UniProtKB - P20509 (DPOL_VACCC)
DNA polymerase
POL
Functioni
Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).
By similarityCatalytic activityi
- EC:2.7.7.7
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- hydrolase activity Source: UniProtKB-KW
- nucleotide binding Source: InterPro
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA replication Source: UniProtKB-KW
- viral DNA genome replication Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, DNA-directed DNA polymerase, Hydrolase, Multifunctional enzyme, Nucleotidyltransferase, Transferase |
Biological process | DNA recombination, DNA replication, Viral DNA replication |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:POL ORF Names:E9L |
Organismi | Vaccinia virus (strain Copenhagen) (VACV) |
Taxonomic identifieri | 10249 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046532 | 1 – 1006 | DNA polymeraseAdd BLAST | 1006 |
Interactioni
Subunit structurei
Interacts with A20.
Component of the Uracil-DNA glycosylase(UDG)-A20-polymerase complex; A20 and UDG form a heterodimeric processivity factor that associates with E9 to form the processive polymerase holoenzyme (By similarity).
By similarityProtein-protein interaction databases
IntActi | P20509, 1 interactor |
Structurei
Secondary structure
3D structure databases
SASBDBi | P20509 |
SMRi | P20509 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.90.1600.10, 2 hits |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR013617, DNA-dir_DNA_pol_B_vir_insert IPR043502, DNA/RNA_pol_sf IPR023211, DNA_pol_palm_dom_sf IPR013660, DNApol_B_exo_N IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF08408, DNA_pol_B_3, 1 hit PF03104, DNA_pol_B_exo1, 1 hit PF08452, DNAP_B_exo_N, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDVRCINWFE SHGENRFLYL KSRCRNGETV FIRFPHYFYY VVTDEIYQSL
60 70 80 90 100
SPPPFNARPL GKMRTIDIDE TISYNLDIKD RKCSVADMWL IEEPKKRSIQ
110 120 130 140 150
NATMDEFLNI SWFYISNGIS PDGCYSLDEQ YLTKINNGCY HCDDPRNCFA
160 170 180 190 200
KKIPRFDIPR SYLFLDIECH FDKKFPSVFI NPISHTSYCY IDLSGKRLLF
210 220 230 240 250
TLINEEMLTE QEIQEAVDRG CLRIQSLMEM DYERELVLCS EIVLLRIAKQ
260 270 280 290 300
LLELTFDYVV TFNGHNFDLR YITNRLELLT GEKIIFRSPD KKEAVHLCIY
310 320 330 340 350
ERNQSSHKGV GGMANTTFHV NNNNGTIFFD LYSFIQKSEK LDSYKLDSIS
360 370 380 390 400
KNAFSCMGKV LNRGVREMTF IGDDTTDAKG KAAAFAKVLT TGNYVTVDED
410 420 430 440 450
IICKVIRKDI WENGFKVVLL CPTLPNDTYK LSFGKDDVDL AQMYKDYNLN
460 470 480 490 500
IALDMARYCI HDACLCQYLW EYYGVETKTD AGASTYVLPQ SMVFEYRAST
510 520 530 540 550
VIKGPLLKLL LETKTILVRS ETKQKFPYEG GKVFAPKQKM FSNNVLIFDY
560 570 580 590 600
NSLYPNVCIF GNLSPETLVG VVVSTNRLEE EINNQLLLQK YPPPRYITVH
610 620 630 640 650
CEPRLPNLIS EIAIFDRSIE GTIPRLLRTF LAERARYKKM LKQATSSTEK
660 670 680 690 700
AIYDSMQYTY KIVANSVYGL MGFRNSALYS YASAKSCTSI GRRMILYLES
710 720 730 740 750
VLNGAELSNG MLRFANPLSN PFYMDDRDIN PIVKTSLPID YRFRFRSVYG
760 770 780 790 800
DTDSVFTEID SQDVDKSIEI AKELERLINN RVLFNNFKIE FEAVYKNLIM
810 820 830 840 850
QSKKKYTTMK YSASSNSKSV PERINKGTSE TRRDVSKFHK NMIKTYKTRL
860 870 880 890 900
SEMLSEGRMN SNQVCIDILR SLETDLRSEF DSRSSPLELF MLSRMHHSNY
910 920 930 940 950
KSADNPNMYL VTEYNKNNPE TIELGERYYF AYICPANVPW TKKLVNIKTY
960 970 980 990 1000
ETIIDRSFKL GSDQRIFYEV YFKRLTSEIV NLLDNKVLCI SFFERMFGSK
PTFYEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35027 Genomic DNA Translation: AAA48049.1 |
PIRi | D42509, DJVZ4I |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35027 Genomic DNA Translation: AAA48049.1 |
PIRi | D42509, DJVZ4I |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5N2E | X-ray | 2.74 | A | 2-1006 | [»] | |
5N2G | X-ray | 2.78 | A | 2-1005 | [»] | |
5N2H | X-ray | 2.81 | A | 2-1005 | [»] | |
SASBDBi | P20509 | |||||
SMRi | P20509 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P20509, 1 interactor |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.90.1600.10, 2 hits |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR013617, DNA-dir_DNA_pol_B_vir_insert IPR043502, DNA/RNA_pol_sf IPR023211, DNA_pol_palm_dom_sf IPR013660, DNApol_B_exo_N IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF08408, DNA_pol_B_3, 1 hit PF03104, DNA_pol_B_exo1, 1 hit PF08452, DNAP_B_exo_N, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPOL_VACCC | |
Accessioni | P20509Primary (citable) accession number: P20509 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | September 29, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families