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Entry version 191 (07 Apr 2021)
Sequence version 3 (01 Mar 2004)
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Protein

Segmentation protein cap'n'collar

Gene

cnc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in posterior cephalic patterning. Probable subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. Isoform B may have a repressive effect on Dfd response elements, thereby modifying the activity and specificity of the Hox system and moving the body anterior/posterior axis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-983231, Factors involved in megakaryocyte development and platelet production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P20482

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Segmentation protein cap'n'collar
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cnc
ORF Names:CG43286
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0262975, cnc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000764581 – 1383Segmentation protein cap'n'collarAdd BLAST1383

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20482

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Embryonic expression of isoform B is localized to the mandibular segment and the hypopharyngeal and labral primordia first detectable in late blastoderm stages. Embryonic expression of isoforms B and C is ubiquitous.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoforms A and C are maternally and zygotically expressed in embryos. Isoform A reduced between 2-12 hours embryos and then increases. Isoform B is expressed in later embryonic stages. Isoform C has the lowest expression level of the isoforms.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0262975, Expressed in arthropod fat body and 47 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P20482, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20482, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
67688, 42 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P20482

Protein interaction database and analysis system

More...
IntActi
P20482, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297671

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20482

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1195 – 1258bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1197 – 1234Basic motifPROSITE-ProRule annotationAdd BLAST38
Regioni1237 – 1258Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi588 – 616His-richAdd BLAST29
Compositional biasi1332 – 1379Gln-richAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3863, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20482

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPMIETQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20482

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004827, bZIP
IPR004826, bZIP_Maf
IPR008917, TF_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03131, bZIP_Maf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338, BRLZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47454, SSF47454, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: P20482-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISNKKSYAM KMLQLALALS LLHYNPDYLL HRWDSQLELG THGDGWELEM
60 70 80 90 100
LRTVHRLDMD HNPYGNRKGL SPRIEDLLNF DDPSLGGMAN GIGGCKLPPR
110 120 130 140 150
FNGSTFVMNL HNTTGNSSVQ TAALQDVQST SAAATGGTMV VGTGGAPTSG
160 170 180 190 200
GQTSGSALGE IHIDTASLDP GNANHSPLHP TSELDTFLTP HALQDQRSIW
210 220 230 240 250
EQNLADLYDY NDLSLQTSPY ANLPLKDGQP QPSNSSHLDL SLAALLHGFT
260 270 280 290 300
GGSGAPLSTA ALNDSTPHPR NLGSVTNNSA GRSDDGEESL YLGRLFGEDE
310 320 330 340 350
DEDYEGELIG GVANACEVEG LTTDEPFGSN CFANEVEIGD DEEESEIAEV
360 370 380 390 400
LYKQDVDLGF SLDQEAIINA SYASGNSAAT NVKSKPEDET KSSDPSISES
410 420 430 440 450
SGFKDTDVNA ENEASAASVD DIEKLKALEE LQQDKDKNNE NQLEDITNEW
460 470 480 490 500
NGIPFTIDNE TGEYIRLPLD ELLNDVLKLS EFPLQDDLSN DPVASTSQAA
510 520 530 540 550
AAFNENQAQR IVSETGEDLL SGEGISSKQN RNEAKNKDND PEKADGDSFS
560 570 580 590 600
VSDFEELQNS VGSPLFDLDE DAKKELDEML QSAVPSYHHP HPHHGHPHAH
610 620 630 640 650
PHSHHHASMH HAHAHHAAAA AAAHQRAVQQ ANYGGGVGVG VGVGVGVGSG
660 670 680 690 700
TGSAFQRQPA AGGFHHGHHQ GRMPRLNRSV SMERLQDFAT YFSPIPSMVG
710 720 730 740 750
GVSDMSPYPH HYPGYSYQAS PSNGAPGTPG QHGQYGSGAN ATLQPPPPPP
760 770 780 790 800
PPHHAAMLHH PNAALGDICP TGQPHYGHNL GSAVTSSMHL TNSSHEADGA
810 820 830 840 850
AAAAAAYKVE HDLMYYGNTS SDINQTDGFI NSIFTDEDLH LMDMNESFCR
860 870 880 890 900
MVDNSTSNNS SVLGLPSSGH VSNGSGSSAQ LGAGNPHGNQ ANGASGGVGS
910 920 930 940 950
MSGSAVGAGA TGMTADLLAS GGAGAQGGAD RLDASSDSAV SSMGSERVPS
960 970 980 990 1000
LSDGEWGEGS DSAQDYHQGK YGGPYDFSYN NNSRLSTATR QPPVAQKKHQ
1010 1020 1030 1040 1050
LYGKRDPHKQ TPSALPPTAP PAAATAVQSQ SIKYEYDAGY ASSGMASGGI
1060 1070 1080 1090 1100
SEPGAMGPAL SKDYHHHQPY GMGASGSAFS GDYTVRPSPR TSQDLVQLNH
1110 1120 1130 1140 1150
TYSLPQGSGS LPRPQARDKK PLVATKTASK GASAGNSSSV GGNSSNLEEE
1160 1170 1180 1190 1200
HLTRDEKRAR SLNIPISVPD IINLPMDEFN ERLSKYDLSE NQLSLIRDIR
1210 1220 1230 1240 1250
RRGKNKVAAQ NCRKRKLDQI LTLEDEVNAV VKRKTQLNQD RDHLESERKR
1260 1270 1280 1290 1300
ISNKFAMLHR HVFQYLRDPE GNPCSPADYS LQQAADGSVY LLPREKSEGN
1310 1320 1330 1340 1350
NTATAASNAV SSASGGSLNG HVPTQAPMHS HQSHGMQAQH VVGGMSQQQQ
1360 1370 1380
QQSRLPPHLQ QQHHLQSQQQ QPGGQQQQQH RKE
Length:1,383
Mass (Da):147,412
Last modified:March 1, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i014325A4DC1C45F7
GO
Isoform B (identifier: P20482-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-578: Missing.

Show »
Length:805
Mass (Da):85,162
Checksum:i89090FBBAEA82838
GO
Isoform A (identifier: P20482-3) [UniParc]FASTAAdd to basket
Also known as: D, E, F, G

The sequence of this isoform differs from the canonical sequence as follows:
     1-850: Missing.

Show »
Length:533
Mass (Da):56,532
Checksum:iE70C0C24CADD9D3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K6E1A0A0B4K6E1_DROME
Cap-n-collar, isoform J
cnc 5134, anon-WO0153538.6, anon-WO0153538.7, BcDNA:RE05559, CG13826
1,383Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHP5A0A0B4KHP5_DROME
Cap-n-collar, isoform O
cnc 5134, anon-WO0153538.6, anon-WO0153538.7, BcDNA:RE05559, CG13826
1,430Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGT0A0A0B4KGT0_DROME
Cap-n-collar, isoform P
cnc 5134, anon-WO0153538.6, anon-WO0153538.7, BcDNA:RE05559, CG13826
711Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6G8A0A0B4K6G8_DROME
Cap-n-collar, isoform F
cnc 5134, anon-WO0153538.6, anon-WO0153538.7, BcDNA:RE05559, CG13826
533Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6Z0A0A0B4K6Z0_DROME
Cap-n-collar, isoform I
cnc 5134, anon-WO0153538.6, anon-WO0153538.7, BcDNA:RE05559, CG13826
1,133Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC72898 differs from that shown. Reason: Frameshift.Curated
The sequence ABE01198 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence ACV32772 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137G → A in AAC72898 (PubMed:9778513).Curated1
Sequence conflicti150G → S in AAC72898 (PubMed:9778513).Curated1
Sequence conflicti301D → E in AAC72898 (PubMed:9778513).Curated1
Sequence conflicti309I → V in AAC72898 (PubMed:9778513).Curated1
Sequence conflicti309I → V in ABE01198 (Ref. 6) Curated1
Sequence conflicti370A → G in AAC72898 (PubMed:9778513).Curated1
Sequence conflicti583A → T in AAC72898 (PubMed:9778513).Curated1
Sequence conflicti583A → T in ACV32772 (Ref. 6) Curated1
Sequence conflicti928G → R in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti935S → T in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti980N → K in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti999H → Q in AAC72897 (PubMed:9778513).Curated1
Sequence conflicti1031S → R in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti1031S → R in AAC72897 (PubMed:9778513).Curated1
Sequence conflicti1076G → R in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti1076G → R in AAC72896 (PubMed:9778513).Curated1
Sequence conflicti1076G → R in AAC72897 (PubMed:9778513).Curated1
Sequence conflicti1076G → R in AAC72898 (PubMed:9778513).Curated1
Sequence conflicti1118D → H in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti1118D → H in AAC72897 (PubMed:9778513).Curated1
Sequence conflicti1199I → L in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti1275S → W in AAB59246 (PubMed:1911393).Curated1
Sequence conflicti1275S → W in AAC72897 (PubMed:9778513).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0094581 – 850Missing in isoform A. 3 PublicationsAdd BLAST850
Alternative sequenceiVSP_0094571 – 578Missing in isoform B. 2 PublicationsAdd BLAST578

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37495 mRNA Translation: AAB59246.1
AF070062 mRNA Translation: AAC72896.1
AF070063 mRNA Translation: AAC72897.1
AF070064 mRNA Translation: AAC72898.1 Frameshift.
AE014297 Genomic DNA Translation: AAF56108.1
AE014297 Genomic DNA Translation: AAF56109.2
AE014297 Genomic DNA Translation: AAF56111.2
AE014297 Genomic DNA Translation: AAN13930.1
AE014297 Genomic DNA Translation: AAN13931.1
AE014297 Genomic DNA Translation: AAN13932.1
AE014297 Genomic DNA Translation: AAN13933.1
AY061154 mRNA Translation: AAL28702.1
BT024968 mRNA Translation: ABE01198.1 Sequence problems.
BT099672 mRNA Translation: ACV32772.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
A33111
T13936

NCBI Reference Sequences

More...
RefSeqi
NP_001247256.1, NM_001260327.2 [P20482-3]
NP_001247257.1, NM_001260328.1 [P20482-3]
NP_001247259.1, NM_001260330.1 [P20482-1]
NP_001247260.1, NM_001260331.1 [P20482-1]
NP_732833.1, NM_170053.3 [P20482-1]
NP_732834.1, NM_170054.4 [P20482-2]
NP_732835.1, NM_170055.2 [P20482-3]
NP_732836.1, NM_170056.2 [P20482-3]
NP_732837.1, NM_170057.2 [P20482-3]
NP_732838.2, NM_170058.2
NP_732839.1, NM_170059.3 [P20482-3]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0306744; FBpp0297667; FBgn0262975 [P20482-3]
FBtr0306745; FBpp0297668; FBgn0262975 [P20482-3]
FBtr0306746; FBpp0297669; FBgn0262975 [P20482-3]
FBtr0306747; FBpp0297670; FBgn0262975 [P20482-3]
FBtr0306748; FBpp0297671; FBgn0262975 [P20482-1]
FBtr0306749; FBpp0297672; FBgn0262975 [P20482-2]
FBtr0306750; FBpp0297673; FBgn0262975 [P20482-3]
FBtr0306751; FBpp0297674; FBgn0262975 [P20482-3]
FBtr0306753; FBpp0297676; FBgn0262975 [P20482-1]
FBtr0306754; FBpp0297677; FBgn0262975 [P20482-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
42743

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG43286

UCSC genome browser

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UCSCi
CG17894-RD, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37495 mRNA Translation: AAB59246.1
AF070062 mRNA Translation: AAC72896.1
AF070063 mRNA Translation: AAC72897.1
AF070064 mRNA Translation: AAC72898.1 Frameshift.
AE014297 Genomic DNA Translation: AAF56108.1
AE014297 Genomic DNA Translation: AAF56109.2
AE014297 Genomic DNA Translation: AAF56111.2
AE014297 Genomic DNA Translation: AAN13930.1
AE014297 Genomic DNA Translation: AAN13931.1
AE014297 Genomic DNA Translation: AAN13932.1
AE014297 Genomic DNA Translation: AAN13933.1
AY061154 mRNA Translation: AAL28702.1
BT024968 mRNA Translation: ABE01198.1 Sequence problems.
BT099672 mRNA Translation: ACV32772.1 Different initiation.
PIRiA33111
T13936
RefSeqiNP_001247256.1, NM_001260327.2 [P20482-3]
NP_001247257.1, NM_001260328.1 [P20482-3]
NP_001247259.1, NM_001260330.1 [P20482-1]
NP_001247260.1, NM_001260331.1 [P20482-1]
NP_732833.1, NM_170053.3 [P20482-1]
NP_732834.1, NM_170054.4 [P20482-2]
NP_732835.1, NM_170055.2 [P20482-3]
NP_732836.1, NM_170056.2 [P20482-3]
NP_732837.1, NM_170057.2 [P20482-3]
NP_732838.2, NM_170058.2
NP_732839.1, NM_170059.3 [P20482-3]

3D structure databases

SMRiP20482
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi67688, 42 interactors
ELMiP20482
IntActiP20482, 8 interactors
STRINGi7227.FBpp0297671

Proteomic databases

PaxDbiP20482

Genome annotation databases

EnsemblMetazoaiFBtr0306744; FBpp0297667; FBgn0262975 [P20482-3]
FBtr0306745; FBpp0297668; FBgn0262975 [P20482-3]
FBtr0306746; FBpp0297669; FBgn0262975 [P20482-3]
FBtr0306747; FBpp0297670; FBgn0262975 [P20482-3]
FBtr0306748; FBpp0297671; FBgn0262975 [P20482-1]
FBtr0306749; FBpp0297672; FBgn0262975 [P20482-2]
FBtr0306750; FBpp0297673; FBgn0262975 [P20482-3]
FBtr0306751; FBpp0297674; FBgn0262975 [P20482-3]
FBtr0306753; FBpp0297676; FBgn0262975 [P20482-1]
FBtr0306754; FBpp0297677; FBgn0262975 [P20482-1]
GeneIDi42743
KEGGidme:Dmel_CG43286
UCSCiCG17894-RD, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42743
FlyBaseiFBgn0262975, cnc

Phylogenomic databases

eggNOGiKOG3863, Eukaryota
InParanoidiP20482
OMAiVPMIETQ
PhylomeDBiP20482

Enzyme and pathway databases

ReactomeiR-DME-983231, Factors involved in megakaryocyte development and platelet production
SignaLinkiP20482

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
42743, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
cnc, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42743

Protein Ontology

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PROi
PR:P20482

Gene expression databases

BgeeiFBgn0262975, Expressed in arthropod fat body and 47 other tissues
ExpressionAtlasiP20482, baseline and differential
GenevisibleiP20482, DM

Family and domain databases

InterProiView protein in InterPro
IPR004827, bZIP
IPR004826, bZIP_Maf
IPR008917, TF_DNA-bd_sf
PfamiView protein in Pfam
PF03131, bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
SUPFAMiSSF47454, SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20482
Secondary accession number(s): A4V398
, C7LAC2, O96506, Q1WWD8, Q9TZS3, Q9VCP6, Q9VCP8, Q9VCP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 1, 2004
Last modified: April 7, 2021
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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