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Protein

Pro-thyrotropin-releasing hormone

Gene

TRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.1 Publication

GO - Molecular functioni

  • thyrotropin-releasing hormone activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-thyrotropin-releasing hormone
Short name:
Pro-TRH
Alternative name(s):
Prothyroliberin
Cleaved into the following chain:
Alternative name(s):
Protirelin
TSH-releasing factor
Thyroliberin
Thyrotropin-releasing factor
Short name:
TRF
Gene namesi
Name:TRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000170893.3
HGNCiHGNC:12298 TRH
MIMi613879 gene
neXtProtiNX_P20396

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7200
MalaCardsiTRH
OpenTargetsiENSG00000170893
Orphaneti238670 Isolated thyrotropin-releasing hormone deficiency
PharmGKBiPA36978

Polymorphism and mutation databases

DMDMi135841

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002250925 – 242Pro-thyrotropin-releasing hormoneAdd BLAST218
PeptideiPRO_000002251084 – 86Thyrotropin-releasing hormone3
PeptideiPRO_0000022511114 – 116Thyrotropin-releasing hormone3
PeptideiPRO_0000022512135 – 137Thyrotropin-releasing hormone3
PeptideiPRO_0000022513152 – 154Thyrotropin-releasing hormone3
PeptideiPRO_0000022514186 – 188Thyrotropin-releasing hormone3
PeptideiPRO_0000022515227 – 229Thyrotropin-releasing hormone3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86Proline amideBy similarity1
Modified residuei116Proline amideBy similarity1
Modified residuei137Proline amideBy similarity1
Modified residuei154Proline amideBy similarity1
Modified residuei188Proline amideBy similarity1
Modified residuei229Proline amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP20396
PeptideAtlasiP20396
PRIDEiP20396
ProteomicsDBi53760

PTM databases

iPTMnetiP20396
PhosphoSitePlusiP20396

Expressioni

Tissue specificityi

Hypothalamus. Expressed in the hair follicle epithelium (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000170893 Expressed in 82 organ(s), highest expression level in endometrium
CleanExiHS_TRH
ExpressionAtlasiP20396 baseline and differential
GenevisibleiP20396 HS

Organism-specific databases

HPAiHPA035596

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20396, 2 interactors
STRINGi9606.ENSP00000303452

Chemistry databases

BindingDBiP20396

Structurei

3D structure databases

ProteinModelPortaliP20396
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRH family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IXZK Eukaryota
ENOG4111JXZ LUCA
GeneTreeiENSGT00390000016951
HOGENOMiHOG000054194
HOVERGENiHBG083494
InParanoidiP20396
KOiK05253
OMAiHPGKRAL
OrthoDBiEOG091G0M01
PhylomeDBiP20396
TreeFamiTF332073

Family and domain databases

InterProiView protein in InterPro
IPR008857 TRH
PANTHERiPTHR17530 PTHR17530, 1 hit
PfamiView protein in Pfam
PF05438 TRH, 1 hit
PIRSFiPIRSF001795 TRH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P20396-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE
60 70 80 90 100
RLLFLRENIQ RLQGDQGEHS ASQIFQSDWL SKRQHPGKRE EEEEEGVEEE
110 120 130 140 150
EEEEGGAVGP HKRQHPGRRE DEASWSVDVT QHKRQHPGRR SPWLAYAVPK
160 170 180 190 200
RQHPGRRLAD PKAQRSWEEE EEEEEREEDL MPEKRQHPGK RALGGPCGPQ
210 220 230 240
GAYGQAGLLL GLLDDLSRSQ GAEEKRQHPG RRAAWVREPL EE
Length:242
Mass (Da):27,404
Last modified:February 1, 1991 - v1
Checksum:i8C0F9D915B32F29F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFM1D6RFM1_HUMAN
Pro-thyrotropin-releasing hormone
TRH
238Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0147878L → V. Corresponds to variant dbSNP:rs5658EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63582, M63581 Genomic DNA Translation: AAA36480.1
AK313473 mRNA Translation: BAG36258.1
CH471052 Genomic DNA Translation: EAW79229.1
BC069375 mRNA Translation: AAH69375.1
BC074888 mRNA Translation: AAH74888.1
BC074889 mRNA Translation: AAH74889.1
BC110515 mRNA Translation: AAI10516.1
BC110516 mRNA Translation: AAI10517.1
CCDSiCCDS3066.1
PIRiA34550 RHHUT
RefSeqiNP_009048.1, NM_007117.4
UniGeneiHs.182231
Hs.732877

Genome annotation databases

EnsembliENST00000302649; ENSP00000303452; ENSG00000170893
GeneIDi7200
KEGGihsa:7200
UCSCiuc003enc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Thyrotropin-releasing hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63582, M63581 Genomic DNA Translation: AAA36480.1
AK313473 mRNA Translation: BAG36258.1
CH471052 Genomic DNA Translation: EAW79229.1
BC069375 mRNA Translation: AAH69375.1
BC074888 mRNA Translation: AAH74888.1
BC074889 mRNA Translation: AAH74889.1
BC110515 mRNA Translation: AAI10516.1
BC110516 mRNA Translation: AAI10517.1
CCDSiCCDS3066.1
PIRiA34550 RHHUT
RefSeqiNP_009048.1, NM_007117.4
UniGeneiHs.182231
Hs.732877

3D structure databases

ProteinModelPortaliP20396
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP20396, 2 interactors
STRINGi9606.ENSP00000303452

Chemistry databases

BindingDBiP20396

PTM databases

iPTMnetiP20396
PhosphoSitePlusiP20396

Polymorphism and mutation databases

DMDMi135841

Proteomic databases

PaxDbiP20396
PeptideAtlasiP20396
PRIDEiP20396
ProteomicsDBi53760

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302649; ENSP00000303452; ENSG00000170893
GeneIDi7200
KEGGihsa:7200
UCSCiuc003enc.5 human

Organism-specific databases

CTDi7200
DisGeNETi7200
EuPathDBiHostDB:ENSG00000170893.3
GeneCardsiTRH
HGNCiHGNC:12298 TRH
HPAiHPA035596
MalaCardsiTRH
MIMi613879 gene
neXtProtiNX_P20396
OpenTargetsiENSG00000170893
Orphaneti238670 Isolated thyrotropin-releasing hormone deficiency
PharmGKBiPA36978
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXZK Eukaryota
ENOG4111JXZ LUCA
GeneTreeiENSGT00390000016951
HOGENOMiHOG000054194
HOVERGENiHBG083494
InParanoidiP20396
KOiK05253
OMAiHPGKRAL
OrthoDBiEOG091G0M01
PhylomeDBiP20396
TreeFamiTF332073

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GenomeRNAii7200
PROiPR:P20396
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170893 Expressed in 82 organ(s), highest expression level in endometrium
CleanExiHS_TRH
ExpressionAtlasiP20396 baseline and differential
GenevisibleiP20396 HS

Family and domain databases

InterProiView protein in InterPro
IPR008857 TRH
PANTHERiPTHR17530 PTHR17530, 1 hit
PfamiView protein in Pfam
PF05438 TRH, 1 hit
PIRSFiPIRSF001795 TRH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRH_HUMAN
AccessioniPrimary (citable) accession number: P20396
Secondary accession number(s): B2R8R1, Q2TB83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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