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Protein

Exendin-3

Gene
N/A
Organism
Heloderma horridum horridum (Mexican beaded lizard)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates vasoactive intestinal peptide (VIP) receptors in high concentrations (>100 nM), resulting in both an increase in cAMP and amylase secretion from pancreatic acini, although at low concentrations (between 0.3 and 3 nM) it increases cAMP without stimulating amylase release. Stimulates the GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor impairing toxin, Hypotensive agent, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Exendin-3
Alternative name(s):
Glucagon-like 3
OrganismiHeloderma horridum horridum (Mexican beaded lizard)
Taxonomic identifieri8552 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaAnguimorphaNeoanguimorphaHelodermatidaeHeloderma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Biotechnological usei

[Lys(40)((68)Ga-DOTA)]exendin-3 is a promising tracer to visualize insulinomas (neuroendocrine tumors derived from pancreatic beta-cells in which GLP1R is expressed at >90%) with PET imaging.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000027113622 – 45Add BLAST24
PeptideiPRO_000004474848 – 86Exendin-3Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86Serine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP20394
SMRiP20394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG081487

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20394-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIILWLCVF GLFLATLFPV SWQMPVESGL SSEDSASSES FASKIKRHSD
60 70 80
GTFTSDLSKQ MEEEAVRLFI EWLKNGGPSS GAPPPSG
Length:87
Mass (Da):9,481
Last modified:January 9, 2007 - v2
Checksum:iE66FA6F15AE5F127
GO

Mass spectrometryi

Molecular mass is 4203.2 Da from positions 48 - 86. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580309 mRNA Translation: CAE30483.1
PIRiA23674 HWGH3Z

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580309 mRNA Translation: CAE30483.1
PIRiA23674 HWGH3Z

3D structure databases

ProteinModelPortaliP20394
SMRiP20394
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG081487

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXE3_HELHO
AccessioniPrimary (citable) accession number: P20394
Secondary accession number(s): Q7SZU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 9, 2007
Last modified: November 22, 2017
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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