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Protein

4-carboxymuconolactone decarboxylase

Gene

pcaC

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2.

Pathwayi: beta-ketoadipate pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-carboxy-cis,cis-muconate cycloisomerase (pcaB)
  2. 4-carboxymuconolactone decarboxylase (pcaC)
This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processAromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciASP62977:ACIAD_RS07880-MONOMER
UniPathwayi
UPA00157;UER00266

Names & Taxonomyi

Protein namesi
Recommended name:
4-carboxymuconolactone decarboxylase (EC:4.1.1.44)
Short name:
CMD
Gene namesi
Name:pcaC
Ordered Locus Names:ACIAD1710
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797981 – 1344-carboxymuconolactone decarboxylaseAdd BLAST134

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD1710

Structurei

3D structure databases

ProteinModelPortaliP20370
SMRiP20370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108UWZ Bacteria
COG0599 LUCA
HOGENOMiHOG000034935
KOiK01607
OMAiWDEMGVE
OrthoDBiPOG091H0CJX

Family and domain databases

Gene3Di1.20.1290.10, 1 hit
InterProiView protein in InterPro
IPR029032 AhpD-like
IPR003779 CMD-like
IPR012788 Decarb_PcaC
PfamiView protein in Pfam
PF02627 CMD, 1 hit
SUPFAMiSSF69118 SSF69118, 1 hit
TIGRFAMsiTIGR02425 decarb_PcaC, 1 hit

Sequencei

Sequence statusi: Complete.

P20370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDEQRYKQG LEVRTEVLGE KHVNRSLENL NDFNQDFQNF ISRFAWGEVW
60 70 80 90 100
SRPGLPRHTR SLVTIAVLLA LGREDELRMH LRACFNNGVT KDELKELILH
110 120 130
CSLYAGLPAS NAAMHMAEEV FKDLGIAPEK VNKD
Length:134
Mass (Da):15,364
Last modified:August 31, 2004 - v2
Checksum:iDEE1D61BE1C28A60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79 – 80MH → ID in AAC37152 (PubMed:2298704).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05770 Genomic DNA Translation: AAC37152.1
CR543861 Genomic DNA Translation: CAG68552.1
PIRiB35119
RefSeqiWP_004926631.1, NC_005966.1

Genome annotation databases

EnsemblBacteriaiCAG68552; CAG68552; ACIAD1710
KEGGiaci:ACIAD1710

Similar proteinsi

Entry informationi

Entry nameiDC4C_ACIAD
AccessioniPrimary (citable) accession number: P20370
Secondary accession number(s): Q6FBL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 31, 2004
Last modified: September 12, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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