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Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

Ms4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-MMU-2454202 Fc epsilon receptor (FCERI) signaling
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-2871837 FCERI mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:Ms4a2
Synonyms:Fce1b, Fcer1b, Ms4a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95495 Ms4a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 71HelicalSequence analysisAdd BLAST20
Topological domaini72 – 89ExtracellularSequence analysisAdd BLAST18
Transmembranei90 – 109HelicalSequence analysisAdd BLAST20
Topological domaini110 – 122CytoplasmicSequence analysisAdd BLAST13
Transmembranei123 – 142HelicalSequence analysisAdd BLAST20
Topological domaini143 – 171ExtracellularSequence analysisAdd BLAST29
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Topological domaini192 – 235CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586301 – 235High affinity immunoglobulin epsilon receptor subunit betaAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphotyrosineCombined sources1
Modified residuei216PhosphotyrosineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei220PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP20490
PRIDEiP20490

PTM databases

iPTMnetiP20490
PhosphoSitePlusiP20490

Expressioni

Gene expression databases

BgeeiENSMUSG00000024680 Expressed in 46 organ(s), highest expression level in bone marrow
ExpressionAtlasiP20490 baseline and differential
GenevisibleiP20490 MM

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR (By similarity). Interacts with FGR and FES/FPS. Interacts with LYN.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199615, 2 interactors
STRINGi10090.ENSMUSP00000127373

Structurei

3D structure databases

ProteinModelPortaliP20490
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J28C Eukaryota
ENOG4111DU9 LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000060211
HOVERGENiHBG051600
InParanoidiP20490
KOiK08090
OMAiNKVPDDR
OrthoDBiEOG091G0IBB
PhylomeDBiP20490
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030420 MS4A2
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF66 PTHR23320:SF66, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P20490-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTENRSRAD LALPNPQESS SAPDIELLEA SPAKAAPPKQ TWRTFLKKEL
60 70 80 90 100
EFLGATQILV GLICLCFGTI VCSVLYVSDF DEEVLLLYKL GYPFWGAVLF
110 120 130 140 150
VLSGFLSIIS ERKNTLYLVR GSLGANIVSS IAAGTGIAML ILNLTNNFAY
160 170 180 190 200
MNNCKNVTED DGCFVASFTT ELVLMMLFLT ILAFCSAVLF TIYRIGQELE
210 220 230
SKKVPDDRLY EELNVYSPIY SELEDKGETS SPVDS
Length:235
Mass (Da):25,963
Last modified:February 1, 1991 - v1
Checksum:i1C2D6BF195738168
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UNT6Q3UNT6_MOUSE
High affinity immunoglobulin epsilo...
Ms4a2
198Annotation score:
A0A087WPM9A0A087WPM9_MOUSE
High affinity immunoglobulin epsilo...
Ms4a2
202Annotation score:
A0A0B4J1P0A0A0B4J1P0_MOUSE
High affinity immunoglobulin epsilo...
Ms4a2
125Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05019 mRNA Translation: AAA37601.1
AB033617 Genomic DNA Translation: BAA94839.1
CCDSiCCDS29604.1
PIRiB34342
RefSeqiNP_038544.1, NM_013516.2
UniGeneiMm.329735

Genome annotation databases

EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680
GeneIDi14126
KEGGimmu:14126
UCSCiuc008gsn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05019 mRNA Translation: AAA37601.1
AB033617 Genomic DNA Translation: BAA94839.1
CCDSiCCDS29604.1
PIRiB34342
RefSeqiNP_038544.1, NM_013516.2
UniGeneiMm.329735

3D structure databases

ProteinModelPortaliP20490
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199615, 2 interactors
STRINGi10090.ENSMUSP00000127373

PTM databases

iPTMnetiP20490
PhosphoSitePlusiP20490

Proteomic databases

PaxDbiP20490
PRIDEiP20490

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680
GeneIDi14126
KEGGimmu:14126
UCSCiuc008gsn.2 mouse

Organism-specific databases

CTDi2206
MGIiMGI:95495 Ms4a2

Phylogenomic databases

eggNOGiENOG410J28C Eukaryota
ENOG4111DU9 LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000060211
HOVERGENiHBG051600
InParanoidiP20490
KOiK08090
OMAiNKVPDDR
OrthoDBiEOG091G0IBB
PhylomeDBiP20490
TreeFamiTF335157

Enzyme and pathway databases

ReactomeiR-MMU-2454202 Fc epsilon receptor (FCERI) signaling
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-2871837 FCERI mediated NF-kB activation

Miscellaneous databases

PROiPR:P20490
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024680 Expressed in 46 organ(s), highest expression level in bone marrow
ExpressionAtlasiP20490 baseline and differential
GenevisibleiP20490 MM

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030420 MS4A2
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF66 PTHR23320:SF66, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCERB_MOUSE
AccessioniPrimary (citable) accession number: P20490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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