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Protein

Buccalin

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulatory neuropeptide, acting presynaptically on nerve terminals to inhibit acetylcholine release.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAplysia californica (California sea hare)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6500 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiidaAplysioideaAplysiidaeAplysia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000188126 – 62Sequence analysisAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000188263 – 74Buccalin-DAdd BLAST12
PeptideiPRO_000000188378 – 88Buccalin-EAdd BLAST11
PeptideiPRO_000000188493 – 102Buccalin-F10
PeptideiPRO_0000001885106 – 116Buccalin-GAdd BLAST11
PeptideiPRO_0000001886120 – 129Buccalin-HSequence analysis10
PeptideiPRO_0000001887133 – 143Buccalin-AAdd BLAST11
PeptideiPRO_0000001888147 – 157Buccalin-AAdd BLAST11
PeptideiPRO_0000001889161 – 171Buccalin-AAdd BLAST11
PeptideiPRO_0000001890175 – 185Buccalin-AAdd BLAST11
PeptideiPRO_0000001891189 – 199Buccalin-AAdd BLAST11
PeptideiPRO_0000001892203 – 213Buccalin-AAdd BLAST11
PeptideiPRO_0000001893217 – 227Buccalin-ISequence analysisAdd BLAST11
PeptideiPRO_0000001894231 – 241Buccalin-JSequence analysisAdd BLAST11
PeptideiPRO_0000001895245 – 254Buccalin-KSequence analysis10
PeptideiPRO_0000001896258 – 267Buccalin-LSequence analysis10
PeptideiPRO_0000001897271 – 281Buccalin-JSequence analysisAdd BLAST11
PeptideiPRO_0000001898285 – 294Buccalin-LSequence analysis10
PeptideiPRO_0000001899298 – 307Buccalin-LSequence analysis10
PeptideiPRO_0000001900311 – 321Buccalin-BAdd BLAST11
PeptideiPRO_0000001901325 – 335Buccalin-MAdd BLAST11
PeptideiPRO_0000001902339 – 349Buccalin gene-predicted acidic peptide ASequence analysisAdd BLAST11
PeptideiPRO_0000001903353 – 363Buccalin-NAdd BLAST11
PeptideiPRO_0000001904367 – 377Buccalin-BAdd BLAST11
PeptideiPRO_0000001905381 – 391Buccalin-OSequence analysisAdd BLAST11
PeptideiPRO_0000001906396 – 405Buccalin-PSequence analysis10
PeptideiPRO_0000001907409 – 419Buccalin-QAdd BLAST11
PeptideiPRO_0000001908424 – 433Buccalin-R10
PeptideiPRO_0000001909437 – 447Buccalin-CAdd BLAST11
PeptideiPRO_0000001910451 – 461Buccalin-CAdd BLAST11
PeptideiPRO_0000001911465 – 475Buccalin-SAdd BLAST11
PeptideiPRO_0000001912479 – 492Buccalin gene-predicted acidic peptide BSequence analysisAdd BLAST14
PropeptideiPRO_0000001913495 – 505Sequence analysisAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei74Valine amide1 Publication1
Modified residuei88Leucine amide1 Publication1
Modified residuei102Leucine amide1 Publication1
Modified residuei106Pyrrolidone carboxylic acidSequence analysis1
Modified residuei116Isoleucine amide1 Publication1
Modified residuei129Leucine amide1 Publication1
Modified residuei143Leucine amide2 Publications1
Modified residuei157Leucine amide2 Publications1
Modified residuei171Leucine amide2 Publications1
Modified residuei185Leucine amide2 Publications1
Modified residuei199Leucine amide2 Publications1
Modified residuei213Leucine amide2 Publications1
Modified residuei227Leucine amide1 Publication1
Modified residuei241Leucine amide1 Publication1
Modified residuei254Leucine amide1 Publication1
Modified residuei267Leucine amide1 Publication1
Modified residuei281Leucine amide1 Publication1
Modified residuei294Leucine amide1 Publication1
Modified residuei307Leucine amide1 Publication1
Modified residuei321Leucine amide1 Publication1
Modified residuei335Leucine amide1 Publication1
Modified residuei349Glutamic acid 1-amide1 Publication1
Modified residuei363Leucine amide1 Publication1
Modified residuei377Leucine amide1 Publication1
Modified residuei391Leucine amide1 Publication1
Modified residuei405Leucine amide1 Publication1
Modified residuei419Leucine amide1 Publication1
Modified residuei433Leucine amide1 Publication1
Modified residuei447Isoleucine amide1 Publication1
Modified residuei461Isoleucine amide1 Publication1
Modified residuei465Pyrrolidone carboxylic acidSequence analysis1
Modified residuei475Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P20481

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cholinergic motor neuron B15 innervating buccal muscles in Aplysia.

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P20481-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHHRGHRHI LLYVSLALSL GLALAEDATD PSDDTGSFDD VEAVSEEADL
60 70 80 90 100
DPYSMSQELN KRPNVDPYSY LPSVGKRAFD HYGFTGGLGK RKIDHFGFVG
110 120 130 140 150
GLGKRQIDPL GFSGGIGKRY DSFAYSAGLG KRGMDSLAFS GGLGKRGMDS
160 170 180 190 200
LAFSGGLGKR GMDSLAFSGG LGKRGMDSLA FSGGLGKRGM DSLAFSGGLG
210 220 230 240 250
KRGMDSLAFS GGLGKRGMDS FTFAPGLGKR GMDSLAFAGG LGKRMDGFAF
260 270 280 290 300
APGLGKRMDS FAFAPGLGKR GMDSLAFAGG LGKRMDSFAF APGLGKRMDS
310 320 330 340 350
FAFAPGLGKR GLDRYGFVGG LGKRGMDHFA FTGGLGKRDS GEASGDLEEG
360 370 380 390 400
KRGLDAYSFT GALGKRGLDR YGFVGGLGKR GMDDFAFSPG LGKKRMDSFM
410 420 430 440 450
FGSRLGKRGM DRFSFSGHLG KRKMDQFSFG PGLGKRGFDH YGFTGGIGKR
460 470 480 490 500
GFDHYGFTGG IGKRQLDPML FSGRLGKRSS SEQEEEDVRQ VEKRSTTEEQ

SSKSL
Length:505
Mass (Da):53,517
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC17DB022C818D51
GO

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 1059.1±0.4 Da from positions 93 - 102. Determined by MALDI. 1 Publication
Molecular mass is 1101.6±0.0 Da from positions 106 - 116. Determined by MALDI. 1 Publication
Molecular mass is 1052.8±0.3 Da from positions 133 - 143. Determined by MALDI. Buccalin-A.1 Publication
Molecular mass is 1053.6±0.1 Da from positions 258 - 267. Determined by MALDI. 1 Publication
Molecular mass is 1151.9±0.3 Da from positions 311 - 321. Determined by MALDI. Buccalin-B.1 Publication
Molecular mass is 1150.6±0.1 Da from positions 325 - 335. Determined by MALDI. 1 Publication
Molecular mass is 1112.9±0.4 Da from positions 353 - 363. Determined by MALDI. 1 Publication
Molecular mass is 1251.6±0.0 Da from positions 409 - 419. Determined by MALDI. 1 Publication
Molecular mass is 1096.7±0.2 Da from positions 424 - 433. Determined by MALDI. 1 Publication
Molecular mass is 1168.7±0.2 Da from positions 437 - 447. Determined by MALDI. Buccalin-C.1 Publication
Molecular mass is 1274.9±0.2 Da from positions 465 - 475. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S64298 mRNA Translation: AAB27696.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A35594

NCBI Reference Sequences

More...
RefSeqi
NP_001191649.1, NM_001204720.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Acl.5094

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100533443

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64298 mRNA Translation: AAB27696.2
PIRiA35594
RefSeqiNP_001191649.1, NM_001204720.1
UniGeneiAcl.5094

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Proteomic databases

PRIDEiP20481

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533443

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBUCC_APLCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20481
Secondary accession number(s): Q9TWM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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