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Entry version 83 (18 Sep 2019)
Sequence version 1 (01 Feb 1991)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Bunyamwera virus (BUNV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism. It consists in the hijacking and cleavage via N-terminal endonuclease activity of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are not polyadenylated. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi34Manganese 1; via tele nitrogenBy similarity1
Metal bindingi79Manganese 1By similarity1
Metal bindingi79Manganese 2By similarity1
Metal bindingi92Manganese 1By similarity1
Metal bindingi93Manganese 1; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processUbl conjugation pathway, Viral RNA replication
LigandManganese, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48, EC:3.1.-.-)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBunyamwera virus (BUNV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri35304 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPeribunyaviridaeOrthobunyavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Homo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002476 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002220201 – 2238RNA-directed RNA polymerase LAdd BLAST2238

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P20470

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimerizes; the oligomeric structure is essential for the polymerase activity.

Interacts with the nucleocapsid protein N.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20470

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1016 – 1207RdRp catalyticPROSITE-ProRule annotationAdd BLAST192

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal possesses an endonuclease domain that is essential for viral cap-dependent transcription.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
66at10239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029124 L_protein_N
IPR007099 RNA-dir_pol_NSvirus
IPR014384 RNA-dir_pol_orthobunyavirus
IPR007322 RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF15518 L_protein_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000824 L_OrthobunV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P20470-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDQAYDQYL HRIQAARTAT VAKDISADIL EARHDYFGRE LCNSLGIEYK
60 70 80 90 100
NNVLLDEIIL DVVPGVNLLN YNIPNVTPDN YIWDGHFLII LDYKVSVGND
110 120 130 140 150
SSEITYKKYT SLILPVMSEL GIDTEIAIIR ANPVTYQISI IGEEFKQRFP
160 170 180 190 200
NIPIQLDFGR FFELRKMLLD KFADDEEFLM MIAHGDFTLT APWCTSDTPE
210 220 230 240 250
LEEHEIFQEF INSMPPRFVS LFKEAVNFSA YSSERWNTFL YRARAETEVD
260 270 280 290 300
YNQFLSDKAH KIFMLEGDYM RPTQAEIDKG WELMSQRVYT EREIITDVTK
310 320 330 340 350
QKPSIHFIWV KNADRKLIGS TAKLIYLSNS LQSITEQSTW TDALKAIGKS
360 370 380 390 400
MDIDGKVGQY ETLCAERKMI ARSTGKKVDN KRLEAVKIGN ALVLWEQQFI
410 420 430 440 450
LANDLFKNQE RQKFMKNFFG IGKHKSFKDK TSSDIETDKP KILDFNNTIV
460 470 480 490 500
LMAARTMVNK NKALLAKDNT LQDLHPIIMQ YASEIKEASK DTFDALLKIS
510 520 530 540 550
KTCFWQCIVD VSTIMRNILA VSQYNRHNTF RVAMCANDSV YALVFPSSDI
560 570 580 590 600
KTKRATVVFS IVCMHKEKND LMDAGALFTT LECKNKEYIS ISKAIRLDKE
610 620 630 640 650
RCQRIVSSPG LFILSSMLLY NNNPEVNLVD VLNFTFYTSL SITKSMLSLT
660 670 680 690 700
EPSRYMIMNS LAISSHVRDY IAEKFSPYTK TLFSVYMVNL IKRGCASANE
710 720 730 740 750
QSSKIQLRNI YLSDYDITQK GVNDGRNLDS IWFPGKVNLK EYINQIYLPF
760 770 780 790 800
YFNAKGLHEK HHVMIDLAKT VLEIEMNQRS DNLGIWSKAE KKQHVNLPIL
810 820 830 840 850
IHSIAKSLIL DTSRHNHLRN RVESRNNFRR SITTISTFTS SKSCIKIGDF
860 870 880 890 900
REIKDKETEK SKKSTEKFDK KFRLSNPLFL EDEEANLEVQ HCNYRALIQK
910 920 930 940 950
IPNYKDYISV KVFDRLYELL KNGVLTDKPF IELAMEMMKN HKEFSFTFFN
960 970 980 990 1000
KGQKTAKDRE IFVGEFEAKM CMYVVERISK ERCKLNTDEM ISEPGDSKLK
1010 1020 1030 1040 1050
ILEKKAEEEI RYIVERTKDS IIKGDPSKAL KLEINADMSK WSAQDVFYKY
1060 1070 1080 1090 1100
FWLIAMDPIL YPAEKTRILY FMCNYMQKLL ILPDDLIANI LDQKRPYNDD
1110 1120 1130 1140 1150
LILEMTNGLN YNYVQIKRNW LQGNFNYISS YVHSCAMLVY KDILKECMKL
1160 1170 1180 1190 1200
LDGDCLINSM VHSDDNQTSL AIIQNKVSDQ IVIQYAANTF ESVCLTFGCQ
1210 1220 1230 1240 1250
ANMKKTYITH TCKEFVSLFN LHGEPLSVFG RFLLPSVGDC AYIGPYEDLA
1260 1270 1280 1290 1300
SRLSAAQQSL KHGCPPSLVW LAISCSHWIT FFTYNMLDDQ INAPQQHLPF
1310 1320 1330 1340 1350
NNRKEIPVEL NGYLNAPLYL IALVGLEAGN LWFLINILKK LVPLDKQKET
1360 1370 1380 1390 1400
IQSQCLHLCN SIDKLTESEK FKLKILRYLT LDTEMSVDNN MGETSDMRSR
1410 1420 1430 1440 1450
SLLTPRKFTT LGSLNKLVSY NDFRSSLDDQ RFTDNLNFML NNPELLVTKG
1460 1470 1480 1490 1500
ENKEQFMQSV LFRYNSKRFK ESLSIQNPAQ LFIEQILFSH KPIIDYSSIF
1510 1520 1530 1540 1550
DKLTSLAEAD IIEELPEIIG RVTFPQAYQM INRDIGQLPL DIDDIKLIFR
1560 1570 1580 1590 1600
YCILNDPLMI TAANTSLLCV KGTPQDRTGL SASQMPEFRN MKLIHHSPAL
1610 1620 1630 1640 1650
VLKAFSKGTS DIPGADPIEL EKDLHHLNEF VETTAIKEKI LHNIDNPPKH
1660 1670 1680 1690 1700
LIGNEILIYR IREMTKLYQV CYDYVKSTEH KVKIFILPMK SYTAIDFCTL
1710 1720 1730 1740 1750
IQGNTISDNK WYTMHYLKQI ASGSIKGNIV TTSTSEQIIA NECFRVLCHF
1760 1770 1780 1790 1800
ADSFVEEASR LSFINEVLDN FTYKNISVNS LFNTLLASTT RLDFIPLLFR
1810 1820 1830 1840 1850
LKVLTQTDLN RFDALKTNER VSWNNWQTNR SLNSGLIDLT ISGYLRSIRV
1860 1870 1880 1890 1900
VGEDNKLKIA ELTIPNFYPN TVFHAGNKLL NSRHGLKFEY MEEIVLDEKY
1910 1920 1930 1940 1950
NYYITYQKKR AHIYTYQVST IEHILRRNNE GLQSRGPRYN KMVPVCPVVL
1960 1970 1980 1990 2000
SVRDELFRMS LENVFSLNMT NFSMSRLFVS PDEVATVKKA HMSKMMFFSG
2010 2020 2030 2040 2050
PTIKAGIINL TSLMRTQELL TLNYDNLCKS SIVPFCRILE CNGDEQGELI
2060 2070 2080 2090 2100
FLSDEVMDFT ISEEIESMPL FTIRYQKRGT EIMTYKNAIM KLVSAGVDEI
2110 2120 2130 2140 2150
KEVFDFSKQG FYSKKNLGII NTICSIINIL ETNEWSTILY NSFHIAMLLE
2160 2170 2180 2190 2200
SMDREFHMFT LPEAFFINVA GGVVNWTKLL KFIKSLPVIE QEPWSMMMSR
2210 2220 2230
FVEKTVYLIE REMNKDVDFT DFLDELEFSS GKSLFTFF
Length:2,238
Mass (Da):258,670
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1ED00AB156BAC8DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14383 Genomic RNA Translation: CAA32553.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A33744 RRVUBY

NCBI Reference Sequences

More...
RefSeqi
NP_047211.1, NC_001925.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2648215

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:2648215

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14383 Genomic RNA Translation: CAA32553.1
PIRiA33744 RRVUBY
RefSeqiNP_047211.1, NC_001925.1

3D structure databases

SMRiP20470
ModBaseiSearch...

Proteomic databases

PRIDEiP20470

Genome annotation databases

GeneIDi2648215
KEGGivg:2648215

Phylogenomic databases

OrthoDBi66at10239

Family and domain databases

InterProiView protein in InterPro
IPR029124 L_protein_N
IPR007099 RNA-dir_pol_NSvirus
IPR014384 RNA-dir_pol_orthobunyavirus
IPR007322 RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF15518 L_protein_N, 1 hit
PIRSFiPIRSF000824 L_OrthobunV, 1 hit
PROSITEiView protein in PROSITE
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_BUNYW
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20470
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 18, 2019
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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