Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

Fcer1g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells (PubMed:14764707). As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset (PubMed:19098920). Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766) (Probable). May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation (PubMed:17086186). Also involved in integrin alpha-2/ITGA2-mediated platelet activation (PubMed:9171347).Curated5 Publications

GO - Molecular functioni

  • IgE binding Source: MGI
  • IgE receptor activity Source: MGI
  • IgG binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor
Biological processImmunity, Innate immunity
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-75892 Platelet Adhesion to exposed collagen

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:Fcer1g2 PublicationsImported
Synonyms:Fce1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95496 Fcer1g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 23ExtracellularSequence analysis5
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 86CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Knockout mice are resistant to IgE-mediated systemic anaphylaxis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi29D → A: Increases IL3-induced production of IL4 by basophils. 1 Publication1
Mutagenesisi39L → A: Impairs interaction with CSF2RB. Impairs IL3-induced production of IL4 by basophils. 1 Publication1
Mutagenesisi65 – 86Missing : Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen. 1 PublicationAdd BLAST22
Mutagenesisi65Y → P: Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen; when associated with P-76. Impairs IL3-induced production of IL4 by basophils; when associated with P-76. 2 Publications1
Mutagenesisi76Y → P: Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen; when associated with P-65. Impairs IL3-induced production of IL4 by basophils; when associated with P-65. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001650319 – 86High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainBy similarity
Modified residuei65PhosphotyrosineCombined sources1
Modified residuei76PhosphotyrosineCombined sources1
Modified residuei78PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP20491
PaxDbiP20491
PeptideAtlasiP20491
PRIDEiP20491

PTM databases

iPTMnetiP20491
PhosphoSitePlusiP20491
SwissPalmiP20491

Expressioni

Tissue specificityi

Expressed in mast cells (at protein level) (PubMed:14764707). Expressed in basophils (at protein level) (PubMed:19098920).2 Publications

Gene expression databases

BgeeiENSMUSG00000058715 Expressed in 169 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiP20491 baseline and differential
GenevisibleiP20491 MM

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (By similarity). Associates with CLEC6A (PubMed:17050534). Interacts with CLEC4E (PubMed:23602766, PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (PubMed:17086186). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (PubMed:19098920). Interacts with CD300LH; the interaction may be indirect (PubMed:20817736). Interacts with CD300LD (PubMed:20817736). Interacts with TARM1 (By similarity).By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Jak2Q621202EBI-9306159,EBI-646604

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199616, 2 interactors
IntActiP20491, 1 interactor
STRINGi10090.ENSMUSP00000078875

Structurei

3D structure databases

ProteinModelPortaliP20491
SMRiP20491
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 82ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ Eukaryota
ENOG410Z3W0 LUCA
GeneTreeiENSGT00390000003894
HOGENOMiHOG000293158
HOVERGENiHBG051601
InParanoidiP20491
KOiK07983
OMAiYCRLKLQ
PhylomeDBiP20491
TreeFamiTF330937

Family and domain databases

InterProiView protein in InterPro
IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma
IPR003110 Phos_immunorcpt_sig_ITAM
PfamiView protein in Pfam
PF02189 ITAM, 1 hit
PF11628 TCR_zetazeta, 1 hit
SMARTiView protein in SMART
SM00077 ITAM, 1 hit
PROSITEiView protein in PROSITE
PS51055 ITAM_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P20491-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISAVILFLL LLVEQAAALG EPQLCYILDA VLFLYGIVLT LLYCRLKIQV
60 70 80
RKAAIASREK ADAVYTGLNT RSQETYETLK HEKPPQ
Length:86
Mass (Da):9,652
Last modified:February 1, 1991 - v1
Checksum:i83184DE22FCC9ECB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YVS1A0A0A6YVS1_MOUSE
High affinity immunoglobulin epsilo...
Fcer1g
92Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05020 mRNA Translation: AAA37602.1
BC034163 mRNA Translation: AAH34163.1
CCDSiCCDS15483.1
RefSeqiNP_034315.1, NM_010185.4
UniGeneiMm.22673

Genome annotation databases

EnsembliENSMUST00000079957; ENSMUSP00000078875; ENSMUSG00000058715
GeneIDi14127
KEGGimmu:14127
UCSCiuc007dnl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05020 mRNA Translation: AAA37602.1
BC034163 mRNA Translation: AAH34163.1
CCDSiCCDS15483.1
RefSeqiNP_034315.1, NM_010185.4
UniGeneiMm.22673

3D structure databases

ProteinModelPortaliP20491
SMRiP20491
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199616, 2 interactors
IntActiP20491, 1 interactor
STRINGi10090.ENSMUSP00000078875

PTM databases

iPTMnetiP20491
PhosphoSitePlusiP20491
SwissPalmiP20491

Proteomic databases

MaxQBiP20491
PaxDbiP20491
PeptideAtlasiP20491
PRIDEiP20491

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079957; ENSMUSP00000078875; ENSMUSG00000058715
GeneIDi14127
KEGGimmu:14127
UCSCiuc007dnl.1 mouse

Organism-specific databases

CTDi2207
MGIiMGI:95496 Fcer1g

Phylogenomic databases

eggNOGiENOG410J5TQ Eukaryota
ENOG410Z3W0 LUCA
GeneTreeiENSGT00390000003894
HOGENOMiHOG000293158
HOVERGENiHBG051601
InParanoidiP20491
KOiK07983
OMAiYCRLKLQ
PhylomeDBiP20491
TreeFamiTF330937

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-75892 Platelet Adhesion to exposed collagen

Miscellaneous databases

PROiPR:P20491
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058715 Expressed in 169 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiP20491 baseline and differential
GenevisibleiP20491 MM

Family and domain databases

InterProiView protein in InterPro
IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma
IPR003110 Phos_immunorcpt_sig_ITAM
PfamiView protein in Pfam
PF02189 ITAM, 1 hit
PF11628 TCR_zetazeta, 1 hit
SMARTiView protein in SMART
SM00077 ITAM, 1 hit
PROSITEiView protein in PROSITE
PS51055 ITAM_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCERG_MOUSE
AccessioniPrimary (citable) accession number: P20491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again