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Protein

Parvalbumin alpha

Gene

PVALB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:PVALB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100362.12
HGNCiHGNC:9704 PVALB
MIMi168890 gene
neXtProtiNX_P20472

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52D → A: Inactivation. 1 Publication1
Mutagenesisi63E → V: Inactivation. 1 Publication1
Mutagenesisi91D → A: Inactivation. 1 Publication1
Mutagenesisi102E → V: Inactivation. 1 Publication1

Organism-specific databases

DisGeNETi5816
OpenTargetsiENSG00000100362
PharmGKBiPA34049

Chemistry databases

DrugBankiDB01942 Formic Acid

Polymorphism and mutation databases

BioMutaiPVALB
DMDMi131100

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000735882 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP20472
PaxDbiP20472
PeptideAtlasiP20472
PRIDEiP20472
ProteomicsDBi53761

PTM databases

iPTMnetiP20472
PhosphoSitePlusiP20472

Expressioni

Gene expression databases

BgeeiENSG00000100362
CleanExiHS_PVALB
ExpressionAtlasiP20472 baseline and differential
GenevisibleiP20472 HS

Organism-specific databases

HPAiCAB002515
HPA048536

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111774, 1 interactor
STRINGi9606.ENSP00000216200

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni3 – 8Combined sources6
Helixi9 – 18Combined sources10
Beta strandi21 – 23Combined sources3
Helixi27 – 33Combined sources7
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Helixi61 – 64Combined sources4
Turni65 – 67Combined sources3
Helixi68 – 71Combined sources4
Helixi80 – 90Combined sources11
Beta strandi92 – 98Combined sources7
Helixi100 – 106Combined sources7
Turni107 – 109Combined sources3

3D structure databases

ProteinModelPortaliP20472
SMRiP20472
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20472

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP20472
OMAiAVDSFDH
OrthoDBiEOG091G0ZAO
PhylomeDBiP20472
TreeFamiTF332342

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDLLNAE DIKKAVGAFS ATDSFDHKKF FQMVGLKKKS ADDVKKVFHM
60 70 80 90 100
LDKDKSGFIE EDELGFILKG FSPDARDLSA KETKMLMAAG DKDGDGKIGV
110
DEFSTLVAES
Length:110
Mass (Da):12,059
Last modified:January 23, 2007 - v2
Checksum:i03ABDD22E24AEA11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4T → N in AAH96113 (PubMed:15489334).Curated1
Sequence conflicti99 – 100Missing in CAA45134 (PubMed:2614829).Curated2

Mass spectrometryi

Molecular mass is 11927±0.76 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63578 Genomic DNA Translation: CAA45134.1
X52695
, X52696, X52697, X52698 Genomic DNA Translation: CAA36924.1
X63070 mRNA Translation: CAA44792.1
CR456552 mRNA Translation: CAG30438.1
AK311832 mRNA Translation: BAG34774.1
Z82184 Genomic DNA No translation available.
Z82185 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60118.1
BC069300 mRNA Translation: AAH69300.1
BC096112 mRNA Translation: AAH96112.1
BC096113 mRNA Translation: AAH96113.1
BC096114 mRNA Translation: AAH96114.1
BC096115 mRNA Translation: AAH96115.1
CCDSiCCDS13933.1
PIRiS07531
RefSeqiNP_001302461.1, NM_001315532.1
NP_002845.1, NM_002854.2
UniGeneiHs.295449

Genome annotation databases

EnsembliENST00000216200; ENSP00000216200; ENSG00000100362
ENST00000417718; ENSP00000400247; ENSG00000100362
ENST00000620986; ENSP00000480913; ENSG00000274665
ENST00000625893; ENSP00000486144; ENSG00000274665
GeneIDi5816
KEGGihsa:5816
UCSCiuc003apx.4 human

Similar proteinsi

Entry informationi

Entry nameiPRVA_HUMAN
AccessioniPrimary (citable) accession number: P20472
Secondary accession number(s): B2R4H7
, P78378, Q4VB78, Q5R3Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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