
3.40.1170.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00612

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007695, DNA_mismatch_repair_MutS-lik_N
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR016151, DNA_mismatch_repair_MutS_N
IPR036187, DNA_mismatch_repair_MutS_sf
IPR007860, DNA_mmatch_repair_MutS_con_dom
IPR036678, MutS_con_dom_sf
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01624, MutS_I, 1 hit
PF05188, MutS_II, 1 hit
PF05192, MutS_III, 1 hit
PF00488, MutS_V, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
SSF53150, SSF53150, 1 hit
SSF55271, SSF55271, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P20585-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKPASGG LAASSSAPAR QAVLSRFFQS TGSLKSTSSS TGAADQVDPG 
        60         70         80         90        100
AAAAAAAAAA AAPPAPPAPA FPPQLPPHIA TEIDRRKKRP LENDGPVKKK 
       110        120        130        140        150
VKKVQQKEGG SDLGMSGNSE PKKCLRTRNV SKSLEKLKEF CCDSALPQSR 
       160        170        180        190        200
VQTESLQERF AVLPKCTDFD DISLLHAKNA VSSEDSKRQI NQKDTTLFDL 
       210        220        230        240        250
SQFGSSNTSH ENLQKTASKS ANKRSKSIYT PLELQYIEMK QQHKDAVLCV 
       260        270        280        290        300
ECGYKYRFFG EDAEIAAREL NIYCHLDHNF MTASIPTHRL FVHVRRLVAK 
       310        320        330        340        350
GYKVGVVKQT ETAALKAIGD NRSSLFSRKL TALYTKSTLI GEDVNPLIKL 
       360        370        380        390        400
DDAVNVDEIM TDTSTSYLLC ISENKENVRD KKKGNIFIGI VGVQPATGEV 
       410        420        430        440        450
VFDSFQDSAS RSELETRMSS LQPVELLLPS ALSEQTEALI HRATSVSVQD 
       460        470        480        490        500
DRIRVERMDN IYFEYSHAFQ AVTEFYAKDT VDIKGSQIIS GIVNLEKPVI 
       510        520        530        540        550
CSLAAIIKYL KEFNLEKMLS KPENFKQLSS KMEFMTINGT TLRNLEILQN 
       560        570        580        590        600
QTDMKTKGSL LWVLDHTKTS FGRRKLKKWV TQPLLKLREI NARLDAVSEV 
       610        620        630        640        650
LHSESSVFGQ IENHLRKLPD IERGLCSIYH KKCSTQEFFL IVKTLYHLKS 
       660        670        680        690        700
EFQAIIPAVN SHIQSDLLRT VILEIPELLS PVEHYLKILN EQAAKVGDKT 
       710        720        730        740        750
ELFKDLSDFP LIKKRKDEIQ GVIDEIRMHL QEIRKILKNP SAQYVTVSGQ 
       760        770        780        790        800
EFMIEIKNSA VSCIPTDWVK VGSTKAVSRF HSPFIVENYR HLNQLREQLV 
       810        820        830        840        850
LDCSAEWLDF LEKFSEHYHS LCKAVHHLAT VDCIFSLAKV AKQGDYCRPT 
       860        870        880        890        900
VQEERKIVIK NGRHPVIDVL LGEQDQYVPN NTDLSEDSER VMIITGPNMG 
       910        920        930        940        950
GKSSYIKQVA LITIMAQIGS YVPAEEATIG IVDGIFTRMG AADNIYKGQS 
       960        970        980        990       1000
TFMEELTDTA EIIRKATSQS LVILDELGRG TSTHDGIAIA YATLEYFIRD 
      1010       1020       1030       1040       1050
VKSLTLFVTH YPPVCELEKN YSHQVGNYHM GFLVSEDESK LDPGAAEQVP 
      1060       1070       1080       1090       1100
DFVTFLYQIT RGIAARSYGL NVAKLADVPG EILKKAAHKS KELEGLINTK 
      1110       1120       1130 
RKRLKYFAKL WTMHNAQDLQ KWTEEFNMEE TQTSLLH
Length:1,137
Mass (Da):127,412
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBAE6B84D3F86032
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A590UJW0A0A590UJW0_HUMAN
DNA mismatch repair protein Msh3
MSH3
1,081Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJN8A0A590UJN8_HUMAN
DNA mismatch repair protein Msh3
MSH3
1,072Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UKC9A0A590UKC9_HUMAN
DNA mismatch repair protein Msh3
MSH3
946Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK39A0A590UK39_HUMAN
DNA mismatch repair protein Msh3
MSH3
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11817 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61A → T in AAI30435 (PubMed:15489334).Curated1
Sequence conflicti622E → G in AAB47281 (PubMed:2722860).Curated1
Sequence conflicti622E → G in BAD27111 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02093457 – 65Missing 2 Publications9
Natural variantiVAR_02093562A → AAAA1 Publication1
Natural variantiVAR_02093679I → V6 PublicationsCorresponds to variant dbSNP:rs1650697Ensembl.1
Natural variantiVAR_016160709F → L1 PublicationCorresponds to variant dbSNP:rs1805354EnsemblClinVar.1
Natural variantiVAR_055251789Y → F. Corresponds to variant dbSNP:rs10067975Ensembl.1
Natural variantiVAR_016161949Q → R5 PublicationsCorresponds to variant dbSNP:rs184967EnsemblClinVar.1
Natural variantiVAR_0161621045A → T5 PublicationsCorresponds to variant dbSNP:rs26279EnsemblClinVar.1
Natural variantiVAR_0161631054T → A. Corresponds to variant dbSNP:rs1805131Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04810 mRNA Translation: AAB47281.1
U61981 mRNA Translation: AAB06045.1
D61419 Genomic DNA Translation: BAD27111.1
AY275681 Genomic DNA Translation: AAP13535.1
AC008434 Genomic DNA No translation available.
AC010270 Genomic DNA No translation available.
AC022493 Genomic DNA No translation available.
BC011817 mRNA Translation: AAH11817.1 Sequence problems.
BC130434 mRNA Translation: AAI30435.1
BC130436 mRNA Translation: AAI30437.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34195.1

Protein sequence database of the Protein Information Resource

More...PIRi		A33507

NCBI Reference Sequences

More...RefSeqi		NP_002430.3, NM_002439.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265081; ENSP00000265081; ENSG00000113318

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4437

UCSC genome browser

More...UCSCi		uc003kgz.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04810 mRNA Translation: AAB47281.1
U61981 mRNA Translation: AAB06045.1
D61419 Genomic DNA Translation: BAD27111.1
AY275681 Genomic DNA Translation: AAP13535.1
AC008434 Genomic DNA No translation available.
AC010270 Genomic DNA No translation available.
AC022493 Genomic DNA No translation available.
BC011817 mRNA Translation: AAH11817.1 Sequence problems.
BC130434 mRNA Translation: AAI30435.1
BC130436 mRNA Translation: AAI30437.1
CCDSiCCDS34195.1
PIRiA33507
RefSeqiNP_002430.3, NM_002439.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3THWX-ray3.09B219-1134[»]
3THXX-ray2.70B219-1134[»]
3THYX-ray2.89B219-1134[»]
3THZX-ray4.30B219-1134[»]
SMRiP20585
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110574, 54 interactors
ComplexPortaliCPX-77, DNA mismatch repair MutSbeta complex
CORUMiP20585
DIPiDIP-35127N
IntActiP20585, 22 interactors
MINTiP20585
STRINGi9606.ENSP00000265081

PTM databases

iPTMnetiP20585
PhosphoSitePlusiP20585

Polymorphism and mutation databases

BioMutaiMSH3
DMDMi317373576

Proteomic databases

EPDiP20585
jPOSTiP20585
MassIVEiP20585
MaxQBiP20585
PaxDbiP20585
PeptideAtlasiP20585
PRIDEiP20585
ProteomicsDBi53762

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24651, 270 antibodies

Genome annotation databases

EnsembliENST00000265081; ENSP00000265081; ENSG00000113318
GeneIDi4437
KEGGihsa:4437
UCSCiuc003kgz.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4437
DisGeNETi4437
EuPathDBiHostDB:ENSG00000113318.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		MSH3
HGNCiHGNC:7326, MSH3
HPAiENSG00000113318, Low tissue specificity
MalaCardsiMSH3
MIMi600887, gene
608089, phenotype
617100, phenotype
neXtProtiNX_P20585
OpenTargetsiENSG00000113318
Orphaneti480536, MSH3-related attenuated familial adenomatous polyposis
PharmGKBiPA31134

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0218, Eukaryota
GeneTreeiENSGT00550000074949
HOGENOMiCLU_002472_0_1_1
InParanoidiP20585
OMAiLHIAPCE
OrthoDBi138168at2759
PhylomeDBiP20585
TreeFamiTF300525

Enzyme and pathway databases

PathwayCommonsiP20585
ReactomeiR-HSA-5358606, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5632927, Defective Mismatch Repair Associated With MSH3
R-HSA-5632928, Defective Mismatch Repair Associated With MSH2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4437, 6 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MSH3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MSH3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4437
PharosiP20585, Tbio

Protein Ontology

More...PROi		PR:P20585
RNActiP20585, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000113318, Expressed in bronchial epithelial cell and 248 other tissues
GenevisibleiP20585, HS

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
IDEALiIID00612
InterProiView protein in InterPro
IPR007695, DNA_mismatch_repair_MutS-lik_N
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR016151, DNA_mismatch_repair_MutS_N
IPR036187, DNA_mismatch_repair_MutS_sf
IPR007860, DNA_mmatch_repair_MutS_con_dom
IPR036678, MutS_con_dom_sf
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF01624, MutS_I, 1 hit
PF05188, MutS_II, 1 hit
PF05192, MutS_III, 1 hit
PF00488, MutS_V, 1 hit
SMARTiView protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SUPFAMiSSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
SSF53150, SSF53150, 1 hit
SSF55271, SSF55271, 1 hit
PROSITEiView protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSH3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20585
Secondary accession number(s): A1L480
, A1L482, A6NMM6, Q6PJT5, Q86UQ6, Q92867
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 11, 2011
Last modified: December 2, 2020
This is version 193 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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