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Protein

Pro-MCH

Gene

PMCH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hormone, Neuropeptide
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiP20382

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-MCH
Cleaved into the following 3 chains:
Neuropeptide-glycine-glutamic acid
Short name:
NGE
Short name:
Neuropeptide G-E
Neuropeptide-glutamic acid-isoleucine
Short name:
NEI
Short name:
Neuropeptide E-I
Gene namesi
Name:PMCH
Synonyms:MCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000183395.4
HGNCiHGNC:9109 PMCH
MIMi176795 gene
neXtProtiNX_P20382

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5367
OpenTargetsiENSG00000183395
PharmGKBiPA33435

Polymorphism and mutation databases

BioMutaiPMCH
DMDMi229462960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001910422 – 165Pro-MCHAdd BLAST144
PeptideiPRO_0000019105110 – 128Neuropeptide-glycine-glutamic acidSequence analysisAdd BLAST19
PeptideiPRO_0000019106131 – 143Neuropeptide-glutamic acid-isoleucineAdd BLAST13
PeptideiPRO_0000019107147 – 165Melanin-concentrating hormoneAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143Isoleucine amideBy similarity1
Disulfide bondi153 ↔ 162By similarity

Post-translational modificationi

Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP20382
PeptideAtlasiP20382
PRIDEiP20382
ProteomicsDBi53758

Miscellaneous databases

PMAP-CutDBiQ8WVG0

Expressioni

Tissue specificityi

Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.1 Publication

Gene expression databases

BgeeiENSG00000183395
CleanExiHS_PMCH
GenevisibleiP20382 HS

Organism-specific databases

HPAiHPA046055
HPA061884

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111380, 14 interactors
STRINGi9606.ENSP00000332225

Structurei

3D structure databases

ProteinModelPortaliP20382
SMRiP20382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW1Y Eukaryota
ENOG410XWB7 LUCA
GeneTreeiENSGT00390000004984
HOGENOMiHOG000230520
HOVERGENiHBG052429
InParanoidiP20382
KOiK05229
OMAiAGSKHNF
OrthoDBiEOG091G0R53
PhylomeDBiP20382
TreeFamiTF330944

Family and domain databases

InterProiView protein in InterPro
IPR005456 Prepro-melanin_conc_hormone
PANTHERiPTHR12091 PTHR12091, 1 hit
PfamiView protein in Pfam
PF05824 Pro-MCH, 1 hit
PRINTSiPR01641 PROMCHFAMILY

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK
60 70 80 90 100
EDTAEKSVIA PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL
110 120 130 140 150
AIKPYLALKG SVAFPAENGV QNTESTQEKR EIGDEENSAK FPIGRRDFDM
160
LRCMLGRVYR PCWQV
Length:165
Mass (Da):18,679
Last modified:May 5, 2009 - v3
Checksum:i2339E8938EBEC499
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42F → S in AAB27493 (PubMed:8326825).Curated1
Sequence conflicti104 – 106PYL → GYQ in AAA63214 (PubMed:2149166).Curated3
Sequence conflicti113A → D in AAA63214 (PubMed:2149166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57703 mRNA Translation: AAA63214.1
S63697 Genomic DNA Translation: AAB27493.1
CH471054 Genomic DNA Translation: EAW97693.1
BC018048 mRNA Translation: AAH18048.1
CCDSiCCDS31885.1
PIRiI52634
RefSeqiNP_002665.2, NM_002674.3
UniGeneiHs.707990

Genome annotation databases

EnsembliENST00000329406; ENSP00000332225; ENSG00000183395
GeneIDi5367
KEGGihsa:5367
UCSCiuc001tjl.4 human

Similar proteinsi

Entry informationi

Entry nameiMCH_HUMAN
AccessioniPrimary (citable) accession number: P20382
Secondary accession number(s): Q16044, Q8WVG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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