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Protein

Neuronal acetylcholine receptor subunit alpha-5

Gene

Chrna5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine binding Source: RGD
  • acetylcholine-gated cation-selective channel activity Source: RGD
  • protein heterodimerization activity Source: RGD
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-5
Gene namesi
Name:Chrna5
Synonyms:Acra5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2347 Chrna5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 239ExtracellularSequence analysisAdd BLAST212
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 414CytoplasmicSequence analysisAdd BLAST92
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 452ExtracellularSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094110

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000035828 – 452Neuronal acetylcholine receptor subunit alpha-5Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 169By similarity
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi219 ↔ 220Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20420
PRIDEiP20420

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Chrna4P094836EBI-10828372,EBI-7842410

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-190 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2
CPX-208 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4
CPX-215 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2
IntActiP20420, 3 interactors
STRINGi10116.ENSRNOP00000062227

Chemistry databases

BindingDBiP20420

Structurei

3D structure databases

ProteinModelPortaliP20420
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP20420
PhylomeDBiP20420

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P20420-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQLLAGRWR PTGARRGTRG GLPELSSAAK HEDSLFRDLF EDYERWVRPV
60 70 80 90 100
EHLSDKIKIK FGLAISQLVD VDEKNQLMTT NVWLKQEWID VKLRWNPDDY
110 120 130 140 150
GGIKIIRVPS DSLWIPDIVL FDNADGRFEG ASTKTVVRYN GTVTWTQPAN
160 170 180 190 200
YKSSCTIDVT FFPFDLQNCS MKFGSWTYDG SQVDIILEDQ DVDRTDFFDN
210 220 230 240 250
GEWEIMSAMG SKGNRTDSCC WYPYITYSFV IKRLPLFYTL FLIIPCIGLS
260 270 280 290 300
FLTVVVFYLP SNEGEKISLC TSVLVSLTVF LLVIEEIIPS SSKVIPLIGE
310 320 330 340 350
YLVFTMIFVT LSIMVTVFAI NIHHRSSSTH NAMAPWVRKI FLHKLPKLLC
360 370 380 390 400
MRSHADRYFT QREEAESGAG PKSRNTLEAA LDCIRYITRH VVKENDVREV
410 420 430 440 450
VEDWKFIAQV LDRMFLWTFL LVSIIGTLGL FVPVIYKWAN IIVPVHIGNT

IK
Length:452
Mass (Da):51,874
Last modified:February 1, 1991 - v1
Checksum:i7CEB24553936B2E7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PW50Q6PW50_RAT
Neuronal acetylcholine receptor sub...
Chrna5
452Annotation score:
A0A1B0GWL2A0A1B0GWL2_RAT
Neuronal acetylcholine receptor sub...
Chrna5
348Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05231 mRNA Translation: AAA74475.1
PIRiA35721
UniGeneiRn.40125

Genome annotation databases

UCSCiRGD:2347 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05231 mRNA Translation: AAA74475.1
PIRiA35721
UniGeneiRn.40125

3D structure databases

ProteinModelPortaliP20420
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-190 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2
CPX-208 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4
CPX-215 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2
IntActiP20420, 3 interactors
STRINGi10116.ENSRNOP00000062227

Chemistry databases

BindingDBiP20420
ChEMBLiCHEMBL2094110

Proteomic databases

PaxDbiP20420
PRIDEiP20420

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2347 rat

Organism-specific databases

RGDi2347 Chrna5

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP20420
PhylomeDBiP20420

Miscellaneous databases

PROiPR:P20420

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHA5_RAT
AccessioniPrimary (citable) accession number: P20420
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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