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UniProtKB - P20382 (MCH_HUMAN)
Protein
Pro-MCH
Gene
PMCH
Organism
Homo sapiens (Human)
Status
Functioni
MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
GO - Molecular functioni
- melanin-concentrating hormone activity Source: InterPro
- type 1 melanin-concentrating hormone receptor binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- chemical synaptic transmission Source: InterPro
- feeding behavior Source: UniProtKB
- neuropeptide signaling pathway Source: UniProtKB-KW
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Hormone, Neuropeptide |
Biological process | Differentiation, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | P20382 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P20382 |
SIGNORi | P20382 |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-MCHCleaved into the following 3 chains: |
Gene namesi | Name:PMCH Synonyms:MCH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9109, PMCH |
MIMi | 176795, gene |
neXtProti | NX_P20382 |
VEuPathDBi | HostDB:ENSG00000183395 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- nucleus Source: Ensembl
Other locations
- synapse Source: GOC
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5367 |
OpenTargetsi | ENSG00000183395 |
PharmGKBi | PA33435 |
Miscellaneous databases
Pharosi | P20382, Tbio |
Genetic variation databases
BioMutai | PMCH |
DMDMi | 229462960 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000019104 | 22 – 165 | Pro-MCHAdd BLAST | 144 | |
PeptideiPRO_0000019105 | 110 – 128 | Neuropeptide-glycine-glutamic acidSequence analysisAdd BLAST | 19 | |
PeptideiPRO_0000019106 | 131 – 143 | Neuropeptide-glutamic acid-isoleucineAdd BLAST | 13 | |
PeptideiPRO_0000019107 | 147 – 165 | Melanin-concentrating hormoneAdd BLAST | 19 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 143 | Isoleucine amideBy similarity | 1 | |
Disulfide bondi | 153 ↔ 162 | By similarity |
Post-translational modificationi
Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.1 Publication
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bondProteomic databases
MassIVEi | P20382 |
PaxDbi | P20382 |
PeptideAtlasi | P20382 |
PRIDEi | P20382 |
ProteomicsDBi | 53758 |
Expressioni
Tissue specificityi
Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.1 Publication
Gene expression databases
Bgeei | ENSG00000183395, Expressed in hypothalamus and 105 other tissues |
Genevisiblei | P20382, HS |
Organism-specific databases
HPAi | ENSG00000183395, Tissue enriched (brain) |
Interactioni
GO - Molecular functioni
- melanin-concentrating hormone activity Source: InterPro
- type 1 melanin-concentrating hormone receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111380, 15 interactors |
STRINGi | 9606.ENSP00000332225 |
Miscellaneous databases
RNActi | P20382, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the melanin-concentrating hormone family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZ12, Eukaryota |
GeneTreei | ENSGT00390000004984 |
HOGENOMi | CLU_1610172_0_0_1 |
InParanoidi | P20382 |
OMAi | NTFRMGK |
OrthoDBi | 1451976at2759 |
PhylomeDBi | P20382 |
TreeFami | TF330944 |
Family and domain databases
InterProi | View protein in InterPro IPR005456, Prepro-melanin_conc_hormone |
PANTHERi | PTHR12091, PTHR12091, 1 hit |
Pfami | View protein in Pfam PF05824, Pro-MCH, 1 hit |
PRINTSi | PR01641, PROMCHFAMILY |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P20382-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK
60 70 80 90 100
EDTAEKSVIA PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL
110 120 130 140 150
AIKPYLALKG SVAFPAENGV QNTESTQEKR EIGDEENSAK FPIGRRDFDM
160
LRCMLGRVYR PCWQV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | F → S in AAB27493 (PubMed:8326825).Curated | 1 | |
Sequence conflicti | 104 – 106 | PYL → GYQ in AAA63214 (PubMed:2149166).Curated | 3 | |
Sequence conflicti | 113 | A → D in AAA63214 (PubMed:2149166).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57703 mRNA Translation: AAA63214.1 S63697 Genomic DNA Translation: AAB27493.1 CH471054 Genomic DNA Translation: EAW97693.1 BC018048 mRNA Translation: AAH18048.1 |
CCDSi | CCDS31885.1 |
PIRi | I52634 |
RefSeqi | NP_002665.2, NM_002674.3 |
Genome annotation databases
Ensembli | ENST00000329406; ENSP00000332225; ENSG00000183395 |
GeneIDi | 5367 |
KEGGi | hsa:5367 |
MANE-Selecti | ENST00000329406.5; ENSP00000332225.4; NM_002674.4; NP_002665.2 |
UCSCi | uc001tjl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57703 mRNA Translation: AAA63214.1 S63697 Genomic DNA Translation: AAB27493.1 CH471054 Genomic DNA Translation: EAW97693.1 BC018048 mRNA Translation: AAH18048.1 |
CCDSi | CCDS31885.1 |
PIRi | I52634 |
RefSeqi | NP_002665.2, NM_002674.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 111380, 15 interactors |
STRINGi | 9606.ENSP00000332225 |
Genetic variation databases
BioMutai | PMCH |
DMDMi | 229462960 |
Proteomic databases
MassIVEi | P20382 |
PaxDbi | P20382 |
PeptideAtlasi | P20382 |
PRIDEi | P20382 |
ProteomicsDBi | 53758 |
Protocols and materials databases
Antibodypediai | 18038, 153 antibodies from 24 providers |
DNASUi | 5367 |
Genome annotation databases
Ensembli | ENST00000329406; ENSP00000332225; ENSG00000183395 |
GeneIDi | 5367 |
KEGGi | hsa:5367 |
MANE-Selecti | ENST00000329406.5; ENSP00000332225.4; NM_002674.4; NP_002665.2 |
UCSCi | uc001tjl.4, human |
Organism-specific databases
CTDi | 5367 |
DisGeNETi | 5367 |
GeneCardsi | PMCH |
HGNCi | HGNC:9109, PMCH |
HPAi | ENSG00000183395, Tissue enriched (brain) |
MIMi | 176795, gene |
neXtProti | NX_P20382 |
OpenTargetsi | ENSG00000183395 |
PharmGKBi | PA33435 |
VEuPathDBi | HostDB:ENSG00000183395 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZ12, Eukaryota |
GeneTreei | ENSGT00390000004984 |
HOGENOMi | CLU_1610172_0_0_1 |
InParanoidi | P20382 |
OMAi | NTFRMGK |
OrthoDBi | 1451976at2759 |
PhylomeDBi | P20382 |
TreeFami | TF330944 |
Enzyme and pathway databases
PathwayCommonsi | P20382 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P20382 |
SIGNORi | P20382 |
Miscellaneous databases
BioGRID-ORCSi | 5367, 10 hits in 1005 CRISPR screens |
GenomeRNAii | 5367 |
Pharosi | P20382, Tbio |
PROi | PR:P20382 |
RNActi | P20382, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183395, Expressed in hypothalamus and 105 other tissues |
Genevisiblei | P20382, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005456, Prepro-melanin_conc_hormone |
PANTHERi | PTHR12091, PTHR12091, 1 hit |
Pfami | View protein in Pfam PF05824, Pro-MCH, 1 hit |
PRINTSi | PR01641, PROMCHFAMILY |
MobiDBi | Search... |
Entry informationi
Entry namei | MCH_HUMAN | |
Accessioni | P20382Primary (citable) accession number: P20382 Secondary accession number(s): Q16044, Q8WVG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families