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Entry version 193 (13 Feb 2019)
Sequence version 1 (01 Feb 1991)
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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC3

Gene

RPB8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerases catalyze the transcription. of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.3 Publications

Miscellaneous

Present with 6210 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processRibosome biogenesis, Transcription

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-33723-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-SCE-113418 Formation of the Early Elongation Complex
R-SCE-674695 RNA Polymerase II Pre-transcription Events
R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER
R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SCE-6807505 RNA polymerase II transcribes snRNA genes
R-SCE-72086 mRNA Capping
R-SCE-72165 mRNA Splicing - Minor Pathway
R-SCE-73762 RNA Polymerase I Transcription Initiation
R-SCE-73776 RNA Polymerase II Promoter Escape
R-SCE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SCE-75953 RNA Polymerase II Transcription Initiation
R-SCE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SCE-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-SCE-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Short name:
RNA polymerases I, II, and III subunit ABC3
Alternative name(s):
ABC14.4
ABC14.5
DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPB8
Ordered Locus Names:YOR224C
ORF Names:YOR50-14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YOR224C

Saccharomyces Genome Database

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SGDi
S000005750 RPB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000740012 – 146DNA-directed RNA polymerases I, II, and III subunit RPABC3Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei68PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P20436

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P20436

PRoteomics IDEntifications database

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PRIDEi
P20436

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P20436

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Directly interacts with POLR2A.7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34618, 214 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1664 DNA-directed RNA Polymerase I complex
CPX-2660 DNA-directed RNA polymerase III complex
CPX-2662 DNA-directed RNA polymerase II complex

Database of interacting proteins

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DIPi
DIP-2195N

Protein interaction database and analysis system

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IntActi
P20436, 28 interactors

Molecular INTeraction database

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MINTi
P20436

STRING: functional protein association networks

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STRINGi
4932.YOR224C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A1DNMR-A1-146[»]
1I3QX-ray3.10H1-146[»]
1I50X-ray2.80H1-146[»]
1I6HX-ray3.30H1-146[»]
1K83X-ray2.80H1-146[»]
1NIKX-ray4.10H1-146[»]
1NT9X-ray4.20H1-146[»]
1PQVX-ray3.80H1-146[»]
1R5UX-ray4.50H1-146[»]
1R9SX-ray4.25H1-146[»]
1R9TX-ray3.50H1-146[»]
1SFOX-ray3.61H1-146[»]
1TWAX-ray3.20H1-146[»]
1TWCX-ray3.00H1-146[»]
1TWFX-ray2.30H1-146[»]
1TWGX-ray3.30H1-146[»]
1TWHX-ray3.40H1-146[»]
1WCMX-ray3.80H1-146[»]
1Y1VX-ray3.80H1-146[»]
1Y1WX-ray4.00H1-146[»]
1Y1YX-ray4.00H1-146[»]
1Y77X-ray4.50H1-146[»]
2B63X-ray3.80H1-146[»]
2B8KX-ray4.15H1-146[»]
2E2HX-ray3.95H1-146[»]
2E2IX-ray3.41H1-146[»]
2E2JX-ray3.50H1-146[»]
2JA5X-ray3.80H1-146[»]
2JA6X-ray4.00H1-146[»]
2JA7X-ray3.80H/T1-146[»]
2JA8X-ray3.80H1-146[»]
2NVQX-ray2.90H1-146[»]
2NVTX-ray3.36H1-146[»]
2NVXX-ray3.60H1-146[»]
2NVYX-ray3.40H1-146[»]
2NVZX-ray4.30H1-146[»]
2R7ZX-ray3.80H1-146[»]
2R92X-ray3.80H1-146[»]
2R93X-ray4.00H1-146[»]
2VUMX-ray3.40H1-146[»]
2YU9X-ray3.40H1-146[»]
3CQZX-ray2.80H1-146[»]
3FKIX-ray3.88H1-146[»]
3GTGX-ray3.78H1-146[»]
3GTJX-ray3.42H1-146[»]
3GTKX-ray3.80H1-146[»]
3GTLX-ray3.38H1-146[»]
3GTMX-ray3.80H1-146[»]
3GTOX-ray4.00H1-146[»]
3GTPX-ray3.90H1-146[»]
3GTQX-ray3.80H1-146[»]
3H3VX-ray4.00I1-146[»]
3HOUX-ray3.20H/T1-146[»]
3HOVX-ray3.50H1-146[»]
3HOWX-ray3.60H1-146[»]
3HOXX-ray3.65H1-146[»]
3HOYX-ray3.40H1-146[»]
3HOZX-ray3.65H1-146[»]
3I4MX-ray3.70H1-146[»]
3I4NX-ray3.90H1-146[»]
3J0Kelectron microscopy36.00H1-146[»]
3J1Nelectron microscopy16.00H1-146[»]
3K1FX-ray4.30H1-146[»]
3K7AX-ray3.80H1-146[»]
3M3YX-ray3.18H1-146[»]
3M4OX-ray3.57H1-146[»]
3PO2X-ray3.30H1-146[»]
3PO3X-ray3.30H1-146[»]
3QT1X-ray4.30H1-146[»]
3RZDX-ray3.30H1-146[»]
3RZOX-ray3.00H1-146[»]
3S14X-ray2.85H1-146[»]
3S15X-ray3.30H1-146[»]
3S16X-ray3.24H1-146[»]
3S17X-ray3.20H1-146[»]
3S1MX-ray3.13H1-146[»]
3S1NX-ray3.10H1-146[»]
3S1QX-ray3.30H1-146[»]
3S1RX-ray3.20H1-146[»]
3S2DX-ray3.20H1-146[»]
3S2HX-ray3.30H1-146[»]
4A3BX-ray3.50H1-146[»]
4A3CX-ray3.50H1-146[»]
4A3DX-ray3.40H1-146[»]
4A3EX-ray3.40H1-146[»]
4A3FX-ray3.50H1-146[»]
4A3GX-ray3.50H1-146[»]
4A3IX-ray3.80H1-146[»]
4A3JX-ray3.70H1-146[»]
4A3KX-ray3.50H1-146[»]
4A3LX-ray3.50H1-146[»]
4A3MX-ray3.90H1-146[»]
4A93X-ray3.40H1-146[»]
4BBRX-ray3.40H1-146[»]
4BBSX-ray3.60H1-146[»]
4BXXX-ray3.28H1-146[»]
4BXZX-ray4.80H1-146[»]
4BY1X-ray3.60H1-146[»]
4BY7X-ray3.15H1-146[»]
4C2MX-ray2.80H/W1-146[»]
4C3HX-ray3.27H1-146[»]
4C3IX-ray3.0H1-146[»]
4C3JX-ray3.35H1-146[»]
4V1Melectron microscopy6.60H1-146[»]
4V1Nelectron microscopy7.80H1-146[»]
4V1Oelectron microscopy9.70H1-146[»]
4X67X-ray4.10H1-146[»]
4X6AX-ray3.96H1-146[»]
4Y52X-ray3.50H1-146[»]
4Y7NX-ray3.30H1-146[»]
4YM7X-ray5.50AH/BH/CH/DH/EH/FH1-146[»]
5C3EX-ray3.70H1-146[»]
5C44X-ray3.95H1-146[»]
5C4AX-ray4.20H1-146[»]
5C4JX-ray4.00H1-146[»]
5C4XX-ray4.00H1-146[»]
5FJ8electron microscopy3.90H1-146[»]
5FJ9electron microscopy4.60H1-146[»]
5FJAelectron microscopy4.65H1-146[»]
5FMFelectron microscopy6.00H1-146[»]
5FYWelectron microscopy4.35H1-146[»]
5FZ5electron microscopy8.80H1-146[»]
5G5Lelectron microscopy4.80H1-146[»]
5IP7X-ray3.52H2-146[»]
5IP9X-ray3.90H2-146[»]
5LMXelectron microscopy4.90H1-146[»]
5M3Felectron microscopy3.80H1-146[»]
5M3Melectron microscopy4.00H1-146[»]
5M5Welectron microscopy3.80H1-146[»]
5M5Xelectron microscopy4.00H1-146[»]
5M5Yelectron microscopy4.00H1-146[»]
5M64electron microscopy4.60H1-146[»]
5N5Yelectron microscopy7.70H1-146[»]
5N5Zelectron microscopy7.70H1-146[»]
5N60electron microscopy7.70H1-146[»]
5N61electron microscopy3.40H1-146[»]
5OA1electron microscopy4.40H1-146[»]
5OQJelectron microscopy4.70H1-146[»]
5OQMelectron microscopy5.80H1-146[»]
5OT2X-ray3.20H1-146[»]
5SVAelectron microscopy15.30H1-146[»]
5U5QX-ray3.80H1-146[»]
5VVRelectron microscopy5.80H1-146[»]
5VVSelectron microscopy6.40H1-146[»]
5W4UX-ray3.60H1-146[»]
5W51X-ray3.40H1-146[»]
5W5Yelectron microscopy3.80H1-146[»]
5W64electron microscopy4.20H1-146[»]
5W65electron microscopy4.30H1-146[»]
5W66electron microscopy3.90H1-146[»]
6BLOX-ray3.40H1-146[»]
6BLPX-ray3.20H1-146[»]
6BM2X-ray3.40H1-146[»]
6BM4X-ray2.95H1-146[»]
6BQFX-ray3.35H1-146[»]
6CNBelectron microscopy4.10H1-146[»]
6CNCelectron microscopy4.10H1-146[»]
6CNDelectron microscopy4.80H1-146[»]
6CNFelectron microscopy4.50H1-146[»]
6EU0electron microscopy4.00H1-146[»]
6EU1electron microscopy3.40H1-146[»]
6EU2electron microscopy3.40H1-146[»]
6EU3electron microscopy3.30H1-146[»]
6F40electron microscopy3.70H1-146[»]
6F41electron microscopy4.30H1-146[»]
6F42electron microscopy5.50H1-146[»]
6F44electron microscopy4.20H1-146[»]
6GYKelectron microscopy5.10H1-146[»]
6GYLelectron microscopy4.80H1-146[»]
6GYMelectron microscopy6.70H1-146[»]
6H67electron microscopy3.60H1-146[»]
6H68electron microscopy4.60H1-146[»]
6I84electron microscopy4.40H1-146[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P20436

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20436

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P20436

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 39Non-specific ssDNA bindingBy similarityAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018195

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000175572

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20436

KEGG Orthology (KO)

More...
KOi
K03016

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLLMCLE

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012340 NA-bd_OB-fold
IPR005570 RNA_pol_Rpb8

The PANTHER Classification System

More...
PANTHERi
PTHR10917 PTHR10917, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03870 RNA_pol_Rpb8, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000779 RNA_pol_Rpb8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00658 RPOL8c, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249 SSF50249, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P20436-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNTLFDDIF QVSEVDPGRY NKVCRIEAAS TTQDQCKLTL DINVELFPVA
60 70 80 90 100
AQDSLTVTIA SSLNLEDTPA NDSSATRSWR PPQAGDRSLA DDYDYVMYGT
110 120 130 140
AYKFEEVSKD LIAVYYSFGG LLMRLEGNYR NLNNLKQENA YLLIRR
Length:146
Mass (Da):16,511
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B71693FE6FD8863
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X53289 Genomic DNA Translation: CAA37383.1
X92441 Genomic DNA Translation: CAA63187.1
Z75132 Genomic DNA Translation: CAA99443.1
AY693087 Genomic DNA Translation: AAT93106.1
BK006948 Genomic DNA Translation: DAA10995.1

Protein sequence database of the Protein Information Resource

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PIRi
C34588

NCBI Reference Sequences

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RefSeqi
NP_014867.1, NM_001183643.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YOR224C_mRNA; YOR224C_mRNA; YOR224C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR224C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53289 Genomic DNA Translation: CAA37383.1
X92441 Genomic DNA Translation: CAA63187.1
Z75132 Genomic DNA Translation: CAA99443.1
AY693087 Genomic DNA Translation: AAT93106.1
BK006948 Genomic DNA Translation: DAA10995.1
PIRiC34588
RefSeqiNP_014867.1, NM_001183643.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A1DNMR-A1-146[»]
1I3QX-ray3.10H1-146[»]
1I50X-ray2.80H1-146[»]
1I6HX-ray3.30H1-146[»]
1K83X-ray2.80H1-146[»]
1NIKX-ray4.10H1-146[»]
1NT9X-ray4.20H1-146[»]
1PQVX-ray3.80H1-146[»]
1R5UX-ray4.50H1-146[»]
1R9SX-ray4.25H1-146[»]
1R9TX-ray3.50H1-146[»]
1SFOX-ray3.61H1-146[»]
1TWAX-ray3.20H1-146[»]
1TWCX-ray3.00H1-146[»]
1TWFX-ray2.30H1-146[»]
1TWGX-ray3.30H1-146[»]
1TWHX-ray3.40H1-146[»]
1WCMX-ray3.80H1-146[»]
1Y1VX-ray3.80H1-146[»]
1Y1WX-ray4.00H1-146[»]
1Y1YX-ray4.00H1-146[»]
1Y77X-ray4.50H1-146[»]
2B63X-ray3.80H1-146[»]
2B8KX-ray4.15H1-146[»]
2E2HX-ray3.95H1-146[»]
2E2IX-ray3.41H1-146[»]
2E2JX-ray3.50H1-146[»]
2JA5X-ray3.80H1-146[»]
2JA6X-ray4.00H1-146[»]
2JA7X-ray3.80H/T1-146[»]
2JA8X-ray3.80H1-146[»]
2NVQX-ray2.90H1-146[»]
2NVTX-ray3.36H1-146[»]
2NVXX-ray3.60H1-146[»]
2NVYX-ray3.40H1-146[»]
2NVZX-ray4.30H1-146[»]
2R7ZX-ray3.80H1-146[»]
2R92X-ray3.80H1-146[»]
2R93X-ray4.00H1-146[»]
2VUMX-ray3.40H1-146[»]
2YU9X-ray3.40H1-146[»]
3CQZX-ray2.80H1-146[»]
3FKIX-ray3.88H1-146[»]
3GTGX-ray3.78H1-146[»]
3GTJX-ray3.42H1-146[»]
3GTKX-ray3.80H1-146[»]
3GTLX-ray3.38H1-146[»]
3GTMX-ray3.80H1-146[»]
3GTOX-ray4.00H1-146[»]
3GTPX-ray3.90H1-146[»]
3GTQX-ray3.80H1-146[»]
3H3VX-ray4.00I1-146[»]
3HOUX-ray3.20H/T1-146[»]
3HOVX-ray3.50H1-146[»]
3HOWX-ray3.60H1-146[»]
3HOXX-ray3.65H1-146[»]
3HOYX-ray3.40H1-146[»]
3HOZX-ray3.65H1-146[»]
3I4MX-ray3.70H1-146[»]
3I4NX-ray3.90H1-146[»]
3J0Kelectron microscopy36.00H1-146[»]
3J1Nelectron microscopy16.00H1-146[»]
3K1FX-ray4.30H1-146[»]
3K7AX-ray3.80H1-146[»]
3M3YX-ray3.18H1-146[»]
3M4OX-ray3.57H1-146[»]
3PO2X-ray3.30H1-146[»]
3PO3X-ray3.30H1-146[»]
3QT1X-ray4.30H1-146[»]
3RZDX-ray3.30H1-146[»]
3RZOX-ray3.00H1-146[»]
3S14X-ray2.85H1-146[»]
3S15X-ray3.30H1-146[»]
3S16X-ray3.24H1-146[»]
3S17X-ray3.20H1-146[»]
3S1MX-ray3.13H1-146[»]
3S1NX-ray3.10H1-146[»]
3S1QX-ray3.30H1-146[»]
3S1RX-ray3.20H1-146[»]
3S2DX-ray3.20H1-146[»]
3S2HX-ray3.30H1-146[»]
4A3BX-ray3.50H1-146[»]
4A3CX-ray3.50H1-146[»]
4A3DX-ray3.40H1-146[»]
4A3EX-ray3.40H1-146[»]
4A3FX-ray3.50H1-146[»]
4A3GX-ray3.50H1-146[»]
4A3IX-ray3.80H1-146[»]
4A3JX-ray3.70H1-146[»]
4A3KX-ray3.50H1-146[»]
4A3LX-ray3.50H1-146[»]
4A3MX-ray3.90H1-146[»]
4A93X-ray3.40H1-146[»]
4BBRX-ray3.40H1-146[»]
4BBSX-ray3.60H1-146[»]
4BXXX-ray3.28H1-146[»]
4BXZX-ray4.80H1-146[»]
4BY1X-ray3.60H1-146[»]
4BY7X-ray3.15H1-146[»]
4C2MX-ray2.80H/W1-146[»]
4C3HX-ray3.27H1-146[»]
4C3IX-ray3.0H1-146[»]
4C3JX-ray3.35H1-146[»]
4V1Melectron microscopy6.60H1-146[»]
4V1Nelectron microscopy7.80H1-146[»]
4V1Oelectron microscopy9.70H1-146[»]
4X67X-ray4.10H1-146[»]
4X6AX-ray3.96H1-146[»]
4Y52X-ray3.50H1-146[»]
4Y7NX-ray3.30H1-146[»]
4YM7X-ray5.50AH/BH/CH/DH/EH/FH1-146[»]
5C3EX-ray3.70H1-146[»]
5C44X-ray3.95H1-146[»]
5C4AX-ray4.20H1-146[»]
5C4JX-ray4.00H1-146[»]
5C4XX-ray4.00H1-146[»]
5FJ8electron microscopy3.90H1-146[»]
5FJ9electron microscopy4.60H1-146[»]
5FJAelectron microscopy4.65H1-146[»]
5FMFelectron microscopy6.00H1-146[»]
5FYWelectron microscopy4.35H1-146[»]
5FZ5electron microscopy8.80H1-146[»]
5G5Lelectron microscopy4.80H1-146[»]
5IP7X-ray3.52H2-146[»]
5IP9X-ray3.90H2-146[»]
5LMXelectron microscopy4.90H1-146[»]
5M3Felectron microscopy3.80H1-146[»]
5M3Melectron microscopy4.00H1-146[»]
5M5Welectron microscopy3.80H1-146[»]
5M5Xelectron microscopy4.00H1-146[»]
5M5Yelectron microscopy4.00H1-146[»]
5M64electron microscopy4.60H1-146[»]
5N5Yelectron microscopy7.70H1-146[»]
5N5Zelectron microscopy7.70H1-146[»]
5N60electron microscopy7.70H1-146[»]
5N61electron microscopy3.40H1-146[»]
5OA1electron microscopy4.40H1-146[»]
5OQJelectron microscopy4.70H1-146[»]
5OQMelectron microscopy5.80H1-146[»]
5OT2X-ray3.20H1-146[»]
5SVAelectron microscopy15.30H1-146[»]
5U5QX-ray3.80H1-146[»]
5VVRelectron microscopy5.80H1-146[»]
5VVSelectron microscopy6.40H1-146[»]
5W4UX-ray3.60H1-146[»]
5W51X-ray3.40H1-146[»]
5W5Yelectron microscopy3.80H1-146[»]
5W64electron microscopy4.20H1-146[»]
5W65electron microscopy4.30H1-146[»]
5W66electron microscopy3.90H1-146[»]
6BLOX-ray3.40H1-146[»]
6BLPX-ray3.20H1-146[»]
6BM2X-ray3.40H1-146[»]
6BM4X-ray2.95H1-146[»]
6BQFX-ray3.35H1-146[»]
6CNBelectron microscopy4.10H1-146[»]
6CNCelectron microscopy4.10H1-146[»]
6CNDelectron microscopy4.80H1-146[»]
6CNFelectron microscopy4.50H1-146[»]
6EU0electron microscopy4.00H1-146[»]
6EU1electron microscopy3.40H1-146[»]
6EU2electron microscopy3.40H1-146[»]
6EU3electron microscopy3.30H1-146[»]
6F40electron microscopy3.70H1-146[»]
6F41electron microscopy4.30H1-146[»]
6F42electron microscopy5.50H1-146[»]
6F44electron microscopy4.20H1-146[»]
6GYKelectron microscopy5.10H1-146[»]
6GYLelectron microscopy4.80H1-146[»]
6GYMelectron microscopy6.70H1-146[»]
6H67electron microscopy3.60H1-146[»]
6H68electron microscopy4.60H1-146[»]
6I84electron microscopy4.40H1-146[»]
ProteinModelPortaliP20436
SMRiP20436
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34618, 214 interactors
ComplexPortaliCPX-1664 DNA-directed RNA Polymerase I complex
CPX-2660 DNA-directed RNA polymerase III complex
CPX-2662 DNA-directed RNA polymerase II complex
DIPiDIP-2195N
IntActiP20436, 28 interactors
MINTiP20436
STRINGi4932.YOR224C

PTM databases

iPTMnetiP20436

Proteomic databases

MaxQBiP20436
PaxDbiP20436
PRIDEiP20436

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR224C_mRNA; YOR224C_mRNA; YOR224C
GeneIDi854399
KEGGisce:YOR224C

Organism-specific databases

EuPathDBiFungiDB:YOR224C
SGDiS000005750 RPB8

Phylogenomic databases

GeneTreeiENSGT00390000018195
HOGENOMiHOG000175572
InParanoidiP20436
KOiK03016
OMAiGLLMCLE

Enzyme and pathway databases

BioCyciYEAST:G3O-33723-MONOMER
ReactomeiR-SCE-113418 Formation of the Early Elongation Complex
R-SCE-674695 RNA Polymerase II Pre-transcription Events
R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER
R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SCE-6807505 RNA polymerase II transcribes snRNA genes
R-SCE-72086 mRNA Capping
R-SCE-72165 mRNA Splicing - Minor Pathway
R-SCE-73762 RNA Polymerase I Transcription Initiation
R-SCE-73776 RNA Polymerase II Promoter Escape
R-SCE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SCE-75953 RNA Polymerase II Transcription Initiation
R-SCE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SCE-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-SCE-9018519 Estrogen-dependent gene expression

Miscellaneous databases

EvolutionaryTraceiP20436

Protein Ontology

More...
PROi
PR:P20436

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR005570 RNA_pol_Rpb8
PANTHERiPTHR10917 PTHR10917, 1 hit
PfamiView protein in Pfam
PF03870 RNA_pol_Rpb8, 1 hit
PIRSFiPIRSF000779 RNA_pol_Rpb8, 1 hit
SMARTiView protein in SMART
SM00658 RPOL8c, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPAB3_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20436
Secondary accession number(s): D6W2S9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 13, 2019
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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